scholarly journals Graves’ disease following administration of second dose of SARS-CoV-2 vaccine

2021 ◽  
Vol 14 (12) ◽  
pp. e246432
Author(s):  
Timothy James Goblirsch ◽  
Ambika E Paulson ◽  
Gerti Tashko ◽  
Asefa Jejaw Mekonnen
Keyword(s):  
Young Women ◽  
Healthcare Workers ◽  
Adverse Reactions ◽  
Subacute Thyroiditis ◽  
Graves Disease ◽  
Multinodular Goitre ◽  
Global Pandemic

The SARS-CoV-2 vaccines have had an overwhelming success in curbing the COVID-19 global pandemic, accounting for countless lives saved. Adverse reactions are inevitable, given the vast scale of vaccination required to mitigate future surges of COVID-19. Hyperthyroid disorders have been reported as potential adverse reactions to SARS-CoV-2 vaccines in two patients with Graves’ disease and a group of adults with subacute thyroiditis occurring in young women healthcare workers. We report a case of clinical Graves’ disease in a woman with a previously stable multinodular goitre that occurred 14 days following her second dose of Pfizer-BioNTech SARS-CoV-2 vaccine.

scholarly journals KI and WU Polyomavirus in Respiratory Samples of SARS-CoV-2 Infected Patients

2021 ◽  
Vol 9 (6) ◽  
pp. 1259
Author(s):  
Carla Prezioso ◽  
Ugo Moens ◽  
Giuseppe Oliveto ◽  
Gabriele Brazzini ◽  
Francesca Piacentini ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Healthcare Workers ◽  
Respiratory Pathogens ◽  
Threshold Values ◽  
Cycle Threshold ◽  
Viral Interference ◽  
Disease Outcomes ◽  
Global Pandemic ◽  
Wu Polyomavirus ◽  
Washington University

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has been declared a global pandemic. Our goal was to determine whether co-infections with respiratory polyomaviruses, such as Karolinska Institutet polyomavirus (KIPyV) and Washington University polyomavirus (WUPyV) occur in SARS-CoV-2 infected patients. Oropharyngeal swabs from 150 individuals, 112 symptomatic COVID-19 patients and 38 healthcare workers not infected by SARS-CoV-2, were collected from March 2020 through May 2020 and tested for KIPyV and WUPyV DNA presence. Of the 112 SARS-CoV-2 positive patients, 27 (24.1%) were co-infected with KIPyV, 5 (4.5%) were positive for WUPyV, and 3 (2.7%) were infected simultaneously by KIPyV and WUPyV. Neither KIPyV nor WUPyV DNA was detected in samples of healthcare workers. Significant correlations were found in patients co-infected with SARS-CoV-2 and KIPyV (p < 0.05) and between SARS-CoV-2 cycle threshold values and KIPyV, WUPyV and KIPyV and WUPyV concurrently detected (p < 0.05). These results suggest that KIPyV and WUPyV may behave as opportunistic respiratory pathogens. Additional investigations are needed to understand the epidemiology and the prevalence of respiratory polyomavirus in COVID-19 patients and whether KIPyV and WUPyV could potentially drive viral interference or influence disease outcomes by upregulating SARS-CoV-2 replicative potential.

Type of operation for toxic adenoma, toxic multinodular goitre and Graves’ Disease

2015 ◽  
Vol 87 (1) ◽  
pp. 34-37 ◽  
Author(s):  
S. Lanitis ◽  
K. Karkoulias ◽  
G. Sourtse ◽  
V. Ganis
Keyword(s):  
Graves Disease ◽  
Multinodular Goitre ◽  
Toxic Adenoma

scholarly journals 666 Innovations in ENT Surgery During The COVID-19 Pandemic

2021 ◽  
Vol 108 (Supplement_2) ◽  
Author(s):  
M Aziz ◽  
M Benamer ◽  
S Hany ◽  
Y Sahib
Keyword(s):  
Healthcare Workers ◽  
Sinus Surgery ◽  
Healthcare Team ◽  
Ear Surgery ◽  
The Past ◽  
Ent Surgery ◽  
Global Pandemic ◽  
Theatre Staff ◽  
Reduce Risk ◽  
Nose And Throat

