KY-62, a Polyene Analog of Amphotericin B, for Treatment of Murine Candidiasis
1998 ◽
Vol 42
(1)
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pp. 147-150
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Keyword(s):
ABSTRACT KY-62 is a water-soluble analog of amphotericin B. In vitro testing of five clinical isolates of Candida albicans showed KY-62 to have potency similar to that of amphotericin B. KY-62 was administered to mice infected intravenously with C. albicans. In vivo, KY-62 was effective in immunocompetent mice, with potency similar to that of amphotericin B. KY-62 was well tolerated up to 30 mg/kg of body weight per dose, an amount that would be lethal with amphotericin B. KY-62 was less effective in mice rendered neutropenic with 5-fluorouracil. The addition of flucytosine had little effect. KY-62 may have potential for clinical development.
2005 ◽
Vol 49
(2)
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pp. 638-642
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Keyword(s):
2014 ◽
Vol 59
(2)
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pp. 1341-1343
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Keyword(s):
2001 ◽
Vol 45
(2)
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pp. 485-494
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Keyword(s):
2002 ◽
Vol 46
(5)
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pp. 1240-1245
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Keyword(s):
2006 ◽
Vol 51
(2)
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pp. 510-520
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Keyword(s):
2002 ◽
Vol 46
(7)
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pp. 2310-2312
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1996 ◽
Vol 40
(6)
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pp. 1342-1345
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1998 ◽
Vol 42
(11)
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pp. 3012-3013
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Keyword(s):
1999 ◽
Vol 43
(9)
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pp. 2209-2214
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