scholarly journals A rare case of urachal adenocarcinoma with bone marrow metastasis

2021 ◽  
Vol 14 (4) ◽  
pp. e242315
Author(s):  
Joshua Van Allen
Keyword(s):  
Bone Marrow ◽  
Case Studies ◽  
Rare Case ◽  
Stage Iv ◽  
Bone Marrow Metastasis ◽  
Current Case ◽  
Aggressive Cancer ◽  
Progression Of Disease ◽  
Urachal Cancer ◽  
Urachal Adenocarcinoma

Urachal cancer is a rare and aggressive cancer that often presents in advanced stages. Given the rarity of this malignancy, medical case studies provide one of the few sources of literature available through which clinicians can guide medical management. Surgery is widely considered to be the mainstay of therapy when disease is localised and surgically resectable, therefore most current case studies on urachal cancer focus on surgical management, occasionally with adjuvant chemotherapy. However, few case studies discuss chemotherapy alone in the treatment of metastatic disease. Most studies indicate a median overall survival between 12 and 24 months for metastatic urachal adenocarcinoma. Bone marrow metastasis of solid tumours, when considered alone, portends a poor prognosis. The patient in this case study represents a rare case of stage IV urachal adenocarcinoma metastatic to the bone marrow without progression of disease after 6 months of treatment.

scholarly journals Ganglioneuroma of the External Auditory Canal and Middle Ear

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Hesham Saleh Almofada ◽  
Michael Steven Timms ◽  
M. Anas Dababo
Keyword(s):  
Bone Marrow ◽  
Temporal Bone ◽  
Middle Ear ◽  
External Auditory Canal ◽  
Rare Case ◽  
Clinical Presentation ◽  
Surgical Intervention ◽  
Stage Iv ◽  
Posterior Mediastinum

Objective. We report an extremely rare case of ganglioneuroma involving the external auditory canal and middle ear. Case Report. Ganglioneuromas are rare benign mature tumors thought to originate from sympathetic ganglions, with the highest incidence in the retroperitoneum, adrenal medulla, and posterior mediastinum. We present a case of ganglioneuroma of the external auditory canal and middle ear. At the age of 12 months, the patient was diagnosed with neuroblastoma stage IV with metastasis to the squamous temporal bone, bone marrow, and skull base. He received a high-risk protocol regimen resulting in complete remission. The patient later presented with recurrent right ear discharge at the age of six years and was diagnosed with ganglioneuroma of external auditory canal and middle ear after appropriate investigations. We report in this article the clinical presentation, investigations, surgical intervention, and follow-up. Conclusion. After the literature review and to our knowledge, this is the first reported case of its kind. Ganglioneuroma maturing from neuroblastoma is one of the theories describing pathophysiology of the disease. Ganglioneuroma should be considered in the differential diagnosis of patients presenting with recurrent ear discharge and decreased hearing in treated cases of neuroblastoma with metastases to temporal bone.

scholarly journals S1907 A Rare Case of Bone Marrow Metastasis as the Initial Presentation of Colorectal Cancer

2021 ◽  
Vol 116 (1) ◽  
pp. S837-S837
Author(s):  
Isaac S. Cho ◽  
Adrian Lugo ◽  
Jaydip B. Patel ◽  
Ahad Waraich ◽  
Swetha Chenna ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Bone Marrow ◽  
Rare Case ◽  
Initial Presentation ◽  
Bone Marrow Metastasis

Comprehensive and epidemiological characterization of urachal adenocarcinoma: A pan-Canadian collaboration.

2019 ◽  
Vol 37 (7_suppl) ◽  
pp. 516-516
Author(s):  
Belkaid Wiam ◽  
Zineb Hamilou ◽  
Denis Soulieres ◽  
Christina M. Canil ◽  
Pawel Zalewski ◽  
...  
Keyword(s):  
Stage Iv ◽  
Response To Therapy ◽  
Clinical Genetic ◽  
Medical File ◽  
Molecular Features ◽  
Underlying Malignancy ◽  
Urachal Cancer ◽  
Urachal Adenocarcinoma ◽  
Treatment Consensus

516 Background: Urachal cancer is a rare form of urothelial cancer representing 0,1-0,2% of bladder cancers. The exact underlying cause of urachal cancer is still widely unknown and there is much speculation on multiple factors such as genetic and environmental ones that may play a role. Moreover, given the lack of treatment consensus, we proposed the first study that assesses the clinical, genetic and molecular features of this disease in Canada. Methods: This ongoing study is recruiting in Canadian centers from the year 2005 onwards. The clinical database is constructed using the hospital electronic medical file. In addition, pathological tissues are centralized for molecular and genetic analysis. Results: To this date, 15 patients were included, 12 males and 3 females. Median age was of 49 years old with a disease distribution of Stage II (4), Stage III (3) and Stage IV (4). 8/15 patients developed metastasis after initial cystectomy in the lungs (n = 7), peritoneum (n = 2), lymph nodes (n = 4), and bone (1). Median survival of all patients was 23 months. Metastatic patients after cystectomy had a shorter overall survival (OS) of 21 months compared to non-metastatic patients (OS – not reached). The majority of metastatic patients (6/8) died of their underlying malignancy. Conclusions: This study is an ongoing country-wide effort to expand knowledge of this poorly studied disease. With ongoing accrual, the clinical features will be better defined and further molecular characterization will be performed to better predict response to therapy.

