scholarly journals FRI0383 A RANDOMISED PLACEBO-CONTROLLED CLINICAL TRIAL OF CURCUMA LONGA EXTRACT FOR TREATING SYMPTOMS AND EFFUSION-SYNOVITIS OF KNEE OSTEOARTHRITIS (CURKOA TRIAL)

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 789.2-789
Author(s):  
B. Antony ◽  
Z. Wang ◽  
T. Winzenberg ◽  
G. Cai ◽  
L. Laslett ◽  
...  
Keyword(s):  
Knee Pain ◽  
Visual Analog Scale ◽  
Effect Size ◽  
Curcuma Longa ◽  
Controlled Clinical Trial ◽  
Analog Scale ◽  
Knee Oa ◽  
Knee Effusion ◽  
Structural Progression ◽  
Symptomatic Knee

Background:Pharmacological therapies are limited, associated with off-target effects, are frequently contraindicated, and only modestly effective for pain in osteoarthritis (OA). Effusion and synovitis are common in OA and are associated with symptomatic and structural progression of OA.Curcuma longa(Turmeric) extract has anti-inflammatory effects and is gaining popularity in the treatment of OA despite the lack of high-quality evidence.Objectives:The CurKOA trial aimed to determine the efficacy ofCurcuma longaextract for reducing knee symptoms and effusion-synovitis in patients with symptomatic knee OA and knee effusion-synovitis.Methods:In this randomised, double-blind, placebo-controlled trial, participants with significant knee pain (≥ 40 mm on a 100-mm visual analog scale [VAS]), symptomatic knee OA (by ACR criteria) and ultrasound defined effusion-synovitis were randomised to receiveCurcuma longaextract (80% aqueous based extract standardized to turmerosaccharides + 20% curcuminoids, 2 × 500 mg capsules/day) or identical placebo for 12 weeks. Knee MRI scans were obtained at baseline and 12 weeks. Coprimary outcomes were changes in knee pain assessed by VAS and change in knee effusion-synovitis volume assessed by MRI over 12 weeks.Results:Among 70 participants (36 receivedCurcuma longa, 34 received placebo, age 61.8±8.6 years, 56% female),Curcuma longasignificantly improved VAS knee pain compared to placebo (-9.11mm, 95% confidence interval [CI] [- 17.79 to -0.44]) over 12 weeks, equivalent to a standardised effect size of 0.50. There was no significant between group difference in change in effusion-synovitis volume (3.24 mL [-0.33, 6.82]). There were significantly greater reductions in WOMAC knee pain (-47.22mm [-81.22, -13.22]), WOMAC function (-112.26mm [-222.79 to -1.74]) and significantly more OARSI-OMERACT treatment responders (63% treatment vs. 38% placebo [Risk Ratio=1.64 (1.00 to 2.70)]) in theCurcuma longagroup compared to the placebo group. There was no significant between-group difference in lateral femoral cartilage T2 relaxation time (-0.38 ms [- 1.10 to 0.34]) assessed from compositional MRI. The incidence of adverse events was similar in theCurcuma longa(n=14 (39%)) and placebo (n=18 (53%)) groups over 12 weeks (P=0.24).Conclusion:An extract ofCurcuma longasignificantly improved knee pain in an inflammatory phenotype of knee OA patients over 12 weeks compared to placebo but had no effect on knee effusion-synovitis and cartilage composition assessed using MRI. The moderate effect size of the treatment supports the use ofCurcuma longaextract for the symptomatic management of knee OA.Figure 1.Change in VAS and WOMAC subscale scores in treatment and control groups over the course of the study. (VAS = Visual analog scale, WOMAC = Western Ontario and McMaster University Index, CL = Curcuma longa extract)Disclosure of Interests:None declared

scholarly journals GAMBARAN KEJADIAN NYERI LUTUT DENGAN KECURIGAAN OSTEOARTRITIS LUTUT PADA PERAWAT DI POLIKLINIK RAWAT JALAN BLU RSUP PROF. DR. R. D. KANDOU MANADO

e-CliniC ◽  
2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Rita Purnama Deu
Keyword(s):  
Body Mass Index ◽  
Knee Osteoarthritis ◽  
Knee Pain ◽  
Visual Analog Scale ◽  
Outpatient Treatment ◽  
Analog Scale ◽  
High Heel ◽  
Knee Oa ◽  
Lequesne Index ◽  
Female Nurses