Abstract Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), is responsible for the coronavirus disease 2019 (COVID – 19) global pandemic. Similar coronavirus epidemics over the past years affected healthcare workers significantly. Aerosol generating procedures (AGPs) presented a unique risk to ear, nose and throat (ENT) Surgeons. We introduce various methods of reducing risk in ENT AGPs. Recommendations During trachesostomies we advocate the adoption of a specialist checklist based on ENT UK guidelines. We also advise the use of a clear drape to create a clear barrier between the patient and staff. For ear surgery we advise suturing 2 microscope pieces together end-to-end so that a clear drape can sperate the patient from surgeon. During nasal and sinus surgery, we advise attaching a clear drape to the sterile camera drape used in rigid nasal endoscopy to create a barrier between patient and surgeon. Discussion Our recommendations will create an extra barrier between the patient and the rest of healthcare team. This should reduce the risks to theatre staff from AGPs. Conclusions COVID 19 is a serious health issue affecting healthcare workers, especially during AGPs in ENT surgery. We recommend several techniques to reduce risk. These can also be used during future epidemics.

scholarly journals A Case of Thyrotoxicosis due to Simultaneous Occurrence of Subacute Thyroiditis and Graves’ Disease

2018 ◽  
Vol 2018 ◽  
pp. 1-3
Author(s):  
Kazunori Kageyama ◽  
Noriko Kinoshita ◽  
Makoto Daimon
Keyword(s):  
Thyroid Hormones ◽  
Thyroid Disease ◽  
Rare Case ◽  
Autoimmune Thyroid Disease ◽  
Subacute Thyroiditis ◽  
Simultaneous Occurrence ◽  
Graves Disease ◽  
Inflammatory Disorder ◽  
Autoimmune Thyroid ◽  
Prompt Diagnosis

Subacute thyroiditis is an inflammatory disorder of the thyroid. Graves’ disease is an autoimmune thyroid disease in which thyroid hormones are overproduced. Here we present a rare case of thyrotoxicosis due to the simultaneous occurrence of both diseases. Prompt diagnosis and therapy are required to prevent complications in patients with thyrotoxicosis.

scholarly journals Adverse Reactions of the Second Dose of the BNT162b2 mRNA COVID-19 Vaccine in Healthcare Workers in South Korea

2021 ◽  
Vol 36 (21) ◽  
Author(s):  
Yun Woo Lee ◽  
So Yun Lim ◽  
Ji-Hyang Lee ◽  
Joon Seo Lim ◽  
Miseo Kim ◽  
...  
Keyword(s):  
South Korea ◽  
Healthcare Workers ◽  
Adverse Reactions

scholarly journals Burnout in COVID-19 era - a literature review

2021 ◽  
Vol 11 (8) ◽  
pp. 236-246
Author(s):  
Magdalena Leśniewska ◽  
Ilona Kozioł ◽  
Julia Budzyńska ◽  
Joanna Milanowska
Keyword(s):  
Healthcare Workers ◽  
Young Female ◽  
Database Search ◽  
Occupational Group ◽  
Vulnerable Group ◽  
Global Pandemic ◽  
New Challenges ◽  
Female Nurses ◽  
Task Oriented ◽  
And Task

BACKGROUND:  The COVID-19 pandemic brought changes to daily life of many people. One of those affected by the global pandemic arena was work life. One of the results is burnout due to new challenges and stress associated with them. The most exposed occupational group were healthcare workers as the frontline in the fight against the virus, but not only this group could experience burnout due to the pandemic. AIM OF THE STUDY: The aim of this study was to review the most recent available literature on burnout associated with COVID-19. PubMed, SCOPUS, and Google Scholar databases were reviewed. The Phrase "burnout and covid" was used to search the database. Search criteria were: all open access, 2020 and 2021, psychology and English. After Screening titles and abstracts 21 articles were analyzed in detail.RESULTS:  Many studies have shown that healthcare workers experienced burnout. The most vulnerable group were young, female nurses working with COVID-19 patients.  Burnout was also observed among parents, who started working remotely from home or who had to commute to their workplace despite the pandemic. Remote schooling also contributed to burnout among students and teachers.SUMMARY AND CONCLUSIONS: To reduce the possibility of experiencing burnout there are several actions that could be taken. First of all a positive attitude and task oriented actions are helpful in coping in new, stressful situations. Other solutions are social support and psychotherapy.

scholarly journals MEDIA EDUCATION: the fight against post-truth and misinformation on trafficking in women and girls

2020 ◽  
Vol 6 (6) ◽  
pp. a6en
Author(s):  
Sandra de Souza Machado ◽  
Begoña Sánchez Torrejón ◽  
Víctor Amar Rodríguez
Keyword(s):  
Gender Studies ◽  
Media Literacy ◽  
Young Women ◽  
21St Century ◽  
Gender Violence ◽  
Media Education ◽  
Fake News ◽  
Global Pandemic ◽  
Trafficking In Women ◽  
Women And Girls

Data, discursive and methodological analysis, from the perspective of Communication and Education gender studies, are applied aiming media literacy for a responsive citizenship in the fight against trafficking in women and girls. Questioning gender violence in misinformation, fake news, post-truths, and malicious intentions. Media literacy, co-education and collective awareness function as strategies of action to combat the trafficking of (young) women, which reaches alarming degrees in the 21st century, including during the global pandemic of COVID-19.

