Synthesis of 6-aryl-6H-naphtho[2’,1’:5,6]pyrano[4,3-b]-[1,8]naphthyridines

1988 ◽  
Vol 53 (3) ◽  
pp. 643-645 ◽  
Author(s):  
Kamreddy Rajendar Reddy ◽  
Kaleru Mogilaiah ◽  
Bathula Sreenivasulu
Keyword(s):  
Antibacterial Activity ◽  
Acetic Acid ◽  
Spectral Data ◽  
Sulphuric Acid ◽  
Glacial Acetic Acid ◽  
Catalytic Amount ◽  
Elemental Analyses

A series of new 6-aryl-6H-naphtho[2’,1’:5,6]pyrano[4,3-b][1,8]naphthyridines III have been synthesized by condensing 2-aminonicotinaldehyde (I) with a number of 1-hydroxy-2-naphthyl styryl ketones II in the presence of glacial acetic acid containing a catalytic amount of conc. sulphuric acid. The products have been characterized on the basis of elemental analyses and spectral data. Antibacterial activity of these compounds is negligible.

On the proteid reaction of Adamkiewicz, with contributions to the chemistry of glyoxylic acid

1901 ◽  
Vol 68 (442-450) ◽  
pp. 21-33 ◽  
Keyword(s):  
Acetic Acid ◽  
Sulphuric Acid ◽  
Glacial Acetic Acid ◽  
Glyoxylic Acid ◽  
Violet Colour

In 1874 Adamkiewicz* described the now familiar reaction which results in the production of a violet colour when strong sulphuric acid is added to the solution of a proteid in glacial acetic acid. Adam­kiewicz did not apparently look upon the employment of the acetic acid as introducing anything beyond a certain modification of the action of sulphuric acid.

scholarly journals Synthesis Of 5, 7-Diaryl-1,5-Dihydro (Or 1, 2, 3, 5-Tetrahydro)- Pyrano[2, 3-D] Pyrimidin-2, 4-Diones (Or 2-Thioxo-4-Ones).

2013 ◽  
Vol 25 (2) ◽  
pp. 124-131
Author(s):  
Mohammad Shahid Ullah ◽  
M Giasuddin Ahmed ◽  
UKR Romman ◽  
Kawsari Akhter ◽  
S Mosaddeq Ahmed ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Glacial Acetic Acid ◽  
Barbituric Acid ◽  
Thiobarbituric Acid ◽  
Chemical Society ◽  
Mass Spectral Data ◽  
Phosphorous Pentoxide ◽  
Mass Spectral ◽  
Elemental Analyses ◽  
One Step

Some 5, 7-diaryl-1,5-dihydro (or 1, 2, 3, 5-tetrahydro)- pyrano[2, 3-d] pyrimidin-2, 4- diones (or 2-thioxo-4-ones) (3a-g) has been synthesized in one-step by the cyclocondensation of barbituric acid or thiobarbituric acid (1) with arylideneacetophenones (2a-d), in glacial acetic acid in the presence of phosphorous pentoxide. The structures of the compounds 3a-g were determined by their UV, IR, 1H NMR, 13C NMR, mass spectral data and elemental analyses. Journal of Bangladesh Chemical Society, Vol. 25(2), 124-131, 2012 DOI: http://dx.doi.org/10.3329/jbcs.v25i2.15064

scholarly journals (2S,5R)-2-Isopropyl-5-methylcyclohexanone Hydrazones

Molbank ◽  
10.3390/m1062 ◽  
2019 ◽  
Vol 2019 (2) ◽  
pp. M1062 ◽  
Author(s):  
Mariia Nesterkina ◽  
Dmytro Barbalat ◽  
Ivan Zheltvay ◽  
Ildar Rakipov ◽  
Mehmet Atakay ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Differential Scanning Calorimetry ◽  
Acetic Acid ◽  
Glacial Acetic Acid ◽  
Catalytic Amount ◽  
Phenoxyacetic Acid ◽  
Scanning Calorimetry ◽  
Geometrical Isomers ◽  
Esi Mass Spectrometry ◽  
Amide Conformers

