scholarly journals AB0276 DIFFERENCES BETWEEN IMPACT OF BIOLOGICAL THERAPY AND IMPACT OF CONVENTIONAL TREATMENT ON PRODUCTIVITY AND QUALITY OF LIFE IN PATIENTS WITH RHEUMATOID ARTHRITIS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1437.2-1437
Author(s):  
M. Bogojevic ◽  
N. Miketic ◽  
S. Aligrudic ◽  
R. Medjedovic ◽  
D. Loncar ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Rheumatoid Arthritis ◽  
Work Ability ◽  
Conventional Therapy ◽  
Biological Therapy ◽  
Emotional State ◽  
Health Condition ◽  
Number Of Patients ◽  
Sf 36

Background:Number of patients with rheumatoid arthritis in Montenegro amounts around 3,000, while 8% of them are on biological therapy. This percent is similar, or even higher in comparison to countries that are highly comparable to Montenegro. However, the percentage is still lower than in European countries.Objectives:Objective of the study was to identify the differences between impact of biological and conventional therapy on quality of life of RA patients, their work ability and productivity, mental health, emotional state and social inclusion.Methods:The analysis was based on data gathered from the questionnaires filled by RA patients in Montenegro: 92 patients treated with biological therapy and 78 treated with conventional therapy. More insights and information from examined patients were gathered on two focus groups. Following indicators were used in the study: two indicators that measure work ability and productivity: one monetized – Work Productivity and Activity Impairment Questionnaire General Health V2.0 (WPAI-GH) and one non-monetized – RA Work Instability Scale (RA WIS), and two indicators that measure quality of life – Health Assessment Questionnaire (HAQ-DI) and RAND 36-Item Health Survey (SF-36).Results:WPAI-GH results are used in evaluation of absenteeism and presentism costs per RA patient per annum, which are caused exclusively by rheumatoid arthritis. WPAI-GH results are presented in the following figure. Total cost of absenteeism and presenteeism of RA patients in Montenegro amounts to 3.8 million EUR per annum. Results of RA WIS indicator suggest that patients treated with biological therapy are characterized by low to moderate level of work instability, and patients treated with conventional therapy by moderate level. Patients treated with biological therapy have shown 25% lower level of work instability. HAQ-DI indicator shows that both groups of patients are characterized by mild difficulties to moderate disability in performing everyday activities. However, patients treated with conventional therapy deal with higher level of difficulties, even though their level of RA progression is lower, on average. SF-36 indicator shows that patients treated with conventional therapy have lower level of physical functioning, followed by 26% higher pain intensity. They are 25% more exposed to limitations due to physical health problems caused by RA, and 20% more to limitations due to emotional problems. Patients treated with biological therapy, on average, rate their health with 50% higher rank in comparison to subjective health rate of patients treated with conventional therapy. They also feel that their health has improved during the past year, or stayed approximately the same, while patients treated with conventional therapy feel that their health condition has aggravated, or stayed unchanged.Conclusion:Results show that health condition, emotional state and life quality are better among the patients treated with biological therapy. Also, their productivity is higher compared to patients treated with conventional therapy. This conclusion is additionally supported by the fact that there is more progression of disease among RA patients treated with biological therapy, as well as by the fact that the average duration of RA is almost two times longer among examinees who are on biological therapy than among examinees who are on conventional therapy. Accordingly, access to biological therapy for greater number of patients in earlier stage of disease would result in reduction costs of lost productivity and work disability connected to RA, as well as in mitigation of RA impact on lives and functionality of patients.Figure 1.WPAI-GHDisclosure of Interests:None declared

scholarly journals Quality of life of patients with rheumatoid arthritis under biological therapy

2015 ◽  
Vol 61 (2) ◽  
pp. 126-131 ◽  
Author(s):  
Amanda Figueiredo Barbosa Azevedo ◽  
Katia Cristina Lima de Petribú ◽  
Moacir de Novaes Lima ◽  
André Santos da Silva ◽  
José de Arimatea Rocha Filho ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Rheumatoid Arthritis ◽  
Biological Therapy ◽  
Health Assessment ◽  
Medical Outcomes ◽  
Sf 36 ◽  
Before And After ◽  
Related Quality ◽  
Health Related