Abstract: Osteoarthritis (OA) is a degenerative joint disease associated with destruction of joint cartilages. OA can occur in all joints of the cervical, thoracal, and lumbar vertebrae, pelvis, knees, ankles, hands, and fingers. However, it is most commonly found in the knee joints because these joints bear heavier burden than the other joints. OA patients usually complain pain at the time of doing activities or if there is some load on the affected joint. On a more serious degree, there is continuous pain which disturbs the patient’s mobility. This study aimed to find the incidence knee osteoarthritis among nurses at outpatient treatment of Prof. Dr. R.D. Kandou Hospital. This was a descriptive quantitative study. Sample consisted of 25 nurses. Data were obtained through interviews and questionnaires and then were analyzed by using SPSS. The results showed that the highest numbers of nurses (14 nurses, 56.0%) with suspected knee OA were in the age group of 51-60 years. There were as many as 23 female nurses (92.0%) with suspected knee OA. Based on BMI (Body Mass Index) most of the nurses (13 nurses, 52.0%) were obese I, meanwhile based on the degrees of knee pain most of the nurses (19 nurses, 76.0%) experienced mild pain. Based on the Lequesne index functions most samples (13 nurses, 52.0%) showed mild functional. Based on the usage of high heel shoes most of the female nurses (19 nurses, 76.0%) used high heel shoes. Conclusion: Most of the nurses at outpatient treatment of Prof. Dr. R.D.Kandou Hospital that were suspected of knee osteoarthritis were obese I, had associated mild pain, and showed mild functional tested with Lequesne index funtion. Moreover, most of the female nurses wore high heel shoes.Keywords: knee osteoarthritis , knee pain, Lequesne index parameters, BMT (Body Mass Index), VAS (Visual Analog Scale)Abstrak: Osteoartritis (OA) merupakan penyakit degenerative sendi yang berkaitan dengan kerusakan kartilago sendi. OA dapat mengenai semua persendian dari servikal, thorakal, dan lumbal, panggul, lutut, pergelangan kaki, tangan sampai ke jari-jari, tetapi paling sering ditemukan pada sendi lutut karena pada sendi ini terdapat pembebanan yang lebih besar. Pasien OA biasanya mengeluh nyeri pada waktu melakukan aktivitas atau jika ada pembebanan pada sendi yang terkena. Pada derajat yang lebih berat, nyeri dapat dirasakan terus menerus sehingga sangat mengganggu mobilitas pasien. Penelitian ini bertujuan untuk mengetahui angka kejadian nyeri lutut dengan kecurigaan OA lutut pada perawat di Poliklinik Rawat Jalan BLU RSUP Prof. Dr. R. D Kandou Manado. Penelitian ini menggunakanpendekatan deskriptif kuantitatif. Sampel berjumlah 25 perawat. Data diperoleh melalui kuesioner dan wawancara yang kemudian dianalisis menggunakan SPSS. Hasil penelitian memperlihatkan bahwa perawat yang dicurigai OA lutut terbanyak pada kelompok umur 51-60 tahun sebanyak 14 perawat (56,0 %). Berdasarkan jenis kelamin perawat yang di curigai OA lutut terbanyak pada perempuan yaitu sebanyak 23 perawat (92,0 %). Berdasarkan IMT (Indeks Massa Tubuh) sebagian besar perawat ialah obes I yaitu 13 perawat (52,0 %). Berdasarkan derajat nyeri lutut sebagian besar mengalami nyeri ringan yaitu sebanyak 19 perawat (76,0 %). Berdasarkan indeks Lequesne sebagian besar fungsi fungsional ringan yaitu 13 perawat (52,0 %). Berdasarkan pemakaian sepatu tumit tinggi sebagian besar perawat perempuan menggunakan sepatu tumit tinggi yaitu sebanyak 19 perawat (76,0 %). Simpulan: Sebagian besar perawat di Poliklinik Rawat Jalan BLU RSUP Prof. Dr. R.D. Kandou Manado yang dicurigai osteoartritis lutut termasuk obes I, disertai nyeri ringan, dan indeks Lequesne fungsional ringan. Sebagian besar perawat perempuan menggunakan sepatu tumit tinggi.Kata kunci : osteoartritis lutut, nyeri lutut, parameter indeks Lequesne, VAS (Visual Analog Scale)

