Genome-Scale Analysis of Acetobacterium woodii Identifies Translational Regulation of Acetogenesis

Acetogens are capable of reducing CO 2 to multicarbon compounds (e.g., ethanol or 2,3-butanediol) via the Wood-Ljungdahl pathway. Given that protein synthesis in bacteria is highly energy consuming, acetogens living at the thermodynamic limit of life are inevitably under translation control.

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Genome-scale analysis of syngas fermenting acetogenic bacteria reveals the translational regulation for its autotrophic growth

BMC Genomics ◽

10.1186/s12864-018-5238-0 ◽

2018 ◽

Vol 19 (1) ◽

Cited By ~ 8

Author(s):

Yoseb Song ◽

Jongoh Shin ◽

Sangrak Jin ◽

Jung-Kul Lee ◽

Dong Rip Kim ◽

...

Keyword(s):

Translational Regulation ◽

Scale Analysis ◽

Autotrophic Growth ◽

Acetogenic Bacteria ◽

Genome Scale

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Ionizing Radiation and Translation Control: A Link to Radiation Hormesis?

International Journal of Molecular Sciences ◽

10.3390/ijms21186650 ◽

2020 ◽

Vol 21 (18) ◽

pp. 6650

Author(s):

Usha Kabilan ◽

Tyson E. Graber ◽

Tommy Alain ◽

Dmitry Klokov

Keyword(s):

Protein Synthesis ◽

Ionizing Radiation ◽

Molecular Mechanisms ◽

Low Dose ◽

Mrna Translation ◽

Cellular Responses ◽

Translation Control ◽

Cis Acting ◽

Radiation Hormesis ◽

Downstream Signaling

Protein synthesis, or mRNA translation, is one of the most energy-consuming functions in cells. Translation of mRNA into proteins is thus highly regulated by and integrated with upstream and downstream signaling pathways, dependent on various transacting proteins and cis-acting elements within the substrate mRNAs. Under conditions of stress, such as exposure to ionizing radiation, regulatory mechanisms reprogram protein synthesis to translate mRNAs encoding proteins that ensure proper cellular responses. Interestingly, beneficial responses to low-dose radiation exposure, known as radiation hormesis, have been described in several models, but the molecular mechanisms behind this phenomenon are largely unknown. In this review, we explore how differences in cellular responses to high- vs. low-dose ionizing radiation are realized through the modulation of molecular pathways with a particular emphasis on the regulation of mRNA translation control.

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Rare Human Codons and HCMV Translational Regulation

Journal of Molecular Microbiology and Biotechnology ◽

10.1159/000478093 ◽

2017 ◽

Vol 27 (4) ◽

pp. 213-216 ◽

Cited By ~ 2

Author(s):

Darja Kanduc

Keyword(s):

Protein Synthesis ◽

Codon Usage ◽

Human Cytomegalovirus ◽

Translational Regulation ◽

Protein Production ◽

Nucleotide Sequences ◽

Positive Correlation ◽

Human Host ◽

Rare Codons

Restriction of protein synthesis characterizes human cytomegalovirus (HCMV) latency in the human host. In analyzing the molecular factors that hinder HCMV expression, the present study shows that HCMV genes frequently use 6 rare codons, i.e., GCG (Ala), CCG (Pro), CGT (Arg), CGC (Arg), TCG (Ser), and ACG (Thr). In some instances, the rare host codons are clustered along viral nucleotide sequences and represent the majority in sequences encoding short alanine and proline repeats. Given the positive correlation between codon usage, tRNA content, and protein production, the results support the hypothesis that HCMV usage of rare human codons might hinder HCMV protein synthesis, in this way leading to HCMV latency.

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Genome-scale analysis identifies NEK2, DLGAP5 and ECT2 as promising diagnostic and prognostic biomarkers in human lung cancer

Scientific Reports ◽

10.1038/s41598-017-08615-5 ◽

2017 ◽

Vol 7 (1) ◽

Cited By ~ 15

Author(s):

Yuan-Xiang Shi ◽

Ji-Ye Yin ◽

Yao Shen ◽

Wei Zhang ◽

Hong-Hao Zhou ◽

...

Keyword(s):

Lung Cancer ◽

Human Lung ◽

Prognostic Biomarkers ◽

Human Lung Cancer ◽

Scale Analysis ◽

Genome Scale

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Translational regulation of ribosomal protein synthesis during xenopus development

Cell Differentiation and Development ◽

10.1016/0922-3371(89)90661-8 ◽

1989 ◽

Vol 27 ◽

pp. 219

Author(s):

B. Cardinali ◽

C. Bagni ◽

F. Amaldi ◽

N. Campioni ◽

P. Mariottini ◽

...

Keyword(s):

Protein Synthesis ◽

Ribosomal Protein ◽

Translational Regulation ◽

Xenopus Development ◽

Ribosomal Protein Synthesis

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Role of CDK1 in Translational Regulation in the M-Phase

10.20944/preprints202004.0530.v1 ◽

2020 ◽

Author(s):

Jaroslav Kalous ◽

Denisa Jansova ◽

Andrej Susor

Keyword(s):

Cell Cycle ◽

Protein Synthesis ◽

Translational Regulation ◽

Gene Expression Regulation ◽

Translational Initiation ◽

Initiation Factors ◽

Cellular Events ◽

M Phase ◽

Mitosis And Meiosis

Cyclin dependent kinase 1 (CDK1) has been primarily identified as a key cell cycle regulator in both mitosis and meiosis. Recently, an extramitotic function of CDK1 emerged when evidence was found that CDK1 is involved in many cellular events that are essential for cell proliferation and survival. In this review we summarize the involvement of active CDK1 in the initiation and elongation steps of protein synthesis in eukaryotes. During its activation CDK1 influences the initiation of protein synthesis, promotes the activity of specific translational initiation factors and affects the functioning of a subset of elongation factors. Our review provides insights into gene expression regulation during the transcriptionally silent cell cycle/M-phase and describes quantitative and qualitative translational changes based on the extramitotic role of the cell cycle master regulator CDK1, to optimize temporal synthesis of proteins to sustain division-related processes: mitosis and cytokinesis.

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