scholarly journals OP0031 ARE THE MODIFIED NEW YORK AND ASAS AXIAL SPONDYLOARTHRITIS CRITERIA INTERCHANGEABLE IN THE CLASSIFICATION OF SPONDYLOARTHRITIS PATIENTS WITH RADIOGRAPHIC SACROILIITIS: COMPARISON IN 8 COHORTS?

2019 ◽  
Author(s):  
Anne Boel ◽  
Anna Moltó ◽  
Désirée van der Heijde ◽  
Adrian Ciurea ◽  
Maxime Dougados ◽  
...  
Keyword(s):  
New York ◽  
Axial Spondyloarthritis

Can we use structural lesions seen on MRI of the sacroiliac joints reliably for the classification of patients according to the ASAS axial spondyloarthritis criteria? Data from the DESIR cohort

2016 ◽  
Vol 76 (2) ◽  
pp. 392-398 ◽  
Author(s):  
Pauline A C Bakker ◽  
Rosaline van den Berg ◽  
Gregory Lenczner ◽  
Fabrice Thévenin ◽  
Monique Reijnierse ◽  
...  
Keyword(s):  
New York ◽  
Back Pain ◽  
Axial Spondyloarthritis ◽  
The Other ◽  
Inflammatory Back Pain ◽  
Symptom Duration ◽  
Sacroiliac Joints

ObjectivesInvestigating the utility of adding structural lesions seen on MRI of the sacroiliac joints to the imaging criterion of the Assessment of SpondyloArthritis (ASAS) axial SpondyloArthritis (axSpA) criteria and the utility of replacement of radiographic sacroiliitis by structural lesions on MRI.MethodsTwo well-calibrated readers scored MRI STIR (inflammation, MRI-SI), MRI T1-w images (structural lesions, MRI-SI-s) and radiographs of the sacroiliac joints (X-SI) of patients in the DEvenir des Spondyloarthrites Indifférenciées Récentes cohort (inflammatory back pain: ≥3 months, <3 years, age <50). A third reader adjudicated MRI-SI and X-SI discrepancies. Previously proposed cut-offs for a positive MRI-SI-s were used (based on <5% prevalence among no-SpA patients): erosions (E) ≥3, fatty lesions (FL) ≥3, E/FL ≥5. Patients were classified according to the ASAS axSpA criteria using the various definitions of MRI-SI-s.ResultsOf the 582 patients included in this analysis, 418 fulfilled the ASAS axSpA criteria, of which 127 patients were modified New York (mNY) positive and 134 and 75 were MRI-SI-s positive (E/FL≥5) for readers 1 and 2, respectively. Agreement between mNY and MRI-SI-s (E/FL≥5) was moderate (reader 1: κ: 0.39; reader 2: κ: 0.44). Using the E/FL≥5 cut-off instead of mNY classification did not change in 478 (82.1%) and 469 (80.6%) patients for readers 1 and 2, respectively. Twelve (reader 1) or ten (reader 2) patients would not be classified as axSpA if only MRI-SI-s was performed (in the scenario of replacement of mNY), while three (reader 1) or six (reader 2) patients would be additionally classified as axSpA in both scenarios (replacement of mNY and addition of MRI-SI-s). Similar results were seen for the other cut-offs (E≥3, FL≥3).ConclusionsStructural lesions on MRI can be used reliably either as an addition to or as a substitute for radiographs in the ASAS axSpA classification of patients in our cohort of patients with short symptom duration.

Association of lumbosacral transitional vertebra and sacroiliitis in patients with inflammatory back pain suggesting axial spondyloarthritis

Rheumatology ◽  
2019 ◽  
Vol 59 (7) ◽  
pp. 1679-1683
Author(s):  
Guillermo Carvajal Alegria ◽  
Marie Voirin-Hertz ◽  
Florent Garrigues ◽  
Marion Herbette ◽  
Lucile Deloire ◽  
...  
Keyword(s):  
New York ◽  
Back Pain ◽  
Axial Spondyloarthritis ◽  
Inflammatory Back Pain ◽  
Low Back ◽  
Sacroiliac Joints ◽  
Exact Test ◽  
Lumbosacral Transitional Vertebra ◽  
Potential Impact

