scholarly journals Integrative clinical, genomics and metabolomics data analysis for mainstream precision medicine to investigate COVID-19

2020 ◽  
Vol 7 (1) ◽  
pp. 6-10 ◽  
Author(s):  
Zeeshan Ahmed ◽  
Saman Zeeshan ◽  
David J Foran ◽  
Lawrence C Kleinman ◽  
Fredric E Wondisford ◽  
...  
Keyword(s):  
Machine Learning ◽  
Data Analysis ◽  
Early Detection ◽  
Predictive Biomarkers ◽  
Machine Learning Algorithms ◽  
Prognostic Models ◽  
Genetic Profile ◽  
Metabolomics Data ◽  
Clinical Genomics ◽  
Early Detection And Prevention

Despite significant scientific and medical discoveries, the genetics of novel infectious diseases like COVID-19 remains far from understanding. SARS-CoV-2 is a single-stranded RNA respiratory virus that causes COVID-19 by binding to the ACE2 receptor in the lung and other organs. Understanding its clinical presentation and metabolomic and genetic profile will lead to the discovery of diagnostic, prognostic and predictive biomarkers, which may lead to more effective medical therapy. It is important to investigate correlations and overlap between reported diagnoses of a patient with COVID-19 in clinical data with identified germline and somatic mutations, and highly expressed genes from genomics data analysis. Timely model clinical, genomics and metabolomics data to find statistical patterns across millions of features to identify underlying biological pathways, modifiable risk factors and actionable information that supports early detection and prevention of COVID-19, and development of new therapies for better patient care. Next, ensuring security reconcile noise, need to build and train machine learning prognostic models to find actionable information that supports early detection and prevention of COVID-19. Based on the myriad data, applying appropriate machine learning algorithms to stratify patients, understand scenarios, optimise decision-making, identify high-risk rare variants (including ACE2, TMPRSS2) and making medically relevant predictions. Innovative and intelligent solutions are required to improve the traditional symptom-driven practice, and allow earlier interventions using predictive diagnostics and tailor better personalised treatments, when confronted with the challenges of pandemic situations.

Machine Learning Based Predictive Action on Categorical Non-Sequential Data

2020 ◽  
Vol 13 (5) ◽  
pp. 1020-1030
Author(s):  
Pradeep S. ◽  
Jagadish S. Kallimani
Keyword(s):  
Machine Learning ◽  
Data Analysis ◽  
Categorical Data ◽  
Numerical Data ◽  
Processing Technique ◽  
Machine Learning Algorithms ◽  
Sequential Data ◽  
Industry Standard ◽  
Robust Model ◽  
Future Work

Background: With the advent of data analysis and machine learning, there is a growing impetus of analyzing and generating models on historic data. The data comes in numerous forms and shapes with an abundance of challenges. The most sorted form of data for analysis is the numerical data. With the plethora of algorithms and tools it is quite manageable to deal with such data. Another form of data is of categorical nature, which is subdivided into, ordinal (order wise) and nominal (number wise). This data can be broadly classified as Sequential and Non-Sequential. Sequential data analysis is easier to preprocess using algorithms. Objective: The challenge of applying machine learning algorithms on categorical data of nonsequential nature is dealt in this paper. Methods: Upon implementing several data analysis algorithms on such data, we end up getting a biased result, which makes it impossible to generate a reliable predictive model. In this paper, we will address this problem by walking through a handful of techniques which during our research helped us in dealing with a large categorical data of non-sequential nature. In subsequent sections, we will discuss the possible implementable solutions and shortfalls of these techniques. Results: The methods are applied to sample datasets available in public domain and the results with respect to accuracy of classification are satisfactory. Conclusion: The best pre-processing technique we observed in our research is one hot encoding, which facilitates breaking down the categorical features into binary and feeding it into an Algorithm to predict the outcome. The example that we took is not abstract but it is a real – time production services dataset, which had many complex variations of categorical features. Our Future work includes creating a robust model on such data and deploying it into industry standard applications.

