scholarly journals Artificial intelligence and deep learning in ophthalmology

2018 ◽  
Vol 103 (2) ◽  
pp. 167-175 ◽  
Author(s):  
Daniel Shu Wei Ting ◽  
Louis R Pasquale ◽  
Lily Peng ◽  
John Peter Campbell ◽  
Aaron Y Lee ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Deep Learning ◽  
Language Processing ◽  
Visual Fields ◽  
Classification Performance ◽  
Age Related Macular Degeneration ◽  
Patient Acceptance ◽  
Age Related ◽  
Ocular Imaging ◽  
Fundus Photographs

Artificial intelligence (AI) based on deep learning (DL) has sparked tremendous global interest in recent years. DL has been widely adopted in image recognition, speech recognition and natural language processing, but is only beginning to impact on healthcare. In ophthalmology, DL has been applied to fundus photographs, optical coherence tomography and visual fields, achieving robust classification performance in the detection of diabetic retinopathy and retinopathy of prematurity, the glaucoma-like disc, macular oedema and age-related macular degeneration. DL in ocular imaging may be used in conjunction with telemedicine as a possible solution to screen, diagnose and monitor major eye diseases for patients in primary care and community settings. Nonetheless, there are also potential challenges with DL application in ophthalmology, including clinical and technical challenges, explainability of the algorithm results, medicolegal issues, and physician and patient acceptance of the AI ‘black-box’ algorithms. DL could potentially revolutionise how ophthalmology is practised in the future. This review provides a summary of the state-of-the-art DL systems described for ophthalmic applications, potential challenges in clinical deployment and the path forward.

scholarly journals Development of a Deep-Learning-Based Artificial Intelligence Tool for Differential Diagnosis between Dry and Neovascular Age-Related Macular Degeneration

Diagnostics ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 261
Author(s):  
Tae-Young Heo ◽  
Kyoung Min Kim ◽  
Hyun Kyu Min ◽  
Sun Mi Gu ◽  
Jae Hyun Kim ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Differential Diagnosis ◽  
Deep Learning ◽  
Macular Degeneration ◽  
Data Augmentation ◽  
Treatment Strategies ◽  
Image Data ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Leave One Out

The use of deep-learning-based artificial intelligence (AI) is emerging in ophthalmology, with AI-mediated differential diagnosis of neovascular age-related macular degeneration (AMD) and dry AMD a promising methodology for precise treatment strategies and prognosis. Here, we developed deep learning algorithms and predicted diseases using 399 images of fundus. Based on feature extraction and classification with fully connected layers, we applied the Visual Geometry Group with 16 layers (VGG16) model of convolutional neural networks to classify new images. Image-data augmentation in our model was performed using Keras ImageDataGenerator, and the leave-one-out procedure was used for model cross-validation. The prediction and validation results obtained using the AI AMD diagnosis model showed relevant performance and suitability as well as better diagnostic accuracy than manual review by first-year residents. These results suggest the efficacy of this tool for early differential diagnosis of AMD in situations involving shortages of ophthalmology specialists and other medical devices.

scholarly journals Multimodal Retinal Image Analysis via Deep Learning for the Diagnosis of Intermediate Dry Age-Related Macular Degeneration: A Feasibility Study

2020 ◽  
Vol 2020 ◽  
pp. 1-7 ◽  
Author(s):  
Ehsan Vaghefi ◽  
Sophie Hill ◽  
Hannah M. Kersten ◽  
David Squirrell
Keyword(s):  
Image Analysis ◽  
Deep Learning ◽  
Diagnostic Accuracy ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Fundus Photography ◽  
Multiple Modalities ◽  
Age Related ◽  
Dry Amd ◽  
Fundus Photographs

Background and Objective. To determine if using a multi-input deep learning approach in the image analysis of optical coherence tomography (OCT), OCT angiography (OCT-A), and colour fundus photographs increases the accuracy of a CNN to diagnose intermediate dry age-related macular degeneration (AMD). Patients and Methods. Seventy-five participants were recruited and divided into three cohorts: young healthy (YH), old healthy (OH), and patients with intermediate dry AMD. Colour fundus photography, OCT, and OCT-A scans were performed. The convolutional neural network (CNN) was trained on multiple image modalities at the same time. Results. The CNN trained using OCT alone showed a diagnostic accuracy of 94%, whilst the OCT-A trained CNN resulted in an accuracy of 91%. When multiple modalities were combined, the CNN accuracy increased to 96% in the AMD cohort. Conclusions. Here we demonstrate that superior diagnostic accuracy can be achieved when deep learning is combined with multimodal image analysis.