Summary Objective: assessing health-related quality of life (HRQL) in patients with rheumatoid arthritis (RA), before and after treatment with biological therapy. Methods: a longitudinal study, conducted from November 2010 to September 2011, with implementation of the instruments HAQ II (health assessment questionnaire) and SF-36 (medical outcomes short-from health survey). Barlett test, Anova, Friedman and paired t-test were performed for multiple extracts. Results: 30 patients were evaluated, mean age of 47.6 (SD: 12.25) years and prevalence of females (90%). The mean score of HAQ II before treatment was 1.97, with significant reduction of up to 1.23 after six months of biological therapy (p<0.01). Most of the SF-36 domains showed significant improvement after six months of treatment (p<0.01), highlighting the social aspects, pain, physical functioning, emotional issues, vitality and physical aspects. Conclusion: the use of biologic therapy in patients with RA refractory to standard therapies proved to be an important pharmacological strategy for improving HRQL.

scholarly journals Efficiency in the treatment of juvenile rheumatoid arthritis

2019 ◽  
Vol 5 (2) ◽  
pp. 92-97
Author(s):  
G. Saatova ◽  
A. Ganieva
Keyword(s):  
Quality Of Life ◽  
Rheumatoid Arthritis ◽  
Juvenile Rheumatoid Arthritis ◽  
Treatment Program ◽  
Emotional State ◽  
Social Adaptation ◽  
Treatment Programs ◽  
Traditional Treatment ◽  
Sf 36

The medical and economic efficiency of various treatment programs for juvenile rheumatoid arthritis is analyzed. The use of tocilizumab is 1.9 times more effective than in the group with traditional treatment. Evaluation of the quality of life of patients with juvenile rheumatoid arthritis on the SF-36 scale can be used to assess the effectiveness of treatment by parameters reflecting the physical, psycho-emotional state and social adaptation of the child. The authors note the smallest amount of costs per unit of quality of life of the patient in the tocilizumab treatment program.

scholarly journals POS1455-HPR RELATIONSHIP BETWEEN PSYCHOLOGICAL FACTORS AND MEASURES OF RHEUMATOID ARTHRITIS ACTIVITY

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1011.2-1011
Author(s):  
Y. Olyunin ◽  
V. Rybakova ◽  
E. Likhacheva ◽  
E. Nasonov
Keyword(s):  
Quality Of Life ◽  
Rheumatoid Arthritis ◽  
Psychological Factors ◽  
Global Assessment ◽  
Activity Level ◽  
Anxiety And Depression ◽  
Tender Joint Count ◽  
Sf 36 ◽  
Patient Reported

