scholarly journals Epidemiology and Control of Neosporosis and Neospora caninum

2007 ◽  
Vol 20 (2) ◽  
pp. 323-367 ◽  
Author(s):  
J. P. Dubey ◽  
G. Schares ◽  
L. M. Ortega-Mora
Keyword(s):  
Life Cycle ◽  
New Genus ◽  
Neospora Caninum ◽  
Protozoan Parasite ◽  
Zoonotic Potential ◽  
Human Tissues ◽  
New Genus And Species ◽  
Serious Disease ◽  
And Control

SUMMARY Neospora caninum is a protozoan parasite of animals. Until 1988, it was misidentified as Toxoplasma gondii. Since its first recognition in dogs in 1984 and the description of the new genus and species Neospora caninum in 1988, neosporosis has emerged as a serious disease of cattle and dogs worldwide. Abortions and neonatal mortality are a major problem in livestock operations, and neosporosis is a major cause of abortion in cattle. Although antibodies to N. caninum have been reported, the parasite has not been detected in human tissues. Thus, the zoonotic potential is uncertain. This review is focused mainly on the epidemiology and control of neosporosis in cattle, but worldwide seroprevalences of N. caninum in animals and humans are tabulated. The role of wildlife in the life cycle of N. caninum and strategies for the control of neosporosis in cattle are discussed.

Endogenous and exogenous transplacental transmission of Neospora caninum – how the route of transmission impacts on epidemiology and control of disease

Parasitology ◽  
2009 ◽  
Vol 136 (14) ◽  
pp. 1895-1900 ◽  
Author(s):  
D. J. L. WILLIAMS ◽  
C. S. HARTLEY ◽  
C. BJÖRKMAN ◽  
A. J. TREES
Keyword(s):  
Immune Response ◽  
Vertical Transmission ◽  
Neospora Caninum ◽  
Protozoan Parasite ◽  
Transplacental Transmission ◽  
Highly Efficient ◽  
Route Of Transmission ◽  
And Control

SUMMARYVertical transmission of the protozoan parasite, Neospora caninum is highly efficient and can take two forms – endogenous transplacental transmission resulting from activation of the quiescent bradyzoite stage during pregnancy or exogenous transplacental transmission resulting from ingestion of oocysts during pregnancy. Calves born carrying infection derived from either endogenous or exogenous transplacental transmission are capable of infecting their offspring when they start to breed. This review considers firstly the frequency with which exogenous and endogenous transmission occur, secondly the role of the immune response in controlling N. caninum infection and thirdly how the parasite persists in an immune-competent host and is re-activated during pregnancy.

Fasciola gigantica and Fasciola hybrids in Southeast Asia.

2021 ◽  
pp. 423-460
Author(s):  
Nichola Eliza Davies Calvani ◽  
Jan Šlapeta
Keyword(s):  
Life Cycle ◽  
Southeast Asia ◽  
Smallholder Farmers ◽  
Economic Importance ◽  
Fasciola Gigantica ◽  
Rice Fields ◽  
Control Options ◽  
And Control

Abstract This book chapter describes the life cycle of F. gigantica and its differences from F. hepatica, including its economic importance and control options available, with particular emphasis on the importance of the smallholder farmers and the role of rice fields in maintaining the life cycle in Southeast Asia.

scholarly journals Evidence of Neospora caninum exposure among native Korean goats (Capra hircus coreanae)

2014 ◽  
Vol 59 (No. 12) ◽  
pp. 637-640 ◽  
Author(s):  
BY Jung ◽  
SH Lee ◽  
D. Kwak
Keyword(s):  
Neospora Caninum ◽  
Control Strategies ◽  
Integrated Control ◽  
Protozoan Parasite ◽  
Capra Hircus ◽  
Enzyme Linked Immunosorbent Assay ◽  
Serum Samples ◽  
Caninum Infection ◽  
One Year ◽  
And Control