scholarly journals Multi-task deep learning-based survival analysis on the prognosis of late AMD using the longitudinal data in AREDS

2021 ◽  
Author(s):  
Gregory C Ghahramani ◽  
Matthew Brendel ◽  
Mingquan Lin ◽  
Qingyu Chen ◽  
Tiarnan Keenan ◽  
...  
Keyword(s):  
Deep Learning ◽  
Longitudinal Data ◽  
Vision Loss ◽  
Severe Form ◽  
Image Features ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Fundus Photographs ◽  
Complex Features ◽  
Patients Experience

Age-related macular degeneration (AMD) is the leading cause of vision loss. Some patients experience vision loss over a delayed timeframe, others at a rapid pace. Physicians analyze time-of-visit fundus photographs to predict patient risk of developing late-AMD, the most severe form of AMD. Our study hypothesizes that 1) incorporating historical data improves predictive strength of developing late-AMD and 2) state-of-the-art deep-learning techniques extract more predictive image features than clinicians do. We incorporate longitudinal data from the Age-Related Eye Disease Studies and deep-learning extracted image features in survival settings to predict development of late-AMD. To extract image features, we used multi-task learning frameworks to train convolutional neural networks. Our findings show 1) incorporating longitudinal data improves prediction of late-AMD for clinical standard features, but only the current visit is informative when using complex features and 2) "deep-features" are more informative than clinician derived features. We make codes publicly available at https://github.com/bionlplab/AMD_prognosis_amia2021.

scholarly journals Application of artificial intelligence in cataract management: current and future directions

2022 ◽  
Vol 9 (1) ◽  
Author(s):  
Laura Gutierrez ◽  
Jane Sujuan Lim ◽  
Li Lian Foo ◽  
Wei Yan Yan Ng ◽  
Michelle Yip ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Skill Training ◽  
Tertiary Care ◽  
Age Related Macular Degeneration ◽  
Security And Privacy ◽  
Future Directions ◽  
Clinical Burden ◽  
Age Related ◽  
Fundus Photographs ◽  
Surgical Skill Training

AbstractThe rise of artificial intelligence (AI) has brought breakthroughs in many areas of medicine. In ophthalmology, AI has delivered robust results in the screening and detection of diabetic retinopathy, age-related macular degeneration, glaucoma, and retinopathy of prematurity. Cataract management is another field that can benefit from greater AI application. Cataract  is the leading cause of reversible visual impairment with a rising global clinical burden. Improved diagnosis, monitoring, and surgical management are necessary to address this challenge. In addition, patients in large developing countries often suffer from limited access to tertiary care, a problem further exacerbated by the ongoing COVID-19 pandemic. AI on the other hand, can help transform cataract management by improving automation, efficacy and overcoming geographical barriers. First, AI can be applied as a telediagnostic platform to screen and diagnose patients with cataract using slit-lamp and fundus photographs. This utilizes a deep-learning, convolutional neural network (CNN) to detect and classify referable cataracts appropriately. Second, some of the latest intraocular lens formulas have used AI to enhance prediction accuracy, achieving superior postoperative refractive results compared to traditional formulas. Third, AI can be used to augment cataract surgical skill training by identifying different phases of cataract surgery on video and to optimize operating theater workflows by accurately predicting the duration of surgical procedures. Fourth, some AI CNN models are able to effectively predict the progression of posterior capsule opacification and eventual need for YAG laser capsulotomy. These advances in AI could transform cataract management and enable delivery of efficient ophthalmic services. The key challenges include ethical management of data, ensuring data security and privacy, demonstrating clinically acceptable performance, improving the generalizability of AI models across heterogeneous populations, and improving the trust of end-users.

scholarly journals Labelling of data on fundus color pictures used to train a deep learning model enhances its macular pathology recognition capabilities