Effect of Fatigue on Medial Elbow Torque in Baseball Pitchers: A Simulated Game Analysis

2018 ◽  
Vol 46 (10) ◽  
pp. 2509-2513 ◽  
Author(s):  
Kelechi R. Okoroha ◽  
Jason E. Meldau ◽  
Vincent A. Lizzio ◽  
Fabien Meta ◽  
Jeffrey P. Stephens ◽  
...  
Keyword(s):  
Visual Analog Scale ◽  
Effect Size ◽  
Injury Risk ◽  
Adverse Outcomes ◽  
Mobile Sensor ◽  
Analog Scale ◽  
Game Analysis ◽  
Collegiate Baseball ◽  
Baseball Pitchers ◽  
Simulated Game

Background: The incidence of overuse injury to the elbow among baseball pitchers continues to rise, despite extensive efforts at pitch count regulations and emphasis on proper throwing mechanics. Purpose: To determine if the medial elbow experiences increased torque levels as a baseball pitcher fatigues through the course of a simulated game. Study Design: Descriptive laboratory study. Methods: High school and collegiate baseball pitchers were recruited for this simulated game study. Each pitcher completed a simulated game consisting of 6 innings and a standardized pitching scheme of fastballs, curveballs, and changeups. In total, each pitcher threw 90 pitches. Fatigue was reported per inning with a visual analog scale, and pitch velocity was captured per pitch with a radar gun. Outcome measures were assessed with a validated mobile sensor and included medial elbow torque, arm speed, arm rotation, and arm slot. Linear and quadratic regression modeling was used to evaluate the relationship between pitcher fatigue and pitching kinematics. Results: A total of 11 pitchers (mean age, 17.6 years; range, 15-20 years) completed the study. Visual analog scale fatigue scores increased 0.72 points per inning pitched ( P < .01, effect size = 0.64). Medial elbow torque also increased beyond inning 3, with an increase of 0.84 N·m each inning ( P < .01, effect size = 0.08), while pitch velocity decreased (0.28 mph per inning, P < .01, effect size = 0.27). Fastballs generated the greatest amount of medial elbow torque (49.3 ± 1.4 N·m, P < .01, effect size = 0.24). There were no differences in arm rotation ( P = .42) or arm speed ( P = .80) as the game progressed. However, arm slot decreased with each successive inning (0.73° on average per inning, P = .03, effect size = 0.12). No adverse outcomes were noted with use of the mobile sensor. Conclusion: In this simulated game analysis, pitchers experienced increased fatigue after each successive inning. While the average pitch velocity declined with each successive inning, the torque on the medial elbow increased after inning 3. These findings signify a possible relationship between fatigue and injury risk.

Clinical Efficacy of Intra-articular Mesenchymal Stromal Cells for the Treatment of Knee Osteoarthritis: A Double-Blinded Prospective Randomized Controlled Clinical Trial

2020 ◽  
Vol 48 (3) ◽  
pp. 588-598 ◽  
Author(s):  
Jaime R. Garza ◽  
Richard E. Campbell ◽  
Fotios P. Tjoumakaris ◽  
Kevin B. Freedman ◽  
Lawrence S. Miller ◽  
...  
Keyword(s):  
Low Dose ◽  
Controlled Trial ◽  
Womac Score ◽  
Percentage Change ◽  
Controlled Clinical Trial ◽  
High Dose ◽  
Median Percentage ◽  
Knee Oa ◽  
Symptomatic Knee ◽  
Double Blinded

