SAT0297 Prognosis of Vitamin D Insufficiency: A 3-Year Follow-Up of the Road Study

2015 ◽  
Vol 74 (Suppl 2) ◽  
pp. 765.3-765
Author(s):  
N. Yoshimura ◽  
S. Muraki ◽  
H. Oka ◽  
S. Tanaka ◽  
H. Kawaguchi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Insufficiency ◽  
The Road ◽  
Road Study

scholarly journals Assessing Biomarkers of Breast Cancer Risk in Underserved Women in a Midwestern County

2021 ◽  
Vol 12 ◽  
pp. 215013272110177
Author(s):  
Marla A. DeWitt ◽  
Ivana T. Croghan ◽  
Celine M. Vachon ◽  
Thomas D. Thacher ◽  
Marcia R. Venegas Pont ◽  
...  
Keyword(s):  
Vitamin D ◽  
Mammographic Density ◽  
Small Sample Size ◽  
Vitamin D Insufficiency ◽  
Screening Mammography ◽  
Small Sample ◽  
Vitamin D Status ◽  
Small Pilot Study ◽  
Unexpected Findings

Objective: The primary aim of this study was to evaluate the feasibility of collecting risk factor information and accessing digitized mammographic data in a medically marginalized population. A secondary aim was to examine the association between vitamin D status and mammographic density. Methods: Breast-screening examinations were provided for age-appropriate patients, and a referral for no-cost screening mammography was offered. Study participants were asked to undergo 25-hydroxyvitamin D testing at mammography and 1-year follow-up. Results: Of 62 women approached, 35 (56%) consented to participate. Of 32 participants who had baseline mammography, the median mammographic density measured by VolparaDensity (Volpara Solutions Limited) was 5.7%. After 1 year, 9 women obtained follow-up mammograms, with a median density of 5.7%. Vitamin D status was measured for 31 participants at baseline and 13 participants in the following year. Insufficient vitamin D status (<30 ng/mL) was noted in 77% at each time point. Mammographic density was not significantly correlated with vitamin D status ( P = .06). Conclusions: On the basis of this small pilot study, vitamin D insufficiency is common in this study population. Owing to the small sample size, an association between vitamin D insufficiency and breast density was not clear. Additional unexpected findings included substantial barriers in initial access to care and longitudinal follow-up in this population. Further study of these issues is needed.

Does vitamin D status predict weight gain or increase in waist circumference? Results from the longitudinal Health 2000/2011 Survey

2020 ◽  
Vol 23 (7) ◽  
pp. 1266-1272 ◽  
Author(s):  
Tuija Jääskeläinen ◽  
Satu Männistö ◽  
Tommi Härkänen ◽  
Katri Sääksjärvi ◽  
Seppo Koskinen ◽  
...  
Keyword(s):  
Vitamin D ◽  
Risk Factor ◽  
Weight Gain ◽  
Waist Circumference ◽  
Healthy Lifestyle ◽  
Adult Population ◽  
Population Based ◽  
Vitamin D Insufficiency ◽  
Vitamin D Status

AbstractObjective:To investigate whether vitamin D status predicts weight gain or increase in waist circumference during the 11-year follow-up in general adult population.Design:A population-based longitudinal study.Setting:The study was conducted using data from the nationally representative Health 2000/2011 Survey. The analyses were based on regression models adjusted for sociodemographic and lifestyle factors.Participants:Weight, waist circumference and vitamin D status (serum 25-hydroxyvitamin D concentration analysed with radioimmunoassay) were measured from 2924 participants aged 30–64 years at baseline.Results:In men, low vitamin D status at baseline predicted ≥10 % increase in waist circumference during the follow-up when adjusted for age only (OR for sufficient v. deficient S-25(OH)D 0·41; 95 % CI 0·25, 0·67; P for trend <0·01), but the association with weight gain was only borderline significant. After adjustment for potential confounders, low vitamin D status remained a significant predictor of increase in waist circumference, but the association with weight gain was further attenuated. In women, vitamin D status at baseline did not predict weight gain or increase in waist circumference.Conclusions:Our results suggest that vitamin D insufficiency may be a risk factor of abdominal obesity among men but not among women. In men, it may also increase the risk of weight gain. Further studies are required to confirm these findings and examine potential mechanisms behind them. There is also a possibility that vitamin D is a biomarker of healthy lifestyle rather than an independent risk factor for obesity.

