Non-alcoholic fatty liver disease with obesity as an independent predictor for incident gastric and colorectal cancer: a population-based longitudinal study

BackgroundColorectal cancer is known to be an extrahepatic complication of non-alcoholic fatty liver disease (NAFLD). However, the interaction of NAFLD with obesity for incident colorectal cancer has not been clarified yet. Moreover, the effect of NAFLD and obesity for incident gastric cancer has not been clarified yet. Thus, we investigated whether NAFLD with or without obesity would be a risk factor for incident gastric cancer as well as colorectal cancer.MethodsThe study period was set from 2003 to 2016. NAFLD was diagnosed by abdominal ultrasonography using standardised criteria. We applied the Cox proportional hazards model to investigate the effect of NAFLD with or without obesity at baseline on incident gastric cancer as well as colorectal cancer. Age, sex, lifestyle factors including smoking states, alcohol consumption and exercise, and diabetes were used as covariates.ResultsDuring the study period, 27 944 individuals (16 454 men and 11 490 women) were registered in the NAfld in Gifu Area, Longitudinal Analysis study. During the mean (SD) observational period of 2357 (1458) days, incident gastric cancers were diagnosed in 48 individuals (incident rate 0.48 per 1000 person-years) and incident colorectal cancers were diagnosed in 52 individuals (incident rate 0.51 per 1000 person-years). The adjusted HR of NAFLD with obesity for incident gastric cancer was 3.58 (95% CI 1.73 to 7.38, p=0.001) and that for incident colorectal cancer was 2.96 (95% CI 1.73 to 7.38, p=0.003).ConclusionNAFLD with obesity was a risk factor for both incident gastric cancer and colorectal cancer in apparently healthy Japanese individuals.

Download Full-text

The common adiponutrin variant p.I148M, a genetic risk factor for non-alcoholic fatty liver disease, affects fasting glucose and triglyceride levels

Zeitschrift für Gastroenterologie ◽

10.1055/s-0030-1269564 ◽

2011 ◽

Vol 49 (01) ◽

Author(s):

M Krawczyk ◽

F Grünhage ◽

M Mahler ◽

S Tirziu ◽

M Acalovschi ◽

...

Keyword(s):

Risk Factor ◽

Liver Disease ◽

Fatty Liver ◽

Genetic Risk ◽

Fatty Liver Disease ◽

Fasting Glucose ◽

Genetic Risk Factor ◽

Alcoholic Fatty Liver ◽

The Common ◽

Alcoholic Fatty Liver Disease

Download Full-text

Relationship between Muscle Mass and Non-Alcoholic Fatty Liver Disease

Biology ◽

10.3390/biology10020122 ◽

2021 ◽

Vol 10 (2) ◽

pp. 122

Author(s):

Jun-Hyuk Lee ◽

Hye-Sun Lee ◽

Byoung-Kwon Lee ◽

Yu-Jin Kwon ◽

Ji-Won Lee

Keyword(s):

Skeletal Muscle ◽

Risk Factor ◽

Liver Disease ◽

Fatty Liver ◽

Muscle Mass ◽

Fatty Liver Disease ◽

Skeletal Muscle Mass ◽

Liver Fat ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

Although sarcopenia is known to be a risk factor for non-alcoholic fatty liver disease (NAFLD), whether NAFLD is a risk factor for the development of sarcopenia is not clear. We investigated relationships between NAFLD and low skeletal muscle mass index (LSMI) using three different datasets. Participants were classified into LSMI and normal groups. LSMI was defined as a body mass index (BMI)-adjusted appendicular skeletal muscle mass <0.789 in men and <0.512 in women or as the sex-specific lowest quintile of BMI-adjusted total skeletal muscle mass. NAFLD was determined according to NAFLD liver fat score or abdominal ultrasonography. The NAFLD groups showed a higher hazard ratios (HRs) with 95% confidence intervals (CIs) for LSMI than the normal groups (HRs = 1.21, 95% CIs = 1.05–1.40). The LSMI groups also showed a higher HRs with 95% CIs for NAFLD than normal groups (HRs = 1.56, 95% CIs = 1.38–1.78). Participants with NAFLD had consistently less skeletal muscle mass over 12 years of follow-up. In conclusion, LSMI and NAFLD showed a relationship. Maintaining muscle mass should be emphasized in the management of NAFLD.