Abstract Objective Lumbosacral transitional vertebras (LSTVs) are common in the general population, but their potential impact on the sacroiliac joints is unclear. We aimed to determine the prevalence of LSTVs and to assess their associations with sacroiliitis by standard radiography and MRI in a population with suspected axial spondyloarthritis. Methods The data were from the DESIR cohort of 688 patients aged 18–50 years with inflammatory low back pain for ⩾3 months but &lt;3 years suggesting axial spondyloarthritis. The baseline pelvic radiographs were read by two blinded readers for the presence and type (Castellvi classification) of LSTVs. Associations between LSTVs and other variables collected at baseline and at the diagnosis were assessed using the χ2 test (or Fisher's exact test) or the Mann–Whitney test. Results LSTV was found in 200/688 (29.1%) patients. Castellvi type was Ia in 54 (7.8%), Ib in 76 (11.0%), IIa in 20 (2.9%), IIb in 12 (1.7%), IIIa in 7 (1.0%), IIIb in 21 (3.0%) and IV in 10 (1.4%) patients. Compared with the group without LSTVs, the group with LSTVs had higher proportions of patients meeting modified New York criteria for radiographic sacroiliitis (19% vs 27%, respectively; P = 0.013) and Assessment of SpondyloArthritis international Society MRI criteria for sacroiliitis (29% vs 39%, respectively; P = 0.019). Conclusion In patients with inflammatory back pain suggesting axial spondyloarthritis, LSTVs are associated with both radiographic and MRI sacroiliitis.

scholarly journals Evaluation of the change in structural radiographic sacroiliac joint damage after 2 years of etanercept therapy (EMBARK trial) in comparison to a contemporary control cohort (DESIR cohort) in recent onset axial spondyloarthritis

2017 ◽  
Vol 77 (2) ◽  
pp. 221-227 ◽  
Author(s):  
Maxime Dougados ◽  
Walter P Maksymowych ◽  
Robert B M Landewé ◽  
Anna Moltó ◽  
Pascal Claudepierre ◽  
...  
Keyword(s):  
New York ◽  
Sacroiliac Joint ◽  
Axial Spondyloarthritis ◽  
Joint Damage ◽  
Control Group ◽  
Progression Rate ◽  
Recent Onset ◽  
Link Type ◽  
Factor Therapy ◽  
Adjusted Least Squares

ObjectiveTo compare 2 years of radiographic sacroiliac joint (SIJ) changes in patients with recent onset axial spondyloarthritis (axSpA) receiving etanercept in a clinical trial (EMBARK) to similar patients not receiving biologics in a cohort study (DESIR).MethodsEndpoints were changes at week 104 per the modified New York (mNY) grading system in total SIJ score (primary endpoint) and net percentage of patients with progression defined three ways. Treatment effect was analysed with and without adjustment for baseline covariates.ResultsAt 104 weeks, total SIJ score improved in the etanercept group (n=154, adjusted least-squares mean change: –0.14) and worsened in the control group (n=182, change: 0.08). The adjusted difference between groups (etanercept minus control) was –0.22 (95% CI –0.38 to –0.06), p=0.008. The net percentage of patients with progression was significantly lower in the etanercept versus the control group for two of three binary endpoints: –1.9% versus 1.6% (adjusted difference for etanercept minus control: –4.7%,95% CI –9.9 to 0.5, p=0.07) for change in mNY criteria; –1.9% versus 7.8% (adjusted difference: –18.2%,95% CI –30.9 to –5.6, p=0.005) for change ≥1 grade in ≥1 SIJ; and –0.6% versus 6.7% (adjusted difference: –16.4%,95% CI –27.9 to –5.0, p=0.005) for change ≥1 grade in ≥1 SIJ, with shift from 0 to 1 or 1 to 0 considered no change.ConclusionDespite the slow radiographic SIJ progression rate over 2 years in axSpA, this study suggests a lower rate of progression in the SIJ with etanercept than without anti-tumour necrosis factor therapy.Trial registration numbersNCT01258738, NCT01648907; Post-results.

scholarly journals Evaluation of the performances of ‘typical’ imaging abnormalities of axial spondyloarthritis: results of the cross-sectional ILOS-DESIR study