Background:The patient-reported outcomes are important components of quantitative methods of rheumatoid arthritis (RA) activity assessment which are used to choose the appropriate drug therapy. The value of these parameters can be significantly affected not only by the inflammatory process, but also by the psychological characteristics of the patient and, in particular, by hardiness [1].Objectives:To study the relationship between psychological factors and signs of RA activity.Methods:Patients with RA who met the EULAR/ACR 2010 criteria, and observed at the V. A. Nasonova Research Institute of Rheumatology were included. Clinical examination was performed including patient global assessment (PGA), physician global assessment (PhGA), pain measurement on a visual analog scale, tender joint count (TJC), swollen joint count (SJC). The functional status was determined by HAQ, the quality of life – by SF-36 EQ-5D, the nature of pain – by painDETECT, the presence of anxiety and depression – by HADS. Patients also completed Hardiness Survey questionnaire to assess hardiness (HDS) and 3 components of the HDS – commitment (CMT), control (CT) and challenge (CLN). Disease activity was evaluated with DAS28, CDAI, and RAPID3. All patients signed informed consent to participate in the study. Analysis of the data was performed using Spearman’s rank test, Fisher exact test, qui-square and t-tests.Results:85 patients with RA were included. There were 69 women and 16 men. Mean age was 56.7±13.1 years, disease duration – 7.6±2.7 years. 72 patients were positive for rheumatoid factor, 75 – for anti-cyclic citrullinated peptide antibody. CDAI showed high activity in 15, moderate – in 37, low – in 30, and remission in 3 patients, DAS 28 – in 10, 55, 12, and 8, and RAPID3 – in 24, 25, 15, and 21, respectively. 24 patients had subclinically or clinically expressed anxiety and 15 –subclinically or clinically expressed depression (≥8 according to HADS). In 31 patients, the painDETECT questionnaire revealed possible or probable neuropathic pain. Mean HDS was 84.8±21.7, CMT – 38.9±9.2, CT – 29.4±8.6, CLN – 17.3±7.1. These values were comparable with the corresponding population data for this age group. There was a significant inverse correlation between HDS and RA activity measures, including SJC, TJC, DAS28 (p<0.05), pain, PGA, PhGA, CDAI, RAPID3, and HAQ (p<0.01). In addition, HDS and all its components positively correlated with quality of life, assessed by SF-36 and EQ-5D (p<0.01). In patients with subclinically and clinically expressed anxiety and depression, HDS, CMT, and CT were significantly lower than in patients without anxiety and depression (p<0.01), while the values of CLN in these groups did not differ significantly.Conclusion:The results of the present study suggest that low HDS may be one of the significant factors determining RA activity level because it does not allow patients to adapt adequately to a stressful situation produced by the disease.References:[1]Maddi SR. Am Psychol. 2008 Sep;63(6):563-4.Disclosure of Interests:None declared

scholarly journals A study of patients’ quality of life more than 5 years after trauma: a prospective follow-up

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Fanny Vardon-Bounes ◽  
Romain Gracia ◽  
Timothée Abaziou ◽  
Laure Crognier ◽  
Thierry Seguin ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Economic Impact ◽  
Physical Functioning ◽  
Major Trauma ◽  
Injury Severity ◽  
Number Of Patients ◽  
Sf 36 ◽  
Socio Economic Impact

Abstract Background The long-term fate of severely injured patients in terms of their quality of life is not well known. Our aim was to assess the quality of life of patients who have suffered moderate to severe trauma and to identify primary factors of long-term quality of life impairment. Methods A prospective monocentric study conducted on a number of patients who were victims of moderate to severe injuries during the year 2012. Patients were selected based on an Injury Severity Score (ISS) more than or equal to 9. Quality of life was assessed by the MOS SF-36 and NHP scores as a primary evaluation criterion. The secondary evaluation criteria were the determination of the socio-economic impact on quality of life and the identification of factors associated with disability. Results Two hundred and eight patients were contacted by e-mail or telephone. Fifty-five patients participated in this study (with a participation level of 26.4%), including 78.2% men, with a median age of 46. Significant alterations in quality of life were observed with the NHP and MOS SF-36 scale, including physical and psychological components. This resulted in a major socio-economic impact as 26% of the patients could not resume their professional activities (n = 10), 20% required retraining in other lines of work, and 36.4% had a disability status. The study showed that scores ≤ 85 on the physical functioning variable of the MOS SF 36 scale was associated with disability. Conclusion More than five years after a moderate to severe injury, patients’ quality of life was significantly impacted, resulting in significant socio-economic consequences. Disability secondary to major trauma seems to be associated with a score ≤ 85 on the physical functioning dimension of the MOS SF-36 scale. This study raises the question of whether or not early rehabilitation programs should be implemented in order to limit the long-term impact of major trauma.

scholarly journals Quality of Life among Dialysis Patients in United Arab Emirates

2021 ◽  
Author(s):  
◽  
Abdelbasit Mohamad Abdelhadi Ayoub
Keyword(s):  
Quality Of Life ◽  
United Arab Emirates ◽  
Survey Design ◽  
Community Sample ◽  
Health Condition ◽  
Dialysis Patients ◽  
Cultural Relevancy ◽  
Sf 36 ◽  
Comparative Survey

