THU0069 RHEUMATOID CACHEXIA ASSESSED BY BODY COMPOSITION IS ASSOCIATED WITH WORSE DISEASE IN RHEUMATOID ARTHRITIS PATIENTS WITH NORMAL BODY MASS INDEX

Background: Bioelectrical analysis measures two bioelectrical vectors: Resistance (R) and reactance (Xc). Resistance is the pure opposition of a biological conductor to the flow of an alternating current through the intra and extra-cellular ionic solution and it is inversely related to the dynamics of body fluids and body composition. Objective: The purpose of this study was to determine the reference values of the indexes bioelectrical impedance (BI) for children of normal body mass index in southeastern Brazil of middle-income country. Methods: Two hundred eighty-one children with normal body mass index were included in the study (135 female and 146 male), aged 4 to 129 months, selected from federal public urban school in São Paulo, São Paulo, Brazil, where bioelectrical impedance values resistance (R) and reactance (Xc) values were measured in order to establish reference values of these parameters. Results: The anthropometric variables, body mass index, z-scores and bioelectrical impedance parameters were evaluated. For both genders, the mean and standard deviation of anthropometric variables were: age (months): 73.42 ± 34.65; weight (kg): 23.5 ± 9.46; height (m): 1.16±0.22; BMI (kg/m2): 16.65±1,75; Xc (ohms): 63.92±9.6; R (ohms): 749±75.26. For analysis, the children were stratified into three groups for each gender, being divided by ages: 4 to 23 months; 24 to 71 months and 72 to 129 months. Linear regression analysis showed R had a significant progressive decrease with age (p=0.0003) while Xc had a progressive increase (p=0.0065) with age increase. We analyzed by multiple regression the associations between R and Xc with anthropometric variables by age group to establish the reference values, confidence intervals and the tolerance limits for a new individual observation. Conclusion: The BI reference values were established, in a field where there is a relative lack of publications, and we collected relevant information about resistance and reactance in a population of middle income setting that could be used in epidemiologic studies and could be used reference value in children with altered body composition.

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Neglected extra-articular manifestations in rheumatoid arthritis patients with normal body mass index: reduced skeletal muscle overlapping overfat

Therapeutic Advances in Chronic Disease ◽

10.1177/2040622320975241 ◽

2020 ◽

Vol 11 ◽

pp. 204062232097524

Author(s):

Jian-Zi Lin ◽

Chu-Tao Chen ◽

Jian-Da Ma ◽

Ying-Qian Mo ◽

Qian-Hua Li ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Skeletal Muscle ◽

Body Mass Index ◽

Muscle Mass ◽

Body Mass ◽

Normal Body Mass Index ◽

Fat Percentage ◽

Glucocorticoid Treatment ◽

Normal Body ◽

Control Subjects

Background: Chronic inflammation in rheumatoid arthritis (RA) can induce reduced muscle mass (myopenia) and ectopic fat deposition probably showing normal body mass index (BMI). We aimed to investigate their body composition (BC) characteristics and clinical significance. Methods: BMI and BC were collected in consecutive RA patients and control subjects. Myopenia was defined by appendicular skeletal muscle mass index (ASMI) ⩽7.0 kg/m2 in men and ⩽5.7 kg/m2 in women. Overfat was defined by body fat percentage (BF%) as ⩾25% for men and ⩾35% for women. Results: There were 620 RA patients (57.6% with normal BMI) and 2537 control subjects (62.5% with normal BMI) recruited. After 1:1 age and sex matching with control subjects, RA patients with normal BMI ( n = 240) showed significantly higher prevalence of myopenia (43.3% versus 22.1%) and overfat (19.2% versus 7.1%) as well as myopenia overlapping overfat (17.1% versus 3.3%). In all RA patients with normal BMI ( n = 357), there were 18.2% patients with myopenia overlapping overfat who had the worst radiographic scores and highest rates of previous glucocorticoid treatment and hypertension. Compared with those without, normal BMI RA patients with previous glucocorticoid treatment (24.4% versus 10.3%) or hypertension (27.8% versus 13.6%) had a higher rate of myopenia overlapping overfat. Previous glucocorticoid treatment [odds ratio (OR) = 2.844, 95% confidence interval (CI) 1.441–5.614] and hypertension (OR = 2.452, 95% CI 1.283–4.685) were potential associated factors of myopenia overlapping overfat in RA patients with normal BMI. Conclusion: Myopenia overlapping overfat is an important extra-articular manifestation which should not be ignored in RA patients with normal BMI, especially with glucocorticoid treatment and hypertension.

