Characterization of β-d-N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus

ABSTRACT Chikungunya virus (CHIKV) represents a reemerging global threat to human health. Recent outbreaks across Asia, Europe, Africa, and the Caribbean have prompted renewed scientific interest in this mosquito-borne alphavirus. There are currently no vaccines against CHIKV, and treatment has been limited to nonspecific antiviral agents, with suboptimal outcomes. Herein, we have identified β-d-N 4-hydroxycytidine (NHC) as a novel inhibitor of CHIKV. NHC behaves as a pyrimidine ribonucleoside and selectively inhibits CHIKV replication in cell culture.

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Nitrogen-Based Heterocyclic Compounds: A Promising Class of Antiviral Agents against Chikungunya Virus

Life ◽

10.3390/life11010016 ◽

2020 ◽

Vol 11 (1) ◽

pp. 16

Author(s):

Andreza C. Santana ◽

Ronaldo C. Silva Filho ◽

José C. J. M. D. S. Menezes ◽

Diego Allonso ◽

Vinícius R. Campos

Keyword(s):

Antiviral Activity ◽

Mechanism Of Action ◽

Heterocyclic Compounds ◽

Chikungunya Virus ◽

Antiviral Agents ◽

Antiviral Drug ◽

Important Class ◽

Available Nitrogen ◽

Global Threat ◽

Present Understanding

Arboviruses, in general, are a global threat due to their morbidity and mortality, which results in an important social and economic impact. Chikungunya virus (CHIKV), one of the most relevant arbovirus currently known, is a re-emergent virus that causes a disease named chikungunya fever, characterized by a severe arthralgia (joint pains) that can persist for several months or years in some individuals. Until now, no vaccine or specific antiviral drug is commercially available. Nitrogen heterocyclic scaffolds are found in medications, such as aristeromycin, favipiravir, fluorouracil, 6-azauridine, thioguanine, pyrimethamine, among others. New families of natural and synthetic nitrogen analogous compounds are reported to have significant anti-CHIKV effects. In the present work, we focus on these nitrogen-based heterocyclic compounds as an important class with CHIKV antiviral activity. We summarize the present understanding on this class of compounds against CHIKV and also present their possible mechanism of action.

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Characterization of differentAedes aegyptipopulations in Florida for interfering with chikungunya virus transmission

10.1603/ice.2016.114610 ◽

2016 ◽

Author(s):

Chelsea Smartt

Keyword(s):

Chikungunya Virus ◽

Virus Transmission

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Physicochemical and bacteriological characterization of hospital effluents and their impact on the environment

10.31221/osf.io/rbka9 ◽

2019 ◽

Author(s):

Chem Int

Keyword(s):

Human Health ◽

Fecal Coliforms ◽

Chemical Pollution ◽

Hospital Effluents ◽

Biological Contaminants ◽

Almost All ◽

Direct Discharge ◽

Significant Chemical

Liquid effluents discharged by hospitals may contain chemical and biological contaminants whose main source is the different substances used for the treatment of patients. This type of rejection can present a sanitary potentially dangerous risk for human health and can provoke a strong degradation of diverse environmental compartments mainly water and soils. The present study focuses on the quality of the liquid effluents of Hassani Abdelkader’s hospital of Sidi Bel-Abbes (West of Algeria). The results reveal a significant chemical pollution (COD: 879 mgO2/L, BOD5: 850 mgO2/L, NH4+ : 47.9 mg/l, NO2- : 4.2 mg/l, NO3- : 56.8 mg/l with respect to WHO standard of 90 mgO2/L, 30 mgO2/L, 0.5 mg/l, 1 mg/l and 1 mg/l respectively). However, these effluents are biodegradable since the ratio COD/BOD5 do not exceeded the value of 2 in almost all samples. The presence of pathogen germs is put into evidence such as pseudomonas, the clostridium, the staphylococcus, the fecal coliforms and fecal streptococcus. These results show that the direct discharge of these effluents constitutes a major threat to human health and the environment.

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Faculty Opinions recommendation of Characterization of β-d-N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.727254789.793539886 ◽

2017 ◽

Author(s):

Suresh Mahalingam ◽

Ali Zaid

Keyword(s):

Chikungunya Virus

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Recent Review on Subclass B1 Metallo-β-lactamases Inhibitors: Sword for Antimicrobial Resistance

Current Drug Targets ◽

10.2174/1389450120666181217101812 ◽

2019 ◽

Vol 20 (7) ◽

pp. 756-762 ◽

Cited By ~ 2

Author(s):

Aditi Kaushik ◽

Manish Kaushik ◽

Viney Lather ◽

J.S. Dua

Keyword(s):

Antibiotic Resistance ◽

Multidrug Resistance ◽

Antimicrobial Resistance ◽

Global Health ◽

Human Health ◽

Microbial Pathogens ◽

Present Review ◽

Drug Molecules ◽

Global Threat ◽

Powerful Strategy

An emerging crisis of antibiotic resistance for microbial pathogens is alarming all the nations, posing a global threat to human health. The production of the metallo-β-lactamase enzyme is the most powerful strategy of bacteria to produce resistance. An efficient way to combat this global health threat is the development of broad/non-specific type of metallo-β-lactamase inhibitors, which can inhibit the different isoforms of the enzyme. Till date, there are no clinically active drugs against metallo- β-lactamase. The lack of efficient drug molecules against MBLs carrying bacteria requires continuous research efforts to overcome the problem of multidrug-resistance bacteria. The present review will discuss the clinically potent molecules against different variants of B1 metallo-β-lactamase.

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