<p>Background: Quality of Life (QOL) has emerged as an important parameter for evaluating the quality of health care for patients with renal failure. The QOL of dialysis patients in the United Arab Emirates (UAE) has not previously been studied. This research examined the cultural relevancy of two QOL tools and compared the QOL between dialysis patients and a sample from the community in UAE. Method: A descriptive comparative survey design was used to study the QOL of 161 dialysis patients and 350 participants from the community. Dialysis patients completed the SF-36 and the QOL Index dialysis version tool. Participants from the community completed the SF-36 and QOL Index generic version tool. Both samples also completed three open-ended questions about the cultural relevancy of the tools. Analysis using descriptive and inferential statistics was done within and between groups to establish similarities and differences in QOL scores. Open-ended questions were analysed thematically. Results: The overall QOL for dialysis patients was rated lower when self-assessed using the SF-36 compared with the community sample (58.92 vs. 75.02, p = <0.0001). Furthermore, the overall QOL for dialysis patients was rated almost the same when self-assessed using the QOL Index compared with the community sample (77.2 vs. 78.6, p = 0.421). Moreover, the total scores of both tools were higher in the community sample (75.02 vs. 78.6). The comparison between the statistically significant variables for both samples revealed contradictory results with the two tools. The majority of participants considered both tools culturally relevant in general. There were more questions that were not answered by participants in the QOL Index by both samples compared with the SF-36. Conclusion: In the UAE the SF 36 and the QOL Index capture different aspects of quality of life. Clinicians and researchers need to be aware of these differences when using these tools. An effective way of establishing the cultural relevancy of QOL tools involves comparing the QOL of a group with a health condition with a sample from the community, asking the participants about their views of the cultural relevancy of the tools, examining missing data, and asking participants open-ended questions about what they value in life.</p>

scholarly journals Effectiveness of Tocilizumab after switching from intravenous to subcutaneous formulation in patients with rheumatoid arthritis: A single-centre experience

2021 ◽  
Vol 38 (3) ◽  
pp. 247-256
Author(s):  
Sonja Stojanović ◽  
Bojana Stamenković ◽  
Jovan Nedović ◽  
Ivana Aleksić ◽  
Jovana Cvetković
Keyword(s):  
Quality Of Life ◽  
Rheumatoid Arthritis ◽  
Drug Administration ◽  
Joint Destruction ◽  
Drug Formulation ◽  
Life Assessment ◽  
Drug Effectiveness ◽  
Therapeutic Modalities ◽  
Number Of Patients

Nowadays, the appropriate control of rheumatoid arthritis (RA) involves the absence of clinical disease activity, delaying joint destruction as long as possible and adequate quality of life of the affected. With currently available therapeutic modalities, this therapeutic goal can be achieved in a large number of patients. The aim of this research was to determine the effectiveness of an IL-6 blocker (Tocilizumab) in patients with RA in everyday clinical practice. We also analyzed whether a change in the mode of drug administration (switching from intravenous to subcutaneous drug formulation) had an impact on drug effectiveness (using the DAS 28 SE and CDAI indexes) and quality of life of patients with RA (HAQ, Beck Depression Inventory, FACIT F score and SF 36 questionnaire). The study included 53 subjects diagnosed with RA, treated with Tocilizumab. After a six-month use of subcutaneous Tocilizumab, we concluded that the method of drug administration did not have an impact on its effectiveness and on all the examined parameters of quality of life assessment.

