Effect of Growth Phase Feeding Strategies on Succinate Production by Metabolically Engineered Escherichia coli
2009 ◽
Vol 76
(4)
◽
pp. 1298-1300
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Keyword(s):
ABSTRACT Aerobic growth conditions significantly influenced anaerobic succinate production in two-stage fermentation by Escherichia coli AFP111 with knockouts in rpoS, pflAB, ldhA, and ptsG genes. At a low cell growth rate limited by glucose, enzymes involved in the reductive arm of the tricarboxylic acid cycle and the glyoxylate shunt showed elevated activities, providing AFP111 with intracellular redox balance and increased succinic acid yield and productivity.
Keyword(s):
Aerobic Fermentation of d-Glucose by an Evolved Cytochrome Oxidase-Deficient Escherichia coli Strain
2008 ◽
Vol 74
(24)
◽
pp. 7561-7569
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Keyword(s):
E Coli
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Keyword(s):
1954 ◽
Vol 49
(1)
◽
pp. 7-18
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Keyword(s):
1998 ◽
Vol 180
(22)
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pp. 5989-5996
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