Airpnp: Auto- and Integrated Regulation of Polynucleotide Phosphorylase
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The properties and expression of polynucleotide phosphorylase (PNPase), capable of both RNA degradation and polymerization, have been studied for 60 years. In this issue of theJournal of Bacteriology,Park et al.(H. Park, H. Yakhnin, M. Connolly, T. Romeo, and P. Babitzke, J Bacteriol 197:3751–3759, 2015,http://dx.doi.org/10.1128/JB.00721-15) write the latest chapter on the complex regulation ofpnpgene expression involving CsrA. I describe how this new piece of the puzzle fits into the global scheme of PNPase autoregulation and how this is influenced by central carbon metabolism at both the posttranscriptional level and that of enzyme activity.
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2020 ◽
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2012 ◽
Vol 43
(2)
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pp. 181-187
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