Application of Chitosan in Veterinary Vaccine Production

2018 ◽  
Vol 54 (5) ◽  
pp. 518-521 ◽  
Author(s):  
A. I. Albulov ◽  
M. A. Frolova ◽  
A. V. Grin ◽  
E. I. Kovaleva ◽  
N. V. Melnik ◽  
...  
Keyword(s):  
Vaccine Production ◽  
Veterinary Vaccine

scholarly journals Veterinary vaccine production using bioreactors: scale up study from laboratory and pd up to commercial production

2015 ◽  
Vol 9 (S9) ◽  
Author(s):  
Lídia Garcia ◽  
Maria Turon ◽  
Marta Comellas ◽  
Mercedes Mouriño ◽  
Alicia Urniza
Keyword(s):  
Scale Up ◽  
Commercial Production ◽  
Vaccine Production ◽  
Veterinary Vaccine ◽  
Scale Up Study

scholarly journals Comparative study on three locally developed live orf virus vaccines for sheep in Saudi Arabia

2012 ◽  
Vol 79 (1) ◽  
Author(s):  
Fahdel M. Housawi ◽  
Eltayb M. Abuelzein ◽  
Ahmed A. Gamee ◽  
Adel I. Alafaleq
Keyword(s):  
Saudi Arabia ◽  
Comparative Study ◽  
Protective Efficacy ◽  
Healing Time ◽  
Orf Virus ◽  
Vaccine Production ◽  
Veterinary Vaccine ◽  
Virulent Virus ◽  
And Performance ◽  
Selection Of

The epidemiology of orf virus infection in Saudi Arabia (SA) has been researched since 1990. The results obtained during this period indicate that the disease is widespread, has great economic impact and that no vaccine has been used against it. The present study compares the immunogenicity and protective efficacy of three locally developed live orf virus vaccines. Two of them differ in their passage history in Vero cell culture and the third was used as a virulent virus in glycerine buffer. To the best of the authors’ knowledge, no similar comparative study has been conducted in the Middle East utilising three types of vaccines prepared from the same virus strain. Selection of the candidate seed orf virus and performance of the quality control tests were as laid out by the OIE for veterinary vaccine production. The vaccine seed virus was a field orf virus isolated from a previous orf outbreak in Saudi Arabia. A simple novel formula was developed to calculate the rate of reduction in the healing time (RHT %) in the challenged sheep. This allowed direct comparison of the efficacy of the three types of vaccines employed in the present study. The efficacy of each vaccine was tested on a cohort of local Noemi sheep.

scholarly journals Veterinary vaccine development: The helical project

2020 ◽  
Vol 4 (1) ◽  
pp. 042-047
Author(s):  
Dereja Iyasu Angani
Keyword(s):  
Production Process ◽  
Infection Prevention ◽  
Development Process ◽  
Vaccine Development ◽  
Vaccine Production ◽  
The Public ◽  
Health Implication ◽  
Veterinary Vaccine ◽  
Improper Use

Vaccine production process have been fuzzy journey to the public and, in some degrees, to those in the setting. By clearly showing the lengthy and challenging journey of vaccine development process, thereby suggesting the economic and health implication of improper use of veterinary vaccines, the paper tries to add the attention given to infection prevention. Starting from the foundations, the types and requirements of veterinary vaccines are described. The paper concludes with current research and regulatory quos in the topic.

scholarly journals Process Validation and Critical Regulatory Requirements in Manufacturing of Inactivated Veterinary Vaccines

2018 ◽  
Vol 3 (2) ◽  
Keyword(s):  
Process Design ◽  
Scientific Evidence ◽  
Good Manufacturing Practice ◽  
Critical Parameters ◽  
Design Stage ◽  
Vaccine Production ◽  
Regulatory Requirement ◽  
Process Validation ◽  
Veterinary Vaccine ◽  
Process Qualification