scholarly journals A rare case of lupus-related gastrointestinal vasculitis presenting as rectal gangrene

2019 ◽  
Vol 2019 (4) ◽  
Author(s):  
Yi Liang ◽  
Angelina Di Re ◽  
Toufic El Khoury
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Abdominal Pain ◽  
Acute Abdomen ◽  
Case Studies ◽  
Lupus Erythematosus ◽  
Rare Case ◽  
Rare Condition ◽  
Free Fluid ◽  
Systemic Lupus ◽  
Current Case

Abstract Systemic lupus erythematosus (SLE) related gastrointestinal vasculitis is a rare condition limited to case studies within the literature however, no cases of rectal gangrene and perforation have been previously described. A 32-year-old male presented with abdominal pain, vomiting and fevers. CT demonstrated free gas and free fluid around the rectum indicative of a perforation. He proceeded to urgent laparotomy, confirming a diagnosis of rectal infarction and perforation. Uniquely, the involved segment of gangrene extended from the rectosigmoid to the anorectal junction. A Hartmanns procedure was performed. Histopathology confirmed underlying stenosis of the rectal arteries secondary to chronic vasculitis related to the affected areas. The current case is a unique presentation of SLE-related vasculitis. It highlights the need to judiciously investigate SLE patients presenting with surgical acute abdomen.

Circle therapy for headache management: case studies

2020 ◽  
Vol 24 (1) ◽  
pp. 101-104
Author(s):  
Muhammad Rafiq
Keyword(s):  
Pain Intensity ◽  
Case Studies ◽  
Rating Scale ◽  
Psychological Pain ◽  
Current Case ◽  
Paired Samples ◽  
Subjective Pain ◽  
Headache Management ◽  
Test Use ◽  
Pain Rating Scale

Recent findings have indicated that hypnotic interventions produce significant decrease in pain intensity. This current case studies are focused to highlight significant impact on pain management including headache. All the patients underwent a complete observation and clinical interview and only patients with psychological pain were included in the study group. For the management of headache, a novel hypnotic intervention - Circle Therapy (CT), was applied on a group of ten patients indicating their pain intensity in the range of 8-10 on subjective pain rating scale. According to rating scale, headache above 8 was considered as severe, 5-8 moderate and < 5 as mild.  CT is a brief hypnotic technique limited to about 10 min. Post hypnosis ratings were also measured. The pre and post hypnosis data were recorded and analyzed by paired samples t test. Use of CT showed significant results between pre and post rating e.g. 9 ± 0.25 vs. 1 ± 0.21 (p < 0.001). This brief CT intervention provided an immediate relief from headache, however, this is limited to few case studies focusing on just headache. So, we recommend large sample studies to document the effects of CT in different types of pain. Citation: Rafiq M. Circle therapy for headache management: case studies. Anaesth pain intensive care 2020;24(1):__ DOI: https://doi.org/10.35975/apic.v24i1. Received – 28 December 2019; Reviewed – 10 January 2020; Accepted - 10 January 2020;

The Economic Impact of the Covid-19 Outbreak : Evidence from Indonesia

2020 ◽  
Vol 5 (3) ◽  
Author(s):  
Ahmad Ulil Albab Al Umar ◽  
Herninda Pitaloka ◽  
Eka Resmi Hartati ◽  
Dessy Fitria
Keyword(s):  
Stock Market ◽  
Economic Impact ◽  
Case Studies ◽  
Capital Market ◽  
Descriptive Study ◽  
Current Case ◽  
Quantitative Descriptive Study ◽  
Quantitative Descriptive ◽  
The Capital Market

This research aims to analyses the economic impact of the COVID 19 outbreak toward the stock market in Indonesia. This research is a quantitative descriptive study by collecting various sources from journals and current case studies about COVID 19 outbreak. The technique of collecting data uses quotations and related news. The results in this study are COVID-19 pandemic outbreak has a pretty bad impact on the capital market, where the occurrence of this pandemic has affected many investors in making investment actions that are very influential on the Stock Market.  

scholarly journals EP1.15-27 One Case of Mucinous Carcinoma of Thymus Caused Bone Marrow Metastasis

2019 ◽  
Vol 14 (10) ◽  
pp. S1062-S1063
Author(s):  
T. Omori ◽  
H. Takahashi ◽  
T. Tachibana ◽  
O. Uchida ◽  
H. Hirano ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mucinous Carcinoma ◽  
Bone Marrow Metastasis
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