scholarly journals Cancer in HIV-positive and HIV-negative adolescents and young adults in South Africa: a cross-sectional study

BMJ Open ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. e043941
Author(s):  
Tafadzwa Dhokotera ◽  
Julia Bohlius ◽  
Matthias Egger ◽  
Adrian Spoerri ◽  
Jabulani Ronnie Ncayiyana ◽  
...  
Keyword(s):  
South Africa ◽  
Young Adults ◽  
Cross Sectional Study ◽  
Adolescents And Young Adults ◽  
Hiv Positive ◽  
Sectional Study ◽  
Hiv Status ◽  
Cross Sectional ◽  
Laboratory Service ◽  
Living With Hiv

ObjectiveTo determine the spectrum of cancers in adolescents and young adults (AYAs) living with and without HIV in South Africa.DesignCross-sectional study with cancer records provided by the National Cancer Registry (NCR) and HIV records from the National Health Laboratory Service (NHLS).Setting and participantsThe NHLS is the largest provider of pathology services in the South African public sector. The NCR is a division of the NHLS. We included AYAs (aged 10–24 years) diagnosed with cancer by public health sector laboratories between 2004 and 2014 (n=8479). HIV status was obtained through record linkages and text mining.Primary and secondary outcomesWe determined the spectrum of cancers by HIV status in AYAs. We used multivariable logistic regression to describe the association of cancer in AYAs with HIV, adjusting for age, sex, ethnicity and calendar period. We imputed (post hoc) the HIV status for AYA with unknown HIV status.Results8479 AYAs were diagnosed with cancer, HIV status was known for 45% (n=3812). Of those whose status was known, about half were HIV positive (n=1853). AYAs living with HIV were more likely to have Kaposi’s sarcoma (adjusted OR (aOR) 218, 95% CI 89.9 to 530), cervical cancer (aOR 2.18, 95% CI 1.23 to 3.89), non-Hodgkin’s lymphoma (aOR 2.12, 95% CI 1.69 to 2.66) and anogenital cancers other than cervix (aOR 2.73, 95% CI 1.27 to 5.86) than AYAs without HIV. About 44% (n=1062) of AYAs with HIV-related cancers had not been tested for HIV.ConclusionsTargeted HIV testing for AYAs diagnosed with cancer, followed by immediate start of antiretroviral therapy, screening for cervical precancer and vaccination against human papilloma virus is needed to decrease cancer burden in AYAs living with HIV in South Africa.

scholarly journals Cancer in HIV-positive and HIV-negative adolescents and young adults in South Africa: a cross-sectional study

2020 ◽  
Author(s):  
Tafadzwa G Dhokotera ◽  
Julia Bohlius ◽  
Matthias Egger ◽  
Adrian Spoerri ◽  
Jabulani Ncayiyana ◽  
...  
Keyword(s):  
South Africa ◽  
Cervical Cancer ◽  
Cross Sectional Study ◽  
Hiv Positive ◽  
Sectional Study ◽  
Hiv Status ◽  
Cross Sectional ◽  
Cancer Data ◽  
Living With Hiv ◽  
Hiv Negative

Objective: To determine the spectrum of cancers in AYAs living with HIV in South Africa compared to their HIV negative peers. Design: Cross sectional study with cancer data provided by the National Cancer Registry and HIV data from the National Health Laboratory Service. Setting and participants: The NHLS is the largest provider of pathology services in the South African public sector with an estimated coverage of 80%. The NCR is a division of the NHLS. We included AYAs (aged 10-24 years) diagnosed with cancer by public health sector laboratories between 2004 and 2014 (n=8 479). We included 3 672 in the complete case analysis. Primary and secondary outcomes: We used linked NCR and NHLS data to determine the spectrum of cancers by HIV status in AYAs. We also used multivariable logistic regression to describe the association of cancer in AYAs with HIV, adjusting for age, sex (as appropriate), ethnicity, and calendar period. Due to the large proportion of unknown HIV status we also imputed (post-hoc) the missing HIV status. Results: From 2004-2014, 8 479 AYAs were diagnosed with cancer, HIV status was known for only 45% (n=3812); of those whose status was known, about half were HIV positive (n=1853). AYAs living with HIV were more likely to have Kaposi's sarcoma (adjusted odds ratio (aOR) 218, 95% CI 89.9-530), cervical cancer (aOR 2.18, 95% CI 1.23-3.89), non-Hodgkin's lymphoma (aOR 2.12, 95% CI 1.69-2.66), and anogenital cancers other than cervix (aOR 2.73, 95% CI 1.27-5.86). About 44% (n=1 062) of AYAs with HIV related cancers had not been tested for HIV, though they were very likely to have the disease. Conclusions: Cancer burden in AYAs living with HIV in South Africa could be reduced by screening young women for cervical cancer and vaccinating them against human papilloma virus (HPV) infection.