2021 ◽  
Author(s):  
KhP Takhchidi ◽  
PV Gliznitsa ◽  
SN Svetozarskiy ◽  
AI Bursov ◽  
KA Shusterzon
Keyword(s):  
Neural Network ◽  
Deep Learning ◽  
Learning Algorithm ◽  
Image Data ◽  
Diagnostic Methods ◽  
Age Related Macular Degeneration ◽  
Screening Programs ◽  
Deep Learning Algorithm ◽  
Age Related ◽  
Fundus Photographs

Retinal diseases remain one of the leading causes of visual impairments in the world. The development of automated diagnostic methods can improve the efficiency and availability of the macular pathology mass screening programs. The objective of this work was to develop and validate deep learning algorithms detecting macular pathology (age-related macular degeneration, AMD) based on the analysis of color fundus photographs with and without data labeling. We used 1200 color fundus photographs from local databases, including 575 retinal images of AMD patients and 625 pictures of the retina of healthy people. The deep learning algorithm was deployed in the Faster RCNN neural network with ResNet50 for convolution. The process employed the transfer learning method. As a result, in the absence of labeling, the accuracy of the model was unsatisfactory (79%) because the neural network selected the areas of attention incorrectly. Data labeling improved the efficacy of the developed method: with the test dataset, the model determined the areas with informative features adequately, and the classification accuracy reached 96.6%. Thus, image data labeling significantly improves the accuracy of retinal color images recognition by a neural network and enables development and training of effective models with limited datasets.

scholarly journals Automatic detection of 39 fundus diseases and conditions in retinal photographs using deep neural networks

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Ling-Ping Cen ◽  
Jie Ji ◽  
Jian-Wei Lin ◽  
Si-Tong Ju ◽  
Hong-Jie Lin ◽  
...  
Keyword(s):  
Deep Learning ◽  
High Efficiency ◽  
Characteristic Curve ◽  
Weighted Average ◽  
Age Related Macular Degeneration ◽  
Learning Platform ◽  
Age Related ◽  
Public Data ◽  
Primary Test ◽  
Retinal Fundus

AbstractRetinal fundus diseases can lead to irreversible visual impairment without timely diagnoses and appropriate treatments. Single disease-based deep learning algorithms had been developed for the detection of diabetic retinopathy, age-related macular degeneration, and glaucoma. Here, we developed a deep learning platform (DLP) capable of detecting multiple common referable fundus diseases and conditions (39 classes) by using 249,620 fundus images marked with 275,543 labels from heterogenous sources. Our DLP achieved a frequency-weighted average F1 score of 0.923, sensitivity of 0.978, specificity of 0.996 and area under the receiver operating characteristic curve (AUC) of 0.9984 for multi-label classification in the primary test dataset and reached the average level of retina specialists. External multihospital test, public data test and tele-reading application also showed high efficiency for multiple retinal diseases and conditions detection. These results indicate that our DLP can be applied for retinal fundus disease triage, especially in remote areas around the world.

Artificial Intelligence and Human Rights: Four Realms of Discussion: Summary of Remarks

2020 ◽  
Vol 114 ◽  
pp. 242-245
Author(s):  
Jootaek Lee
Keyword(s):  
Artificial Intelligence ◽  
Machine Learning ◽  
Decision Making ◽  
Deep Learning ◽  
Language Processing ◽  
Human Reasoning ◽  
The Past ◽  
Making Choices ◽  
Data Capturing ◽  
Intensive Procedures

The term, Artificial Intelligence (AI), has changed since it was first coined by John MacCarthy in 1956. AI, believed to have been created with Kurt Gödel's unprovable computational statements in 1931, is now called deep learning or machine learning. AI is defined as a computer machine with the ability to make predictions about the future and solve complex tasks, using algorithms. The AI algorithms are enhanced and become effective with big data capturing the present and the past while still necessarily reflecting human biases into models and equations. AI is also capable of making choices like humans, mirroring human reasoning. AI can help robots to efficiently repeat the same labor intensive procedures in factories and can analyze historic and present data efficiently through deep learning, natural language processing, and anomaly detection. Thus, AI covers a spectrum of augmented intelligence relating to prediction, autonomous intelligence relating to decision making, automated intelligence for labor robots, and assisted intelligence for data analysis.

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