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KEJADIAN PENYAKIT HIPERTENSI DAN INDEKS MASSA TUBUH PADA PEREMPUAN YANG TINGGAL DI PEDESAAN DAN PERKOTAAN

Jurnal Kesehatan Kusuma Husada ◽

10.34035/jk.v10i2.388 ◽

2019 ◽

pp. 127-136

Author(s):

Venti Agustina

Keyword(s):

Blood Pressure ◽

Body Mass Index ◽

Body Mass ◽

Rural Women ◽

Urban Areas ◽

Stage I ◽

Normal Body Mass Index ◽

Cross Sectional ◽

Normal Body ◽

Stadium I

Hipertensiadalah penyebab kematian utama di Indonesia. Kematian akibat hipertensi lebih banyak terjadi di perkotaan dibandingkan di desa. Tingginya kejadian hipertensi dipengaruhi oleh faktor yang dapat dikontrol (obesitas,berat badan lebih, konsumsi garam berlebih,aktivitas fisik rendah, perokok, dan konsumsi alkohol) dan faktor yang tidak dapat dikontrol (genetik, usia, dan jenis kelamin). Penelitian bertujuan memberikan gambarandistribusi tekanan darah dan indeks massa tubuh (IMT) pendudukperempuan di kota maupun di desa.Desain penelitian adalah deskriptif kuatitatif dengan pendekatan cross sectional. Data primer didapatkan melalui pengukuran tekanan darah, tinggi badan dan berat badan. Penelitian dilakukan di Desa Kutowinangun Kidul, Kecamatan Tingkir,Salatiga yang mewakili penduduk perempuan di perkotaan dan Desa Batur, Kecamatan Getasan, Kabupaten Semarangyang mewakili penduduk perempuan pedesaan. Adapun jumlah sampel masing-masing 66 respondendan 72responden. Hasil penelitian menunjukkan bahwa kejadian penyakit hipertensi, resiko obese dan obese lebih didominasi oleh respondendi perkotaan dibandingkan di pedesaan dengan rentang usia di atas 46 tahun. Respondendi desa dengan indeks massa tubuh normal cenderung mengalami pre-hipertensi (8,3%) dan hipertensi stadium I (6,9%) sementararesponden dengan resiko obese dan obese cenderung mengalami hipertensi stadium I (1,4%).Respondendi kota dengan indeks massa tubuh normal cenderung mengalami pre hipertensi (6,06%), hipertensi stadium I (4,5%) dan II (7,5%). Responden dengan resiko obese cenderung mengalami hipertensi stadium I (4,5%), dan responden dengan obese I dan II cenderung mengalami pre-hipertensi (4,5%). Hypertension is the leading cause of death in Indonesia. Deaths due to hypertension are more common in urban areas than in villages. The high incidence of hypertension is influenced by factors that can be controlled (obesity, overweight, excessive salt consumption, low physical activity, smokers, and alcohol consumption) and factors that cannot be controlled (genetic, age, and sex). The study aimed to provide an overview of blood pressure distribution and body mass index (BMI) of female residents in cities and villages. The study design was descriptive quantitative with a cross sectional approach. Primary data was obtained through measurements of blood pressure, height and weight. The study was conducted in Kutowinangun Kidul Village, Tingkir Subdistrict, Salatiga representing women in urban areas and Batur Village, Getasan Subdistrict, Semarang Regency, representing rural women. The number of samples was 66 respondents and 72 respondents respectively. The results showed that the incidence of hypertension, the risk of obese and obese was more dominated by respondents in urban areas than in rural areas with ages above 46 years. Respondents in villages with normal body mass index tended to experience pre-hypertension (8.3%) and stage I hypertension (6.9%) while respondents with obese and obese risk tended to experience stage I hypertension (1.4%). Respondents in cities with normal body mass index tended to experience pre-hypertension (6.06%), stage I hypertension (4.5%) and II (7.5%). Respondents with obese risk tended to experience stage I hypertension (4.5%), and respondents with obese I and II tended to experience pre-hypertension (4.5%).

