scholarly journals Efficient high-throughput SARS-CoV-2 testing to detect asymptomatic carriers

2020 ◽  
Vol 6 (37) ◽  
pp. eabc5961 ◽  
Author(s):  
Noam Shental ◽  
Shlomia Levy ◽  
Vered Wuvshet ◽  
Shosh Skorniakov ◽  
Bar Shalem ◽  
...  
Keyword(s):  
Health Care ◽  
Severe Acute Respiratory Syndrome ◽  
Health Care Workers ◽  
Symptom Onset ◽  
Diagnostic Testing ◽  
Disease Spread ◽  
Viral Shedding ◽  
Care Workers ◽  
Pooling Strategy ◽  
Combinatorial Pooling

Recent reports suggest that 10 to 30% of severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) infected patients are asymptomatic and that viral shedding may occur before symptom onset. Therefore, there is an urgent need to increase diagnostic testing capabilities to prevent disease spread. We developed P-BEST, a method for Pooling-Based Efficient SARS-CoV-2 Testing, which identifies all positive subjects within a set of samples using a single round of testing. Each sample is assigned into multiple pools using a combinatorial pooling strategy based on compressed sensing. We pooled sets of 384 samples into 48 pools, providing both an eightfold increase in testing efficiency and an eightfold reduction in test costs, while identifying up to five positive carriers. We then used P-BEST to screen 1115 health care workers using 144 tests. P- BEST provides an efficient and easy-to-implement solution for increasing testing capacity that can be easily integrated into diagnostic laboratories.

scholarly journals A super-spreader of SARS-CoV-2 in incubation period among health-care workers

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Chaojie Wei ◽  
Yufeng Yuan ◽  
Zhenshun Cheng
Keyword(s):  
Health Care ◽  
Severe Acute Respiratory Syndrome ◽  
World Health Organization ◽  
Incubation Period ◽  
Health Care Workers ◽  
World Health ◽  
Doctor Who ◽  
Care Workers ◽  
Potential Sources ◽  
Health Organization

AbstractSince the coronavirus disease 2019 (COVID-19) identified in Wuhan, Hubei, China in December 2019, it has been characterized as a pandemic by World Health Organization (WHO). It was reported that asymptomatic persons are potential sources of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We present an outbreak among health-care workers incited by a doctor who cared a patient with COVID-19 in a Hospital in Wuhan, Hubei, China, which indicates existence of super-spreader even during incubation period.

scholarly journals COVID-19 infection outbreak among health care workers: perspective from a low-middle income country

2020 ◽  
Vol 90 (3) ◽  
Author(s):  
Nishanth Dev ◽  
Vijay Kumar ◽  
Jhuma Sankar
Keyword(s):  
Health Care ◽  
Severe Acute Respiratory Syndrome ◽  
Health Care Workers ◽  
Middle Income Country ◽  
Income Country ◽  
Middle Income ◽  
Corona Virus ◽  
Care Workers ◽  
Global Threat

To the Editor, The new pandemic COVID -19 caused by Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) is a global threat. So far, more than 11 million infections and more than five hundred thousand deaths have been reported worldwide. In India the number of cases as of 5th July, 2020 is 6,73,165 with 19,268 deaths. Health care workers (HCWs) have been the backbone of this pandemic since the very beginning...

scholarly journals Infection, screening, and psychological stress of health care workers with COVID-19 in a non-frontline clinical department

2020 ◽  
pp. 1-25
Author(s):  
Ge Wang ◽  
Jia-Lun Guan ◽  
Xiu-Qing Zhu ◽  
Mu-Ru Wang ◽  
Dan Fang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Health Care ◽  
Psychological Stress ◽  
Health Care Workers ◽  
Close Contact ◽  
Endoscopic Examination ◽  
Viral Shedding ◽  
Clinical Department ◽  
Care Workers ◽  
Ward Rounds

