Cyclopropanes of 5-nitrofuran series

1979 ◽  
Vol 44 (2) ◽  
pp. 420-423 ◽  
Author(s):  
Josef Prousek ◽  
Adolf Jurášek ◽  
Miloslava Dandárová ◽  
Jaroslav Kováč
Keyword(s):  
Spectral Data ◽  
Reaction Products ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
H Nmr

5-Nitrofurfuryl trichloromethyl sulphone (I) was reacted with paraformaldehyde in methanol in the presence of piperidine as catalyst to give 1-(5-nitro-2-furyl)-1-trichloromethylsulphonyl-2-(5-nitro-2-furyl)cyclopropane. This substance was also obtained from 1-(5-nitro-2-furyl)-1-trichloromethylsulphonyl-2-(5-nitro-2-furyl)ethylene and diazomethane. The reaction products were characterized by IR, UV, 1H NMR and mass spectral data.

scholarly journals Synthesis and Antimicrobial Activity ofSome New 2-Substituted Benzothiazole Derivatives

2009 ◽  
Vol 6 (3) ◽  
pp. 775-779 ◽  
Author(s):  
B. Rajeeva ◽  
N. Srinivasulu ◽  
S. M. Shantakumar
Keyword(s):  
Antimicrobial Activity ◽  
Spectral Data ◽  
Diffusion Method ◽  
Disc Diffusion ◽  
Phosphoryl Chloride ◽  
Mass Spectral Data ◽  
Disc Diffusion Method ◽  
Mass Spectral ◽  
Benzothiazole Derivatives ◽  
H Nmr

Some new 2-(5-substituted-1,3,4-oxadiazole-2-yl)-1,3- benzothiazole(3a-j)were synthesized by refluxing benzothiazolyl carboxyhydrazide with different aryl acids in phosphoryl chloride. Structures of the synthesized compounds were established on the basis of1H NMR and Mass spectral data. The anti microbial activity of the synthesized compounds was evaluated by disc diffusion method.

Synthesis, spectroscopic and electrochemical investigations of supramolecular nickel(II)tetraazaporphyrin complexes

2005 ◽  
Vol 09 (07) ◽  
pp. 509-518 ◽  
Author(s):  
Rajendra Prasad ◽  
Ajay Kumar
Keyword(s):  
Cyclic Voltammetry ◽  
Spectral Data ◽  
Electronic Absorption ◽  
Electronic Interaction ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
H Nmr ◽  
High Degree

The ( bpy )2 Ru II and ( phen )2 Ru II moieties were linked to [ Ni ( OBTTAP )]1, periphery through coordinate bonds in order to synthesize cationic di- and pentanuclear complexes 2-5 that were obtained as PF 6− salts. They were characterized by IR, 1 H NMR, UV-vis, and mass spectral data. The electronic absorption, emission and redox data of these bichromophoric systems indicate the presence of a high degree of intercomponent electronic interaction. The position and relative intensities of the Soret and Q bands in these complexes is altered due to peripheral binding of the metal units. The compounds were non-emissive for the Q band excitation but, Soret excitation led to a strong S 2 emission, observed between 400-450 nm. In cyclic voltammetry, the compounds exhibited one Ru centered oxidation together with one or two OBTTAP centered oxidations. The Ru II/ Ru III oxidations were observed at significantly lower potentials as compared to the corresponding simple maleonitrile-benzylthioether complexes and has been interpretted in terms of weaker d π( S )– d π( Ru ) interactions.

scholarly journals Synthesis and Antimicrobial Activity of (2-Methoxy/2-Amino)-6-{4'-[(4'''-Chlorophenyl) (Phenyl) Methyl Amino] Phenyl}-4-Aryl Nicotinonitrile

2015 ◽  
Vol 49 ◽  
pp. 99-103
Author(s):  
J.V. Guna ◽  
V.N. Bhadani ◽  
H.D. Purohit ◽  
Dipak M. Purohit
Keyword(s):  
Antimicrobial Activity ◽  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Spectral Data ◽  
Elemental Analysis ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
H Nmr ◽  
Bacteria And Fungi ◽  
Layer Chromatography

2- Methoxy – 6 - {4' - [(4'''- Chlorophenyl) (phenyl) methyl amino] phenyl} - 4 - aryl nicotinonitrile (3a-3l) and 2-Amino-6-{4'-[(4'''-Chlorophenyl)(phenyl)methyl amino]phenyl}-4-aryl nicotinonitrile (4a-4l) have been synthesized. The products have been assayed for their antimicrobial activity against Gram +ve, Gram -ve bacteria and fungi. The structure of the products has been elucidated by IR, 1H-NMR, mass spectral data, elemental analysis and thin layer chromatography.

