Infection-associated biofilms and statins: protocol for systematic review

IntroductionOwing to their propensity for being associated with infections, biofilms have become a focus in infectious disease research. There is evidence suggesting that statins, which are commonly used for prevention of cardiovascular disease, may prevent biofilm-associated infections, but this association has not been well-understood.Methods and analysisThis systematic review protocol will include six database searches from their inception to 20 August 2020. A medical librarian will conduct the searches in PubMed, EMBASE, Web of Science, CINAHL, LILACS and CENTRAL, without any limits. Bibliographies of selected articles, previously published reviews and high-yield journals that publish on statins and/or biofilms will be searched to identify additional articles. The screening and data extraction will be conducted by two independent reviewers using DistillerSR. All included papers will also be evaluated for quality using Cochrane Risk of Bias Assessment tool, and we will examine for publication bias. If there are two or more studies with quantitative estimates that can be combined, we will conduct a meta-analysis after assessing for heterogeneity. We will report all findings according to the Preferred Reporting Items for Systematic reviews and Analyses-P framework.Ethics and disseminationThere are conflicting results on the effect of statins on biofilm-associated infections. The rise of antibiotic resistance in medical settings warrants a deeper understanding of this association, especially if statins can be used as a novel antibiotic. The findings of this review will assess the association between statin use and biofilm-associated infection to inform future medical practice. No formal ethical review is required for this protocol. All findings will be published in a peer-reviewed journal.PROSPERO registration numberCRD42020193985.

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Risk factors for premature coronary artery disease (PCAD) in adults: a systematic review protocol

F1000Research ◽

10.12688/f1000research.74926.1 ◽

2021 ◽

Vol 10 ◽

pp. 1228

Author(s):

Adeel Khoja ◽

Prabha H. Andraweera ◽

Zohra S. Lassi ◽

Mingyue Zheng ◽

Maleesa M. Pathirana ◽

...

Keyword(s):

Risk Factors ◽

Systematic Review ◽

Data Extraction ◽

Meta Analysis ◽

Grey Literature ◽

Mean Difference ◽

Premature Coronary Artery Disease ◽

Registration Number ◽

Review Protocol ◽

Artery Disease

PCAD possesses a public health challenge resulting in years of productive life lost and an escalating burden on health systems. Objective of this review is to compare modifiable and non-modifiable risk factors for PCAD compared to those without PCAD. This review will include all comparative observational studies conducted in adults aged >18 years with confirmed diagnosis of PCAD (on angiography) compared to those without PCAD. Databases to be searched include; PubMed, CINAHL, Embase, Web of Science, and grey literature (Google Scholar). All identified studies will be screened for title and abstract and full-text against the inclusion criteria on Covidence software. Data relevant to exposures and outcomes will be extracted from all included studies. All studies selected for data extraction will be critically appraised for methodological quality. Meta-analysis using random-effects model will be performed using Review Manager 5.3. Effect sizes for categorical risk factors will be expressed as odds ratios with 95% confidence intervals. For risk factors measured in continuous form, mean difference (if units are consistent) otherwise standardized mean difference (if units are different across studies) will be reported. Heterogeneity between studies will be assessed using I2 test statistics. GRADE will be used to assess the certainty of the findings. Systematic review registration number: PROSPERO Registration # CRD42020173216

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What does my neighbourhood have to do with my weight? A protocol for systematic review and meta-analysis of the association between neighbourhood socioeconomic status and body weight

BMJ Open ◽

10.1136/bmjopen-2017-017567 ◽

2017 ◽

Vol 7 (9) ◽

pp. e017567

Author(s):

Shimels Hussien Mohammed ◽

Mulugeta Molla Birhanu ◽

Tesfamichael Awoke Sissay ◽

Tesfa Dejenie Habtewold ◽

Balewgizie Sileshi Tegegn ◽

...

Keyword(s):

