scholarly journals High-Throughput CRISPR Screens To Dissect Macrophage- Shigella Interactions

mBio ◽  
2021 ◽  
Vol 12 (6) ◽  
Author(s):  
Yong Lai ◽  
Liang Cui ◽  
Gregory H. Babunovic ◽  
Sarah M. Fortune ◽  
John G. Doench ◽  
...  

Treatment for shigellosis is becoming increasingly difficult as resistance to antibiotics becomes more prevalent. One way to prevent this significant public health problem from developing into a full-blown crisis is to approach shigellosis intervention from the point of view of the host.

2014 ◽  
Vol 59 (1) ◽  
pp. 727-729 ◽  
Author(s):  
E. Aldasoro ◽  
M. J. Pinazo ◽  
I. Oliveira ◽  
J. Munoz ◽  
E. Posada ◽  
...  

ABSTRACTChagas disease is a parasitic infection that leads to a significant public health problem in countries where the disease is endemic and where it is nonendemic. Benznidazole is the most commonly used drug for the etiological treatment of Chagas disease. Patients treated with benznidazole suffer frequent adverse drug reactions. Although arthralgia is common, arthritis has been reported as a very rare side effect. The objective of this study was to describe arthritis in a cohort ofTrypanosoma cruzi-infected patients treated with benznidazole.


1994 ◽  
Vol 19 (1) ◽  
pp. 55-65 ◽  
Author(s):  
Alan E. Rauch ◽  
Richard Weininger ◽  
Donald Pasquale ◽  
Peter T. Burkart ◽  
Harry G. Dunn ◽  
...  

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 4180
Author(s):  
Ascensión Marcos

The emergence of the SARS-CoV virus in December 2019 saw the beginning of an unprecedented pandemic that represents the most significant public health problem in recent memory [...]


Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 3705
Author(s):  
Shujuan Li ◽  
Xue Cheng ◽  
Dongmei Yu ◽  
Liyun Zhao ◽  
Hongyan Ren

Globally, anemia among school-age children (SAC) remains a serious public health problem, impacting their growth, development, educational attainment and future learning potential. National and subnational anemia prevalence among SAC in China has not been assessed recently. Based on data from Chinese Nutrition and Health Surveillance (2016–2017), the current anemia status of SAC in primary schools in China was investigated. Anemia prevalence of SAC in primary schools in China was 4.4%, dropping 63.6% compared with that in 2002. Even though anemia was no longer a significant public health problem at the national level, there were significant spatial disparities of anemia prevalence in different areas: anemia prevalence in 63% of provinces of northern and eastern China has lowered to below 5%, while in provinces of southern China, it was still ranging from 5% to 11.0%, about 3 times of other areas. For those children in southern China, mother’s education level (OR = 1.24, p = 0.04) and father’s education level (OR = 1.27, p = 0.01) below senior high school, eating meat less than 3 times per week (OR = 1.18, p = 0.01) were risk factors of anemia. Older age (OR = 0.35–0.72, p < 0.01) was a protective factor. Targeted interventions should be taken to improve SAC anemia in Southern China, despite anemia of SAC in primary schools no longer being a significant public health problem.


2020 ◽  
Author(s):  
Nicole Kravitz-Wirtz ◽  
Amanda Aubel ◽  
Julia Schleimer ◽  
Rocco Pallin ◽  
Garen Wintemute

AbstractIMPORTANCEViolence is a significant public health problem that has become entwined with the coronavirus pandemic. Conditions that contribute to violence—poverty, unemployment, lack of available resources, isolation, hopelessness, and loss—have intensified and are further compounded by the recent surge in firearm sales, which is itself a risk factor for firearm-related harm.OBJECTIVETo describe individuals’ worry about violence for themselves and others in the context of the pandemic, pandemic-related unfair treatment, as well as the prevalence of and reasons for firearm acquisition and changes in firearm storage practices due to the pandemic. DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study used data from the California Safety and Wellbeing Survey, a statewide Internet survey of 2,870 California adults (18 years of age and older) conducted from July 14 to July 27, 2020. Responses were weighted to be representative of the state population of adults.MAIN OUTCOMES AND MEASURESSurvey topics for this study included: changes in worry about violence happening to oneself, by type of violence and location, before and during the pandemic; concern someone else might physically hurt another person or themselves on purpose due to a pandemic-related loss; experiences of unfair treatment related to the pandemic; firearm and ammunition acquisition and changes in firearm storage practices due to the pandemic; and participation in civic and political activities “in response to gun violence” during the pandemic.RESULTSWorry about violence significantly increased during the pandemic for all violence types except mass shootings. More than 1 in 10 respondents were concerned that someone they know might intentionally harm another person (12.2%) or themselves (13.1%). Of those concerned about self-harm for someone else, 7.5% said it was because the person had suffered a pandemic-related loss. An estimated 110,000 individuals acquired a firearm in response to the pandemic (2.4% of current firearm owners), including 47,000 new owners. Approximately 55,000 individuals (1.2% of owners) who currently store at least one firearm loaded and not locked up said they had adopted this unsecure storage practice in response to the pandemic.CONCLUSIONS AND RELEVANCEGiven the impulsive nature of many types of violence, short-term crisis interventions, such as options for temporary firearm storage outside the home, extreme risk protection orders, and efforts involving community-based violence intervention workers, may be critical for reducing violence-related harm now and following other societal shocks.Key PointsQUESTIONSHas the coronavirus pandemic modified (1) individuals’ worry about violence for themselves or others, (2) the prevalence of and reasons for firearm and ammunition acquisition, and (3) firearm storage practices?FINDINGSIn this cross-sectional, population-representative survey of 2,870 adults in California, worry about multiple types of violence for oneself increased during the pandemic; pandemic-related loss contributed to concern that someone else might physically harm themselves on purpose; an estimated 110,000 people acquired firearms due to the pandemic (2.4% of firearm owners in the state), including approximately 47,000 new owners; and 6.7% of owners who currently store firearms loaded and not locked up adopted this unsecure storage practice in response to the pandemic.MEANINGViolence is a significant public health problem that touches the lives of far more people than is typically recognized. The coronavirus pandemic and efforts to lessen its spread have compounded this burden.


2006 ◽  
Vol 13 (5) ◽  
pp. 185-186
Author(s):  
S. P. Stratton ◽  
M. S. Stratton ◽  
D. S. Alberts

Skin cancer presents a significant public health problem because of its increasing incidence in the United States, Australia, Northern Europe, and other temperate climates around the world. [...]


2019 ◽  
pp. 306-318
Author(s):  
Tommy Rappold ◽  
Matthew Digiusto ◽  
M-Irfan Suleman

Chapter 18 covers the basics of pediatric pain management. Pediatric pain is a significant public health problem leading to lost days of school, increased use of the healthcare system, and multifactorial impact on all aspects of a child’s life. Pediatric patients present special clinical challenges because of variabilities in metabolism, susceptibility to disease and side effects, ability to communicate, developmental stage, coping skills, and support systems. This chapter serves as an introduction to the main features of pediatric pain management and reviews pain assessment, common causes of pain both acute and chronic, and basic nonpharmacologic and pharmacologic strategies in patients ranging from neonates to adolescents.


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