Repurposing Thiram and Disulfiram as Antibacterial Agents for Multidrug-Resistant Staphylococcus aureus Infections
Keyword(s):
ABSTRACT Thiram and disulfiram were evaluated as antibacterial agents against multidrug-resistant Staphylococcus aureus. Against a 30-member panel comprised of vancomycin-susceptible, vancomycin-intermediate, and vancomycin-resistant S. aureus strains, the MIC90 values of the respective test agents were 4 and 16 μg/ml. Additional analyses revealed that thiram and disulfiram are rapid-acting bacteriostatic agents with narrow, Gram-positive-bacterium spectrum activity. Synergy studies further determined that disulfiram increases the vancomycin susceptibility of three clinical vancomycin-resistant S. aureus strains in vitro, thus establishing a potential use in combination therapy.
2016 ◽
Vol 60
(4)
◽
pp. 2352-2358
◽
2016 ◽
Vol 54
(9)
◽
pp. 2225-2232
◽
2011 ◽
Vol 56
(3)
◽
pp. 1584-1587
◽
2016 ◽
Vol 60
(7)
◽
pp. 4342-4345
◽
2016 ◽
Vol 60
(5)
◽
pp. 3178-3182
◽
Keyword(s):
2011 ◽
Vol 56
(1)
◽
pp. 202-207
◽
2012 ◽
Vol 56
(10)
◽
pp. 5296-5302
◽
Keyword(s):
2015 ◽
Vol 59
(5)
◽
pp. 2842-2848
◽