Systematic Review ◽

Socioeconomic Status ◽

Data Extraction ◽

Meta Analysis ◽

Cross Sectional ◽

Registration Number ◽

Newcastle Ottawa Scale ◽

Neighbourhood Socioeconomic Status ◽

Using Data

IntroductionIndividuals living in poor neighbourhoods are at a higher risk of overweight/obesity. There is no systematic review and meta-analysis study on the association of neighbourhood socioeconomic status (NSES) with overweight/obesity. We aimed to systematically review and meta-analyse the existing evidence on the association of NSES with overweight/obesity.Methods and analysisCross-sectional, case–control and cohort studies published in English from inception to 15 May 2017 will be systematically searched using the following databases: PubMed, EMBASE, Web of Sciences and Google Scholar. Selection, screening, reviewing and data extraction will be done by two reviewers, independently and in duplicate. The Newcastle–Ottawa Scale (NOS) will be used to assess the quality of evidence. Publication bias will be checked by visual inspection of funnel plots and Egger’s regression test. Heterogeneity will be checked by Higgins’s method (I2statistics). Meta-analysis will be done to estimate the pooled OR. Narrative synthesis will be performed if meta-analysis is not feasible due to high heterogeneity of studies.Ethics and disseminationEthical clearance is not required as we will be using data from published articles. Findings will be communicated through a publication in a peer-reviewed journal and presentations at professional conferences.PROSPERO registration numberCRD42017063889.

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Evidence on Respectful Maternity Care For Adolescents: A Systematic Review Protocol

10.21203/rs.3.rs-67728/v2 ◽

2021 ◽

Author(s):

Helen H Habib ◽

Jefferson Mwaisaka ◽

Kwasi Torpey ◽

Ernest Tei Maya ◽

Augustine Ankomah

Keyword(s):

Systematic Review ◽

Quality Assessment ◽

Maternity Care ◽

Assessment Tool ◽

Data Extraction ◽

Respectful Maternity Care ◽

Great Promise ◽

Systematic Review Protocol ◽

Health And Human Rights ◽

Review Protocol

Abstract Background: Intrapartum mistreatment of women is a globally rising public health and human rights phenomenon. The issue reportedly has severe maternal and neonatal outcomes including mortality, and generally leads to a decreased satisfaction with maternity care. Intrapartum mistreatment, despite being ubiquitous, indicates higher incidence among adolescent parturients who are simultaneously at a higher risk of maternal morbidity and mortality. Studies have suggested that Respectful Maternity Care (RMC) interventions reduce intrapartum mistreatment and improve clinical outcomes for women and neonates in general. However, evidence on the effect of RMC on adolescents is unclear. Hence the specific aim of this study is to synthesise the available evidence relating to the provision of RMC for adolescents during childbirth.Methods: The methodology of the proposed systematic review follows the procedural guideline depicted in the preferred reporting items for systematic review protocol. The review will include all observational and intervention studies conducted between January 1, 1990 and April 30, 2020. Electronic databases including MEDLINE, PubMed, ScienceDirect, Cochrane, CINAHL, PsycINFO, Scopus, Google Scholar, and Web of Science will be searched to retrieve available studies using the appropriate search strings. The search results will be appraised with Joanna Briggs Institute quality assessment tool. The selection of relevant studies, data extraction, and quality assessment of individual studies will be carried out by two independent authors. Results: A systematic narrative synthesis of the resultant studies will be done, and the relevant themes extracted. Findings will also be summarised in tables.Discussion: Respectful Maternity Care for adolescents holds great promise for improved maternal and neonatal care. However, there is a gap in knowledge on the interventions that work and the extent of their effectiveness. Findings from this study will be beneficial in improving Adolescents Sexual and Reproductive Health and Rights (ASRHR) and reducing maternal mortality, especially for adolescents.Systematic review registration: PROSPERO (Submitted 21 August 2020)

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Prevalence and predictors of medication non-adherence among patients with multimorbidity: A systematic review protocol

HRB Open Research ◽

10.12688/hrbopenres.12961.1 ◽

2019 ◽

Vol 2 ◽

pp. 29

Author(s):

Louise Foley ◽

James Larkin ◽

Richard Lombard-Vance ◽

Andrew W. Murphy ◽

Gerard J. Molloy

Keyword(s):