Background: Currently, there are limited nonoperative treatment options available for knee osteoarthritis (OA). Cell-based therapies have emerged as promising treatments for knee OA. Autologous stromal vascular fraction (SVF) has been identified as an efficient medium for intra-articular administration of progenitor cells and mesenchymal stem cells derived from adipose tissue. Hypothesis: Patients receiving intra-articular SVF would show significantly greater improvement than patients receiving placebo injections, and this improvement would be dose dependent. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: This was a multisite prospective double-blinded randomized placebo-controlled clinical trial. Adult patients with symptomatic knee OA were eligible. Thirty-nine patients were randomized to high-dose SVF, low-dose SVF, or placebo (1:1:1). SVF was obtained via liposuction, processed to create the cellular implant, and injected during the same clinical visit. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores and magnetic resonance images were obtained preoperatively and at 6 and 12 months after injection. The Wilcoxon rank sum nonparametric test was utilized to assess statistical significance, and the Hodges-Lehmann location shift was used to assess superiority. Results: The median percentage change in WOMAC score at 6 months after injection for the high-dose, low-dose, and placebo groups was 83.9%, 51.5%, and 25.0%, respectively. The high- and low-dose groups had statistically significant changes in WOMAC scores when compared with the placebo group (high dose, P = .04; low dose, P = .02). The improvements were dose dependent. The median percentage change in WOMAC score from baseline to 1 year after injection for the high-dose, low-dose, and placebo groups was 89.5%, 68.2%, and 0%, respectively. The high- and low-dose groups displayed a greater percentage change at 12 months when compared with the placebo group (high dose, P = .006; low dose, P = .009). Magnetic resonance image review revealed no changes in cartilage thickness after treatment. No serious adverse events were reported. Conclusion: Intra-articular SVF injections can significantly decrease knee OA symptoms and pain for at least 12 months. The efficacy and safety demonstrated in this placebo-controlled trial support its implementation as a treatment option for symptomatic knee OA. Registration: NCT02726945 (ClinicalTrials.gov identifier)

The Effectiveness of the Mézières Method in Elite Rhythmic Gymnastics Athletes With Low Back Pain: A Randomized Controlled Trial

2020 ◽  
Vol 29 (7) ◽  
pp. 913-919
Author(s):  
Orges Lena ◽  
Jasemin Todri ◽  
Ardita Todri ◽  
José Luis Martínez Gil ◽  
Maria Gomez Gallego
Keyword(s):  
Randomized Controlled Trial ◽  
Low Back Pain ◽  
Back Pain ◽  
Visual Analog Scale ◽  
Effect Size ◽  
Controlled Trial ◽  
Low Back ◽  
Analog Scale ◽  
Randomized Controlled ◽  
Rhythmic Gymnastics

Context: One of the main reasons why athletes with a high physical condition suffer from low back pain disease is because they often participate in sports that involve disc compression movements during flexion, lifting loads, or torsion movement. Objectives: This study aims to examine the effectiveness of the postural treatment of the Mézières method on elite rhythmic gymnastics athletes with low back pain. Design: Double-blind, randomized, controlled trial. Setting: The sports hall of “Puente Tocinos,” Murcia, Spain. Participants: Ninety gymnastics athletes were randomized into 2 parallel groups (intervention: n = 39; control: n = 51), of whom 98.9% were women (women = 89; man = 1). Intervention: The Mézières method postural therapy was implemented. It lasted about 60 minutes in repeated sessions of 2 to 3 meetings per week by counting in overall 60 sessions during a 24-week period. Main Outcome Measures: Visual analog scale of pain, sit and reach flexibility test, Runtastic (pedometer performance android application), Roland–Morris Questionnaire for the physical disability, and the Health Status Questionnaire were used. Results: The univariate analysis of variance and independent sample t test revealed a significant improvement in the intervention group concerning the visual analog scale pain assessment scale (P < .05, ), and, also, the between-groups effect size was high during the 24 sessions of treatment (d > 0.8) compared with the control one. The same situation persists even for Roland–Morris Questionnaire (P < .05, ), physical score (P < .05, ), mental score (P < .05, ), sit and reach flexibility test (P < .05, ), and Runtastic performance (P < .05, ), where the between-groups effect size was high during the 24 sessions of treatment (d > 0.8). Conclusion: The Mézières method treatment performed on athletes with low back pain has caused positive effects on all the outcomes analyzed compared with the ones of control group.

