Attenuating the mortality risk of high serum uric acid: the role of physical activity underused

AbstractBackgroundThe role of blood uric acid and more recently bilirubin as biomarkers in symptomatic motor PD has been increasingly established in the literature.ObjectiveOur present study assessed the role of serum uric acid and total bilirubin as putative biomarkers in a prodromal PD cohort followed longitudinally.MethodsLongitudinal 5-year serum uric acid and total bilirubin measurement data of 65 Prodromal PD patients (including REM Sleep Behavior disorder (RBD), N=39 and Hyposmia, N=26) with an abnormal DATSCAN imaging were downloaded from the Parkinson’s Progression Markers Initiative (PPMI) database. This cohort was compared with 423 de novo sporadic PD patients and 196 healthy controls enrolled in the same study.ResultsAfter adjusting for age, sex and Body Mass Index (BMI), baseline and 5-year longitudinal serum uric acid levels were higher in the Prodromal cohort and RBD subgroup as compared to the motor PD cohort. This was also true for longitudinal measurements in the Hyposmic subgroup. In contrast, baseline and longitudinal serum total bilirubin did not differ between each prodromal group and the PD cohort.ConclusionsOur results are indicative of a role of serum uric acid (but probably not of total bilirubin) as a marker of neuroprotection, in a certain subgroup of premotor patients exhibiting exclusively non motor features (hyposmia or RBD). It is possible that an inherent antioxidant resistance of a subset of RBD or hyposmia patients with high serum uric acid level delayed or precluded the emergence of a motor PD phenotype as opposed to the PD cohort.

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503-P: Inhibition of Glucose Transporter 9 Increases Serum Uric Acid Level but Attenuates Renal Albumin Excretion in Streptozotocin-Induced Diabetic Rats: A Role of Hepatic Uric Acid Metabolism

Diabetes ◽

10.2337/db19-503-p ◽

2019 ◽

Vol 68 (Supplement 1) ◽

pp. 503-P

Author(s):

CHUPING CHEN ◽

JIANMIN RAN ◽

RUYI ZHANG ◽

GUANGSHU CHEN ◽

PING ZHU ◽

...

Keyword(s):

Uric Acid ◽

Serum Uric Acid ◽

Uric Acid Level ◽

Acid Level ◽

Glucose Transporter ◽

Acid Metabolism ◽

Serum Uric Acid Level ◽

Diabetic Rats ◽

Glucose Transporter 9

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Management of Gouty Arthritis with special reference to Vatarakta - A Case Report

Journal of Ayurveda and Integrated Medical Sciences (JAIMS) ◽

10.21760/jaims.v2i4.9374 ◽

2017 ◽

Vol 2 (4) ◽

Author(s):

V. Balendu Krishnan ◽

Prashanth A. S.

Keyword(s):

Uric Acid ◽

Case Report ◽

Serum Uric Acid ◽

Serum Uric Acid Level ◽

Gouty Arthritis ◽

Treatment Protocol ◽

Joint Inflammation ◽

High Serum ◽

Common Disease ◽

Disease Condition

Gouty Arthritis has now become a common disease condition which we deal in Ayurveda, but a proper treatment protocol is not followed in many cases. The case reported here was as a result of improper diet and lack of exercise which resulted in an increase serum uric acid level and joint inflammation. The treatment was given at IPD level diagnosing it as Gambhira Vatarakta with valid Chikitsa Siddhanta. This case report provides us a guidelines that even a chronic gouty arthritis with a very high serum uric acid can be treated as per Vataraktha Chikitsa Siddhanta in Ayurveda.

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The Effects of a Long-Term Physical Activity Intervention on Serum Uric Acid in Older Adults at Risk for Physical Disability

Journal of Aging and Physical Activity ◽

10.1123/japa.2012-0018 ◽

2014 ◽

Vol 22 (1) ◽

pp. 25-33 ◽

Cited By ~ 7

Author(s):

Kristen M. Beavers ◽

Fang-Chi Hsu ◽

Monica C. Serra ◽

Veronica Yank ◽

Marco Pahor ◽

...

