Pulmonary hypoplasia: lung weight and radial alveolar count as criteria of diagnosis.

The type and severity of underdevelopment of the lungs in infants with three congenital malformations were studied in histologic sections. The mean lung weight:body weight ratios were significantly decreased in infants who had diaphragmatic hernia, anencephaly, and a group of renal anomalies. Radial alveolar counts of the distal airways were also significantly decreased, although the range for each group included normal values. The data suggest that decreased proximal branching is a component of pulmonary hypoplasia in these malformations, because in the majority of infants, the decrease in lung weight was greater than could be explained by the decrease in the number of peripheral air spaces. No apparent qualitative differences in the type of hypoplasia were found in these infants; changes in the histologic appearance were correlated with severity and were independent of the type of associated malformation.

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Discordance for Potter’s Syndrome in a Dichorionic Diamniotic Twin Pregnancy—An Unusual Case Report

Medicina ◽

10.3390/medicina56030109 ◽

2020 ◽

Vol 56 (3) ◽

pp. 109

Author(s):

Stoyan Kostov ◽

Stanislav Slavchev ◽

Deyan Dzhenkov ◽

Strahil Strashilov ◽

Angel Yordanov

Keyword(s):

Case Report ◽

Twin Pregnancy ◽

Unusual Case ◽

Pulmonary Hypoplasia ◽

Multiple Pregnancy ◽

Weight Ratio ◽

Pulmonary Complications ◽

Body Weight Ratio ◽

Lung Weight ◽

Unusual Case Report

Introduction: Potter’s syndrome, also known as Potter’s sequence, is an uncommon and fatal disorder. Potter’s sequence in a multiple pregnancy is uncommon, and its frequency remains unknown. Worldwide in a diamniotic twin pregnancy, there are only a few cases described. Case report: We present an unusual case discordance for Potter’s syndrome in a dichorionic diamniotic twin pregnancy. Twin A had the typical physical and histological Potter’s findings. Twin B had normal respiratory function and normal physical examination findings. There are many controversies about this condition in diamniotic twin pregnancy. One case report concluded that that the presence of a normal co-twin in diamniotic pregnancy prevented the cutaneous features seen in Potter’s syndrome and ameliorated the pulmonary complications, whereas two other case studies reported that the affected twin had extrarenal features typical of the syndrome. Conclusion: We performed an autopsy and calculated lung weight/body weight ratio to diagnose pulmonary hypoplasia. Histopathologic examination of lungs and kidneys was performed. We concluded that the appearance of extrarenal features in the affected twin depends on the amniocity.

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EFFECT OF DIFFERENT DOSES OF PREDNISOLONE AND ADRENOCORTICOTROPHIC HORMONE (ACTH) ON LYMPHATIC LUNG CLEARANCE AND ON EXPERIMENTAL SILICOSIS

Acta Endocrinologica ◽

10.1530/acta.0.0630325 ◽

1970 ◽

Vol 63 (2) ◽

pp. 325-337

Author(s):

Carl-Johan Göthe

Keyword(s):

Lymph Nodes ◽

Lymphatic System ◽

The Body ◽

Lung Weight ◽

Lung Clearance ◽

Dust Transport ◽

Fine Particulate ◽

Quartz Dust ◽

Different Doses ◽

Stimulation Of

ABSTRACT The effect of three doses of prednisolone and ACTH respectively on the weight of the body, the lungs and the hilar lymph nodes was studied on rats killed one month after the intratracheal (i.t.) injection of 50 mg of fine-particulate quartz. The prednisolone was administered via the drinking water, and the ACTH was injected intraperitoneally during the period between the i.t. injection of quartz dust and the killing of the animals. Prednisolone causes the rats to become cachectic and reduces the weight of the hilar lymph nodes. It also retards the transport of quartz dust from the lungs via the lymphatics. All these effects increase with increasing doses of prednisolone. However, its effect on the lung weight is insignificant. ACTH does not affect the body weight, but retards the weight increase of the lungs and the hilar lymph nodes. These effects increase with increasing doses of ACTH, and seem to be connected with an ability of ACTH to promote the clearance of quartz dust from the lungs and hilar lymph nodes. The method used, however, does not make it possible to differentiate quantitatively between any ACTH effects on the bronchogenie and lymphatic lung-clearance mechanisms. Available data, however, indicate that the stimulation of the dust transport from the lungs and hilar lymph nodes is, at least to some extent, related to the lymphatic system.

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Effect of prenatal isoxsuprine on pulmonary oxygen toxicity in the newborn rat

Journal of Applied Physiology ◽

10.1152/jappl.1980.48.3.505 ◽

1980 ◽

Vol 48 (3) ◽

pp. 505-510 ◽

Cited By ~ 1

Author(s):

L. Frank ◽

J. Summerville ◽

D. Massaro

Keyword(s):

