scholarly journals Body mass index and outcomes of patients with laparoscopic adrenalectomy: a systematic review and meta-analysis protocol

BMJ Open ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. e028579
Author(s):  
Celestin Danwang ◽  
Valirie Ndip Agbor ◽  
Jean Joel Bigna

IntroductionRecent advances in the field of medical imaging and minimal invasive surgery have improved the diagnosis and treatment of adrenal incidentalomas. Recent studies suggest increased morbidity and mortality among patients with obesity following laparoscopic adrenalectomy compared with patients without obesity. However, this claim remains to be ascertained. This review seeks to assess the outcome of patients with and without obesity after adrenalectomy.Methods and designWe will include cohort studies, case-control studies, cross-sectional studies and case series with more than 30 participants. EMBASE, Medline and Web of Science (Web of Science Core Collection, Current Contents Connect, KCI-Korean Journal Database, SciELO Citation Index, Russian Science Citation Index) will be searched for relevant abstracts of studies published between 1 January 2000 and 31 May 2019, without language restriction. The review will be reported according to the Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines. After screening of abstracts, study selection, data extraction and methodological quality assessment, we shall assess the studies individually for clinical and statistical heterogeneity. Random-effect meta-analysis will be used to pool studies judged to be clinically homogenous. The Harbord’s test and visual inspection of funnel plots will be used to assess publication bias. Results will be presented by country and region.Ethics and disseminationSince primary data are not collected in this study, ethical approval is not required. This review is expected to provide relevant data on the impact of body mass index on the outcome of laparoscopic adrenalectomy. The final report will be published in a peer-reviewed journal.PROSPERO registration numberCRD42018117070.Review statusPreliminary searches.

2019 ◽  
Vol 300 (5) ◽  
pp. 1201-1210 ◽  
Author(s):  
Akilew A. Adane ◽  
Carrington C. J. Shepherd ◽  
Faye J. Lim ◽  
Scott W. White ◽  
Brad M. Farrant ◽  
...  

Urolithiasis ◽  
2018 ◽  
Vol 46 (6) ◽  
pp. 523-533
Author(s):  
Qing Wang ◽  
Weijie Hu ◽  
Yuchao Lu ◽  
Henglong Hu ◽  
Jiaqiao Zhang ◽  
...  

2019 ◽  
Vol 25 (3-4) ◽  
pp. 74-79 ◽  
Author(s):  
Sumanta Saha ◽  
Sujata Saha

<b><i>Aims:</i></b> To date, it is largely unknown how body mass index (BMI), gestational weight (GW), and stored vitamin D (25(OH)D) levels change in the vitamin D-supplemented gestational diabetes mellitus (GDM) patients, irrespective of their pre-pregnancy BMI. Therefore, to study this association, a prospective systematic review and meta-analysis protocol is proposed here. <b><i>Methods:</i></b> Primarily, different databases (PubMed, Embase and Scopus) will be searched (without any limitation to date or language) for randomised parallel-arm trials comparing GW, BMI and stored vitamin D level in the body among GDM patients who were supplemented and not supplemented with vitamin D, besides their conventional GDM care. The study selection process and the consecutive risk of bias assessment will adhere to the PRISMA 2009 flow chart and the Cochrane collaboration’s guideline, respectively. These interventions’ effect on the respective outcomes will be compared by meta-analysis (along with an assessment of the statistical heterogeneity) when comparable data will be available from at least 4 studies. Subgroup analysis and Egger’s meta-regression will follow if an adequate number of trials are available. Narrative reporting will be considered when a quantitative comparison is not feasible for any of the outcomes. <b><i>Conclusion:</i></b> The proposed review aims to compare the BMI, GW, and 25(OH)D levels in the blood between the vitamin D supplemented and not supplemented GDM patients.


2021 ◽  
Vol 10 (23) ◽  
pp. 5556
Author(s):  
Maria Irene Bellini ◽  
Mikhail Nozdrin ◽  
Liset Pengel ◽  
Simon Knight ◽  
Vassilios Papalois

Background and Aims: Recipient demographics affect outcomes after kidney transplantation. The aim of this study was to assess, for kidneys retrieved from living donors, the effect of recipient sex, ethnicity, and body mass index (BMI) on delayed graft function (DGF) and one-year graft function, incidence of acute rejection (AR), and recipient and graft survivals. Methods: A systematic review and meta-analysis was performed. EMBASE and MEDLINE databases were searched using algorithms through Ovid. Web of Science collection, BIOSIS, CABI, Korean Journal database, Russian Science Citation Index, and SciELO were searched through Web of Science. Cochrane database was also searched. Risk of bias was assessed using the NHBLI tools. Data analysis was performed using Revman 5.4. Mean difference (MD) and risk ratio (RR) were used in analysis. Results: A total of 5129 studies were identified; 24 studies met the inclusion criteria and were analysed. Female recipients were found to have a significantly lower serum creatinine 1-year-post renal transplantation (MD: −0.24 mg/dL 95%CI: −0.18 to −0.29 p < 0.01) compared to male recipients. No significant difference in survival between male and female recipients nor between Caucasians and Africans was observed (p = 0.08). However, Caucasian recipients had a higher 1-year graft survival compared to African recipients (95% CI 0.52−0.98) with also a lower incidence of DGF (RR = 0.63 p < 0.01) and AR (RR = 0.55 p < 0.01). Recipient obesity (BMI > 30) was found to have no effect on 1-year recipient (p = 0.28) and graft survival (p = 0.93) compared to non-obese recipients although non-obese recipients had a lower rate of DGF (RR = 0.65 p < 0.01) and AR (RR = 0.81 p < 0.01) compared to obese recipients. Conclusions: Gender mismatch between male recipients and female donors has negative impact on graft survival. African ethnicity and obesity do not to influence recipient and graft survival but negatively affect DGF and AR rates.


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