scholarly journals Periocular contact dermatitis with use of topical voriconazole 1% in mycotic keratitis

2018 ◽  
pp. bcr-2018-226498 ◽  
Author(s):  
Pranita Sahay ◽  
Mohamed Ibrahime Asif ◽  
Prafulla Kumar Maharana ◽  
Jeewan S Titiyal
Keyword(s):  
Contact Dermatitis ◽  
Patch Test ◽  
Clinical Examination ◽  
Fungal Keratitis ◽  
Orbital Cellulitis ◽  
Burning Sensation ◽  
Mycotic Keratitis ◽  
Oral Antihistamine ◽  
Skin Patch

We present two cases of culture-proven fungal keratitis on natamycin treatment which developed periocular erythema, oedema, burning sensation and pruritus within 48 hours of the addition of topical voriconazole. On clinical examination, periocular erythema with induration was noted. A diagnosis of orbital cellulitis was suspected, but the absence of pain and tenderness refuted the diagnosis on clinical grounds. A dermatology consultation was sought, and a diagnosis of periocular contact dermatitis with voriconazole was made. A skin patch test was performed with the same medication; however, it was negative. Topical voriconazole therapy was withdrawn, and the patient was prescribed cold compresses and oral antihistamine medication, to which they responded well.

scholarly journals Analysis of skin patch test results and metalloproteinase-2 levels in a patient with contact dermatitis

2015 ◽  
Vol 3 ◽  
pp. 154-161 ◽  
Author(s):  
Milena Wojciechowska ◽  
Rafał Czajkowski ◽  
Bogna Kowaliszyn ◽  
Magdalena Żbikowska-Gotz ◽  
Zbigniew Bartuzi
Keyword(s):  
Contact Dermatitis ◽  
Patch Test ◽  
Test Results ◽  
Skin Patch

Late reactions to patch test preparations with reduced concentrations of p-phenylenediamine: a multicentre investigation of the German Contact Dermatitis Research Group

2011 ◽  
Vol 64 (4) ◽  
pp. 196-202 ◽  
Author(s):  
Uwe Hillen ◽  
Heinrich Dickel ◽  
Harald Löffler ◽  
Wolfgang Pfützner ◽  
Vera Mahler ◽  
...  
Keyword(s):  
Contact Dermatitis ◽  
Patch Test ◽  
Research Group

scholarly journals Patch Test Results of Patients with Occupational Contact Dermatitis

2019 ◽  
Vol 29 (3) ◽  
pp. 113-119
Author(s):  
Semih GÜDER ◽  
Şafak METEKOĞLU ◽  
İlteriş Oğuz TOPAL ◽  
Mehmet MELİKOĞLU
Keyword(s):  
Contact Dermatitis ◽  
Patch Test ◽  
Test Results ◽  
Occupational Contact Dermatitis ◽  
Occupational Contact

scholarly journals Profile of fungal keratitis in a Sub-Himalayan territory of north India

2021 ◽  
Vol 17 (4) ◽  
pp. 356-364
Author(s):  
Anil Kumar Verma ◽  
Anuradha Sood ◽  
Anil Chauhan ◽  
Rajeev Tuli ◽  
Subhash Chand Jaryal
Keyword(s):  
Corneal Ulcer ◽  
Diagnostic Value ◽  
Fungal Species ◽  
Fungal Keratitis ◽  
North India ◽  
Mycotic Keratitis ◽  
Predisposing Factor ◽  
Direct Microscopy ◽  
Corneal Ulcers ◽  
Wet Mount

Aim: To study the microbiological and epidemiological profile of patients with suppurative corneal ulcer presenting in a rural referral center situated in a Sub-Himalayan territory of north India. The study was conducted to evaluate the epidemiology and frequency of mycotic keratitis among the patients of suppurative corneal ulcer and to identify various fungal species as etiological agents. Methods: Corneal scrapings from 56 patients of suppurative corneal ulcers were subjected to direct microscopy and culture. Results: Of the 56 cases of suppurative corneal ulcer investigated, fungal etiology was identified in 18 (32%) cases. Most of the patients (82.1%) worked in agriculture. Trivial trauma with vegetative matter was the most common predisposing factor. Fusarium and Acremonium species were the most common fungi isolated, followed by Aspergillus. Four cases of rare mycotic keratitis caused by Paecilomyces lilacinus, Scedosporium apiospermum, Monilia sitophila, and Ulocladium species were detected. Four cases were smear positive (10% KOH wet mount) but culture negative. Analysis of KOH wet mount was done using culture as gold standard. The sensitivity and specificity of KOH wet mount was 71.43% and 90.48%, respectively. Conclusion: Direct microscopy and culture has a greater diagnostic value in the management of suppurative corneal ulcer. The authors have observed changes in the pattern of organisms identified as cause of fungal keratitis in the region. Rare species of fungi may also be detected if corneal scrapings are collected for direct microscopy and culture from all the cases of suppurative corneal ulcers greater than 2 mm.

