The effects of lipophilicity on the inhibition of denaturation of serum albumin and on the activation of fibrinolysis observed with a series of benzyloxyarylaliphatic acids

Activation of fibrinolysis and inhibition of denaturation of serum albumin by a series of substituted benzyloxyarylaliphatic acids have been measured and analyzed in relation to the physico-chemical parameters of these acids. The lipophilicity of the benzyloxy derivatives was characterized both by the tabulated parameters π and by experimental data obtained by TLC. Regression analysis has revealed that the derivatives manifest higher lipophilicities in both the activation of fibrinolysis and the inhibition of denaturation, and that these lipophilicities are better described by the tabulated data than by experimental values. Taking into account the earlier results of regression analysis of erythrocyte membrane stabilization and antiinflammatory activity it can be judged that the role of lipophilicities of these substances is influenced by the nature of their interaction with the biological system.

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Assessment of diversity and physico-chemical parameters of cyanobacteria, diatoms and other algal species in the paddy fields of Belagavi district, Karnataka

Plant Science Today ◽

10.14719/pst.2020.7.3.753 ◽

2020 ◽

Vol 7 (3) ◽

pp. 378-382

Author(s):

Santoshkumar Jayagoudar ◽

Pradeep Bhat ◽

Ankita Magdum ◽

Duradundi Sakreppagol ◽

Laxmi Murgod ◽

...

Keyword(s):

Algal Species ◽

Soil Samples ◽

Chemical Parameters ◽

Range Estimation ◽

The North ◽

Physico Chemical ◽

Water And Soil Samples ◽

Study Sites ◽

Good Range

Algae are the diverse group of organisms in the soil and aquatic environment. The role of them in soil fertility enhancement has been extensively studied worldwide. Belagavi is a tropical agricultural belt in the North Karnataka region with highly fertile soil. Water and soil samples were collected randomly from the paddy field of 15–20 well-distributed spots in 4 selected locations viz Kusumali, Jamboti, Kinaye and Piranwadi. The identification revealed the presence of 94 species and 71 genera in the investigated sites. Among all, 62 species belonged to Bacillariophyceae, 14 species to Chlorophyceae, 10 species to Cyanophyceae, 3 to Xanthophyceae, followed by Trebouxiophyceae and Zygnematophyceae (2 species each) and one species of Ulvophyceae. The maximum number of 62 species was recorded from Kusamali, followed by 49 species in Kinaye, 44 in Jamboti and 35 in Piranwadi. The month of February had the highest number of species (61), decreased to 45 in March, 42 in April and 37 in May. Among the physicochemical parameters analysed for the soil samples, it was found that the pH of the soil is slightly acidic in all the study sites ranged between 5.03–5.85. Further, the electrical conductivity (EC) varied from 0.27–0.345 dS/m, found to be in a good range. Estimation of available micro and macronutrients of soil were measured, and it was found to be at low to moderate levels. The present study indicates the extensive distribution of different classes of algae in the rice fields of four study locations in Belagavi.

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Effects of Physico-Chemical Parameters on Actinomycetes Communities during Composting of Agricultural Waste

Sustainability ◽

10.3390/su11082229 ◽

2019 ◽

Vol 11 (8) ◽

pp. 2229

Author(s):

Yuanping Li ◽

Yanrong Chen ◽

Yaoning Chen ◽

Yanxin Wu ◽

Chun Zhang ◽

...

Keyword(s):

Regression Analysis ◽

Moisture Content ◽

16S Rdna ◽

Community Composition ◽

Agricultural Waste ◽

Chemical Parameters ◽

16S Rdna Gene ◽

Rdna Gene ◽

Gene Abundance ◽

Physico Chemical

The objective of this study was to investigate the influence of physico-chemical parameters on Actinomycetes communities and to prioritize those parameters that contributed to Actinomycetes community composition during the composting of agricultural waste. Denaturing gradient gel electrophoresis of polymerase chain reaction (PCR-DGGE) and redundancy analysis (RDA) were used to determine the relationships between those parameters and Actinomycetes community composition. Quantitative PCR (qPCR) and regression analysis were used to monitor the 16S rDNA copy numbers of Actinomycetes and to analyse the correlations between physico-chemical parameters and Actinomyces 16S rDNA gene abundance, respectively. The RDA results showed that moisture content, water soluble carbon (WSC) and pH (p < 0.05) made the main contributions to the temporal variations of Actinomycetes community composition. The output of the regression analysis indicated that moisture content (R2 = 0.407, p < 0.01) showed a negative linear relationship with the Actinomyces 16S rDNA gene abundance.

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Benzyloxyarylaliphatic acids: Synthesis and quantitative relations between structure and antiinflammatory activity

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19822514 ◽

1982 ◽

Vol 47 (9) ◽

pp. 2514-2524 ◽

Cited By ~ 3

Author(s):

Miroslav Kuchař ◽

Václav Rejholec ◽

Bohumila Brunová ◽

Jaroslava Grimová ◽

Oluše Matoušová ◽

...