Non-linear growth trends of toe flexor muscle strength among children, adolescents, and young adults: a cross-sectional study

2018 ◽  
Vol 118 (5) ◽  
pp. 1003-1010 ◽  
Author(s):  
Noriteru Morita ◽  
Junichiro Yamauchi ◽  
Ryosuke Fukuoka ◽  
Toshiyuki Kurihara ◽  
Mitsuo Otsuka ◽  
...  
Keyword(s):  
Young Adults ◽  
Muscle Strength ◽  
Linear Growth ◽  
Cross Sectional Study ◽  
Adolescents And Young Adults ◽  
Sectional Study ◽  
Flexor Muscle ◽  
Cross Sectional ◽  
Growth Trends ◽  
Non Linear

scholarly journals Clinical and non-clinical variables associated with preventive and curative dental service utilisation: a cross-sectional study among adolescents and young adults in Central Mexico

BMJ Open ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. e027101 ◽  
Author(s):  
Carlo Eduardo Medina-Solís ◽  
José Obed García-Cortés ◽  
José Luis Robles-Minaya ◽  
Juan Fernando Casanova-Rosado ◽  
Jairo Mariel-Cárdenas ◽  
...  
Keyword(s):  
Young Adults ◽  
Oral Health ◽  
Preventive Services ◽  
Cross Sectional Study ◽  
Adolescents And Young Adults ◽  
Caries Experience ◽  
Service Utilisation ◽  
Use Of Self ◽  
Sectional Study ◽  
Cross Sectional

ObjectiveThe present study aimed to identify preventive and curative dental health service utilisation (DHSU) in the context of associated clinical and non-clinical factors among adolescents and young adults in Mexico.DesignCross-sectional study.SettingApplicants to a public university in Mexico.ParticipantsParticipants were 638 adolescents and young adults aged 16–25 randomly selected from university applicants.InterventionsData were collected using a self-administered questionnaire filled out by the students. For assessment of dental caries experience, we used the index of decayed, missing and filled teeth.Primary outcomeThe dependent variable was DHSU in the previous 12 months, coded as 0=non-use, 1=use of curative services and 2=use of preventive services.ResultsThe mean age was 18.76±1.76 years, and 49.2% were women. The prevalence of DHSU was 40.9% (95% CI 37.1 to 44.8) for curative services and 22.9% (95% CI 19.7 to 26.3) for preventive services. The variables associated with curative services were age, sex, mother’s education, dental pain in the previous 12 months, caries experience, use of self-care devices and oral health knowledge. For preventive services, the variables associated were mother’s education, dental pain in the previous 12 months, caries experience, use of self-care devices and self-perception of oral health.ConclusionsWhile differences emerged by type of service, a number of variables (sociodemographic and socioeconomic characteristics as well as dental factors) remained in the final model. Greater oral health needs and socioeconomic inequalities remained as predictors of both types of DHSU. Given the differences revealed by our study, oral health policies should refer those seeking dental care for oral diseases to preventive services, and promote the use of such services among the poorer and less educated population groups.

scholarly journals Dental pain and associated factors in Mexican adolescents and young adults: a cross‐sectional study

2020 ◽  
Vol 70 (6) ◽  
pp. 455-461
Author(s):  
José Obed García‐Cortés ◽  
Jairo Mariel‐Cárdenas ◽  
Ricardo Martinez‐Rider ◽  
Rosalina Islas‐Zarazúa ◽  
Rubén Rosa‐Santillana ◽  
...  
Keyword(s):  
Young Adults ◽  
Associated Factors ◽  
Dental Pain ◽  
Cross Sectional Study ◽  
Adolescents And Young Adults ◽  
Sectional Study ◽  
Cross Sectional ◽  
Mexican Adolescents

Cross-sectional study of abnormal amygdala development in adolescents and young adults with bipolar disorder

2004 ◽  
Vol 56 (6) ◽  
pp. 399-405 ◽  
Author(s):  
Barbara K. Chen ◽  
Roberto Sassi ◽  
David Axelson ◽  
John P. Hatch ◽  
Marsal Sanches ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Young Adults ◽  
Cross Sectional Study ◽  
Adolescents And Young Adults ◽  
Sectional Study ◽  
Cross Sectional
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