Enzyme Activities ◽

Oxygen Toxicity ◽

Fetal Lung ◽

Antioxidant Enzyme Activities ◽

Newborn Rats ◽

Lung Maturation ◽

Lung Weight ◽

Pregnant Rats ◽

Rat Pups ◽

Hyperoxic Exposure

Isoxsuprine, a beta-sympathomimetic agent used clinically to delay premature parturition and to possibly accelerate fetal lung maturation, was administered to pregnant rats at 48 and 24 h prior to delivery. Newborn rats were placed in 96-98% O2 (or room air) to determine if the prenatal isoxsuprine treatment compromised their tolerance to prolonged hyperoxic exposure. (Exogenous catecholamines are known to exacerbate O2 toxicity in adult animals). Survival of the isoxsuprine-treated pups in O2 (52%) was no different than for control neonates exposed to hyperoxia for 7 days (57%) (P = 0.22). Body weight, lung weight, lung protein, and DNA content of the newborns were also not altered by the prenatal isoxsuprine treatment. Lung antioxidant enzyme activities for superoxide dismutase, catalase, and glutathione peroxidase were the same at birth in the isoxsuprine-treated and control rat pups, and the enzyme activities increased in response to hyperoxic exposure in each group to an equivalent degree. Thus, in utero treatment with isoxsuprine had no apparent adverse effect on newborn rats exposed to a prolonged O2 challenge.

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Hypoxia compared with normoxia alters the effects of nitric oxide in ischemia-reperfusion lung injury

AJP Lung Cellular and Molecular Physiology ◽

10.1152/ajplung.1997.273.3.l504 ◽

1997 ◽

Vol 273 (3) ◽

pp. L504-L512 ◽

Cited By ~ 2

Author(s):

Y. C. Huang ◽

P. W. Fisher ◽

E. Nozik-Grayck ◽

C. A. Piantadosi

Keyword(s):

Nitric Oxide ◽

Lung Injury ◽

Average Rate ◽

Ischemia Reperfusion ◽

Oxidant Stress ◽

No Production ◽

Protective Effects ◽

Lung Weight ◽

Edema Formation ◽

No Donors

Because both the biosynthesis of nitric oxide (NO.) and its metabolic fate are related to molecular O2, we hypothesized that hypoxia would alter the effects of NO. during ischemia-reperfusion (IR) in the lung. In this study, buffer-perfused lungs from rabbits underwent either normoxic IR (AI), in which lungs were ventilated with 21% O2 during ischemia and reperfusion, or hypoxic IR (NI), in which lungs were ventilated with 95% N2 during ischemia followed by reoxygenation with 21% O2. Lung weight gain (WG) and pulmonary artery pressure (Ppa) were monitored continuously, and microvascular pressure (Pmv) was measured after reperfusion to calculate pulmonary vascular resistance. We found that both AI and NI produced acute lung injury, as shown by increased WG and Ppa during reperfusion. In AI, where perfusate PO2 was > 100 mmHg, the administration of the NO. synthase inhibitor N-nitro-L-arginine methyl ester (L-NAME) before ischemia worsened WG and Ppa. Pmv also increased, suggesting a hydrostatic mechanism involved in edema formation. The effects of L-NAME could be attenuated by giving L-arginine and exogenous NO. donors before ischemia or before reperfusion. Partial protection was also provided by superoxide dismutase. In contrast, lung injury in NI at perfusate PO2 of 25-30 mmHg was attenuated by L-NAME; this effect could be reversed by L-arginine. Exogenous NO. donors given either before ischemia or before reperfusion, however, did not increase lung injury. NO. production was measured by quantifying the total nitrogen oxides (NOx) accumulating in the perfusate. The average rate of NOx accumulation was greater in AI than in NI. We conclude that hypoxia prevented the protective effects of NO on AI lung injury. The effects of hypoxia may be related to lower NO. production relative to oxidant stress during IR and/or altered metabolic fates of NO.-mediated production of peroxynitrite by hypoxic ischemia.

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3D Imaging in Unilateral Primary Pulmonary Hypoplasia in an Adult: A Case Report

Case Reports in Radiology ◽

10.1155/2011/659586 ◽

2011 ◽

Vol 2011 ◽

pp. 1-6

Author(s):

Aristida Georgescu ◽

Crinu Nuta ◽

Simona Bondari

Keyword(s):

3D Imaging ◽

Pulmonary Hypoplasia ◽

Left Lung ◽

Left Lobe ◽

X Rays ◽

X Ray ◽

Female Smoker ◽

Multidetector Computer Tomography ◽

Biological Tests ◽

Chest X Ray

Unilateral primary pulmonary hypoplasia is rare in adulthood (UPHA); it is characterized by a decreased number of bronchial segmentation and decreased/absent alveolar air space. Classical chest X-ray may be confusing, and the biological tests are unspecific. We present a case of UPHA in a 60-year-old female, smoker, with 3 term normal deliveries, who presented with late recurrent pneumonias and bronchiectasis-type symptomathology, arterial hypertension, and obesity. Chest X-rays revealed opacity in the left lower pulmonary zone, an apparent hypoaerated upper left lobe and left deviation of the mediastinum. Preoperatory multidetector computer tomography (MDCT) presented a small retrocardiac left lung with 5-6 bronchial segmentation range and cystic appearance. After pneumonectomy the gross specimen showed a small lung with multiple bronchiectasis and small cysts, lined by hyperplasic epithelium, surrounded by stromal fibrosclerosis. We concluded that this UPHA occurred in the 4–7 embryonic weeks, and the 3D MDCT reconstructions offered the best noninvasive diagnosis.

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