scholarly journals Skin Biophysical Parameters and Patch Test Results in People Predisposing to Xiaotong Tiegao Induced Irritant Contact Dermatitis

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Hai-yan Cheng ◽  
Lin-feng Li
Keyword(s):  
Contact Dermatitis ◽  
Patch Test ◽  
Contact Allergy ◽  
Nickel Sulfate ◽  
Tibetan Medicine ◽  
Control Group ◽  
Irritant Contact Dermatitis ◽  
Test Results ◽  
Biophysical Parameters ◽  
Nickel Allergy

Background. Xiaotong Tiegao (XTT) is an ancient topical Tibetan medicine plaster which is widely used in China. Irritant contact dermatitis (ICD) caused by XTT is very common. It is still unclear why some people are more prone to develop ICD. The aim of this study is to study the baseline skin biophysical parameters and patch test results in individuals predisposing to XTT induced ICD. Methods. During a four-month period, 149 healthy volunteers with ICD and 50 volunteers without ICD after applying XTT were recruited. The skin biophysical parameters were measured, and contact allergy to 20 common allergens was patch tested, at two weeks after the ICD was recovered. Results. There were no significant differences in age and sex between ICD and control groups. It was found that skin median melanin value (176.50 vs 189.50, P < 0.05, Mann-Whitney U-test) and erythema value (319.90 ± 70.49 vs 347.93 ± 84.55, P < 0.05, Independent-Samples T test) were much lower in ICD than control group. Overall patch test results were not different, but the positivity rate of nickel sulfate (15.44% vs 4.00%, P < 0.05, Fisher’s exact test) was significantly higher in ICD group. Conclusions. In conclusion, people with nickel allergy, lower values of skin melanin, and erythema are predisposing to develop ICD.

scholarly journals Comparison of Mycotic Keratitis with Nonmycotic Keratitis: An Epidemiological Study

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Mohammad M. Khater ◽  
Nehal S. Shehab ◽  
Anwar S. El-Badry
Keyword(s):  
Antifungal Therapy ◽  
Outpatient Clinic ◽  
Rural Areas ◽  
Clinical Findings ◽  
Fungal Keratitis ◽  
University Hospital ◽  
Mycotic Keratitis ◽  
Urban Residence ◽  
Sewage Disposal ◽  
Epidemiological Features

Purpose. This work aims to study the problems encountered with and the different epidemiological features of patients with fungal keratitis.Patients and Methods. All cases with keratitis attending the Outpatient Clinic of Ophthalmology Department at Tanta University Hospital during three years from the first of January 2011 to the end of December 2013 were selected and carefully examined and cases with mycotic keratitis were further examined and investigated.Results. From 66303 attendants during this period with different complaints, there were 361 cases (0.54%) with mycotic keratitis and 473 cases (0.71%) of nonmycotic origin. Mycotic keratitis is common between 40 and 60 years, more in farmers (64%), families with large number and large crowding index, rural than urban residence, and patients with outdoor water sources and insanitary sewage disposal. Positive fungal cultures were obtained in 84.5% and were negative in 15.5% of cases in spite of their typical clinical findings for diagnosis and their improvement with antifungal therapy.Conclusion. Mycotic keratitis is more frequent in farmers, rural areas, outdoor water supply, insanitary sewage disposal, and patients preceded with organic trauma. Atypical clinical findings were found in some cases and not all cases improved with specific antifungal therapy.

Patch Test Practice Patterns of Members of the American Contact Dermatitis Society

Dermatitis ◽  
2020 ◽  
Vol 31 (4) ◽  
pp. 272-275
Author(s):  
Larissa G. Rodriguez-Homs ◽  
James Taylor ◽  
Beiyu Liu ◽  
Cynthia L. Green ◽  
Bruce Brod ◽  
...  
Keyword(s):  
Contact Dermatitis ◽  
Patch Test ◽  
Practice Patterns ◽  
Test Practice
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