Hydrazones were obtained in 76–78% yield via condensation of (2S,5R)-2-isopropyl-5-methylcyclohexanone with 4-R-phenoxyacetic acid hydrazides in the presence of a catalytic amount of glacial acetic acid. The structure of the target compounds has been established by FTIR-ATR, Raman, 1H-NMR and 13C-NMR spectral analysis and EI/FAB/ESI mass spectrometry. Thermal properties of hydrazones 3a–3e were elucidated by differential scanning calorimetry (DSC) and their purity by HPLC coupled to mass spectrometry. Synthesized compounds were found to exist as Z/E geometrical isomers about C=N bond and cis/trans amide conformers.

scholarly journals Synthesis and Biological Evaluation of Some Novel 1, 3, 5-Trisubstituted Pyrazolines

2010 ◽  
Vol 7 (1) ◽  
pp. 295-298 ◽  
Author(s):  
B. C. Revanasiddappa ◽  
R. Nagendra Rao ◽  
E. V. S. Subrahmanyam ◽  
D. Satyanarayana
Keyword(s):  
Antimicrobial Activity ◽  
Acetic Acid ◽  
Spectral Data ◽  
Glacial Acetic Acid ◽  
Biological Evaluation ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
H Nmr ◽  
Synthesis And Biological Evaluation

A new series of chalcones (3a-j) were synthesized by condensation of simple aldehydes with substituted acetophenones in presence of alkali. The resulted chalcones upon cyclization in presence of glacial acetic acid with isoniazid (INH) will yields the title compounds (4a-j). The newly synthesized compounds were assigned on the basis of IR,1H NMR, and Mass spectral data. All the final compounds were evaluated for theirin vitroantimicrobial activity.

scholarly journals A Study on the Synthesis of 5, 7-Diaryl-1,2,3,4-tetrahydro-2, 4-dioxo-5H-pyrano [2,3-d]pyrimidines

1970 ◽  
Vol 41 (3) ◽  
pp. 119-128 ◽  
Author(s):  
MG Ahmed ◽  
UKR Romman ◽  
SM Ahmed ◽  
Khondaker Akhter ◽  
ME Halim ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Spectral Data ◽  
1H Nmr ◽  
13C Nmr ◽  
Glacial Acetic Acid ◽  
Barbituric Acid ◽  
Aqueous Ethanol ◽  
Single Step ◽  
Phosphorous Pentoxide

5,7-Diphenyl-1,2,3,4-tetrahydro-2,4-dioxo-5H-pyrano[2,3-d]pyrimidine (4a) has been synthesized in single-step by the condensation of barbituric acid (1) with benzylideneacetophenone (2a) in glacial acetic acid in the presence of phosphorous pentoxide. Reaction of barbituric acid (1) with arylideneacetophenones (2b-d) which gave the corresponding adducts of 5-(1,3-diaryl-1-oxopropyl) pyrimidine (1H, 3H, 5H)-2,4,6-triones (3a-c) previously in 50 % aqueous ethanol which on further reflux in gl. acetic acid in the presence of phosphorous pentoxide also gave the corresponding pyranopyrimidines 5,7-diaryl-1,2,3,4-tetrahydro-2,4-dioxo-5H-pyrano [2,3- d]pyrimidines (4b-d). The structures of the compounds 4a-d were characterized by their UV, IR, 1H NMR and 13C NMR spectral data. Bangladesh J. Sci. Ind. Res. 41(3-4), 119-128, 2006

scholarly journals Validation Of Spectrophotometry-Visble Method On The Determination Of Borax Levels In Meatballs

2021 ◽  
Vol 8 (2) ◽  
pp. 41
Author(s):  
Sudjarwo Sudjarwo ◽  
Poedjiarti S ◽  
Angerina N
Keyword(s):  
Acetic Acid ◽  
Sulphuric Acid ◽  
Glacial Acetic Acid ◽  
Food Product ◽  
Reaction Conditions ◽  
Optimum Result ◽  
Quantitation Limit ◽  
Temperature Time