Efficacy of Kinesio Taping and McConnell Taping Techniques in the Management of Anterior Knee Pain

2020 ◽  
Vol 29 (1) ◽  
pp. 79-86
Author(s):  
Rumit S. Kakar ◽  
Hilary B. Greenberger ◽  
Patrick O. McKeon
Keyword(s):  
Knee Pain ◽  
Visual Analog Scale ◽  
Anterior Knee Pain ◽  
Pain Syndrome ◽  
Patellofemoral Pain Syndrome ◽  
Patellofemoral Pain ◽  
Drop Jump ◽  
Analog Scale ◽  
Kinesio Taping ◽  
Anterior Knee

Context: Anterior knee pain also known as patellofemoral pain syndrome is a frequently encountered musculoskeletal disorder that worsens with activity. The multifactorial etiology of patellofemoral pain syndrome alters lower-extremity mechanics, increasing patellofemoral joint stresses during weight-bearing tasks. Kinesio and McConnell tapings are often incorporated into the treatment, but their efficacy is still unclear. Objective: To test the efficacy of Kinesio taping, McConnell taping, and sham taping in improving knee mechanics and reducing pain during activity. Design: Cross-sectional design. Setting: Clinical biomechanics laboratory. Participants: Ten participants (age: 20.3 [1.5] y, height: 169.9 [10.4] cm, and mass: 70.17 [13.1] kg) with anterior knee pain and no history of trauma. Intervention: Three trials each of squat, drop jump, and step-down tasks with 3 taping conditions in a counterbalanced order. Main Outcome Measures: Two-dimensional motion capture data of lower-extremities in frontal and sagittal planes were recorded and analyzed using 3 iPads and Spark Motion® application. Pooled effect sizes (Hedges’ g), 95% confidence intervals, and repeated-measures analysis of variance (P < .05) compared baseline and taping conditions during exercises for pain Visual Analog Scale and knee flexion in all exercises, hip abduction during step-down and drop jump, frontal plane projection during step-downs, and knee translation in sagittal plane during squats. Results: Significant reductions in Visual Analog Scale were recorded during squats between tapes (F2.505,12.867 = 3.407, P = .04, Hedges’ g = −0.70). Pairwise comparison showed a decrease in Visual Analog Scale for sham taping (mean difference = 1.14 cm, P = .01) and Kinesio taping (mean difference = 1.54 cm, P = .02) compared with baseline during squats. Conclusions: A variety of taping methods can potentially reduce perceived pain in individuals with patellofemoral pain syndrome, allowing clinicians to perform rehabilitation exercises. Sensory effects associated with short-term taping may be sufficient enough to modify knee pain acutely by afferent input blocking nocioceptive pain before the participants could adapt. Most interestingly, the sham taping technique demonstrated promise for enhancing functional outcomes, depending on the length of the tape and area covered.

scholarly journals Comparação do nível de dor femoropatelar, atividade física e qualidade de vida entre adolescentes do sexo feminino e masculino

2017 ◽  
Vol 27 (1) ◽  
pp. 25250 ◽  
Author(s):  
Marina Cabral Waiteman ◽  
Maira Bergamaschi Coura ◽  
Cynthia Gobbi ◽  
Ronaldo Valdir Briani ◽  
Danilo De Oliveira Silva ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Knee Pain ◽  
Visual Analog Scale ◽  
Female Adolescents ◽  
Analog Scale ◽  
Public And Private ◽  
Male Adolescents ◽  
Insidious Onset

