Enzymatic Degradation of Capsules Based on Polyelectrolyte Polypeptide–Polysaccharide Complex for the Controlled Release of DNA

In recent decades, many novel methods by using nanoparticles (NPs) have been investigated for diagnosis, drug delivery and treatment of cancer. Accordingly, the potential of NPs as carriers is very significant for the delivery of anticancer drugs, because cancer treatment with NPs has led to the improvement of some of the drug delivery limitations such as low blood circulation time and bioavailability, lack of water solubility, drug adverse effect. In addition, the NPs protect drugs against enzymatic degradation and can lead to the targeted and/or controlled release of the drug. The present review focuses on the potential of NPs that can help the targeted and/or controlled delivery of anticancer agents for cancer therapy.

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Multilayer Capsules of Bovine Serum Albumin and Tannic Acid for Controlled Release by Enzymatic Degradation

ACS Applied Materials & Interfaces ◽

10.1021/acsami.5b03263 ◽

2015 ◽

Vol 7 (22) ◽

pp. 11732-11740 ◽

Cited By ~ 80

Author(s):

Maria V. Lomova ◽

Anna I. Brichkina ◽

Maxim V. Kiryukhin ◽

Elena N. Vasina ◽

Anton M. Pavlov ◽

...

Keyword(s):

Controlled Release ◽

Bovine Serum Albumin ◽

Serum Albumin ◽

Tannic Acid ◽

Bovine Serum ◽

Enzymatic Degradation

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Enzymatically degradable, starch-based layer-by-layer films: application to cytocompatible single-cell nanoencapsulation

Soft Matter ◽

10.1039/d0sm00876a ◽

2020 ◽

Vol 16 (26) ◽

pp. 6063-6071 ◽

Cited By ~ 3

Author(s):

Hee Chul Moon ◽

Sol Han ◽

João Borges ◽

Tamagno Pesqueira ◽

Hyunwoo Choi ◽

...

Keyword(s):

Saccharomyces Cerevisiae ◽

Controlled Release ◽

Single Cell ◽

Enzymatic Degradation ◽

Layer By Layer

Starch-based layer-by-layer (LbL) nanofilms are formed and enzymatically degraded on individual Saccharomyces cerevisiae in a highly cytocompatible fashion. Their enzymatic degradation by α-amylase is also exploited for the controlled release of DNA.

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Biodegradable Blends of Grafted Dextrin with PLGA-block-PEG Copolymer as a Carrier for Controlled Release of Herbicides into Soil

Materials ◽

10.3390/ma13040832 ◽

2020 ◽

Vol 13 (4) ◽

pp. 832 ◽

Cited By ~ 1

Author(s):

Kamila Lewicka ◽

Piotr Rychter ◽

Małgorzata Pastusiak ◽

Henryk Janeczek ◽

Piotr Dobrzynski

Keyword(s):

Controlled Release ◽

Polymer Matrix ◽

Enzymatic Degradation ◽

Plant Protection ◽

Degradation Products ◽

The Matrix ◽

Poly Ethylene Oxide ◽

Poly Ethylene ◽

Unchanged Form ◽

Potential Use

The presented work aimed to test influence of poly(L-lactide-co-glycolide)-block-poly (ethylene oxide) copolymer modification by blending with grafted dextrin or maltodextrin on the course of degradation in soil and the usefulness of such material as a matrix in the controlled release of herbicides. The modification should be to obtain homogenous blends with better susceptibility to enzymatic degradation. Among all tested blends, which were proposed as a carrier for potential use in the controlled release of plant protection agents, PLGA-block-PEG copolymer blended with grafted dextrin yielded very promising results for their future applications, and what is very importantly proposed formulations provide herbicides in unchanged form into soil within few months of release. The modification PLAGA/PEG copolymer by blending with modificated dextrins affects the improvement of the release profile. The weekly release rates for both selected herbicides (metazachlor and pendimethalin) were constant for a period of 12 weeks. Enzymatic degradation of modified dextrin combined with leaching of the degradation products into medium caused significant erosion of the polymer matrix, thereby leading to acceleration of water diffusion into the polymer matrix and allowing for easier leaching of herbicides outside the matrix.

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Controlled release and targeting of polypeptide-deposited liposomes by enzymatic degradation

Polymer Journal ◽

10.1038/s41428-019-0232-1 ◽

2019 ◽

Vol 51 (11) ◽

pp. 1223-1230

Author(s):

Yuuka Fukui ◽

Hikari Otsuka ◽

Keiji Fujimoto

Keyword(s):

Controlled Release ◽

Enzymatic Degradation

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Controlled release triggered by enzymatic degradation for DDS using alginate hydrogel microparticles

The Proceedings of Mechanical Engineering Congress Japan ◽

10.1299/jsmemecj.2018.j0220305 ◽

2018 ◽

Vol 2018 (0) ◽

pp. J0220305

Author(s):

Hideo MIYAHARA ◽

Yuta KURASHINA ◽

Yuki OGAWA ◽

Ayumu KURIHARA ◽

Tomohiko YOSHIDA ◽

...

Keyword(s):

Controlled Release ◽

Enzymatic Degradation ◽

Alginate Hydrogel ◽

Hydrogel Microparticles

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Role of the exosporial membrane in attachment and germination of C. sporogenes

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100146035 ◽

1993 ◽

Vol 51 ◽

pp. 38-39

Author(s):

B.J. Panessa-Warren ◽

G.T. Tortora ◽

J.B. Warren

Keyword(s):

Enzymatic Degradation ◽

Light Transmission ◽

Extended Period ◽

Growth Conditions ◽

Clostridium Sporogenes ◽

Radiation Chemical ◽

Physical Trauma ◽

Extended Contact ◽

Cold Pressure

Some bacteria are capable of forming highly resistant spores when environmental conditions are not adequate for growth. Depending on the genus and species of the bacterium, these endospores are resistant in varying degrees to heat, cold, pressure, enzymatic degradation, ionizing radiation, chemical sterilants,physical trauma and organic solvents. The genus Clostridium, responsible for botulism poisoning, tetanus, gas gangrene and diarrhea in man, produces endospores which are highly resistant. Although some sporocides can kill Clostridial spores, the spores require extended contact with a sporocidal agent to achieve spore death. In most clinical situations, this extended period of treatment is not possible nor practical. This investigation examines Clostridium sporogenes endospores by light, transmission and scanning electron microscopy under various dormant and growth conditions, cataloging each stage in the germination and outgrowth process, and analyzing the role played by the exosporial membrane in the attachment and germination of the spore.

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