Downregulation of the DNA-Binding Activity of Nuclear Factor-κB p65 Subunit in Porphyromonas gingivalis Fimbria-Induced Tolerance
2004 ◽
Vol 72
(2)
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pp. 1188-1191
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Keyword(s):
ABSTRACT Porphyromonas gingivalis fimbriae induce high levels of nuclear factor-κB (NF-κB)-dependent cytokine release upon primary but not secondary stimulation of monocytic cells (FimA tolerance). In this study, fimbriae induced Toll-like receptor-mediated activation of both p50 and p65 subunits of NF-κB upon primary cellular activation. However, activation of the transactivating p65 subunit (but not of the transcriptionally inactive p50 subunit) was significantly inhibited in fimbria-restimulated cells. Moreover, expression of a NF-κB-dependent reporter gene was inhibited upon secondary stimulation with fimbriae. NF-κB p65 downregulation may thus contribute to induction of FimA tolerance.
2001 ◽
Vol 29
(6)
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pp. 688-691
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1995 ◽
Vol 197
(2)
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pp. 101-104
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2000 ◽
Vol 288
(1)
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pp. 45-48
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Keyword(s):
2005 ◽
Vol 28
(3)
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pp. 274-279
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Keyword(s):
2012 ◽
Vol 11
(6)
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pp. 814-821
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Keyword(s):
2010 ◽
Vol 37
(6)
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pp. 512-521
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Keyword(s):