Aims: To compare the level of pain, physical activity, and quality of life of female and male adolescents with patellofemoral pain.Methods: A total of 46 female adolescents and 46 male adolescents aged 12 to 18 years were recruited from public and private schools in the town of Presidente Prudente, São Paulo, Brazil. To be included in the study, adolescents needed to report knee pain of insidious onset, exacerbated in some activities, and lasting for at least 6 weeks. In addition, adolescents should report worse pain over the previous week of at least 30 mm on the Visual Analog Scale and could not show signs, symptoms or any occurrence of any other knee dysfunction. The participants were requested to mark their self-reported knee pain in the last month on a Visual Analog Scale. The level of physical activity was evaluated by the Baecke Questionnaire of Habitual Physical Activity and the quality of life subscale of the Knee Outcome in Osteoarthritis Survey questionnaire was used to investigate the participants’ quality of life. The independent t-test was used to find differences between the groups regarding the level of physical activity, quality of life, and knee pain.Results: According to the Visual Analog Scale, male adolescents presented a level of knee pain of 5.1±1.4 in the previous month and female adolescents, of 4.4±1.6 (p = 0.029). The physical activity score was 8.8±1.3 for male adolescents and 7.5±1.6 for female ones (p<0.001). The quality of life subscale scores were 77.9±19.0 for adolescent girls and 70.8±13.5 for male adolescents (p=0.042).Conclusions: Among adolescents with patellofemoral pain, males had a higher level of knee pain, higher level of physical activity, and lower quality of life compared to female adolescents.

scholarly journals EFFICACY AND SAFETY OF CURCUMA LONGA EXTRACT IN THE TREATMENT OF OSTEOARTHRITIS: A SYSTEMATIC REVIEW

2019 ◽  
pp. 140-145
Author(s):  
ALESSA FAHIRA ◽  
ALLYSA SORAYA ◽  
ARMAND ACHMADSYAH ◽  
RANI WARDANI HAKIM
Keyword(s):  
Adverse Effects ◽  
Randomized Controlled Trials ◽  
Visual Analog Scale ◽  
Curcuma Longa ◽  
Control Group ◽  
Controlled Trials ◽  
Analog Scale ◽  
Randomized Controlled ◽  
Natural Remedies

Objective: Osteoarthritis (OA) is a chronic disease caused by inflammation of the tissue and bony structure of the joint, which affects more than 235 million people worldwide. Due to the adverse effects caused by the long-term use of standard treatment of OA, the attempt to find natural remedies to treat chronic diseases continues to rise. Curcuma longa is known to have anti-inflammatory effects, which may impact the pathophysiology of OA. While many randomized controlled trials show the efficacy of Curcuma longa extract in the treatment of OA, there has been no comprehensive review of this evidence. Methods: We systematically searched PubMed, Cochrane, Scopus, ProQuest, EBSCOhost, and ScienceDirect for randomized controlled trials that evaluated Curcuma longa extract (CE extract) vs. control (placebo or other therapy). Three trials were identified. Data were then extracted from the studies and summarized descriptively. Results: Across all trials, Curcuma longa therapy was proven to reduce Visual Analog Scale (VAS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores significantly compared to the control group. Adverse effects were less likely to appear in patients treated with Curcuma longa extract compared to other groups. Conclusion: CL extract is beneficial as an alternative medication for OA treatment, shown by the reduced scores of the Visual Analog Scale (VAS) and WOMAC in all studies we reviewed.

THU0454 OA Pain Phenotypes Associated with Structural Progression and Change in Pain Over Time in Two Phase III Clinical Studies with Symptomatic Knee OA

2015 ◽  
Vol 74 (Suppl 2) ◽  
pp. 364.2-365
Author(s):  
A.R. Bihlet ◽  
A.-C. Bay-Jensen ◽  
M.A. Karsdal ◽  
I. Byrjalsen ◽  
B.J. Riis ◽  
...  
Keyword(s):  
Clinical Studies ◽  
Phase Iii ◽  
Two Phase ◽  
Knee Oa ◽  
Structural Progression ◽  
Symptomatic Knee ◽  
Over Time

scholarly journals Combination of platelet-rich plasma and hyaluronic acid in the treatment of moderate and severe osteoarthritis of the knee joint