ABSTRACT Objective: To investigate risk factors and psychological stress of health care workers (HCWs) with COVID-19 in a non-frontline clinical department. Methods: Data of 2 source patients and all HCWs with infection risk were obtained in a department in Wuhan from January to February 2020. A questionnaire was designed to evaluate psychological stress of COVID-19 on HCWs. Results: The overall infection rate was 4.8% in HCWs. 10 of 25 HCWs who contacted with 2 source patients were diagnosed with confirmed COVID-19 (8/10) and suspected COVID-19 (2/10). Other 2 HCWs were transmitted by other patients or colleagues. Close care behaviours included physical examination (6/12), life nursing (4/12), ward rounds (4/12), endoscopic examination (2/12). Contacts fluctuated from 1 to 24 times and each contact was short (8.1 min ± 5.6 min). HCWs wore surgical masks (11/12), gloves (7/12), and isolation clothing (3/12) when providing medical care. Most HCWs experienced a mild course with 2 asymptomatic infections, taking 9.8 days and 20.9 days to obtain viral shedding and clinical cure, respectively. Psychological stress included worry (58.3%), anxiety (83.3%), depression (58.3%), and insomnia (58.3%). Conclusions: Close contact with COVID-19 patients and insufficient protection were key risk factors. Precaution measures and psychological support on COVID-19 is urgently required for HCWs.

scholarly journals Hemodialysis with Cohort Isolation to Prevent Secondary Transmission during a COVID-19 Outbreak in Korea

2020 ◽  
Vol 31 (7) ◽  
pp. 1398-1408 ◽  
Author(s):  
Jang-Hee Cho ◽  
Seok Hui Kang ◽  
Hayne Cho Park ◽  
Dong Ki Kim ◽  
Sang-Ho Lee ◽  
...  
Keyword(s):  
Health Care ◽  
Severe Acute Respiratory Syndrome ◽  
Health Care Workers ◽  
Screening Test ◽  
Multicenter Cohort Study ◽  
Secondary Transmission ◽  
Care Workers ◽  
Rapid Spread ◽  
Health Care Associated Infections ◽  
Close Contacts

Background Health care–associated infections during previous coronavirus epidemics involving severe acute respiratory syndrome and Middle East respiratory syndrome resulted from human-to-human transmission in hemodialysis (HD) facilities. The effect of a strategy of HD with cohort isolation—separate dialysis sessions for close contacts of patients with confirmed coronavirus disease 2019 (COVID-19)—on the prevention of secondary transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in HD units is unknown.MethodsOur multicenter cohort study of an HD with cohort isolation strategy enrolled close contacts of patients with confirmed COVID-19, including patients on HD and health care workers in HD units. Close contacts had been identified by epidemiologic investigation and tested negative on an immediate screening test for SARS-CoV-2.ResultsAs of March 14, 11 patients on HD and 7 health care workers from 11 HD centers were diagnosed as having COVID-19. The immediate screening test was performed in 306 people, and among them, 302 close contacts with negative test results were enrolled. HD with cohort isolation was performed among all close contacts for a median of 14 days in seven centers. During cohort isolation, nine patients showed symptoms but tested negative for SARS-CoV-2. Two health care workers in the HD units (0.66% of the total group) were diagnosed at the termination test for SARS-CoV-2.ConclusionsThe transmission of COVID-19 can be controlled without closure of HD centers by implementing preemptive activities, including early detection with rapid testing, cohort isolation, collaboration between institutions, and continuous monitoring of infection. Our strategy and experience may provide helpful guidance for circumstances involving the rapid spread of infectious diseases such as COVID-19.

Fear of Severe Acute Respiratory Syndrome (SARS) Among Health Care Workers.

2005 ◽  
Vol 73 (2) ◽  
pp. 344-349 ◽  
Author(s):  
Samuel M. Y. Ho ◽  
Rosalie S. Y. Kwong-Lo ◽  
Christine W. Y. Mak ◽  
Joe S. Wong
Keyword(s):  
Health Care ◽  
Severe Acute Respiratory Syndrome ◽  
Health Care Workers ◽  
Care Workers
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