scholarly journals Synthesis and Biological Evaluation of Some Novel 1, 3, 5-Trisubstituted Pyrazolines

2010 ◽  
Vol 7 (1) ◽  
pp. 295-298 ◽  
Author(s):  
B. C. Revanasiddappa ◽  
R. Nagendra Rao ◽  
E. V. S. Subrahmanyam ◽  
D. Satyanarayana
Keyword(s):  
Antimicrobial Activity ◽  
Acetic Acid ◽  
Spectral Data ◽  
Glacial Acetic Acid ◽  
Biological Evaluation ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
H Nmr ◽  
Synthesis And Biological Evaluation

A new series of chalcones (3a-j) were synthesized by condensation of simple aldehydes with substituted acetophenones in presence of alkali. The resulted chalcones upon cyclization in presence of glacial acetic acid with isoniazid (INH) will yields the title compounds (4a-j). The newly synthesized compounds were assigned on the basis of IR,1H NMR, and Mass spectral data. All the final compounds were evaluated for theirin vitroantimicrobial activity.

scholarly journals Synthesis, Characterization, and Biological Evaluation of Some New Functionalized Terphenyl Derivatives

2012 ◽  
Vol 2012 ◽  
pp. 1-13 ◽  
Author(s):  
Seranthimata Samshuddin ◽  
Badiadka Narayana ◽  
Balladka Kunhanna Sarojini ◽  
Divya N. Shetty ◽  
Nalilu Suchetha Kumari
Keyword(s):  
Antimicrobial Activity ◽  
Antioxidant Activity ◽  
Spectral Data ◽  
Antioxidant Properties ◽  
Biological Evaluation ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
H Nmr

New functionalized terphenyl derivatives incorporating various heterocyclic rings are prepared by using 4,4′′-difluoro-5′-hydroxy-1,1′:3′,1′′-terphenyl-4′-carbohydrazide as a key intermediate derived from 4,4′-difluoro chalcone, a versatile synthone. All the derivatives are characterized by 1H NMR, IR, and mass spectral data. All the synthesized products are screened for their in vitro antimicrobial and antioxidant properties. The majority of the tested compounds exhibited significant antioxidant activity and some of them showed good antimicrobial activity.

Partially oxidized porphyrazines

2006 ◽  
Vol 10 (07) ◽  
pp. 996-1002 ◽  
Author(s):  
Ayhan Nazli ◽  
Ergün Gonca ◽  
Ahmet Gül
Keyword(s):  
Spectral Data ◽  
Elemental Analysis ◽  
Trifluoroacetic Acid ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
H Nmr ◽  
Ft Ir ◽  
New Compounds

Magnesium porphyrazinate substituted with eight (1-naphthyl) groups on the peripheral positions has been synthesized by cyclotetramerization of 3,4-(1-naphthyl)pyrroline-2,5-diimine, 4-(1-naphthyl)pyrroline-2,5-diimine in the presence of magnesium butanolate. Its demetalation by treatment with trifluoroacetic acid, resulted in a partially oxidized product, namely, octakis(1-naphthyl)-2-seco-porphyrazine-2,3-dione. Further reaction of this product with copper(II) acetate, zinc(II) acetate and cobalt(II) acetate led to the metallo derivatives, [octakis(1-naphthyl)-2-seco-2,3-dioxoporphyrazinato]M(II) ( M = Cu , Zn or Co ). These new compounds have been characterized by elemental analysis, together with FT-IR, 1 H NMR, UV-vis and mass spectral data.

Synthesis, antiviral, cytotoxicity and antitumor evaluations of A4 type of porphyrin derivatives

2015 ◽  
Vol 19 (06) ◽  
pp. 753-768 ◽  
Author(s):  
Ahmed A. Fadda ◽  
Rasha E. El-Mekawy ◽  
Ahmed I. El-Shafei
Keyword(s):  
Spectral Data ◽  
Moderate Degree ◽  
Tumor Cell Lines ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
H Nmr ◽  
Porphyrin Derivatives ◽  
Hiv 1 ◽  
C Nmr ◽  
Hsv 1

This manuscript describes the synthesis of a new series of porphyrin structures 4a–4m, 7, 9, 12 and 14. These structures were investigated against two types of viruses such as HIV-1 and HSV-1. Also they were screened for their antitumor activity. Among all tested compounds, it was found that compound 4b showed a high activity against HIV-1 and HSV-1 and against four different tumor cell lines. Most of the tested compounds showed a moderate degree of a potent antimicrobial activity. The structure of these compounds was confirmed on the basis of their analytical and spectral data such as UV-vis, IR, 13 C NMR, 1 H NMR spectroscopy and mass spectral data.

