Acute nail changes after manicure with acrylate containing nail polish

Abstract Purpose Onycholysis and paronychia has been associated with chemotherapy treatment for women with breast cancer. Our primary aim was to investigate the effectiveness of different topical interventions to ameliorate nail toxicity. Secondary aims were to explore the full range and severity of possible nail changes associated with taxane-based chemotherapy and the specific impact this had on quality of life, using two novel measures. Methods This was an exploratory randomised controlled trial of three topical interventions (standard care, nail polish or specialist nail drops) for the prevention or reduction of nail changes induced by taxane-based chemotherapy. Outcomes included nail toxicity assessed at three time points (baseline, 3 weeks and 3 months post completion of chemotherapy) using two novel clinical tools (NToX-G12, NToX-QoL) and the Common Terminology Criteria for Adverse Events (CTCAE v3) and EQ-5D-5L.Results A total of 105 women were recruited (35 in each arm) and monitored up to three months post completion of chemotherapy. Almost 20% of patients were over the age of 60 years. There were 26 withdrawals, the majority from the nail polish arm. Residual Maximum Likelihood REML analysis indicated a significant arm, time and interaction effect for each intervention (p<0.001). Less nail toxicity was observed in patients receiving specialist nail drops or standard care arms in comparison to those using nail polish.Conclusion This study provides evidence to support clinicians’ suggestions on nail care recommendations based on the patients’ needs and preferences. Future investigations into comparing or combining cryotherapy and topical solutions that can support patient’s decisions are warranted.

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Distinctive Nail Changes in Advanced Hepatic Cirrhosis

Gastroenterology ◽

10.1016/s0016-5085(19)36030-5 ◽

1955 ◽

Vol 29 (2) ◽

pp. 258-261 ◽

Cited By ~ 6

Author(s):

Dennis A.J. Morey ◽

James O. Burke

Keyword(s):

Hepatic Cirrhosis ◽

Nail Changes

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Determination of Selected Phthalates in Some Commercial Cosmetic Products by HPLC-UV

Combinatorial Chemistry & High Throughput Screening ◽

10.2174/1386207323666200630113850 ◽

2020 ◽

Vol 23 (10) ◽

pp. 1010-1022

Author(s):

Emrah Dural

Keyword(s):

High Performance ◽

Phthalate Esters ◽

High Sensitivity ◽

Hplc Method ◽

Cosmetic Products ◽

Limit Of Quantification ◽

Nail Polish ◽

Accuracy And Precision ◽

Butyl Phthalate

Aim and scope: Due to the serious toxicological risks and their widespread use, quantitative determination of phthalates in cosmetic products have importance for public health. The aim of this study was to develop a validated simple, rapid and reliable high-performance liquid chromatography (HPLC) method for the determination of phthalates which are; dimethyl phthalate (DMP), diethyl phthalate (DEP), benzyl butyl phthalate (BBP), di-n-butyl phthalate (DBP), di(2- ethylhexyl) phthalate (DEHP), in cosmetic products and to investigate these phthalate (PHT) levels in 48 cosmetic products marketing in Sivas, Turkey. Materials and Methods: Separation was achieved by a reverse-phase ACE-5 C18 column (4.6 x 250 mm, 5.0 μm). As the mobile phase, 5 mM KH2PO4 and acetonitrile were used gradiently at 1.5 ml min-1. All PHT esters were detected at 230 nm and the run time was taking 21 minutes. Results: This method showed the high sensitivity value the limit of quantification (LOQ) values for which are below 0.64 μg mL-1 of all phthalates. Method linearity was ≥0.999 (r2). Accuracy and precision values of all phthalates were calculated between (-6.5) and 6.6 (RE%) and ≤6.2 (RSD%), respectively. Average recovery was between 94.8% and 99.6%. Forty-eight samples used for both babies and adults were successfully analyzed by the developed method. Results have shown that, DMP (340.7 μg mL-1 ±323.7), DEP (1852.1 μg mL-1 ± 2192.0), and DBP (691.3 μg mL-1 ± 1378.5) were used highly in nail polish, fragrance and cream products, respectively. Conclusion: Phthalate esters, which are mostly detected in the content of fragrance, cream and nail polish products and our research in general, are DEP (1852.1 μg mL-1 ± 2192.0), DBP (691.3 μg mL-1 ± 1378.5) and DMP (340.7 μg mL-1 ±323.7), respectively. Phthalates were found in the content of all 48 cosmetic products examined, and the most detected phthalates in general average were DEP (581.7 μg mL-1 + 1405.2) with a rate of 79.2%. The unexpectedly high phthalate content in the examined cosmetic products revealed a great risk of these products on human health. The developed method is a simple, sensitive, reliable and economical alternative for the determination of phthalates in the content of cosmetic products, it can be used to identify phthalate esters in different products after some modifications.