Neospora caninum is a protozoan parasite that causes abortion in ruminants, including goats. The objective of the present study was to determine the seroprevalence of N. caninum in native Korean goats (Capra hircus coreanae). A commercial enzyme-linked immunosorbent assay kit was used to analyse 464 serum samples for the presence of N. caninum antibodies. Four samples (0.9%, 95% confidence intervals – CI: 0.0–1.7) were found to be positive for N. caninum antibodies. The seroprevalence was analysed according to age (less than to one year, young; more than or equal one year, adult; and unknown), sampling season (April to September, warm; October to March, cold), and region (northern, central, and southern). However, there were no statistically significant differences in seroprevalence according to age, season, and region (P > 0.05). This is the first report on the seroprevalence of N. caninum in native Korean goats. The results of this study indicate a nationwide distribution of N. caninum among goats, with a relatively low prevalence. Therefore, the implementation of integrated control strategies as well as measures for prevention and control of N. caninum infection among goats is recommended.

Investigating the role of wild carnivores in the epidemiology of bovine neosporosis

Parasitology ◽  
2012 ◽  
Vol 140 (3) ◽  
pp. 296-302 ◽  
Author(s):  
PETER STUART ◽  
ANNETTA ZINTL ◽  
THEO DE WAAL ◽  
GRACE MULCAHY ◽  
CONALL HAWKINS ◽  
...  
Keyword(s):  
Neospora Caninum ◽  
American Mink ◽  
Protozoan Parasite ◽  
Meles Meles ◽  
Pcr Analysis ◽  
Red Foxes ◽  
Bovine Neosporosis ◽  
Low Prevalence ◽  
Local Ecology

SUMMARYNeospora caninumis a protozoan parasite, primarily associated with bovine abortion. The only definitive hosts discovered to date are carnivores. This study aimed to identify the role of mammalian carnivores in the epidemiology of bovine neosporosis. A sample bank of serum, fecal and brain samples was established: American mink (Mustela vison), red foxes (Vulpes vulpes), pine martens (Martes martes), badgers (Meles meles), stoats (Mustela erminea), otters (Lutra lutra) and feral ferrets (Mustela putorius). Approximately 1% of mink and 1% of fox samples were positive by IFAT. According to PCR analysis of DNA extracted from brain tissue, 3% of the mink, 4% of the otters and 6% of the foxes examined were infected withN. caninum.All fecal samples tested negative forN. caninumDNA (n = 311), suggesting that the species that tested positive were intermediate not definitive hosts. This is the first time that tissues from mustelids have tested positive forN. caninum. The need to test 2 relatively large (∼200 mg) targeted parts of the brain to avoid false negatives was also identified. The relatively low prevalence ofN. caninumin Irish carnivores suggests that the local ecology of a species has an important influence on its epidemiological role.

scholarly journals Neospora caninum and Wildlife

2013 ◽  
Vol 2013 ◽  
pp. 1-23 ◽  
Author(s):  
Sonia Almería
Keyword(s):  
Life Cycle ◽  
Current Knowledge ◽  
Neospora Caninum ◽  
Control Measures ◽  
Sylvatic Cycle ◽  
Zoo Animals ◽  
Wild Dogs ◽  
Cattle Farms ◽  
Important Disease

Bovine neosporosis caused by Neospora caninum is among the main causes of abortion in cattle nowadays. At present there is no effective treatment or vaccine. Serological evidence in domestic, wild, and zoo animals indicates that many species have been exposed to this parasite. However, many aspects of the life cycle of N. caninum are unknown and the role of wildlife in the life cycle of N. caninum is still not completely elucidated. In North America, there are data consistent with a sylvatic cycle involving white tailed-deer and canids and in Australia a plausible sylvatic cycle could be occurring between wild dogs and their macropod preys. In Europe, a similar sylvatic cycle has not been established but is very likely. The present review is a comprehensive and up to date summary of the current knowledge on the sylvatic cycle of N. caninum, species affected and their geographical distribution. These findings could have important implications in both sylvatic and domestic cycles since infected wildlife may influence the prevalence of infection in cattle farms in the same areas. Wildlife will need to be taken into account in the control measures to reduce the economical losses associated with this important disease in cattle farms.