2020 ◽  
Vol 28 (4) ◽  
pp. 31-35
Author(s):  
Muthanna Abdul Razaq ◽  
Anmar Ahmed Qasim ◽  
Thamer Mohammed Assim ◽  
Ramzi Ramzi
Keyword(s):  
Hyaluronic Acid ◽  
Physical Function ◽  
Effect Size ◽  
Platelet Rich Plasma ◽  
Womac Score ◽  
Osteoarthritis Of The Knee ◽  
Knee Oa ◽  
Womac Index ◽  
Symptomatic Knee ◽  
Mean Differences

The study aimed to determine the effectiveness of monthly intra-articular injection of combination of PRP and hyaluronic acid in improvement of outcome of knee OA. It was conducted as open clinical trial on a convenient sample of 17 patients with unilateral or bilateral symptomatic knee OA in rheumatology and orthopedic clinics at Al-Jumhoori Teaching Hospital in Mosul, Iraq during 1st of Jan to 30th Jun, 2018. The patients received intra-articular injection of combination of plate rich plasma (PRP) and hyaluronic acid (HA) monthly for three months. The outcome assessment was carried out 4 weeks after the last injection using WOMAC index. The results revealed that WOMAC index subscales was reduced significantly (p <0.001) after treatment by followings mean differences: 3.88 in pain (95% CI: 3.18-4.58); 1.29 in stiffness (95% CI: 0.85-1.73); 9.29 in physical function (95% CI: 6.70-11.88); and 14.47 in total score (95% CI: 11.20-17.73). The intervention effect size were as follows: 1.23 in pain; 1.49 in stiffness; 1.11 in physical function, and 1.20 in total WOMAC score. Overall, effect size of combination of PRP and HA intra-articular injection is classified as large effect size (> 0.8) in improving outcome of knee OA. A combination of PRP and HA has large synergistic effect size in improving outcome of moderate and severe OA of knee.

scholarly journals KARAOKE: Krill oil versus placebo in the treatment of knee osteoarthritis: protocol for a randomised controlled trial

2019 ◽  
Author(s):  
Laura L Laslett ◽  
Benny Antony ◽  
Anita Wluka ◽  
Catherine Hill ◽  
Lyn March ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Disease Progression ◽  
Knee Pain ◽  
Controlled Trial ◽  
Safety Data ◽  
Treatment Compliance ◽  
Krill Oil ◽  
Knee Oa ◽  
Knee Effusion ◽  
Secondary Outcomes

Abstract Background: Knee osteoarthritis (OA) is a common and important cause of pain and disability, but interventions aimed at structural modification have been disappointing. While OA affects the whole joint, synovitis and effusion have been recognised as having a role in the pathogenesis of OA. Krill oil reduces knee pain and systemic inflammation and could be used for targeting inflammatory mechanisms of OA. Methods: 260 patients with clinical knee OA, significant knee pain and effusion-synovitis present on MRI will be recruited in 5 Australian cities (Hobart, Melbourne, Sydney, Adelaide and Perth). They will be randomly allocated to the two arms of the study, receiving 2g/day krill oil or inert placebo daily for 6 months. MRI of the study knee will be performed at screening, and after 6 months. Knee symptoms, function and MRI structural abnormalities will be assessed using validated methods. Safety data will be recorded. Primary outcomes are absolute change in knee pain (assessed by visual analog score) and change in size of knee effusion-synovitis over 24 weeks. Secondary outcomes include improvement in knee pain over 4, 8, 12, 16 and 20 weeks. The primary analyses will be intention-to-treat analyses of primary and secondary outcomes. Per protocol analyses adjusting for missing data and for treatment compliance will be performed as the secondary analyses. Discussion: This study will provide high-quality evidence to assess whether krill oil 2g/day reduces pain and effusion-synovitis size in older adults with clinical knee OA and knee effusion-synovitis. If krill oil is effective and confirmed to be safe, we will provide compelling evidence that krill oil improves pain and function, changes disease trajectory and slows disease progression in OA. Given the lack of approved therapies for slowing disease progression in OA, and moderate cost of krill oil, these findings will be readily translated into clinical practice.

Sign in / Sign up

Export Citation Format

Share Document