scholarly journals Tolerance of Benznidazole in Treatment of Chagas' Disease in Adults

2010 ◽  
Vol 54 (11) ◽  
pp. 4896-4899 ◽  
Author(s):  
María-Jesús Pinazo ◽  
José Muñoz ◽  
Elizabeth Posada ◽  
Paulo López-Chejade ◽  
Montserrat Gállego ◽  
...  
Keyword(s):  
Public Health ◽  
Side Effects ◽  
Trypanosoma Cruzi ◽  
European Country ◽  
Chagas Disease ◽  
Health Problem ◽  
Public Health Problem ◽  
Acute Stage ◽  
Chronic Stage

ABSTRACT Chagas’ disease is an emerging public health problem in areas where the disease is not endemic. Treatment with benznidazole has shown efficacy in the acute stage of the disease, but its efficacy in the chronic stage remains controversial, and unwanted side effects are more frequent and severe in adults than in children. This study describes the profile of side effects of benznidazole in a cohort of Trypanosoma cruzi-infected patients in a European country.

Development of new dinuclear Fe(III) coordination compounds with in vitro nanomolar antitrypanosomal activity

2021 ◽  
Author(s):  
Felipe Figuerôa Moreira ◽  
Juliana de Araujo Portes ◽  
Nathalia Florencia Barros Azeredo ◽  
Christiane Fernandes ◽  
Adolfo Horn ◽  
...  
Keyword(s):  
Public Health ◽  
Trypanosoma Cruzi ◽  
Chagas Disease ◽  
Health Problem ◽  
Coordination Compounds ◽  
Public Health Problem ◽  
Neglected Tropical Disease ◽  
Major Public Health Problem ◽  
Protozoan Pathogen

Chagas disease is a neglected tropical disease caused by the protozoan pathogen Trypanosoma cruzi. The disease is the major public health problem affecting about 6 to 7 million people worldwide,...

Chagas disease and coumarins: a review of natural and synthetic coumarins as anti-Trypanosoma cruzi agents

2020 ◽  
Vol 21 ◽  
Author(s):  
Guilherme Arraché Gonçalves ◽  
Hugo Cerecetto ◽  
Gilsane Lino von Poser ◽  
Rômulo Faria Santos Canto ◽  
Vera Lucia Eifler-Lima
Keyword(s):  
Public Health ◽  
Trypanosoma Cruzi ◽  
Chagas Disease ◽  
Health Problem ◽  
Biological Activities ◽  
Wide Spectrum ◽  
Public Health Problem ◽  
Neglected Tropical Disease ◽  
Limited Efficacy ◽  
Natural And Synthetic

The complexity of Chagas disease is still a challenge in endemic regions and an emergent public health problem in non-endemic countries. The causative agent of this neglected tropical disease, Trypanosoma cruzi, is mainly transmitted by triatomine vectors and possesses multiple epidemiologically important strains. Current chemotherapeutics are outdated and their limited efficacy is one of the major reasons for treatment discontinuation. In this context, it is urgent the development of novel, safe and economically accessible antichagasic drugs. Various classes of heterocycles and natural compounds have been described as potential antichagasic scaffolds, and coumarins are no exception. These versatile compounds have a wide spectrum of biological activities, and numerous natural and synthetic coumarins have been reported with antichagasic potential. The aim of this review is to discuss the available literature between 2001 and 2020 regarding natural and synthetic coumarins with anti-Trypanosoma cruzi activity. Moreover, some of the studies herein comprised are dedicated to the potential of coumarins to inhibit promising targets in Trypanosoma cruzi.

scholarly journals Arthritis and Benznidazole: More Closely Related than We Thought

2014 ◽  
Vol 59 (1) ◽  
pp. 727-729 ◽  
Author(s):  
E. Aldasoro ◽  
M. J. Pinazo ◽  
I. Oliveira ◽  
J. Munoz ◽  
E. Posada ◽  
...  
Keyword(s):  
Public Health ◽  
Chagas Disease ◽  
Health Problem ◽  
Parasitic Infection ◽  
Public Health Problem ◽  
Drug Reactions ◽  
Content Type ◽  
Significant Public Health Problem ◽  
Rare Side Effect ◽  
Significant Public Health

ABSTRACTChagas disease is a parasitic infection that leads to a significant public health problem in countries where the disease is endemic and where it is nonendemic. Benznidazole is the most commonly used drug for the etiological treatment of Chagas disease. Patients treated with benznidazole suffer frequent adverse drug reactions. Although arthralgia is common, arthritis has been reported as a very rare side effect. The objective of this study was to describe arthritis in a cohort ofTrypanosoma cruzi-infected patients treated with benznidazole.

DISTRIBUTION OF TRIATOMINES (HETEROPTERA: REDUVIIDAE) ASSOCIATED WITH HUMAN HABITATION AND POTENTIAL RISK AREAS IN SIX STATES OF THE MEXICAN REPUBLIC

2020 ◽  
Vol 5 ◽  
Author(s):  
José Ismael Benítez-Alva ◽  
Herón Huerta ◽  
Juan Luis Téllez-Rendón
Keyword(s):  
Public Health ◽  
Latin America ◽  
Trypanosoma Cruzi ◽  
Potential Risk ◽  
Health Problem ◽  
Natural Infection ◽  
Public Health Problem ◽  
Distribution Maps ◽  
Risk Areas ◽  
Human Habitation

