scholarly journals Altered Spatial and Temporal Gait Parameters in Mice Infected with Ross River Virus

mSphere ◽  
2021 ◽  
Author(s):  
Eranga Abeyratne ◽  
Ronak Reshamwala ◽  
Todd Shelper ◽  
Xiang Liu ◽  
Ali Zaid ◽  
...  
Keyword(s):  
Mouse Models ◽  
Therapeutic Strategies ◽  
Clinical Disease ◽  
Ross River Virus ◽  
Preclinical Development ◽  
Gait Parameters ◽  
Alphavirus Infection

Mouse models that accurately replicate the immunopathogenesis and clinical disease of alphavirus infection are vital to the preclinical development of therapeutic strategies that target alphavirus infection and disease. Current models rely on subjective scoring made through experienced observation of infected mice.

scholarly journals Mouse Models of Glioblastoma for the Evaluation of Novel Therapeutic Strategies

2021 ◽  
Author(s):  
Alexander F Haddad ◽  
Jacob S Young ◽  
Dominic Amara ◽  
Mitchel S Berger ◽  
David R Raleigh ◽  
...  
Keyword(s):  
Mouse Models ◽  
Standard Of Care ◽  
Therapeutic Strategies ◽  
Genetically Engineered ◽  
Genetically Engineered Mouse Models ◽  
Advantages And Disadvantages ◽  
Developmental Therapeutics ◽  
Xenograft Models ◽  
Novel Therapeutic Strategies ◽  
Novel Therapeutic

Abstract Glioblastoma (GBM) is an incurable brain tumor with a median survival of approximately 15 months despite an aggressive standard of care that includes surgery, chemotherapy, and ionizing radiation. Mouse models have advanced our understanding of GBM biology and the development of novel therapeutic strategies for GBM patients. However, model selection is crucial when testing developmental therapeutics, and each mouse model of GBM has unique advantages and disadvantages that can influence the validity and translatability of experimental results. To shed light on this process, we discuss the strengths and limitations of 3 types of mouse GBM models in this review: syngeneic models, genetically engineered mouse models (GEMMs), and xenograft models, including traditional xenograft cell lines and patient-derived xenograft (PDX) models.

scholarly journals Gut Microbiota Influences Experimental Outcomes in Mouse Models of Colorectal Cancer

Genes ◽  
2019 ◽  
Vol 10 (11) ◽  
pp. 900 ◽  
Author(s):  
Alyssa A. Leystra ◽  
Margie L. Clapper
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Experimental Design ◽  
Gut Microbiota ◽  
Mouse Models ◽  
Therapeutic Strategies ◽  
Response To Therapy ◽  
Valuable Resource ◽  
Disease Phenotypes ◽  
Experimental Findings

Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. Mouse models are a valuable resource for use throughout the development and testing of new therapeutic strategies for CRC. Tumorigenesis and response to therapy in humans and mouse models alike are influenced by the microbial communities that colonize the gut. Differences in the composition of the gut microbiota can confound experimental findings and reduce the replicability and translatability of the resulting data. Despite this, the contribution of resident microbiota to preclinical tumor models is often underappreciated. This review does the following: (1) summarizes evidence that the gut microbiota influence CRC disease phenotypes; (2) outlines factors that can influence the composition of the gut microbiota; and (3) provides strategies that can be incorporated into the experimental design, to account for the influence of the microbiota on intestinal phenotypes in mouse models of CRC. Through careful experimental design and documentation, mouse models can continue to rapidly advance efforts to prevent and treat colon cancer.

scholarly journals Humanized Mouse Models of Clinical Disease

2017 ◽  
Vol 12 (1) ◽  
pp. 187-215 ◽  
Author(s):  
Nicole C. Walsh ◽  
Laurie L. Kenney ◽  
Sonal Jangalwe ◽  
Ken-Edwin Aryee ◽  
Dale L. Greiner ◽  
...  
Keyword(s):  
Mouse Models ◽  
Clinical Disease ◽  
Humanized Mouse ◽  
Humanized Mouse Models

Ross River virus (Togaviridae: Alphavirus) infection (epidemic polyarthritis) in American Samoa

1981 ◽  
Vol 75 (3) ◽  
pp. 426-431 ◽  
Author(s):  
Robert B. Tesh ◽  
Robert G. McLean ◽  
Donald A. Shroyer ◽  
Charles H. Calisher ◽  
Leon Rosen
Keyword(s):  
American Samoa ◽  
Ross River Virus ◽  
Epidemic Polyarthritis ◽  
Alphavirus Infection

scholarly journals Esophageal Cancer: Insights from Mouse Models

2015 ◽  
Vol 8s1 ◽  
pp. CGM.S21218 ◽  
Author(s):  
Marie-Pier Tétreault
Keyword(s):  
Esophageal Cancer ◽  
Mouse Models ◽  
Molecular Mechanisms ◽  
Human Subjects ◽  
Surgical Techniques ◽  
Therapeutic Strategies ◽  
Human Cancers ◽  
Genetic Modifications ◽  
Wide Range ◽  
Gestation Time

Esophageal cancer is the eighth leading cause of cancer and the sixth most common cause of cancer-related death worldwide. Despite recent advances in the development of surgical techniques in combination with the use of radiotherapy and chemotherapy, the prognosis for esophageal cancer remains poor. The cellular and molecular mechanisms that drive the pathogenesis of esophageal cancer are still poorly understood. Hence, understanding these mechanisms is crucial to improving outcomes for patients with esophageal cancer. Mouse models constitute valuable tools for modeling human cancers and for the preclinical testing of therapeutic strategies in a manner not possible in human subjects. Mice are excellent models for studying human cancers because they are similar to humans at the physiological and molecular levels and because they have a shorter gestation time and life cycle. Moreover, a wide range of well-developed technologies for introducing genetic modifications into mice are currently available. In this review, we describe how different mouse models are used to study esophageal cancer.

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