Borax, in illictic additive substance, is added on certain food product as a e preservative and rubbery. Therefore, the determination of borax in the food product such as meatball is very impotant in view of meatball is a food product often consumed by community. Vis- Spectrophotometric method with curcumine 0.125% as a reagent and glacial acetic acid-sulphuric acid has been used for determination of borax in this research. Curcumin reagent was selected because sensitivity of the method and the reproducibility of the results are affected by quality of the reagent other than rigorous observance of the reaction conditions (temperature, time, reagent quantities). Glacial acetic acid- sulphuric acid was used to create acid condition, so that curcumin and boron form a violetred 2:1 complex called rosocyanin. The optimum result was obtained when 1/. ml solution of 0.125% curcuumin and 1.0 ml concentrated sulphuric acid were added and the absorbance was measured after 70 minutes at 547 nm. The results showed linear regression y = 1.3127x – 0.0994, r = 0.9690 > r table (n = 5) is 0.878 and p = 0.007 (p< 0.01) and Vxo is was 15,53%. The detection limit and quantitation limit were 9.7.10-4 ppm and 2.94. 10-3 ppm respectively. The recovery and coefficient variation were 47.56%±3,92%. Determination of borax in three meatball samples which were taken from a location in Surabaya showed that the sample contained borax with concentration of 0.0205; 0.0151; 0.0210 (% w/w) respectively.

Synthesis, characterization and biological activity of Pyrazoline derivatives

2021 ◽  
pp. 6223-6227
Author(s):  
Saras Kumar Jain ◽  
Rohit Singhal ◽  
Neetesh K. Jain
Keyword(s):  
Crystal Structure ◽  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Acetic Acid ◽  
Biological Activity ◽  
Spectroscopic Data ◽  
Glacial Acetic Acid ◽  
Retardation Factor ◽  
Physical Parameters ◽  
Pyrazoline Derivative

Pyrazoline is dihydropyrazole having only one endocyclic double bond. Synthesis of pyrazoline derivatives from chalcones is an active arena of investigation due to established pharmacological result. In present study, chalcones were prepared by reacting of acetophenone with benzaldehyde. Then prepared chalcones react with isoniazid in the presence of glacial acetic acid results pyrazoline derivative. Physical parameters such as color, crystal structure, solubility, melting point, retardation factor (Rf) and % yield was evaluated. Confirmations of structures of all synthesized derivatives, were done by spectroscopic data of IR, 1HNMR and Mass spectroscopy. Also, all synthesized compounds were evaluated for antibacterial activity against B. subtilis, S. aureus, P.aeruginosa and E.coli, and antifungal activity was accomplished against C. albicans and A. niger at the different conc. and concluded that some compounds have excellent antimicrobial activity and most of the synthesized compounds exhibits moderate antimicrobial activity.

Two new pyrrolo[2,3-d]pyrimidines (7-deazapurines): ultrasonic-assisted synthesis, experimental and theoretical characterizations as well as antibacterial evaluation

2017 ◽  
Vol 72 (7) ◽  
pp. 481-487
Author(s):  
Simin Vazirimehr ◽  
Abolghasem Davoodnia ◽  
S. Ali Beyramabadi ◽  
Mahboobeh Nakhaei-Moghaddam ◽  
Niloofar Tavakoli-Hoseini
Keyword(s):  
Acetic Acid ◽  
Glacial Acetic Acid ◽  
Nuclear Overhauser Effect ◽  
Micrococcus Luteus ◽  
Chemical Shifts ◽  
Catalytic Amount ◽  
Structural Isomer ◽  
Dilution Method ◽  
Agar Dilution Method ◽  
Microtiter Plates

AbstractTwo new pyrrolo[2,3-d]pyrimidines (7-deazapurines) were synthesized in high yields by the reaction of 2-amino-1-methyl-4,5-diphenyl-1H-pyrrole-3-carbonitrile with triethyl orthoformate followed by cyclocondensation with methyl or benzyl amine in refluxing glacial acetic acid or using ultrasonic irradiation containing a catalytic amount of glacial acetic acid at 60°C. For each product, the correct structural isomer was identified using the FT-IR, 1H NMR, 13C NMR, 2D nuclear Overhauser effect spectroscopy spectral and microanalytical data together with comparison of the experimental and calculated chemical shifts at the B3LYP/6-31+G(d,p) level of theory. Furthermore, the synthesized compounds were evaluated for their antibacterial activity against Gram-positive bacteria (Staphylococcus aureus and Micrococcus luteus) and Gram-negative bacteria (Escherichia coli) by the agar dilution method using 24-well microtiter plates.