scholarly journals Fittkaulus maculatus a new genus and species from northern Brazil (Leptophlebiidae: Ephemeroptera)

1978 ◽  
Vol 8 (2) ◽  
pp. 293-298 ◽  
Author(s):  
Harry M. Savage ◽  
William L. Peters
Keyword(s):  
Life Cycle ◽  
New Genus ◽  
Guiana Shield ◽  
New Genus And Species ◽  
Male And Female ◽  
Life Cycle Stages ◽  
Northern Brazil

Abstract A new genus and species of Leptophlebiidae, Fittkaulus maculatus, is described from male and female imagos, subimagos, and nymphs collected from streams of the eastern Guiana Shield, Pará State, Brazil. Association of life cycle stages is by rearing. Fittkaulus appears to be most closely related to Terpides Demoulin.

Iron-modulated pseudocyst formation inTritrichomonas foetus

Parasitology ◽  
2016 ◽  
Vol 143 (8) ◽  
pp. 1034-1042 ◽  
Author(s):  
CÁSSIA CASTRO ◽  
RUBEM FIGUEIREDO SADOK MENNA-BARRETO ◽  
NILMA DE SOUZA FERNANDES ◽  
LEONARDO SABOIA-VAHIA ◽  
GEOVANE DIAS-LOPES ◽  
...  
Keyword(s):  
Life Cycle ◽  
Cell Biology ◽  
Proteolytic Enzymes ◽  
Essential Element ◽  
Protozoan Parasite ◽  
Transformation Process ◽  
Morphological Transformation ◽  
Iron Depletion ◽  
Transmission Electron

SUMMARYIron is an essential element for the survival of trichomonads during host–parasite interaction. The availability of this metal modulates several metabolic pathways of the parasites and regulates the expression of virulence factors such as adhesins and proteolytic enzymes. In this study, we investigated the effect of iron depletion on the morphology and life cycle ofTritrichomonas foetus. Scanning and transmission electron microscopy analyses revealed that depletion of iron from the culture medium (named TYM-DIP inducer medium) induces morphological transformation of typical pear-shaped trophozoites into spherical and non-motile pseudocysts. Remarkably, inoculation of pseudocysts into an iron-rich medium (standard TYM medium), or addition of FeSO4to a TYM-DIP inducer medium reverted the morphological transformation process and typical trophozoites were recovered. These results show that pseudocysts are viable forms of the parasite and highlight the role of iron as a modulator of the parasite phenotype. Although iron is required for the survival ofT. foetus, iron depletion does not cause a cellular collapse of pseudocysts, but instead induces phenotypic alterations, probably in order to allow the parasite to survive conditions of nutritional stress. Together, these findings support previous studies that suggest pseudocysts are a resistance form in the life cycle ofT. foetusand enable new approaches to understanding the multifactorial role of iron in the cell biology of this protozoan parasite.

scholarly journals First Report of Seroprevalence and Risk Factors ofNeospora caninumInfection in Tibetan Sheep in China

2018 ◽  
Vol 2018 ◽  
pp. 1-4 ◽  
Author(s):  
Lan-Bi Nie ◽  
Wei Cong ◽  
Yang Zou ◽  
Dong-Hui Zhou ◽  
Qin-Li Liang ◽  
...  
Keyword(s):  
Competitive Inhibition ◽  
Neospora Caninum ◽  
Statistical Significance ◽  
Protozoan Parasite ◽  
Gansu Province ◽  
Serum Samples ◽  
First Report ◽  
Tibetan Sheep ◽  
Production Areas ◽  
And Control