Chagas disease is a real public health problem in Latin America, caused by the flagellate protozoan<br />Trypanosoma cruzi and described by Carlos Chagas in 1909. T. cruzi is transmitted by bloodsucking<br />insects of the subfamily Triatominae which thrive in sylvatic, peridomestic, and domestic habitats,<br />being in the latter two a potential risk to public health because of their role as vectors. We review the<br />distribution of triatomines associated with human habitation and their natural infection with T. cruzi<br />from the states of Aguascalientes, Chiapas, Guerrero, Jalisco, Michoacán, and Oaxaca. Based on<br />samples received in the Laboratory of Entomology of the Institute of Epidemiological Diagnosis and<br />Reference (InDRE-SSA) during the period 2006 to 2010, distribution maps and stratification of potential<br />areas of risk were made. A total of 1910 specimens of seven species of triatomines were identified.<br />Triatoma barberi, Meccus longipennis and M. pallidipennis were the species with the highest rate of<br />infection with T. cruzi; M. pallidipennis and T. dimidiata were the most widely distributed species.

scholarly journals A MULTIDISCIPLINARY, COLLABORATIVE, INTER-AGENCY AND COMPREHENSIVE APPROACH FOR THE CONTROL OF CHAGAS DISEASE AS A PUBLIC HEALTH PROBLEM IN GUATEMALA

Acta Tropica ◽  
2021 ◽  
pp. 106157
Author(s):  
María Carlota Monroy ◽  
Daniel Penados ◽  
José Pineda ◽  
Elisa Laparra Ruiz ◽  
Emmanuel O. Agreda ◽  
...  
Keyword(s):  
Public Health ◽  
Chagas Disease ◽  
Health Problem ◽  
Public Health Problem ◽  
Comprehensive Approach

Basics of Pediatric Pain Management

2019 ◽  
pp. 306-318
Author(s):  
Tommy Rappold ◽  
Matthew Digiusto ◽  
M-Irfan Suleman
Keyword(s):  
Public Health ◽  
Pain Management ◽  
Side Effects ◽  
Health Problem ◽  
Coping Skills ◽  
Public Health Problem ◽  
Pediatric Pain ◽  
Significant Public Health Problem ◽  
Common Causes ◽  
Significant Public Health

Chapter 18 covers the basics of pediatric pain management. Pediatric pain is a significant public health problem leading to lost days of school, increased use of the healthcare system, and multifactorial impact on all aspects of a child’s life. Pediatric patients present special clinical challenges because of variabilities in metabolism, susceptibility to disease and side effects, ability to communicate, developmental stage, coping skills, and support systems. This chapter serves as an introduction to the main features of pediatric pain management and reviews pain assessment, common causes of pain both acute and chronic, and basic nonpharmacologic and pharmacologic strategies in patients ranging from neonates to adolescents.

scholarly journals Image-Based In Vitro Screening Reveals the Trypanostatic Activity of Hydroxymethylnitrofurazone against Trypanosoma cruzi

2021 ◽  
Vol 22 (13) ◽  
pp. 6930
Author(s):  
Cauê Benito Scarim ◽  
Francisco Olmo ◽  
Elizabeth Igne Ferreira ◽  
Chung Man Chin ◽  
John M. Kelly ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Chagas Disease ◽  
Ex Vivo ◽  
Therapeutic Option ◽  
Acute Stage ◽  
Reporter Strain ◽  
Fluorescent Reporter ◽  
Chronic Stage

Hydroxymethylnitrofurazone (NFOH) is a therapeutic candidate for Chagas disease (CD). It has negligible hepatotoxicity in a murine model compared to the front-line drug benznidazole (BZN). Here, using Trypanosoma cruzi strains that express bioluminescent and/or fluorescent reporter proteins, we further investigated the in vitro and in vivo activity of NFOH to define whether the compound is trypanocidal or trypanostatic. The in vitro activity was assessed by exploiting the fluorescent reporter strain using wash-out assays and real-time microscopy. For animal experimentation, BALB/c mice were inoculated with the bioluminescent reporter strain and assessed by highly sensitive in vivo and ex vivo imaging. Cyclophosphamide treatment was used to promote parasite relapse in the chronic stage of infection. Our data show that NFOH acts by a trypanostatic mechanism, and that it is more active than BZN in vitro against the infectious trypomastigote form of Trypanosoma cruzi. We also found that it is more effective at curing experimental infections in the chronic stage, compared with the acute stage, a feature that it shares with BZN. Therefore, given its reduced toxicity, enhanced anti-trypomastigote activity, and curative properties, NFOH can be considered as a potential therapeutic option for Chagas disease, perhaps in combination with other trypanocidal agents.

scholarly journals THE UNEXPECTED MEDIASTINAL EXTENSION IN A CASE OF LUNG CANCER: THE ROLE OF IMAGING AND MULTIPLE SIDE-EFFECTS WITH CLINICAL RELEVANCE FOLLOWING TOPIRAMATE THERAPY

2018 ◽  
Vol 6 (9) ◽  
pp. 478-486
Author(s):  
Daniela Cipu ◽  
Dan Simion Cipu ◽  
Agneta Maria Pusztai ◽  
Anca Alexandra Matusz
Keyword(s):  
Public Health ◽  
Lung Cancer ◽  
Side Effects ◽  
Health Problem ◽  
Correct Diagnosis ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
The World ◽  
Mediastinal Extension

Bronchopulmonary neoplasm is the first cause of cancer mortality in the world and a major public health problem, affecting 17% of men and 12% of women; in this context it is very important and necessary to establish the correct diagnosis in the early stages of the disease in order to initiate the required surgical therapy [1]

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