Systematic Review ◽

Full Text ◽

Chronic Conditions ◽

Data Extraction ◽

Meta Analysis ◽

Intervention Development ◽

Evidence Base ◽

Multiple Chronic Conditions ◽

Review Protocol ◽

Form Quality

Introduction: Patients with multimorbidity are expected to adhere to complex medication regimens in order to manage their multiple chronic conditions. It has been reported the likelihood of adherence decreases as patients are prescribed more medications. Much medication adherence research to date is dominated by a single-disease focus, which is at odds with the rising prevalence of multimorbidity and may artificially underestimate the complexity of managing chronic illness. This review aims to describe the prevalence of medication non-adherence among patients with multimorbidity, and to identify potential predictors of non-adherence in this population. Methods: A systematic review will be conducted and reported according to PRISMA guidelines. PubMed, EMBASE, CINAHL and PsycINFO will be searched using a predefined search strategy from 2009–2019. Quantitative studies will be considered eligible for review if prevalence of medication non-adherence among adults with two or more chronic conditions is reported. Studies will be included in the review if available in English full text. Titles and abstracts will be screened by single review, with 20% of screening cross-checked by a second reviewer. Full-text articles will be screened by two independent reviewers, noting reasons for exclusions. Data extraction will be performed using a predefined extraction form. Quality and risk of bias assessment will be conducted using criteria for observational studies outlined by Sanderson et al. (2007). A narrative synthesis and, if feasible, meta-analysis will be conducted. Discussion: By exploring medication non-adherence from a multimorbidity perspective, the review aims to inform an evidence base for intervention development which accounts for the rising prevalence of patients with multiple chronic conditions. Study registration: The systematic review is prospectively registered in PROSPERO (CRD42019133849); registered on 12 June 2019.

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Pharmacogenetics of Type 2 diabetes mellitus: A Systematic Review Protocol (Preprint)

10.2196/preprints.13605 ◽

2019 ◽

Author(s):

Hamid Reza Aghaei Meybodi ◽

Negar Sarhangi ◽

Anoosh Naghavi ◽

Marzieh Rahbaran ◽

Maryam Hassani Doabsari ◽

...

Keyword(s):

Systematic Review ◽

Type 2 Diabetes ◽

Data Extraction ◽

Relevant Information ◽

Risk Of Bias ◽

Cochrane Database ◽

Registration Number ◽

Newcastle Ottawa Scale ◽

Review Protocol

UNSTRUCTURED The objective of this systematic review is to determine the effect of genetic variants that associate with antidiabetic medications and their efficacy and toxicity in T2DM patients. The understanding may allow interventions for improving management of T2DM and later systematically evaluated in more in-depth studies. We will have performed a comprehensive search using PubMed, Scopus, EMBASE, Web of Sciences and Cochrane database from 1990 to 2018. Relevant journals and references of all included studies will be hand searched to find the additional studied. Eligible studies such as pharmacogenetics studies in terms of drug response and toxicity in the type 2 diabetes patients and performed just on human will be included. Data extraction and quality assessment will be carried out by two independent reviewers and disagreements will be resolved through third expert reviewer. Risk of bias will be assessed with the Cochrane Risk of Bias tool for randomized studies and Newcastle-Ottawa Scale (NOS) for observational Studies. Narrative synthesis will be conducted by the combination of key findings. The results of this study will be submitted to a peer-reviewed journal for publication and also presented at PROSPERO. We expect this review will provide highly relevant information for clinicians, pharmaceutical industry that will benefit from the summary of the best available data regarding the efficacy of antidiabetic medication in the aspect of pharmacogenetics. PROSPERO Registration number (CRD42018104843)

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Differences In Chronic Pain Prevalence Between Men And Women At Mid-Life: A Systematic Review Protocol

10.21203/rs.3.rs-1192864/v1 ◽

2021 ◽

Author(s):

Catherine Borra ◽

Rebecca Hardy

Keyword(s):

Systematic Review ◽

Chronic Pain ◽

Life Course ◽

Assessment Tool ◽

Social Research ◽

Data Extraction ◽

Meta Analysis ◽

Men And Women ◽

Prevalence Studies ◽

The Life Course

Abstract Background: Epidemiological literature has revealed differences in chronic pain (CP) prevalence in men and women. Women have been found to be more likely to develop CP compared to men at different points of the life-course, such as childhood and old age. Less is known about differences in prevalence by sex during mid-life. While CP is most prevalent later in life, biological and physical changes in mid-life may predispose to an earlier differentiation in CP distribution – for example due to the menopause. The aim of this study is to describe the prevalence of CP at midlife in men and women, and to identify how these differences relate to results pertaining to other periods in the life-course. Methods: This systematic review follows PRISMA guidelines. An electronic search will identify appropriate studies in the following databases: MEDLINE, to be accessed through Web of Science; and EMBASE, AMED and PSYCHinfo to be accessed through OVID. Two reviewers will independently screen each title and abstract and subsequently each full text following the inclusion criteria outlined in this protocol. The reference lists of eligible papers will also be screened to identify any further eligible studies. Any inconsistencies between reviewer decisions will be resolved through discussion. Studies eligible for data extraction will report estimates of CP prevalence, of prevalence for each sex, and difference in prevalence between sexes. Two reviewers will conduct data extraction using a standardised data extraction form. Quality assessment will be conducted using a risk of bias assessment tool for prevalence studies. The findings will be reported in a narrative synthesis and will comment on expected heterogeneity, following the Social Research Council Methods Programme guidelines. A random effects meta-analysis will be conducted where the reviewers can justify combining results.Discussion: This review will summarise the prevalence of CP in men and women at mid-life, based on existing evidence. It is expected that the results will identify gaps in knowledge and areas for further research.Systematic review registration: PROSPERO: CRD42021295895

