Molecular Epidemiology of Multidrug-Resistant Acinetobacter baumannii in a Tertiary Care Hospital in Naples, Italy, Shows the Emergence of a Novel Epidemic Clone

Acinetobacterinfection is increasing in hospitals and now it is considered as a global threat, as it can be easily transmitted and remain viable in the hospital environment for a long time due to its multidrug-resistant status, resistance to desiccation, and tendency to adhere to inanimate surfaces. Outbreaks caused by multidrug-resistantAcinetobacter baumannii(MDRAB) are difficult to control and have substantial morbidity and mortality, especially in vulnerable host. Here we are describing an outbreak of multidrug-resistantAcinetobacter baumanniiin burn unit of a tertiary care hospital in India followed by its investigation and infection control measures taken to curtail the outbreak. Outbreak investigation and environmental sampling are the key factors which help in deciding the infection control strategies for control of outbreak. Implementation of contact precautions, hand hygiene, personnel protective equipment, environmental disinfection, isolation of patients, and training of health care workers are effective measures to control the outbreak of MDRAB in burn unit.

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Aerosolized Colistin for the Treatment of Multidrug-resistant Acinetobacter baumannii Pneumonia: Experience in a Tertiary Care Hospital in Northern Taiwan

Journal of Microbiology Immunology and Infection ◽

10.1016/s1684-1182(10)60050-3 ◽

2010 ◽

Vol 43 (4) ◽

pp. 323-331 ◽

Cited By ~ 27

Author(s):

Cheng-Chih Lin ◽

Te-Chu Liu ◽

Chen-Feng Kuo ◽

Chang-Pan Liu ◽

Chun-Ming Lee

Keyword(s):

Acinetobacter Baumannii ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Multidrug Resistant ◽

Care Hospital ◽

Northern Taiwan

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Outbreak of (OXA-66 carbapenemase) multidrug-resistant Acinetobacter baumannii in a Spanish tertiary-care hospital: Epidemiology and study of patient movements

International Journal of Infectious Diseases ◽

10.1016/j.ijid.2010.02.1582 ◽

2010 ◽

Vol 14 ◽

pp. e42-e43 ◽

Cited By ~ 1

Author(s):

F. Gonzalez ◽

E. Culebras ◽

J. Head ◽

M. Gomez ◽

G. Morales ◽

...

Keyword(s):

Acinetobacter Baumannii ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Multidrug Resistant ◽

Care Hospital ◽

Hospital Epidemiology

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MDR BACTERIAL INFECTIONS IN CRITICALLY ILL COVID-19 PATIENTS IN A TERTIARY CARE HOSPITAL (OF PAKISTAN)

Pakistan Armed Forces Medical Journal ◽

10.51253/pafmj.v71i3.5478 ◽

2021 ◽

Vol 71 (3) ◽

pp. 1027-32

Author(s):

Nadia Tayyab ◽

Warda Furqan ◽

Amnah Nasrullah ◽

Javaid Usman ◽

Sakhawat Ali ◽

...

Keyword(s):

Acinetobacter Baumannii ◽

Bacterial Growth ◽

Enterococcus Faecium ◽

Bacterial Infections ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Multidrug Resistant ◽

Klebsiella Pneumonia ◽

Care Hospital ◽

Blood Samples

Objective: To identify antimicrobial susceptibility pattern of multidrug resistant bacteria causing secondary infections in COVID-19 patients in ICU’ sofa tertiary care hospital. Study Design: Cross–sectional study. Place and Duration of Study: Department of Microbiology, Pak Emirates Military Hospital, Rawalpindi, from Apr to Jul 2020. Methodology: This study included blood samples and endotracheal aspirates from 114 critically ill COVID-19 patients. Peripheral blood specimens were collected fromthe patients with secondary bacterial blood stream infections and endotracheal aspirates were collected from patients with ventilator associated pneumonia for culture and sensitivity. The results were interpreted according to Clinical & Laboratory Standard Institute (CLSI) 2020. Results: A total of 114 COVID-19 patients were admitted in ICU during that time period. Fourteen (12.28%) were female and 100 (87.71%) were male, age distribution was between 36-82 years. Sixty six paired blood samples were sent to the microbiology lab out of which 51 (77.2%) showed bacterial growth while 15 (22.7%) samples were negative. Out of 50 endotracheal aspirates, 42 showed bacterial growth (84%) and 8 samples did not show any significant bacterial growth (16%). Most of the endotracheal aspirates showed growth of >1 bacterial isolates. The most common gram-negative organisms were Acinetobacter baumannii (n=54) and Klebsiella pneumonia (n=26) and most common gram-positive organism isolated was Enterococcus faecium (n=9). All isolated organisms were multidrug resistant. Conclusion: Poor antimicrobial stewardship particularly in critical care units resulted in secondary bacterial infections in COVID-19 patients. The pathogens isolated were multidrug resistant including Acinetobacter baumannii, Klebsiella pneumonia and Enterococcus faecium.

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