Autoantibodies to thyroxin and triiodothyronine in the immunoglobulin G fraction of serum.

1988 ◽  
Vol 34 (12) ◽  
pp. 2561-2562 ◽  
Author(s):  
L Li Calzi ◽  
S Benvenga ◽  
S Battiato ◽  
F Santini ◽  
F Trimarchi
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Human Serum ◽  
Immunoglobulin G ◽  
Subacute Thyroiditis ◽  
Total Serum ◽  
Graves Disease ◽  
Carrier Proteins ◽  
Weak Binding ◽  
Idiopathic Myxedema

Abstract Thyroid hormone antibodies (THAbs)--i.e., antibodies to thyroxin (T4) and triiodothyronine (T3)--are detected rarely in human serum, where they are searched for, possibly because of a quantitatively minimal interaction between thyroid hormones (the haptens) and serum IgGs (the antibodies). The weak binding could result from these facts: (a) there are already six physiological carrier proteins for thyroid hormones; (b) THAbs usually account for a very small fraction of the total serum IgGs; (c) THAbs may have--as reported in the literature--a relatively low affinity. To ascertain whether THAbs could pass undetected in serum, we measured antibodies to T3 and T4 in both the serum and the corresponding IgG fraction of six normal persons and 45 patients with various thyroid diseases (Graves' disease, idiopathic myxedema, Hashimoto's thyroiditis, subacute thyroiditis, tumors), using radioimmunoprecipitation. The prevalence of antibodies to T4 was 0/51 in both the sera and the IgG fractions; the prevalence of antibodies to T3 was 1/51 in both materials. Because all of the sera that tested THAb negative were confirmed to be so in the THAb assay of the IgG fraction, we conclude that the prevalence of serum THAbs is not underestimated and that autoimmunization against thyroid hormones is really a rare phenomenon.

scholarly journals Circulating activated T cell subsets in autoimmune thyroid diseases: Differences between untreated and treated patients

1991 ◽  
Vol 125 (5) ◽  
pp. 502-509 ◽  
Author(s):  
Hiroyuki Ohashi ◽  
Tadamasa Okugawa ◽  
Mitsuyasu Itoh
Keyword(s):  
Autoimmune Thyroiditis ◽  
Hashimoto’S Thyroiditis ◽  
Subacute Thyroiditis ◽  
T Cell Subsets ◽  
Hashimoto's Thyroiditis ◽  
Graves Disease ◽  
Cell Surface Antigens ◽  
Autoimmune Thyroid Diseases ◽  
Immune System Activation ◽  
Hla Dr

Abstract. To investigate the relationships between lymphocyte subsets and thyroid function, peripheral blood lymphocytes were analysed with cell surface antigens of activated (HLA-DR+) T, helper T (CD4+2H4−, CD4+4B4+) and suppressor-inducer T (CD4+2H4+, CD4+4B4−) cells subsets in 56 patients with Graves' disease, 16 patients with Hashimoto's thyroiditis, 7 patients with typical subacute thyroiditis and 2 patients with the thyrotoxic phase of autoimmune thyroiditis. Both patients with Graves' disease and Hashimoto's thyroiditis had increased percentages of HLA-DR+T (Ia+CD3+) cells as well as HLA-DR+ helper-inducer T (Ia+CD4+) cells, which seemed to be independent of treatments. The percentage of HLA-DR+ suppressor-cytotoxic T (Ia+CD8+) cells was increased in euthyroid or hypothyroid patients with Graves' disease following treatment, but was normal in hyperthyroid patients. The percentages of Ia+CD4+ cells and Ia+CD8+ were also increased in patients with thyrotoxic phases of subacute thyroiditis and autoimmune thyroiditis, whereas these abnormal values normalized in the remission phase. These findings suggest that an increase in Ia+CD4+ cells characteristically occurs during immune system activation in patients with hyperthyroid Graves' disease, Hashimoto's thyroiditis and the thyrotoxic phase of subacute thyroiditis, whereas the activated CD8+ cells in Graves' disease are induced by antithyroidal therapy.

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