Neospora caninumis an intracellular protozoan parasite which can cause abortion and stillbirth in ruminants. However, there is no information on Tibetan sheepN. caninuminfection in China. A total of 2187 serum samples were collected from Tibetan sheep in the major production areas of Luqu, Maqu, and Tianzhu in Gansu province, and Nyingchi in southeast Tibet, China. All samples were analyzed for the presence of antibodies toN. caninumusing a competitive-inhibition enzyme-linked immunoassay. Of the 2187 serum samples, 184 (8.4%, 95% CI 7.3-9.6) were testedN. caninumseropositive. TheN. caninumseroprevalence ranged from 4.4% (95% CI 1.4–7.4) to 11.3% (95% CI 8.2–14.4) among different regions, seasons, ages, and pregnancies, and there was no statistical significance among those groups (P> 0.05). Seroprevalence in male (10.8% 69/638) (95% CI 8.4–13.2) was significantly higher than in female (7.4% 115/1549) (OR =1.51, 95% CI 6.1–8.7) (P< 0.01). To our knowledge, this is the first report ofN. caninumseroprevalence in Tibetan sheep in China, which provides baseline data for the prevention and control ofN. caninuminfection in Tibetan sheep.

Isolation and characterization of cellulolytic anaerobic fungi and associated mycoplasmas from the rumen of a steer fed a roughage diet

1990 ◽  
Vol 36 (7) ◽  
pp. 513-517 ◽  
Author(s):  
H. Kudo ◽  
K. D. Jakober ◽  
R. C. Phillippe ◽  
K.-J. Cheng ◽  
D. J. S. Barr ◽  
...  
Keyword(s):  
Key Words ◽  
New Genus ◽  
Anaerobic Fungi ◽  
Ecological Role ◽  
New Genus And Species ◽  
Fermentation Products ◽  
Isolation And Characterization ◽  
Neocallimastix Patriciarum

The isolation of 12 strains of cellulolytic fungi from the rumen of a roughage-fed steer is described. These represented three different genera, including one new genus and species (Orpinomyces bovis). The organisms were indistinguishable on the basis of fermentation products from cellulose, and their fermentation patterns were very similar to those of rumen fungi isolated in other countries. Mycoplasmas were found to be associated with 7 of the 12 isolates. The ecological role of the association of the mycoplasmas with rumen fungi is still unknown. Key words: Orpinomyces bovis, Piromyces communis, Neocallimastix patriciarum.

scholarly journals Toll-Like Receptor 3–TRIF Pathway Activation by Neospora caninum RNA Enhances Infection Control in Mice

2019 ◽  
Vol 87 (4) ◽  
Author(s):  
Vanessa dos Santos Miranda ◽  
Flávia Batista Ferreira França ◽  
Mylla Spirandelli da Costa ◽  
Vanessa Resende Souza Silva ◽  
Caroline Martins Mota ◽  
...  
Keyword(s):  
Neospora Caninum ◽  
Parasitophorous Vacuole ◽  
Protozoan Parasite ◽  
Interferon Response ◽  
Economic Losses ◽  
Toll Like Receptor ◽  
Content Type ◽  
Pathway Activation ◽  
Th1 Immune Responses

ABSTRACT Neospora caninum is a protozoan parasite closely related to Toxoplasma gondii and has been studied for causing neuromuscular disease in dogs and abortions in cattle. It is recognized as one of the main transmissible causes of reproductive failure in cattle and consequent economic losses to the sector. In that sense, this study aimed to evaluate the role of Toll-like receptor 3 (TLR3)–TRIF-dependent resistance against N. caninum infection in mice. We observed that TLR3−/− and TRIF−/− mice presented higher parasite burdens, increased inflammatory lesions, and reduced production of interleukin 12p40 (IL-12p40), tumor necrosis factor (TNF), gamma interferon (IFN-γ), and nitric oxide (NO). Unlike those of T. gondii, N. caninum tachyzoites and RNA recruited TLR3 to the parasitophorous vacuole (PV) and translocated interferon response factor 3 (IRF3) to the nucleus. We also observed that N. caninum upregulated the expression of TRIF in murine macrophages, which in turn upregulated IFN-α and IFN-β in the presence of the parasite. Furthermore, TRIF−/− infected macrophages produced lower levels of IL-12p40, while exogenous IFN-α replacement was able to completely restore the production of this key cytokine. Our results show that the TLR3-TRIF signaling pathway enhances resistance against N. caninum infection in mice, since it improves Th1 immune responses that result in controlled parasitism and reduced tissue inflammation, which are hallmarks of the disease.

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