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Maternal Body Mass Index and Use of Labor Neuraxial Analgesia

Anesthesiology ◽

10.1097/aln.0000000000002322 ◽

2018 ◽

Vol 129 (3) ◽

pp. 448-458 ◽

Cited By ~ 13

Author(s):

Alexander J. Butwick ◽

Cynthia A. Wong ◽

Nan Guo

Keyword(s):

Body Mass Index ◽

Relative Risk ◽

Body Mass ◽

Normal Body Mass Index ◽

Adjusted Relative Risk ◽

Obese Women ◽

Obesity Class ◽

Normal Body ◽

Neuraxial Analgesia ◽

Obese Class

Abstract What We Already Know about This Topic What This Article Tells Us That Is New Background Neuraxial labor analgesia may benefit obese women by optimizing cardiorespiratory function and mitigating complications related to emergency general anesthesia. We hypothesized that obese women have a higher rate of neuraxial analgesia compared with nonobese parturients. Methods Using U.S. natality data, our cohort comprised 17,220,680 deliveries, which accounts for 61.5% of 28 million births in the United States between 2009 and 2015. We examined the relationships between body mass index class and neuraxial labor analgesia, adjusting for sociodemographic, antenatal, pregnancy, and peripartum factors. Results The study cohort comprised 17,220,680 women; 0.1% were underweight, 12.7% were normal body mass index, 37% were overweight, and 28.3%, 13.5%, and 8.4% were obesity class I, II, and III, respectively. Rates of neuraxial analgesia by body mass index class were as follows: underweight, 59.7% (9,030/15,128); normal body mass index, 68.1% (1,487,117/2,182,797); overweight, 70.3% (4,476,685/6,368,656); obesity class I, 71.8% (3,503,321/4,881,938); obesity class II, 73.4% (1,710,099/2,330,028); and obesity class III, 75.6% (1,089,668/1,442,133). Compared to women with normal body mass index, the likelihood of receiving neuraxial analgesia was slightly increased for overweight women (adjusted relative risk, 1.02; 95% CI, 1.02 to 1.02), obese class I (adjusted relative risk, 1.04; 95% CI, 1.04 to 1.04), obese class II (adjusted relative risk, 1.05; 95% CI, 1.05 to 1.05), and obese class III (adjusted relative risk, 1.06; 95% CI, 1.06 to 1.06). Conclusions Our findings suggest that the likelihood of receiving neuraxial analgesia is only marginally increased for morbidly obese women compared to women with normal body mass index.

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Association of Body Fat and Risk of Breast Cancer in Postmenopausal Women With Normal Body Mass Index

JAMA Oncology ◽

10.1001/jamaoncol.2018.5327 ◽

2019 ◽

Vol 5 (2) ◽

pp. 155 ◽

Cited By ~ 31

Author(s):

Neil M. Iyengar ◽

Rhonda Arthur ◽

JoAnn E. Manson ◽

Rowan T. Chlebowski ◽

Candyce H. Kroenke ◽

...

Keyword(s):

Breast Cancer ◽

Body Mass Index ◽

Postmenopausal Women ◽

Body Mass ◽

Body Fat ◽

Normal Body Mass Index ◽

Normal Body

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The effect of insulin resistance on inflammation markers in individuals with obesity

Medical Science and Discovery ◽

10.36472/msd.v8i10.620 ◽

2021 ◽

Vol 8 (10) ◽

pp. 619-622

Author(s):

Hasan Atlı ◽

Erhan Önalan ◽

Burkay Yakar ◽

Deccane Duzenci ◽

Emir Dönder

Keyword(s):

Insulin Resistance ◽

Body Mass Index ◽

Body Mass ◽

Normal Body Mass Index ◽

Low Grade ◽

Inflammation Markers ◽

Predictive Values ◽

Lymphocyte Ratio ◽

Normal Body ◽

Significant Difference

Objective: Obesity has recently been recognized as a chronic low-grade inflammation condition. We aimed to compare the predictive values of insulin resistance and inflammatory indices in individuals with obesity. Materials and Methods: 124 people who had a health check for obesity-related risk factors in our hospital between June 2018 and September 2019 were included in the study. Inflammatory markers of the patients were evaluated. Results: The study group consists of a total of 224 people, and we compared the demographic data and laboratory parameters of the individuals. C-reactive protein (CRP) levels of obese individuals were statistically higher than those with normal body mass index (p <0.001). There was no statistically significant difference between the groups in terms of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) values, among other inflammation markers. A positive and statistically significant correlation was found between body mass index and CRP level (r = 0.334, p <0.001). There was no significant correlation between body mass index and NLR and PLR. Conclusion: As a result, CRP levels of obese individuals were statistically higher than individuals with normal body mass index. No statistically significant difference was found between the groups in terms of NLR and PLR values among other inflammation markers.

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