Download Full-text

Mechanisms of Non-Alcoholic Fatty Liver Disease in the Metabolic Syndrome. A Narrative Review

Antioxidants ◽

10.3390/antiox10020270 ◽

2021 ◽

Vol 10 (2) ◽

pp. 270

Author(s):

Luca Rinaldi ◽

Pia Clara Pafundi ◽

Raffaele Galiero ◽

Alfredo Caturano ◽

Maria Vittoria Morone ◽

...

Keyword(s):

Metabolic Syndrome ◽

Risk Factor ◽

Liver Disease ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Smoking Habit ◽

Lifestyle Modifications ◽

Alcoholic Fatty Liver ◽

The Metabolic Syndrome ◽

Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MS) are two different entities sharing common clinical and physio-pathological features, with insulin resistance (IR) as the most relevant. Large evidence leads to consider it as a risk factor for cardiovascular disease, regardless of age, sex, smoking habit, cholesterolemia, and other elements of MS. Therapeutic strategies remain still unclear, but lifestyle modifications (diet, physical exercise, and weight loss) determine an improvement in IR, MS, and both clinical and histologic liver picture. NAFLD and IR are bidirectionally correlated and, consequently, the development of pre-diabetes and diabetes is the most direct consequence at the extrahepatic level. In turn, type 2 diabetes is a well-known risk factor for multiorgan damage, including an involvement of cardiovascular system, kidney and peripheral nervous system. The increased MS incidence worldwide, above all due to changes in diet and lifestyle, is associated with an equally significant increase in NAFLD, with a subsequent rise in both morbidity and mortality due to both metabolic, hepatic and cardiovascular diseases. Therefore, the slowdown in the increase of the “bad company” constituted by MS and NAFLD, with all the consequent direct and indirect costs, represents one of the main challenges for the National Health Systems.

Download Full-text

Non-alcoholic fatty liver disease as a risk factor for female sexual dysfunction in premenopausal women

PLoS ONE ◽

10.1371/journal.pone.0182708 ◽

2017 ◽

Vol 12 (8) ◽

pp. e0182708 ◽

Cited By ~ 1

Author(s):

Jae Yeon Lee ◽

Dong Wook Shin ◽

Jeong Won Oh ◽

Won Kim ◽

Sae Kyung Joo ◽

...

Keyword(s):

Risk Factor ◽

Liver Disease ◽

Sexual Dysfunction ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Female Sexual Dysfunction ◽

Premenopausal Women ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

Download Full-text

Relationship of Non Alcoholic Fatty Liver Disease (NAFLD) and Serum Level of Thyroid Stimulating Hormone (TSH) in Normal Reference Range

Journal of Advances in Medicine and Medical Research ◽

10.9734/jammr/2021/v33i730872 ◽

2021 ◽

pp. 33-39

Author(s):

Doaa Ameen Khalil ◽

Yasser Mohammed Abdul Raouf ◽

Amal Said Al-Bendary ◽

Kamal Mohamed Okasha

Keyword(s):

Risk Factor ◽

Liver Disease ◽

Serum Level ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Independent Risk Factor ◽

Serum Levels ◽

Thyroid Stimulating Hormone ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

Background: Non-alcoholic fatty liver disease (NAFLD) can increase the incidence of cardiovascular disease and hepatocellular carcinoma. Thyroid hormones also play important roles in hepatic lipid metabolism and hepatic insulin resistance. Hypothyroidism is associated with reduced lipolysis and decreased liver uptake of free fatty acids derived from triglycerides. In recent years, the correlation between overt or subclinical hypothyroidism and NAFLD has been discussed. The relationship between NAFLD and thyroid function parameters remains unclear. Aim: We aimed to evaluate the relationship between serum level of Thyroid Stimulating Hormone (TSH) within normal reference range and Non Alcoholic fatty liver Disease (NAFLD). Subjects and Methods: This is a cross sectional case control study on 40 patients with NAFLD and a control group of 20 healthy individuals, who were attendants of Outpatient Clinic of Internal Medicine Department of Tanta University Hospitals and EL-Menshawy General Hospital from February 2018 to the end of January 2019. Results: In the present study, univariate regression analysis showed that serum levels of AST, FT3, FT4 and Anti-TPO were independent risk factors of NAFLD, while in multivariate analysis the only independent risk factor of NAFLD was Anti-TPO serum level. Conclusion: Serum levels of AST, FT3, FT4 and Anti-TPO were independent risk factors of NAFLD in univariate regression analysis, while in multivariate analysis the only independent risk factor of NAFLD was Anti-TPO serum level. Despite the positive correlation between serum TSH level and grade of NAFLD, the study didn’t show serum TSH level as independent risk factor of NAFLD.

Download Full-text