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Rheological Properties Influence Tackiness, Application and Performance of Nail Polish/Lacquer Formulations

Surface Science and Adhesion in Cosmetics ◽

10.1002/9781119654926.ch4 ◽

2021 ◽

pp. 109-150

Author(s):

Leidy Nallely Jimenez ◽

Carina D. V. Martínez Narváez ◽

Chenxian Xu ◽

Samantha Bacchi ◽

Vivek Sharma

Keyword(s):

Rheological Properties ◽

Nail Polish ◽

And Performance

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A Review of Nail Changes in Acrokeratosis Paraneoplastica (Bazex Syndrome)

Skin Appendage Disorders ◽

10.1159/000513828 ◽

2021 ◽

pp. 1-10

Author(s):

Bipasha Roy ◽

Shari R. Lipner

Keyword(s):

Head And Neck ◽

Squamous Cell ◽

Clinical Presentation ◽

Nail Plate ◽

Squamous Cell Carcinomas ◽

Morbidity And Mortality ◽

Cutaneous Manifestations ◽

Nail Changes ◽

Paraneoplastic Dermatosis ◽

Acrokeratosis Paraneoplastica Bazex

Acrokeratosis paraneoplastica (Bazex syndrome) is a rare paraneoplastic dermatosis associated with internal malignancies. Clinical presentation is characterized by erythematous or violaceous scaly plaques involving the digits, nose, ears, palms, and soles. Nail changes commonly present concurrently with cutaneous manifestations. In this review, we characterize nail changes associated with acrokeratosis paraneoplastica. A total of 48 cases were analyzed. Nail findings were nonspecific, with the most common being nail plate thickening, onycholysis, subungual hyperkeratosis, longitudinal ridging, discoloration, and nail plate loss. In most patients, nail changes involved the majority of fingernails and toenails and most often appeared prior to the diagnosis of malignancy. The most common associated underlying malignancies were squamous cell carcinomas of the head and neck. A diagnosis of acrokeratosis paraneoplastica should be considered in patients with onychodystrophy involving multiple nails with accompanying atypical psoriasiform dermatoses. Screening for internal malignancies may significantly decrease morbidity and mortality for these patients.

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Hyperspectral Imaging for Bloodstain Identification

Sensors ◽

10.3390/s21093045 ◽

2021 ◽

Vol 21 (9) ◽

pp. 3045

Author(s):

Maheen Zulfiqar ◽

Muhammad Ahmad ◽

Ahmed Sohaib ◽

Manuel Mazzara ◽

Salvatore Distefano

Keyword(s):