EFFECTS OF BIOLOGICAL THERAPY ON QUALITY OF LIFE AND PSYCHOEMOTIONAL STATUS OF PATIENTS WITH ULCERATIVE COLITIS

2021 ◽  
Vol 74 (10) ◽  
pp. 2610-2613
Author(s):  
Antonina V. Varvarynets
Keyword(s):  
Quality Of Life ◽  
Ulcerative Colitis ◽  
Biological Therapy ◽  
Old Patients ◽  
Group Iii ◽  
Group I ◽  
Sf 36 ◽  
Nonspecific Ulcerative Colitis ◽  
Social Introversion

The aim: To compare the effects of tofacitinib, adalimumab and budesonide on the quality of life and psychoemotional status of patients with moderate UC. Materials and methods: The study included 104 patients with moderately severe UC aged between 18 and 75 years old. Patients were divided into 3 groups. Group I consisted of patients with UC treated with budesonide 9 mg 1 g / d (BUD; n = 34). Group II – of patients receiving adalimumab at an initial dose of 160 mg and 80 mg at week 2, followed by maintenance dose of 40 mg weekly (ADA; n = 38) and group III, who received tofacitinib 10 mg 2p / d (TOF; n = 32). Evaluation of quality of life and psycho-emotional status of patients was performed using IBDQ, SF-36 and MMRI questionnaires. Results: According to the IBDQ-questionnaire, all groups after treatment had a statistically significant increase in their results: BUD (from 146,44 ± 2,23 to 151,36 ± 2,40), ADA (from 144,28 ± 3,10 to 172,36 ± 3,12), TOF (from 149,22 ± 2, 86 to 184.36 ± 2.88), respectively, p <0.05. Also, after treatment statistically significant changes were seen in patients of all groups in regards to the psychological and physical components of the SF-36 scale. Analysis of the personality profile using MMRI of all groups of patients showed a change in scales 2 (depression), 3 (hysteria), 5 (tenderness-femininity), 6 (paranoia) and 0 (social introversion), which significantly improved in the ADA and TOF groups. Conclusions: Tofacitinib and adalimumab in patients with nonspecific ulcerative colitis of moderate severity had a better effect on quality of life and psychoemotional status compared with budesonide treatment.

Quality of life of osteoporotic patients attending rheumatology rehabilitation in-patient units

2012 ◽  
Vol 153 (33) ◽  
pp. 1314-1319
Author(s):  
Julianna Rozália Sallai ◽  
Gábor Héjj ◽  
István †Ratkó ◽  
Aniella Hunka ◽  
Ilona Márkus ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Rheumatoid Arthritis ◽  
Low Back Pain ◽  
Back Pain ◽  
Chronic Low Back Pain ◽  
Poor Quality ◽  
Low Back ◽  
Life Data ◽  
Sf 36

There has been no report on demographic, social and quality of life data of osteoporotic patients attending rheumatology rehabilitation in-patient units in Hungary. Aim: The authors analyzed the data of osteoporotic patients treated in rheumatology rehabilitation departments as in-patients in four hospitals in Hungary. Methods: Demographic and social data were obtained by using a questionnaire developed by the authors, and quality of life was assessed with the use of the SF-36 questionnaire. The quality of life data of osteoporotic patients were compared to that obtained from patients with rheumatoid arthritis, osteoarthrosis and chronic low back pain who were treated in the same department at the same time. Results: Of the 253 patients who were asked to participate in the study, 211 patients filled out the questionnaires. 25.6% of the patients were male. 58% of the patients were younger than 60 years of age, and 40% of them were heavy physical workers earlier. More than 50% of the patients did not complete secondary school education, and only 6.7% of the patients had a per capita monthly income higher than 100 000 HUF. The quality of life of the osteoporotic patients assessed by SF-36 scored 34.7, which was significantly lower than that of the mean of the Hungarian population scoring 70–90. The SF-36 scores of osteoporotic patients were lower in all domains compared to the scores of patients with rheumatoid arthritis, osteoarthritis and low back pain, although the difference was significant only in the domain of physical activity. The affective role of patients with osteoporosis was significantly lower than those with rheumatoid arthritis and osteoarthritis. Conclusions: Osteoporotic patients attending in-patient rheumatology in-patient rehabilitation units in Hungary have poor quality of life comparable, even worse than that found in patients with rheumatoid arthritis, osteoarthritis and chronic low back pain. Orv. Hetil., 2012, 153, 1314–1319.

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