Marketing customer response scoring model based on machine learning data analysis

2020 ◽  
pp. 1-11
Author(s):  
Tang Yan ◽  
Li Pengfei
Keyword(s):  
Machine Learning ◽  
Data Analysis ◽  
Data Extraction ◽  
Machine Learning Algorithms ◽  
Customer Relationship ◽  
Customer Data ◽  
Modeling And Analysis ◽  
Scoring Model ◽  
Model Based ◽  
Learning Data

In marketing, problems such as the increase in customer data, the increase in the difficulty of data extraction and access, the lack of reliability and accuracy of data analysis, the slow efficiency of data processing, and the inability to effectively transform massive amounts of data into valuable information have become increasingly prominent. In order to study the effect of customer response, based on machine learning algorithms, this paper constructs a marketing customer response scoring model based on machine learning data analysis. In the context of supplier customer relationship management, this article analyzes the supplier’s precision marketing status and existing problems and uses its own development and management characteristics to improve marketing strategies. Moreover, this article uses a combination of database and statistical modeling and analysis to try to establish a customer response scoring model suitable for supplier precision marketing. In addition, this article conducts research and analysis with examples. From the research results, it can be seen that the performance of the model constructed in this article is good.

Machine learning algorithms for smart data analysis in the Internet of things: an overview

2021 ◽  
pp. 307-327
Author(s):  
Mohammed H. Alsharif ◽  
Anabi Hilary Kelechi ◽  
Imran Khan ◽  
Mahmoud A. Albreem ◽  
Abu Jahid ◽  
...  
Keyword(s):  
Machine Learning ◽  
Data Analysis ◽  
Internet Of Things ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
The Internet ◽  
Smart Data ◽  
The Internet Of Things

Machine Learning Algorithms for Early Detection of Bone Metastases in an Experimental Rat Model

10.3791/61235 ◽  
2020 ◽  
Author(s):  
Stephan Ellmann ◽  
Lisa Seyler ◽  
Clarissa Gillmann ◽  
Vanessa Popp ◽  
Christoph Treutlein ◽  
...  
Keyword(s):  
Machine Learning ◽  
Early Detection ◽  
Bone Metastases ◽  
Rat Model ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Experimental Rat Model

scholarly journals An Investigation of Early Detection of Driver Drowsiness Using Ensemble Machine Learning Based on Hybrid Sensing

2020 ◽  
Vol 10 (8) ◽  
pp. 2890
Author(s):  
Jongseong Gwak ◽  
Akinari Hirao ◽  
Motoki Shino
Keyword(s):  
Machine Learning ◽  
Early Detection ◽  
Driving Simulator ◽  
Detection System ◽  
Driving Performance ◽  
Machine Learning Algorithms ◽  
Drowsy Driving ◽  
Physiological Indicators ◽  
Driver Drowsiness ◽  
Behavioral Indices

Drowsy driving is one of the main causes of traffic accidents. To reduce such accidents, early detection of drowsy driving is needed. In previous studies, it was shown that driver drowsiness affected driving performance, behavioral indices, and physiological indices. The purpose of this study is to investigate the feasibility of classification of the alert states of drivers, particularly the slightly drowsy state, based on hybrid sensing of vehicle-based, behavioral, and physiological indicators with consideration for the implementation of these identifications into a detection system. First, we measured the drowsiness level, driving performance, physiological signals (from electroencephalogram and electrocardiogram results), and behavioral indices of a driver using a driving simulator and driver monitoring system. Next, driver alert and drowsy states were identified by machine learning algorithms, and a dataset was constructed from the extracted indices over a period of 10 s. Finally, ensemble algorithms were used for classification. The results showed that the ensemble algorithm can obtain 82.4% classification accuracy using hybrid methods to identify the alert and slightly drowsy states, and 95.4% accuracy classifying the alert and moderately drowsy states. Additionally, the results show that the random forest algorithm can obtain 78.7% accuracy when classifying the alert vs. slightly drowsy states if physiological indicators are excluded and can obtain 89.8% accuracy when classifying the alert vs. moderately drowsy states. These results represent the feasibility of highly accurate early detection of driver drowsiness and the feasibility of implementing a driver drowsiness detection system based on hybrid sensing using non-contact sensors.

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