scholarly journals Health-related quality of life after successful surgery for primary hyperparathyroidism: no additive effect from vitamin D supplementation: results of a double-blind randomized study

2015 ◽  
Vol 172 (2) ◽  
pp. 181-187 ◽  
Author(s):  
Viveca Åberg ◽  
Sophie Norenstedt ◽  
Jan Zedenius ◽  
Maria Sääf ◽  
Jörgen Nordenström ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Insufficiency ◽  
Vitamin D Supplementation ◽  
Study Medication ◽  
Double Blind ◽  
Sf 36 ◽  
Related Quality ◽  
Health Related

ObjectiveVitamin D insufficiency is common in primary hyperparathyroidism (pHPT). Patients with pHPT frequently have a reduced health-related quality of life (HRQoL). Our objectives were to evaluate whether HRQoL in pHPT is associated with vitamin D insufficiency and whether vitamin D supplementation after parathyroidectomy (PTX) could improve HRQoL.DesignA randomized, double-blind study (ClinicalTrials.gov identifier: NCT00982722).MethodsThe study included 150 pHPT patients randomized, 6 weeks after PTX, to daily treatment with either cholecalciferol 1600 IU and calcium carbonate 1000 mg (D+) or calcium carbonate alone (D−). HRQoL was estimated with SF-36 before and after PTX and after 12 months of study medication.ResultsThree-quarters (77%) of the pHPT patients had vitamin D insufficiency, defined as 25OHD <50 nmol/l. The pHPT patients scored lower than a reference population in all domains of SF-36. A total of 135 patients completed the entire study period. Improvements in nearly all domains were registered at the follow-up 6 weeks after PTX. At the end of the study medication period, the D+ group had a significantly higher median serum (s-) 25OHD concentration (76 (65; 93) (lower; upper interquartile ranges) vs 48 (40; 62) nmol/l, P<0.001) and a lower plasma (p-) parathyroid hormone concentration (40 (34; 52) vs 49 (38; 66) ng/l, P=0.01) than the D− group. The improvements in HRQoL remained unchanged at the follow-up 1 year after PTX. Postoperative vitamin D supplementation had no obvious effect on HRQoL.ConclusionPTX resulted in significant improvements in HRQoL. Despite a high prevalence of vitamin D insufficiency, 1 year of postoperative vitamin D supplementation had no obvious beneficial effect on HRQoL.

Mutual associations among musculoskeletal diseases and metabolic syndrome components: A 3-year follow-up of the ROAD study

2014 ◽  
Vol 25 (3) ◽  
pp. 438-448 ◽  
Author(s):  
Noriko Yoshimura ◽  
Shigeyuki Muraki ◽  
Hiroyuki Oka ◽  
Sakae Tanaka ◽  
Hiroshi Kawaguchi ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Musculoskeletal Diseases ◽  
The Road ◽  
Road Study ◽  
Metabolic Syndrome Components

Serum levels of 25-hydroxyvitamin D and the occurrence of musculoskeletal diseases: a 3-year follow-up to the road study

2014 ◽  
Vol 26 (1) ◽  
pp. 151-161 ◽  
Author(s):  
N. Yoshimura ◽  
S. Muraki ◽  
H. Oka ◽  
K. Nakamura ◽  
H. Kawaguchi ◽  
...  
Keyword(s):  
Musculoskeletal Diseases ◽  
Serum Levels ◽  
Hydroxyvitamin D ◽  
The Road ◽  
25 Hydroxyvitamin D ◽  
Road Study

scholarly journals KNOWLEDGE AND PERCEPTIONS OF VITAMIN D DEFICIENCY AMONG THE UNITED ARAB EMIRATES POPULATION

2019 ◽  
pp. 183-186 ◽  
Author(s):  
OSAMA MOHAMED IBRAHIM ◽  
NOOR KIFAH AL-TAMEEMI ◽  
DALIA DAWOUD
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Blood Level ◽  
United Arab Emirates ◽  
Cross Sectional Study ◽  
Vitamin D Insufficiency ◽  
Abu Dhabi ◽  
Sectional Study ◽  
Cross Sectional