Synthesis of 8,10-disubstituted-triazoloperimidines from (E)-3-(dimethylamino)-1-(8- phenyl-8H-[1,2,4]triazolo[4,3-a]perimidin-10-yl)prop-2-en-1-one and Their Antimicrobial Activity

2018 ◽  
Vol 15 (1) ◽  
pp. 126-136 ◽  
Author(s):  
Ghada S. Masaret ◽  
Thoraya A. Farghaly
Keyword(s):  
Antimicrobial Activity ◽  
Acetic Acid ◽  
Hydrazine Hydrate ◽  
Spectral Data ◽  
Organic Compounds ◽  
The Novel ◽  
Hydrazonoyl Chlorides ◽  
Elemental Analyses ◽  
Different Types ◽  
Substituted Pyrazoles

Aim and Objective: Enaminones belay to be extremely stable compounds and constitute a versatile group of salutary precursors for the synthesis of enormous classes of organic compounds. So, in this context, we synthesized a new enaminone, namely, (E)-3-(dimethylamino)-1-(8-phenyl-8H-[1,2,4]triazolo[4,3- a]perimidin-10-yl)prop-2-en-1-one (enaminone 2). Materials and Methods: The reaction of enaminone 2 with different types of hydrazonoyl chlorides or hydrazine hydrate afforded new substituted pyrazoles. Also, the reaction of enaminone with 6-amino-2- thioxopyrimidin-4-one in acetic acid under reflux produced 2-thioxopyridopyrimidinone derivative. The latter thione derivative reacts with hydrazonoyl chlorides to give pyridotriazolopyrimidines. 5-(8-Phenyl-8H- [1,2,4]triazolo[4,3-a]perimidin-10-yl)isoxazole was produced from the reaction of enaminone 2 with hydroxylamine. Results & Conclusion: The structure of all the novel perimidine derivatives was confirmed on the basis of spectral data and elemental analyses. The enaminone and the newly synthesized compounds were tested for their antimicrobial activity, and the results obtained revealed that some derivatives are more potent than the reference drugs used.

scholarly journals A One Pot Synthesis of 5, 7-diaryl-1,5-dihydro (or 1, 2, 3, 5-tetrahydro)- pyrano[2, 3-D] pyrimidin-2, 4-diones (or 2-thioxo-4-ones)

2013 ◽  
Vol 61 (2) ◽  
pp. 167-171 ◽  
Author(s):  
M Mahbubur Rahman ◽  
S Mosaddeq Ahmed ◽  
SMA Hakim Siddiki ◽  
Md Ershad Halim ◽  
Kawsari Akhter ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Glacial Acetic Acid ◽  
Barbituric Acid ◽  
Thiobarbituric Acid ◽  
Mass Spectral Data ◽  
Phosphorous Pentoxide ◽  
One Pot ◽  
Mass Spectral ◽  
Elemental Analyses ◽  
One Step

A number of 5, 7-diaryl-1,5-dihydro (or 1, 2, 3, 5-tetrahydro)- pyrano[2, 3-d] pyrimidin-2, 4-diones (or 2-thioxo-4-ones) (3a-f) have been synthesized in one-step by cyclocondensation of barbituric acid or thiobarbituric acid (1) with arylideneacetophenones (2a-c), in glacial acetic acid in the presence of phosphorous pentoxide. The structures of the compounds 3a-f have been determined by UV, IR, 1H NMR, 13C NMR, mass spectral data and elemental analyses. DOI: http://dx.doi.org/10.3329/dujs.v61i2.17065 Dhaka Univ. J. Sci. 61(2): 167-171, 2013 (July)

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