Keyword(s):

Physical Activity ◽

Older Adults ◽

At Risk ◽

Uric Acid ◽

Health Education ◽

Serum Uric Acid ◽

Physical Disability ◽

Moderate Intensity ◽

Education Intervention ◽

Health Education Intervention

Observational studies show a relationship between elevated serum uric acid (UA) and better physical performance and muscle function. The purpose of this paper was to determine whether regular participation in an exercise intervention, known to improve physical functioning, would result in increased serum UA. For this study, 424 older adults at risk for physical disability were randomized to participate in either a 12-mo moderate-intensity physical activity (PA) or a successful aging (SA) health education intervention. UA was measured at baseline, 6, and 12 mo (n= 368, 341, and 332, respectively). Baseline UA levels were 6.03 ± 1.52 mg/dl and 5.94 ± 1.55 mg/dl in the PA and SA groups, respectively. The adjusted mean UA at month 12 was 4.8% (0.24 mg/dl) higher in the PA compared with the SA group (p= .028). Compared with a health education intervention, a 1-yr PA intervention results in a modest increase in systemic concentration of UA in older adults at risk for mobility disability.

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High serum uric acid and low-grade inflammation are associated with smaller LDL and HDL particles

Atherosclerosis ◽

10.1016/j.atherosclerosis.2008.05.047 ◽

2009 ◽

Vol 203 (1) ◽

pp. 236-242 ◽

Cited By ~ 33

Author(s):

Jelena Vekic ◽

Zorana Jelic-Ivanovic ◽

Vesna Spasojevic-Kalimanovska ◽

Lidija Memon ◽

Aleksandra Zeljkovic ◽

...

Keyword(s):

Uric Acid ◽

Serum Uric Acid ◽

High Serum ◽

Low Grade ◽

Low Grade Inflammation

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Serum Procalcitonin Level and Mortality Risk in Critically ill Patients with Ventilator-Associated Pneumonia

Cellular Physiology and Biochemistry ◽

10.1159/000438557 ◽

2015 ◽

Vol 37 (5) ◽

pp. 1967-1972 ◽

Cited By ~ 5

Author(s):

Bo Li ◽

Xin Zhao ◽

Shumei Li

Keyword(s):

Critically Ill ◽

Mortality Risk ◽

Critically Ill Patients ◽

Cox Regression ◽

High Serum ◽

Ventilator Associated Pneumonia ◽

Prognostic Role ◽

Procalcitonin Level ◽

Increased Risk

Background/Aims: The prognostic role of serum procalcitonin level in critically ill patients with ventilator-associated pneumonia was unclear. The aim of our study was to investigate the relationship between serum procalcitonin level and mortality risk in critically ill patients with ventilator-associated pneumonia. Methods: Data of critically ill patients with ventilator-associated pneumonia were retrospectively collected. Demographics, comorbidities, and serum procalcitonin level were extracted from electronic medical records. The primary outcome was mortality within two months after diagnosis. Multivariable Cox regression analyses were performed to assess the prognostic role of serum procalcitonin level in those patients. Results: A total of 115 critically ill patients with ventilator-associated pneumonia were enrolled in our study. Serum procalcitonin level was not associated with age, gender, or other comorbidities. Univariate Cox regression model showed that high serum procalcitonin level was associated increased risk of morality within 2 months after diagnosis (OR = 2.32, 95% CI 1.25-4.31, P = 0.008). Multivariable Cox regression model showed that high serum procalcitonin level was independently associated increased risk of morality within 2 months after diagnosis (OR = 2.38, 95% CI 1.26-4.50, P = 0.008). Conclusion: High serum procalcitonin level is an independent prognostic biomarker of mortality risk in critically ill patients with ventilator-associated pneumonia, and it's a promising biomarker of prognosis in critically ill patients.

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