Objectives: The purpose of this study is to assess the Vitamin D deficiency awareness and perceptions between the United Arab Emirates (UAE) population. Methods: A cross-sectional study was done among the population of two emirates at the UAE: Abu Dhabi and Sharjah. Results: Overall, 434 participants completed the survey. Majority of people were aware of phenomenon of Vitamin D deficiency, but only 21.4% of them knew that sunlight is considered the main source of Vitamin D. Moreover, less than half of participants check their Vitamin D blood level regularly and around 55% of them follow-up with their physicians after completing the treatment. High proportion of participant females spend <1 h outdoors (60%) and use sunscreen daily (55%) that cause higher prevalence of Vitamin D deficiency among females than males (83% vs. 42%). Conclusion: This research gives some insights regarding the UAE population’s awareness and perceptions of Vitamin D insufficiency. Decreased awareness of sunlight exposure as a major source of Vitamin D, in addition to lifestyle, contributed to Vitamin D deficiency problem among the UAE population, in general, and in females, in particular.

scholarly journals Vitamin D in Type 2 Diabetes: Genetic Susceptibility and the Response to Supplementation

2020 ◽  
Vol 52 (07) ◽  
pp. 492-499
Author(s):  
Marissa Penna-Martinez ◽  
Klaus Badenhoop ◽  
Edith Klahold ◽  
Franziska Bruns ◽  
Christian Seidl ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Vitamin D Insufficiency ◽  
Vitamin D Metabolism ◽  
Risk Alleles ◽  
Before And After ◽  
Cholecalciferol Supplementation ◽  
The Impact

AbstractVariants of vitamin D metabolism-genes may predispose to type 2 diabetes (T2D). This study investigated the impact of these variants on disease susceptibility, Vitamin D, parathyroid hormone, C-peptide and HbA1c levels before and after cholecalciferol supplementation in patients with T2D.Twelve polymorphisms within CYP2R1, CYP27B1, DBP, VDR and CYP24A1 were genotyped in 553 T2D patients and 916 controls. In addition 65 patients receiving either cholecalciferol or placebo were analyzed during 6 months intervention and 6 months follow-up.T2D risk alleles are VDR rs7975232 “G” (pc=0.031), rs1544410 “G” (pc=0.027) and CYP2R1 rs10741657 “A” (pc=0.016). Patients with genotypes CYP27B1 rs10877012 “CC” (pc=4x10-5), DBP rs7041 “GG” (pc=0.003), rs4588 “CC” (pc = 3x10-4), CYP24A1 rs2585426 “CG” (pc=0.006) and rs2248137 “CG” (pc=0.001) showed lower 25(OH)D3 and DBP rs4588 “CC” lower 1,25(OH)2D3 levels (pc=0.005). Whereas DBP rs4588 “CC” (pc=0.009), CYP27B1 rs10877012 “AC” (pc=0.059), VDR rs7975323 “AG” (pc=0.033) and rs1544410 “GG” (pc=0.013) are associated with higher 25(OH)D3 levels at 6 months’ follow-up. Significant PTH suppression was detected for CYP2R1 “AG“ (pc=0.002), DBP rs4588 “CC” (pc<0.001), VDR rs110735810 “CT” (pc<0.001) and CYP24A1 rs2248137 “GG” (pc=0.021).Genetic variants of the vitamin D system predispose to type 2 diabetes and regulate – partially - vitamin D metabolism, concentrations and the vitamin D status. Vitamin D insufficiency is a T2D risk factor. The response to cholecalciferol supplementation can be measured as 25(OH)D3 increment and PTH suppression. This process is regulated by genes of the vitamin D system conferring modest T2D risk.

Sign in / Sign up

Export Citation Format

Share Document