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Necessity of dural tenting sutures in modern neurosurgery: protocol for a systematic review

BMJ Open ◽

10.1136/bmjopen-2018-027904 ◽

2019 ◽

Vol 9 (2) ◽

pp. e027904 ◽

Cited By ~ 1

Author(s):

Łukasz Przepiórka ◽

Przemysław Kunert ◽

Jarosław Żyłkowski ◽

Jan Fortuniak ◽

Patrycja Larysz ◽

...

Keyword(s):

Systematic Review ◽

Systematic Reviews ◽

Meta Analysis ◽

Potential Space ◽

Inclusion Criteria ◽

The Past ◽

Prisma Statement ◽

Ethical Committee Approval ◽

Registration Number ◽

Review Protocol

IntroductionThe ongoing need for dural tenting sutures in a contemporary neurosurgical practice has been questioned in the literature for over two decades. In the past, these sutures were supposed to prevent blood collecting in the potential space between the skull and the dura by elevating the latter. Theoretically, with modern haemostasis and proper postoperative care, this technique should not be necessary and the surgery time can be shortened. Unfortunately, there is no evidence-based proof to either support or reject this hypothesis.Methods and analysisThe systematic review will be performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement and The Cochrane Handbook for Systematic Reviews of Interventions. Eight electronic databases of peer-reviewed journals will be searched, as well as other sources. Eligible articles will be assessed against inclusion criteria. The intervention is not tenting the dura and this will be compared with the usual dural tenting sutures. Where possible, ‘summary of findings’ tables will be generated.Ethics and disseminationEthical committee approval is not required for a systematic review protocol. Findings will be presented at international neurosurgical conferences and published in a peer-reviewed medical journal.PROSPERO registration numberCRD42018097089.

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Zinc supplementation combined with antidepressant drugs for treatment of patients with depression: a systematic review and meta-analysis

Nutrition Reviews ◽

10.1093/nutrit/nuaa039 ◽

2020 ◽

Vol 79 (1) ◽

pp. 1-12

Author(s):

Laís Eloy Machado da Silva ◽

Mônica Leila Portela de Santana ◽

Priscila Ribas de Farias Costa ◽

Emile Miranda Pereira ◽

Carina Márcia Magalhães Nepomuceno ◽

...

Keyword(s):

Systematic Review ◽

Placebo Group ◽

Depressive Symptoms ◽

Zinc Supplementation ◽

Data Extraction ◽

Meta Analysis ◽

Intervention Group ◽

Antidepressant Drugs ◽

Language Restriction ◽

Registration Number

Abstract Context Zinc is an essential trace mineral required for the function of brain and neural structures. The role of zinc supplementation in the prevention and treatment of depression has been suggested in clinical studies that reported a reduction in depressive symptoms. Objective The aim of this review was to determine whether zinc supplementation vs placebo can prevent or improve depressive symptoms in children, adolescents, or adults. Data Sources Five electronic databases were searched, and studies published until September 2019 were included without language restriction. Study Selection Randomized, controlled, crossover trials that evaluated the effect of zinc supplementation vs a comparator for prevention or improvement of depressive symptoms in children, adolescents, or adults were eligible for inclusion. Data Extraction Two authors independently performed data extraction and risk-of-bias assessment. Results The initial search identified 12 322 studies, 5 of which were eligible for meta-analysis. The standardized mean difference (SMD) showed an average reduction of 0.36 point (95%CI, −0.67 to −0.04) in the intervention group compared with the placebo group. Forstudies in which the mean age of participants was ≥ 40 years, the SMD was reduced by 0.61 point (95%CI, −1.12 to −0.09) in the intervention group vs the placebo group. The meta-analysis by sample size (< 60 individuals and ≥ 60 individuals) did not show an effect of zinc supplementation in reducing depressive symptoms (SMD −0.28; 95%CI, −0.67 to −0.10; and SMD −0.52; 95%CI, −1.10 to 0.06). Conclusion Zinc supplementation may reduce depressive symptoms in individuals treated with antidepressant drugs for clinical depression. Systematic Review Registration PROSPERO registration number CRD42018081691.

