Synthesis of several 1-(aminoacyl)-4-cinnamylpiperazines as potential analgetics
1982 ◽
Vol 47
(2)
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pp. 636-643
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Keyword(s):
A reaction of 1-cinnamylpiperazine (III) with chloroacetyl gave the chloroacetyl derivative IV which was subjected to substitution reactions with aniline, 4-phenylpiperidin-4-ol (XIa),4-(4-fluorophenyl)piperidin-4-ol (XIb) and 4-(4-chloro-3-trifluoromethyl)piperidin-4-ol and afforded the title compounds V and VII-IX. Acylation reactions of compounds V and VII with propionyl chloride gave the propionanilide derivative VI and the 4-phenyl-4-propanoyloxypiperidine derivative X. With the exception of compound VIII, the new substances are analgetically less active than 1-butyryl-4-cinnamylpiperazine (I) and as antiinflammatory agents they are little active or inactive.
1977 ◽
Vol 25
(12)
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pp. 3198-3209
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2020 ◽
1960 ◽
2011 ◽
Vol 10
(3)
◽
pp. 203-214
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