Acfr-Like Gene from Clostridium difficile Confers Multiple Antibiotic Resistance by the Same Mechanism as thecfrGene
2015 ◽
Vol 59
(9)
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pp. 5841-5843
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Keyword(s):
23S Rrna
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ABSTRACTThe Cfr RNA methyltransferase causes multiple resistances to peptidyl transferase inhibitors by methylation of A2503 23S rRNA. Manycfr-like gene sequences in the databases code for unknown functions. This study confirms that a Cfr-like protein from aPeptoclostridium difficile(formerlyClostridium difficile) strain does function as a Cfr protein. The enzyme is expressed inEscherichia coliand shows elevated MICs for five classes of antibiotics. A primer extension stop indicates a modification at A2503 in 23S rRNA.
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2011 ◽
Vol 55
(5)
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pp. 2438-2441
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1996 ◽
Vol 178
(9)
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pp. 2507-2513
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1997 ◽
Vol 41
(12)
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pp. 2699-2704
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2015 ◽
Vol 22
(14)
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pp. 10969-10980
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