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Prognostic models for predicting in-hospital paediatric mortality in resource-limited countries: a systematic review

BMJ Open ◽

10.1136/bmjopen-2019-035045 ◽

2020 ◽

Vol 10 (10) ◽

pp. e035045

Author(s):

Morris Ogero ◽

Rachel Jelagat Sarguta ◽

Lucas Malla ◽

Jalemba Aluvaala ◽

Ambrose Agweyu ◽

...

Keyword(s):

Systematic Review ◽

Low Income ◽

Assessment Tool ◽

Data Extraction ◽

Model Development ◽

Risk Of Bias ◽

Prognostic Models ◽

Risk Scores ◽

Eligibility Criteria ◽

Bias Assessment

ObjectivesTo identify and appraise the methodological rigour of multivariable prognostic models predicting in-hospital paediatric mortality in low-income and middle-income countries (LMICs).DesignSystematic review of peer-reviewed journals.Data sourcesMEDLINE, CINAHL, Google Scholar and Web of Science electronic databases since inception to August 2019.Eligibility criteriaWe included model development studies predicting in-hospital paediatric mortality in LMIC.Data extraction and synthesisThis systematic review followed the Checklist for critical Appraisal and data extraction for systematic Reviews of prediction Modelling Studies framework. The risk of bias assessment was conducted using Prediction model Risk of Bias Assessment Tool (PROBAST). No quantitative summary was conducted due to substantial heterogeneity that was observed after assessing the studies included.ResultsOur search strategy identified a total of 4054 unique articles. Among these, 3545 articles were excluded after review of titles and abstracts as they covered non-relevant topics. Full texts of 509 articles were screened for eligibility, of which 15 studies reporting 21 models met the eligibility criteria. Based on the PROBAST tool, risk of bias was assessed in four domains; participant, predictors, outcome and analyses. The domain of statistical analyses was the main area of concern where none of the included models was judged to be of low risk of bias.ConclusionThis review identified 21 models predicting in-hospital paediatric mortality in LMIC. However, most reports characterising these models are of poor quality when judged against recent reporting standards due to a high risk of bias. Future studies should adhere to standardised methodological criteria and progress from identifying new risk scores to validating or adapting existing scores.PROSPERO registration numberCRD42018088599.

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Safety and efficiency of gasless laparoscopy: a systematic review protocol

Systematic Reviews ◽

10.1186/s13643-020-01365-y ◽

2020 ◽

Vol 9 (1) ◽

Author(s):

Haitham Shoman ◽

Simone Sandler ◽

Alexander Peters ◽

Ameer Farooq ◽

Magdalen Gruendl ◽

...

Keyword(s):

Systematic Review ◽

Assessment Tool ◽

Data Extraction ◽

Meta Analysis ◽

A Priori ◽

Risk Of Bias ◽

Conventional Laparoscopy ◽

Eligibility Criteria ◽

Gasless Laparoscopy ◽

Resource Setting

Abstract Background Gasless laparoscopy, developed in the early 1990s, was a means to minimize the clinical and financial challenges of pneumoperitoneum and general anaesthesia. It has been used in a variety of procedures such as in general surgery and gynecology procedures including diagnostic laparoscopy. There has been increasing evidence of the utility of gasless laparoscopy in resource limited settings where diagnostic imaging is not available. In addition, it may help save costs for hospitals. The aim of this study is to conduct a systematic review of the available evidence surrounding the safety and efficiency of gasless laparoscopy compared to conventional laparoscopy and open techniques and to analyze the benefits that gasless laparoscopy has for low resource setting hospitals. Methods This protocol is developed by following the Preferred Reporting Items for Systematic review and Meta-Analysis–Protocols (PRISMA-P). The PRISMA statement guidelines and flowchart will be used to conduct the study itself. MEDLINE (Ovid), Embase, Web of Science, Cochrane Central, and Global Index Medicus (WHO) will be searched and the National Institutes of Health Clinical Trials database. The articles that will be found will be pooled into Covidence article manager software where all the records will be screened for eligibility and duplicates removed. A data extraction spreadsheet will be developed based on variables of interest set a priori. Reviewers will then screen all included studies based on the eligibility criteria. The GRADE tool will be used to assess the quality of the studies and the risk of bias in all the studies will be assessed using the Cochrane Risk assessment tool. The RoB II tool will assed the risk of bias in randomized control studies and the ROBINS I will be used for the non-randomized studies. Discussion This study will be a comprehensive review on all published articles found using this search strategy on the safety and efficiency of the use of gasless laparoscopy. The systematic review outcomes will include safety and efficiency of gasless laparoscopy compared to the use of conventional laparoscopy or laparotomy. Trial registration The study has been registered in PROSPERO under registration number: CRD42017078338

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