RMD Open ◽  
2019 ◽  
Vol 5 (1) ◽  
pp. e000918 ◽  
Author(s):  
Anna Molto ◽  
Laure Gossec ◽  
Marie-Martine Lefèvre-Colau ◽  
Violaine Foltz ◽  
Romain Beaufort ◽  
...  
Keyword(s):  
New York ◽  
Chronic Back Pain ◽  
Axial Spondyloarthritis ◽  
Diagnostic Feature ◽  
Likelihood Ratios ◽  
Cross Sectional ◽  
Recent Onset ◽  
And Performance ◽  
And Gender ◽  
Sensitivity Specificity

ObjectiveTo evaluate the prevalence and performance as axial Spondyloarthritis (axSpA) diagnostic feature of radiographic and MRI lesions ‘typical’ of axSpA of the sacroiliac joint (SIJ) and spine in a mechanical chronic back pain (CBP) population and in an axSpA cohort.MethodsCross-sectional multicentre study. Patients: (1) recent onset axSpA (DESIR cohort) and (2) mechanical non-axSpA CBP matched for age and gender (ILOS study). Imaging: radiographs and MR scans were performed identically in both groups. All images were centrally read, blinded for diagnosis and for other imaging findings in the same patient. Statistical analysis: prevalence of lesions ‘typical of axSpA’ were compared in both groups. Sensitivity, specificity and positive likelihood ratios (LR+) of each lesion (and combination of lesions) were calculated.ResultsA total of 98 patients with CBP were included, and compared with 100 patients with recent onset axSpA. SIJ lesions were consistently more frequent in the axSpA group (35.0% vs 11.8% p<0.001, 35.0% vs 8.4% p<0.001% and 32.0% vs 10.0%. p<0.001 for modified New York criteria, MRI sacroiliitis and ≥3 erosions of the SIJ on MRI, respectively), and performed well (LR+ for ≥3 erosions 3.0 (95% CI 1.6 to 5.8)). Spine lesions were comparable across groups: radiographic lesions were rare, while all MRI lesions were frequent.ConclusionOur study confirms that ‘typical’ lesions can also be observed in patients with non-axSpA CBP but that SIJ lesions by all modalities remain the most valuable for diagnosis, including structural lesions of the SIJ. This suggests the potential interest of adding MRI SIJ structural lesions in the definition of MRI abnormalities for axSpA classification.

VI.—New Classifications of the Brachiopoda

1893 ◽  
Vol 10 (7) ◽  
pp. 318-323
Author(s):  
Agnes Crane
Keyword(s):  
New York ◽  
History Of ◽  
The Individual

Mr. Charles Schuchert of Newhaven, Conn., U.S.A., has recently published in the “American Geologist” (Vol. xi.No. 3) an important and highly suggestive “Classification of the Brachiopoda,” based on the history of the class (Chronogenesis) and the ontogeny of the individual. It embodies the latest results of the remarkable investigations on the Palaeozoic forms of Prof. James Hall and Mr. J. M. Clarke, who have thrown so much light on the evolution of genera among the Brachiopoda in the eighth volume of “The Palæontology of New York” (Part I. Brachiopoda, 1892).

Automated Text Classification of News Articles: A Practical Guide

2020 ◽  
Vol 29 (1) ◽  
pp. 19-42 ◽  
Author(s):  
Pablo Barberá ◽  
Amber E. Boydstun ◽  
Suzanna Linn ◽  
Ryan McMahon ◽  
Jonathan Nagler
Keyword(s):  
New York ◽  
New York Times ◽  
Fixed Number ◽  
Machine Learning Algorithms ◽  
Supervised Machine Learning ◽  
Methodological Choices ◽  
Units Of Analysis ◽  
Human Validation ◽  
Corpus Selection

Automated text analysis methods have made possible the classification of large corpora of text by measures such as topic and tone. Here, we provide a guide to help researchers navigate the consequential decisions they need to make before any measure can be produced from the text. We consider, both theoretically and empirically, the effects of such choices using as a running example efforts to measure the tone of New York Times coverage of the economy. We show that two reasonable approaches to corpus selection yield radically different corpora and we advocate for the use of keyword searches rather than predefined subject categories provided by news archives. We demonstrate the benefits of coding using article segments instead of sentences as units of analysis. We show that, given a fixed number of codings, it is better to increase the number of unique documents coded rather than the number of coders for each document. Finally, we find that supervised machine learning algorithms outperform dictionaries on a number of criteria. Overall, we intend this guide to serve as a reminder to analysts that thoughtfulness and human validation are key to text-as-data methods, particularly in an age when it is all too easy to computationally classify texts without attending to the methodological choices therein.

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