Keyword(s):

Regression Analysis ◽

Aromatic Ring ◽

Erythrocyte Membrane ◽

Antiinflammatory Activity ◽

Structural Parameters ◽

Antiinflammatory Effect ◽

Physico Chemical

The paper describes synthesis of substituted benzyloxyarylaliphatic acids, I-V, and their efficacy in stabilization the erythrocyte membrane against hypotonic haemolysis and their antiinflammatory effect in inhibition of the kaolin oedema. The quantitative relations between these efficacies and the physico-chemical and structural parameters of the acids have been analysed. The two activities depend on the overall lipophilicity and acidity of the acids. In the investigated range of lipophilicity the dependence of the antiinflammatory effect on lipophilicity had a parabolic course, whereas in stabilization of the erythrocyte membrane this dependence was linear. In either case the efficacy was suppressed by extending the connecting chain between the carboxyl and the aromatic ring. Regression analysis suggests that in the group of benzyloxyarylaliphatic acids it is not possible to prepare compounds more effective than 3-chloro-4-benzyloxyphenylacetic acid (benzofenac, Ia) and its 2-methyl analogue IIa.

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Effects of physico-chemical parameters of a model wine on the binding of γ-decalactone on bovine serum albumin

Food Chemistry ◽

10.1016/0308-8146(95)90789-a ◽

1995 ◽

Vol 53 (2) ◽

pp. 203-207 ◽

Cited By ~ 23

Author(s):

C. Druaux ◽

S. Lubbers ◽

C. Charpentier ◽

A. Voilley

Keyword(s):

Bovine Serum Albumin ◽

Serum Albumin ◽

Bovine Serum ◽

Chemical Parameters ◽

Physico Chemical

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Protein cold adaptation: Role of physico-chemical parameters in adaptation of proteins to low temperatures

Journal of Theoretical Biology ◽

10.1016/j.jtbi.2015.07.013 ◽

2015 ◽

Vol 383 ◽

pp. 130-137 ◽

Cited By ~ 4

Author(s):

Soheila Shokrollahzade ◽

Fatemeh Sharifi ◽

Akbar Vaseghi ◽

Maryam Faridounnia ◽

Samad Jahandideh

Keyword(s):

Low Temperatures ◽

Cold Adaptation ◽

Chemical Parameters ◽

Physico Chemical

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Use of QSAR in design of antiinflammatory fluorinated arylalkanoic acids

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19900296 ◽

1990 ◽

Vol 55 (1) ◽

pp. 296-306 ◽

Cited By ~ 4

Author(s):

Miroslav Kuchař ◽

Jaroslava Grimová ◽

Václav Rejholec ◽

Hana Tomková ◽

Magda Jelínková ◽

...

Keyword(s):

Antiinflammatory Activity ◽

Hydrophobic Interactions ◽

Biological Activities ◽

Regression Equations ◽

Chemical Parameters ◽

Pharmacological Profile ◽

Physico Chemical ◽

Layer Chromatography ◽

Fibrinolytic Capacity ◽

Good Coincidence

A series of 3-fluro-4-alkoxyphenylalkanoic acids III was synthetized and their antiinflammatory activity and fibrinolytic capacity was evaluated. The suitable fluorinated derivative with better pharmacological profile than 3-chloro-4-benzyloxyphenylacetic acid (benzofenac) was selected. Experimental, biological activities of acids III were compared with those calculated by introducing the physico-chemical parameters into the formerly derived regression equations. Good coincidence was found out, as well as similarity of the regression derived for the original series of acids extended by the acids III. Lipophilicity of the acids under study was evaluated by partition thin-layer chromatography; the values of log P of benzyloxy derivatives IIIc-IIIf were lower than tabulated values - probably due to the intramolecular hydrophobic interactions of aromatic nuclei.

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Heats of vaporization of nonelectrolytes

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19790307 ◽

1979 ◽

Vol 44 (2) ◽

pp. 307-312

Author(s):

Petr Kyselka ◽

Jiří Rameš ◽

Karel Procházka

Keyword(s):

Experimental Data ◽

Chemical Properties ◽

Approximate Expression ◽

Maximum Deviation ◽

First Order ◽

Critical Data ◽

Physico Chemical ◽

Theory Of Liquids ◽

Nonpolar Liquids ◽

Experimental Values

The first-order perturbation theory of liquids was used for developing an approximate expression suitable for a rapid calculation of the heat of vaporization of nonpolar liquids formed by approximately spherical molecules. The calculation uses only available physico-chemical properties of substances, namely the critical data. The results are tested by a comparison with existing experimental data on a series of nonpolar substances. The agreement between calculated values and experimental data is relatively good. The maximum deviation between theoretical and experimental values does not exceed ±10%.

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Contribution of Physico-Chemical Diagnostic Methods to Assessment of Real Reinforced Concrete Structures

Applied Mechanics and Materials ◽

10.4028/www.scientific.net/amm.253-255.583 ◽

2012 ◽

Vol 253-255 ◽

pp. 583-586 ◽

Cited By ~ 1

Author(s):

Amos Dufka ◽

Jiří Bydžovský

Keyword(s):

Reinforced Concrete ◽

Concrete Strength ◽

Concrete Structures ◽

Diagnostic Methods ◽

Reinforced Concrete Structures ◽

Chemical Parameters ◽

Strength Parameters ◽

Physico Chemical

When assessing a condition of reinforced concrete structures the expert companies mostly place emphasis mainly on determination of material physico-chemical parameters (such as concrete strength parameters, reinforcement placing etc.). These figures are, of course, very important for example for structural analysis of a structure, but for complex assessment of a condition are these data fully insufficient. This article illustrates the role of physico-chemical analysis when assessing a condition of reinforced concrete structures using a specific example.

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