Hyperspectral Imaging ◽

Dna Analysis ◽

Forensic Sciences ◽

Blood Protein ◽

Chemical Methods ◽

Acrylic Paint ◽

Spectral Bands ◽

Nail Polish ◽

Spatial Dimensions ◽

Non Destructive

Blood is key evidence to reconstruct crime scenes in forensic sciences. Blood identification can help to confirm a suspect, and for that reason, several chemical methods are used to reconstruct the crime scene however, these methods can affect subsequent DNA analysis. Therefore, this study presents a non-destructive method for bloodstain identification using Hyperspectral Imaging (HSI, 397–1000 nm range). The proposed method is based on the visualization of heme-components bands in the 500–700 nm spectral range. For experimental and validation purposes, a total of 225 blood (different donors) and non-blood (protein-based ketchup, rust acrylic paint, red acrylic paint, brown acrylic paint, red nail polish, rust nail polish, fake blood, and red ink) samples (HSI cubes, each cube is of size 1000 × 512 × 224, in which 1000 × 512 are the spatial dimensions and 224 spectral bands) were deposited on three substrates (white cotton fabric, white tile, and PVC wall sheet). The samples are imaged for up to three days to include aging. Savitzky Golay filtering has been used to highlight the subtle bands of all samples, particularly the aged ones. Based on the derivative spectrum, important spectral bands were selected to train five different classifiers (SVM, ANN, KNN, Random Forest, and Decision Tree). The comparative analysis reveals that the proposed method outperformed several state-of-the-art methods.

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Incidence of Adverse Cutaneous Reactions to Epidermal Growth Factor Receptor Inhibitors in Patients with Non-Small-Cell Lung Cancer

Dermatology ◽

10.1159/000513233 ◽

2021 ◽

pp. 1-5

Author(s):

Paolo Gisondi ◽

Davide Geat ◽

Alessandra Mattiucci ◽

Fiorella Lombardo ◽

Antonio Santo ◽

...

Keyword(s):

Lung Cancer ◽

Epidermal Growth Factor Receptor ◽

Growth Factor Receptor ◽

Small Cell ◽

Egfr Inhibitor ◽

Small Cell Lung ◽

Nail Changes ◽

Cutaneous Reactions ◽

Epidermal Growth ◽

Oncologic Treatment

Background: Epidermal growth factor receptor (EGFR) inhibitors are routinely used in advanced non-small-cell lung cancer (NSCLC) harboring EGFR mutations. However, their use is associated with gastrointestinal and cutaneous toxicities, including acneiform eruptions, pruritus, xerosis, nail and hair changes. Aside from reducing patients’ quality of life, such cutaneous reactions have a considerable impact on the oncologic treatment given that dose reduction or even drug discontinuation may be necessary, especially for the severe forms. Objectives: To assess the incidence, impact on treatment and management of EGFR inhibitor-related cutaneous reactions in patients with NSCLC. Methods: We conducted a prospective observational study on 87 consecutive patients with advanced NSCLC treated with EGFR-tyrosine kinase inhibitors from January to December 2019. Patients who developed mucocutaneous reactions were evaluated and treated by both oncologists and dermatologists, and underwent dermatologic follow-up until resolution of the cutaneous reaction. Demographic and clinical data were collected for each patient, and the severity of the cutaneous reaction was graded using the Common Terminology Criteria for Adverse Events. Results: Seventy-one patients (81.6%) developed cutaneous reactions. The number of cutaneous reactions per patient was 1 in 37%, 2 in 41% and 3 or more in 22%. The most common cutaneous reactions included acneiform eruptions (56.3%), xerosis ± asteatotic eczema (48.3%), nail changes (39.1%), mucositis (29.9%), pruritus (24.1%) and hair changes (12.6%). Afatinib was associated with a higher rate of nail changes and mucositis (p < 0.01 and p < 0.005, respectively) compared to other agents, while no patient-related predictive factors were identified. Dose reduction was performed in 18% of patients. Multidisciplinary management involving dermatologists allowed to resume the drug in all patients who had discontinued it due to the cutaneous reactions. Conclusions: A multidisciplinary approach to EGFR inhibitor-related cutaneous reactions is advantageous and can reduce the need to discontinue oncologic treatment.

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