Comparative humoral responses to human immunodeficiency virus type 1-p24gag linear B-cell epitopes among individuals showing atypical western immunoblotting reactions and implications for diagnosis.

1993 ◽  
Vol 31 (7) ◽  
pp. 1903-1907
Author(s):  
J C Lallement ◽  
J P Vendrell ◽  
P Corbeau ◽  
J Ducos ◽  
M Segondy ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
B Cell ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Western Immunoblotting ◽  
B Cell Epitopes ◽  
Immunodeficiency Virus ◽  
Humoral Responses ◽  
Linear B

scholarly journals Human immunodeficiency virus type-1 induces a regulatory B cell-like phenotype in vitro

2017 ◽  
Vol 15 (10) ◽  
pp. 917-933 ◽  
Author(s):  
Jacobo Lopez-Abente ◽  
Adrián Prieto-Sanchez ◽  
Maria-Ángeles Muñoz-Fernandez ◽  
Rafael Correa-Rocha ◽  
Marjorie Pion
Keyword(s):  
Human Immunodeficiency Virus ◽  
B Cell ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Regulatory B Cell ◽  
Immunodeficiency Virus

Progressive B Cell Apoptosis and Expression of Fas Ligand during Human Immunodeficiency Virus Type 1 Infection

1997 ◽  
Vol 13 (12) ◽  
pp. 1031-1038 ◽  
Author(s):  
ASTRID SAMUELSSON ◽  
ANDERS SÖNNERBORG ◽  
NICOLE HEUTS ◽  
JOAKIM CÖSTER ◽  
FRANCESCA CHIODI
Keyword(s):  
Human Immunodeficiency Virus ◽  
B Cell ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Cell Apoptosis ◽  
Fas Ligand ◽  
Immunodeficiency Virus

scholarly journals Human Immunodeficiency Virus Type 1-Associated CD40 Ligand Transactivates B Lymphocytes and Promotes Infection of CD4+ T Cells

2007 ◽  
Vol 81 (11) ◽  
pp. 5872-5881 ◽  
Author(s):  
Geneviève Martin ◽  
Jocelyn Roy ◽  
Corinne Barat ◽  
Michel Ouellet ◽  
Caroline Gilbert ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
B Cell ◽  
B Lymphocytes ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Nuclear Translocation ◽  
Cd40 Ligand ◽  
Immunodeficiency Virus ◽  
Hiv 1

ABSTRACT Abnormal activation of B lymphocytes is a feature commonly seen in human immunodeficiency virus type 1 (HIV-1)-infected persons. However, the mechanism(s) responsible for this dysfunction is still poorly understood. Having recently shown that CD40L, the ligand for CD40, is inserted within emerging HIV-1 particles, we hypothesized that the contact between virus-anchored host CD40L and CD40 on the surface of B lymphocytes might result in the activation of this cell type. We report here that CD40L-bearing viruses, but not isogenic virions lacking host-derived CD40L, can induce immunoglobulin G and interleukin-6 production. Furthermore, such viral entities were found to induce B-cell homotypic adhesion. These effects were paralleled at the intracellular level by the nuclear translocation of the ubiquitous transcription factor NF-κB. The presence of host-derived CD40L within virions resulted in an increased virus attachment to B cells and a more-efficient B-cell-mediated transfer of HIV-1 to autologous CD4+ T lymphocytes. All the above processes were independent of the virus-encoded envelope glycoproteins. Altogether, the data gathered from this series of investigations suggest that the incorporation of host-encoded CD40L in HIV-1 is likely to play a role in the B-cell abnormalities that are seen in infected individuals.

Generation of a human immunodeficiency virus type 1 chronically infected monkey B cell line expressing low levels of endogenous TRIM5α

2009 ◽  
Vol 221 (3) ◽  
pp. 760-765 ◽  
Author(s):  
Barbara Ridolfi ◽  
Stefania Catone ◽  
Marco Sgarbanti ◽  
Leonardo Sernicola ◽  
Angela Battistini ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
B Cell ◽  
Cell Line ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Infected Monkey ◽  
Immunodeficiency Virus ◽  
Low Levels

scholarly journals Correlation between Humoral Responses to Human Immunodeficiency Virus Type 1 Envelope and Disease Progression in Early‐Stage Infection

1998 ◽  
Vol 178 (5) ◽  
pp. 1306-1316 ◽  
Author(s):  
Lawrence D. Loomis‐Price ◽  
Josephine H. Cox ◽  
John R. Mascola ◽  
Thomas C. VanCott ◽  
Nelson L. Michael ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Disease Progression ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Early Stage ◽  
Immunodeficiency Virus ◽  
Humoral Responses ◽  
Stage Infection
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