Administration of an Anti-CD8 Monoclonal Antibody Interferes with the Clearance of Chimeric Simian/Human Immunodeficiency Virus during Primary Infections of Rhesus Macaques
1998 ◽
Vol 72
(1)
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pp. 164-169
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Keyword(s):
ABSTRACT Parenteral administration of a mouse anti-human CD8 monoclonal antibody (MAb) to rhesus macaques resulted in a transient depletion of CD8+ cells in both the peripheral blood and lymphoid tissues. When administered during primary chimeric simian/human immunodeficiency virus infections, the CD8 MAb caused marked elevations of plasma and cell-associated virus levels in both the peripheral blood and lymphoid tissues and led to prolonged depletion of CD4 cells. Taken together, these results directly demonstrate that CD8+ T lymphocytes are actively involved in controlling the acute phase of primate lentivirus infections.
1998 ◽
Vol 72
(6)
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pp. 5035-5045
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2001 ◽
Vol 183
(9)
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pp. 1336-1342
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2002 ◽
Vol 76
(16)
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pp. 8433-8445
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Keyword(s):
2000 ◽
Vol 74
(6)
◽
pp. 2558-2566
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2002 ◽
Vol 76
(18)
◽
pp. 9465-9473
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2000 ◽
Vol 42
(1)
◽
pp. 67-73
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Keyword(s):