GEOMORPHIC AND STRUCTURAL MAPPING FOR REMOTE BEDROCK RIVER CORRIDORS IN THE TAIWAN CENTRAL RANGE USING PAIRED OUTCROP AND KILOMETER SCALE UAV SURVEYS

2019 ◽  
Author(s):  
Julia C. Carr ◽  
◽  
Roman A. DiBiase ◽  
En Chao Yeh
Keyword(s):  
Structural Mapping ◽  
River Corridors

PENGARUH KONDISI EKOSISTEM DARAT KORIDOR SUNGAI TERHADAP DANAU RAWA PENING

2018 ◽  
Vol 4 (2) ◽  
Author(s):  
E. Hanggari Sittadewi
Keyword(s):  
Water Quality ◽  
Water Hyacinth ◽  
River Corridors ◽  
River Corridor ◽  
Environment Degradation

Environment degradation in Rawa Pening’s lake is caused of descend lake’s functions for some potentions and activities around the lake. Some problems in the Rawa Pening’s lake has emerged i.e : decrease water quality of lake, abundance of water hyacinth growth and increase sediment in the bottom lake. A research about infl uences of land ecosystem on Panjang and Galeh river corridors for Rawa Pening’s lake has been done. Two rivers named Galeh and Panjang are the largest water contribution in Rawa Pening’s lake. That caused the land characteristic ecosystem of that river corridors gives infl uences in the Rawa Pening’s lake.Key words: land ecosystem, river corridor, water contribution, Rawa Pening Lake.

scholarly journals Structural Mapping of Mutations in Spike, RdRp and Orf3a Genes of SARS-CoV-2 in Influenza Like Illness (ILI) Patients

Viruses ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 136
Author(s):  
Bandar Alosaimi ◽  
Asif Naeem ◽  
Majed F. Alghoribi ◽  
Lilian Okdah ◽  
Maaweya E. Hamed ◽  
...  
Keyword(s):  
Surveillance Systems ◽  
Case Definitions ◽  
Structural Mapping ◽  
Policy Makers ◽  
Influenza Like Illness ◽  
Spike Gene ◽  
Ambulatory Patients ◽  
Community Transmission ◽  
Next Generation Sequencing Ngs ◽  
Epidemiological Link

In December 2019, the emergence of SARS-CoV-2 virus in China led to a pandemic. Since both Influenza Like Illness (ILI) and COVID-19 case definitions overlap, we re-investigated the ILI cases using PCR for the presence of SARS-CoV-2 in 739 nasopharyngeal swabs collected from November 2019 to March 2020. SARS-CoV-2 RNA was found in 37 samples (5%) collected mostly during February 2020. It was followed by confirmation of evolutionary and spatial relationships using next generation sequencing (NGS). We observed that the overall incidence of ILI cases during 2019–2020 influenza season was considerably higher than previous years and was gradually replaced with SARS-CoV-2, which indicated a silent transmission among ambulatory patients. Sequencing of representative isolates confirmed independent introductions and silent transmission earlier than previously thought. Evolutionary and spatial analyses revealed clustering in the GH clade, characterized by three amino acid substitutions in spike gene (D614G), RdRp (P323L) and NS3 (Q57H). P323L causes conformational change near nsp8 binding site that might affect virus replication and transcription. In conclusion, assessment of the community transmission among patients with mild COVID-19 illness, particularly those without epidemiological link for acquiring the virus, is of utmost importance to guide policy makers to optimize public health interventions. The detection of SARS-CoV-2 in ILI cases shows the importance of ILI surveillance systems and warrants its further strengthening to mitigate the ongoing transmission of SARS-CoV-2. The effect of NS3 substitutions on oligomerization or membrane channel function (intra- and extracellular) needs functional validation.

Hydrothermal alteration and structural mapping of the Qolqoleh-Kasnazan shear zone in Iran using remote sensing data

2021 ◽  
Vol 14 (16) ◽  
Author(s):  
Mehdi Maleki ◽  
Shojaeddin Niroomand ◽  
Ehsan Farahbakhsh ◽  
Soroush Modabberi ◽  
Hossein Ali Tajeddin
Keyword(s):  
Remote Sensing ◽  
Shear Zone ◽  
Hydrothermal Alteration ◽  
Remote Sensing Data ◽  
Structural Mapping ◽  
Sensing Data

scholarly journals HIV-1 Envelope Conformation, Allostery, and Dynamics

Viruses ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 852
Author(s):  
Ashley Lauren Bennett ◽  
Rory Henderson
Keyword(s):  
Host Cell ◽  
Conformational Changes ◽  
Neutralizing Antibodies ◽  
Critical Role ◽  
Cell Receptor ◽  
Broadly Neutralizing Antibodies ◽  
Structural Mapping ◽  
Host Cell Receptor ◽  
Immunogen Design ◽  
Hiv 1

The HIV-1 envelope glycoprotein (Env) mediates host cell fusion and is the primary target for HIV-1 vaccine design. The Env undergoes a series of functionally important conformational rearrangements upon engagement of its host cell receptor, CD4. As the sole target for broadly neutralizing antibodies, our understanding of these transitions plays a critical role in vaccine immunogen design. Here, we review available experimental data interrogating the HIV-1 Env conformation and detail computational efforts aimed at delineating the series of conformational changes connecting these rearrangements. These studies have provided a structural mapping of prefusion closed, open, and transition intermediate structures, the allosteric elements controlling rearrangements, and state-to-state transition dynamics. The combination of these investigations and innovations in molecular modeling set the stage for advanced studies examining rearrangements at greater spatial and temporal resolution.

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