Seco-porphyrazines with eight (p-tolyl) and (o-tolyl) units

2008 ◽  
Vol 12 (02) ◽  
pp. 116-122 ◽  
Author(s):  
Ergün Gonca ◽  
Ümmü Gülsüm Baklaci ◽  
Hatice Akin Dinçer
Keyword(s):  
Spectral Data ◽  
Elemental Analysis ◽  
Trifluoroacetic Acid ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
H Nmr ◽  
Ft Ir ◽  
First Time ◽  
Oxidized Products

Magnesium porphyrazinates substituted with eight (p-tolyl) and (o-tolyl) units on the peripheral positions have been synthesized for the first time by cyclotetramerization of 1,2-bis(p-tolyl)maleonitrile and 1,2-bis(o-tolyl)maleonitrile in the presence of magnesium butanolate. Their demetalation by the treatment with trifluoroacetic acid resulted in partially oxidized products, namely, octakis(p-tolyl)-2-seco-porphyrazine-2,3-dione and octakis(o-tolyl)-2-seco-porphyrazine-2,3-dione. Further reactions of these products with copper(II) acetate, zinc(II) acetate and cobalt(II) acetate have led to the metallo derivatives, [octakis(p-tolyl)-2-seco-2,3-dioxoporphyrazinato] M(II) and [octakis(o-tolyl)-2-seco-2,3-dioxoporphyrazinato] M(II) ( M = Cu , Zn , Co ). These novel compounds have been characterized by elemental analysis, together with FT-IR, 1H NMR, UV-vis and mass spectral data.

SYNTHESIS AND ANTICONVULSANT ACTIVITY OF NOVEL 1,3,4-OXADIAZOLE DERIVATIVES

INDIAN DRUGS ◽  
2021 ◽  
Vol 57 (11) ◽  
pp. 40-44
Author(s):  
.Aishwarya T.C ◽  
◽  
James Jainey ◽  
Vijay Kumar M. ◽  
B.C. Revanasiddappa
Keyword(s):  
Spectral Data ◽  
Anticonvulsant Activity ◽  
Aromatic Aldehydes ◽  
Oxidative Cyclization ◽  
Mercuric Oxide ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
H Nmr ◽  
Oxadiazole Derivatives

2 Oxo-2h-chromene-3-carbohydrazide (1) reacts with various aromatic aldehydes to give corresponding 2-oxo-2h-chromene-3-carbohydrazide arylidene hydrazides (SB1-8). Oxidative cyclization of (SB1-8) with mercuric oxide and iodine in DMF medium furnishes the title compounds 3-(5-aryl-1,3,4-oxadiazol2-yl)-2h-chromen-2-ones (2a-h). All the synthesized compounds were assigned structures on the basis of IR, 1 H-NMR and Mass spectral data. Some of the selected compounds were evaluated for In vivo anticonvulsant activity by MES and PTZ models.

Cancentrine. V. The 13C magnetic resonance spectra of cancentrine and some derivatives; the structure of 10-oxocancentrine

1978 ◽  
Vol 56 (18) ◽  
pp. 2467-2471 ◽  
Author(s):  
Herbert L. Holland ◽  
Donald W. Hughes ◽  
David B. MacLean ◽  
Russell G. A. Rodrigo
Keyword(s):  
Magnetic Resonance ◽  
Spectral Data ◽  
Methyl Ether ◽  
Resonance Spectrum ◽  
Chemical Shifts ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
H Nmr ◽  
First Time ◽  
Magnetic Resonance Spectra

The 13C magnetic resonance spectrum of cancentrine is reported. Assignments of chemical shifts have been made by comparison of the cancentrine spectrum with the published spectra of codeine, codeinone, and cularine and with the spectra reported here for the first time of 9,10-dihydrocancentrine methine-O-methyl ether and 10-oxocodeinone. The spectral data so obtained have been used to interpret the 13C spectrum of 10-oxocancentrine, a new alkaloid of the cancentrine family, and to verify the structure deduced for it from 1H nmr, ir, uv, and mass spectral data.

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