Process validation is the most critical regulatory requirement for licensed biopharmaceuticals and vaccine facilities. It is also considered as an economic issue through understanding and controlling any process and subsequently minimizing the processes failures. The process design (PD), process qualification (PQ) and continued process verification (PV) are the main three stages for industry for process validation. It was defined as the collection and evaluation of data, from the process design stage throughout production, to establishe a scientific evidence that a process is consistently delivering high quality products and in accordance with the principles of Good Manufacturing Practice (GMP). The challenges of vaccine production process are not limited to its complicated details which may change the validity of the process but also the cross process that still the biggest challenge. Therefore, process validation in biopharmaceutical industries has the high priority specially vaccine production. In conclusion, continuous monitoring and validation of inactivated veterinary vaccines has the great impact on defects, nonconformance decreasing and processes improvement. Also the critical parameters of process validation of inactivated veterinary vaccine manufacturing are highlighted.

Determination of Specific Activity of Cholera Chemical Vaccine Components using Cell Culture

2020 ◽  
Vol 36 (3) ◽  
pp. 82-89
Author(s):  
O.V. Gromova ◽  
O.S. Durakova ◽  
S.V. Generalov ◽  
L.F. Livanova ◽  
O.A. Volokh
Keyword(s):  
Cell Culture ◽  
Vibrio Cholerae ◽  
Production Control ◽  
Specific Activity ◽  
Methodological Approach ◽  
Toxin Production ◽  
Submerged Cultivation ◽  
Vaccine Production ◽  
Antigenic Activity

Том 36(2020) №3 стр. 82-89; DOI 10.21519/0234-2758-2020-36-3-82-89А.В. Гаева1*, О.В. Громова1, О.С. Дуракова1, С.В. Генералов1, Л.Ф. Ливанова1, О.А. Волох1 Определение специфической активности компонентов холерной химической вакцины с использованием культуры клеток 1ФКУЗ «Российский научно-исследовательский противочумный институт «Микроб»» Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека, Саратов 410005 *[email protected] Поступила - 2019-11-26; После доработки - 2020-03-16; Принята к публикации - 2020-05-15 Список литературы Описаны методы определения динамики продукции токсинов штаммом Vibrio cholerae 569B при глубинном культивировании в биореакторе и антигенной активности специфической фракции холерогена-анатоксина по анатоксинсвязыванию с использованием клеточных культур. Показана высокая степень соответствия результатов, полученных методами, применяемыми для контроля этапов производства холерной химической вакцины и рассмотренными в данной работе. Отмечено, что применение клеточной линии СНО-К1 наиболее перспективно для замены биомоделей на промежуточных этапах контроля активных компонентов холерной химической вакцины. Разработанный методический подход впервые предлагается использовать на этапах производства холерной бивалентной химической вакцины. культура клеток, Vibrio cholerae, холерная химическая вакцина, контроль производства, холера. Vol 36(2020) N 3 p. 82-89; DOI 10.21519/0234-2758-2020-36-3-82-89A.V. Gaeva1*, O.V. Gromova1, O.S. Durakova1, S.V. Generalov1, L.F. Livanova1, O.A. Volokh1 Determination of Specific Activity of Cholera Chemical Vaccine Components using Cell Culture 1Russian Research Anti-Plague Institute «Microbe» of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Saratov, 410005 *[email protected] Received - 26.11.2019; Accepted - 15.05.2020 References The methods has been described to determine the dynamics of toxin production by the Vibrio cholerae 569B strain during submerged cultivation in bioreactor and of the antigenic activity of specific choleragen anatoxin fraction by anatoxin binding levels using cell cultures. High degree of consistency was observed between the results obtained via the method under consideration and those obtained via control methods at different stages of cholera chemical vaccine production. It was shown that the CHO-K1 cell line is the most promising substitute for biomodels at the intermediate stages of control of active cholera chemical vaccine components. The developed methodological approach was first proposed for use at the stages of cholera chemical bivalent vaccine manufacturing. cell culture, Vibrio cholerae, cholera chemical vaccine, production control, cholera.

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