Platelets worsen tuberculosis disease progression: Specific mechanism TBD

2020 ◽  
Vol 12 (546) ◽  
pp. eabc8940
Author(s):  
Steven P. Keller
Keyword(s):  
Disease Progression ◽  
Alveolar Macrophages ◽  
Oxidative Burst ◽  
Specific Mechanism ◽  
Unknown Mechanism ◽  
Tuberculosis Disease

Platelets contribute to the progression of tuberculosis by impairing the oxidative burst of alveolar macrophages via an unknown mechanism.

Particulate Load From Biomass Smoke Is Associated With Increased Oxidative Burst And Reduced Proteolysis in Alveolar Macrophages

2010 ◽  
Author(s):  
Duncan G. Fullerton ◽  
David Mzinza ◽  
Sarah Glennie ◽  
Kondwani Jambo ◽  
Steve Barrett ◽  
...  
Keyword(s):  
Alveolar Macrophages ◽  
Oxidative Burst ◽  
Biomass Smoke

scholarly journals Identification of Probable Early-Onset Biomarkers for Tuberculosis Disease Progression

PLoS ONE ◽  
2011 ◽  
Vol 6 (9) ◽  
pp. e25230 ◽  
Author(s):  
Jayne S. Sutherland ◽  
Philip C. Hill ◽  
Ifedayo M. Adetifa ◽  
Bouke C. de Jong ◽  
Simon Donkor ◽  
...  
Keyword(s):  
Disease Progression ◽  
Early Onset ◽  
Tuberculosis Disease

scholarly journals Lactoferrin Augmentation of the BCG Vaccine Leads to Increased Pulmonary Integrity

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Shen-An Hwang ◽  
Kerry J. Welsh ◽  
Marian L. Kruzel ◽  
Jeffrey K. Actor
Keyword(s):  
Disease Progression ◽  
Pulmonary Disease ◽  
Current Literature ◽  
Molecular Mechanisms ◽  
Bcg Vaccine ◽  
Organism Growth ◽  
Severe Manifestation ◽  
The Individual ◽  
Tuberculosis Disease

The goal of vaccination to prevent tuberculosis disease (TB) is to offer long-term protection to the individual and the community. In addition, the success of any protective TB vaccine should include the ability to limit cavitary formation and disease progression. The current BCG vaccine protects against disseminated TB disease in children by promoting development of antigenic-specific responses. However, its efficacy is limited in preventing postprimary pulmonary disease in adults that is responsible for the majority of disease and transmission. This paper illustrates the use of lactoferrin as an adjuvant to boost efficacy of the BCG vaccine to control organism growth and limit severe manifestation of pulmonary disease. This resulting limitation in pathology may ultimately, limit spread of bacilli and subsequent transmission of organisms between individuals. The current literature is reviewed, and data is presented to support molecular mechanisms underlying lactoferrin's utility as an adjuvant for the BCG vaccine.

scholarly journals Nutritional status positively impacts humoral immunity against its Mycobacterium tuberculosis, disease progression, and vaccine development

PLoS ONE ◽  
2020 ◽  
Vol 15 (8) ◽  
pp. e0237062 ◽  
Author(s):  
Mamiko Niki ◽  
Takashi Yoshiyama ◽  
Hideaki Nagai ◽  
Yuji Miyamoto ◽  
Makoto Niki ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Nutritional Status ◽  
Disease Progression ◽  
Humoral Immunity ◽  
Vaccine Development ◽  
Tuberculosis Disease

Cold Weather Exercise Induces Oxidative Burst Activity In Alveolar Macrophages

2007 ◽  
Vol 39 (Supplement) ◽  
pp. S275
Author(s):  
Michael S. Davis ◽  
Sabrina Cummings ◽  
Katherine Williamson ◽  
Virginia Buechner-Maxwell
Keyword(s):  
Alveolar Macrophages ◽  
Oxidative Burst ◽  
Burst Activity ◽  
Cold Weather ◽  
Oxidative Burst Activity
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