High-Level Resistance to Ceftazidime Conferred by a Novel Enzyme, CTX-M-32, Derived from CTX-M-1 through a Single Asp240-Gly Substitution
2004 ◽
Vol 48
(6)
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pp. 2308-2313
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Keyword(s):
M Gene
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ABSTRACT A clinical strain of Escherichia coli isolated from pleural liquid with high levels of resistance to cefotaxime, ceftazidime, and aztreonam harbors a novel CTX-M gene (bla CTX-M-32) whose amino acid sequence differs from that of CTX-M-1 by a single Asp240-Gly substitution. Moreover, by site-directed mutagenesis we demonstrated that this replacement is a key event in ceftazidime hydrolysis
1992 ◽
Vol 6
(22)
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pp. 3313-3320
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Keyword(s):
2010 ◽
Vol 54
(8)
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pp. 3484-3488
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2000 ◽
Vol 182
(9)
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pp. 2567-2573
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2008 ◽
Vol 53
(1)
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pp. 329-330
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1990 ◽
Vol 108
(3)
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pp. 483-487
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2003 ◽
Vol 69
(5)
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pp. 3011-3014
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Keyword(s):