Lymphoedema in advanced cancer: does subcutaneous needle drainage improve quality of life?

2019 ◽  
pp. bmjspcare-2019-001924
Author(s):  
Amanda Landers ◽  
Julia Holyoake
Keyword(s):  
Quality Of Life ◽  
Lower Limb ◽  
Treatment Options ◽  
Adverse Outcomes ◽  
Improve Quality ◽  
Observational Trial ◽  
Validated Questionnaire ◽  
Before And After ◽  
Mobility Measurement

PurposeLower limb lymphoedema in the palliative care population has limited treatment options. Subcutaneous needle drainage is an underused procedure that has previously been described in the literature for refractory lymphoedema. This study will quantify the potential improvements to quality of life and the adverse outcomes for this group of patients.MethodsThis was a multicentre, non-randomised, observational trial using a validated questionnaire before and after the procedure. A tailored mobility measurement was also used. It extends a published pilot previously undertaken.ResultsThirty-two procedures were performed on 31 patients across three sites. The average drainage volume was 5.5 L. The domain of appearance (3.2 vs 2.8 vs 2.6) improved significantly and was sustained. All of the domains, except appearance, showed a significant improvement at 2 weeks. The cellulitis rate was 6%.ConclusionSubcutaneous needle drainage appears to improve quality of life in those with lower limb lymphoedema facing a life-limiting illness.

scholarly journals A functional electric orthesis on the paretic leg improves quality of life of stroke patients

2006 ◽  
Vol 64 (1) ◽  
pp. 20-23 ◽  
Author(s):  
Mara Renata Fernandes ◽  
Luciane B.C. Carvalho ◽  
Gilmar F. Prado
Keyword(s):  
Quality Of Life ◽  
Social Functioning ◽  
Physical Functioning ◽  
Bodily Pain ◽  
Improve Quality ◽  
Stroke Patients ◽  
Normal Life ◽  
Sf 36 ◽  
Before And After

CONTEXT: Hemiparesia changes quality of life of patients with stroke making difficult a normal life. OBJECTIVE: To evaluate the effect of Functional Eletric Orthesis (FEO) applied over the paretic leg in the quality of life of stroke patients. METHOD: The quality of life of 50 stroke patients of Associacao de Assistencia a Crianca Deficiente (AACD) was evaluated with SF-36 questionnaire before and after the treatment with a FEO for rehabilitation of walking. We analyzed data according to gender and affected hemisphere. RESULTS: The average values from all domains of SF-36 improved significantly (p<0.001). Female patients improved more than male in Emotional Domain (p=0.04) and presented a trend to be better regarding Bodily Pain and Social Functioning. Patients with right hemiparesia improved more than those with left hemiparesia (p=0.02). CONCLUSION: FEO over a paretic leg is efficient to improve quality of life of stroke patients, mainly Physical Functioning.

scholarly journals How Much? How Frequent? How Long? A Clinical Guide to New Therapies in Myelodysplastic Syndromes

Hematology ◽  
2010 ◽  
Vol 2010 (1) ◽  
pp. 314-321 ◽  
Author(s):  
William Blum
Keyword(s):  
Quality Of Life ◽  
Myelodysplastic Syndromes ◽  
Clinical Decision Making ◽  
Treatment Options ◽  
Clinical Decision ◽  
Clinical Results ◽  
Improve Quality ◽  
Substantial Impact ◽  
History Of

AbstractAdvances in the treatment of myelodysplastic syndromes (MDSs) over the last decade have given patients and their hematologists a multitude of treatment options. Therapeutic options now exist that reduce disease-related symptoms, improve quality of life, and alter the natural history of the disease. Three drugs are now specifically Food and Drug Administration-approved for treatment of MDS: (1) azacitidine, (2) decitabine, and (3) lenalidomide. Clinical results with each of these agents, plus results with immunosuppressive therapy, are reviewed to guide clinical decision making. Although each therapy has made a substantial impact in improving the care of patients with MDS, unfortunately MDS treatment in 2010 ultimately fails in most patients, but these therapies provide a foundation on which we can build to further improve outcomes.

Laryngotracheal reconstruction for relapsing polychondritis: case report and review of the literature

2013 ◽  
Vol 127 (9) ◽  
pp. 932-935 ◽  
Author(s):  
C Xie ◽  
N Shah ◽  
P L Shah ◽  
G Sandhu
Keyword(s):  
Quality Of Life ◽  
Hyoid Bone ◽  
Treatment Options ◽  
Relapsing Polychondritis ◽  
Disease Stage ◽  
Improve Quality ◽  
Review Of The Literature ◽  
Laryngotracheal Reconstruction ◽  
Life Threatening

AbstractBackground:Relapsing polychondritis is a multi-system autoimmune disease characterised by the inflammation and destruction of cartilaginous structures. The most common sites are the pinna, nose, laryngotracheobronchial tree and peripheral joints. Airway involvement occurs in up to half of patients affected, at any disease stage. It is the most severe and life-threatening aspect of the disease, and proves to be a therapeutic challenge.Objectives:This article reports our experience of performing laryngotracheal reconstruction in a patient with relapsing polychondritis. A review of the literature is presented, with a focused discussion of airway treatment options.Methods:Laryngotracheal reconstruction for relapsing polychondritis was performed using hyoid bone pedicled on sternohyoid muscle.Conclusion:Airway management in relapsing polychondritis can improve quality of life and palliate patients effectively.

scholarly journals Application of social dance exercise and social support program to improve quality of life for Thai older adults

2019 ◽  
Vol 33 (3) ◽  
pp. 260-266
Author(s):  
Kwanrutai Sampoon ◽  
Nuengruethai Posri ◽  
Boonsri Kittichotpanich
Keyword(s):  
Quality Of Life ◽  
Social Support ◽  
Older Adults ◽  
Intervention Group ◽  
Support Program ◽  
Improve Quality ◽  
Social Dance ◽  
Content Type ◽  
Before And After

Purpose The purpose of this paper is to test the effectiveness of social dance exercise and social support program to improve quality of life (QOL) for older adults in Thailand. Design/methodology/approach A quasi-experimental pre-test and post-test research design was used. The participants were 102 older adults selected by systematic sampling technique. Participants were assigned using the matched-pair technique by age, physical fitness test by the Time up and Go test into intervention and control groups of 51 subjects each. Intervention was conducted for 12 weeks, three times weekly, to improve physical, psychosocial and spiritual domains leading to enhanced QOL as measured by the World Health Organization Quality of Life (WHOQOL–BREF–THAI) assessment parameter. Data on QOL were collected before and after a 12-week training period. Findings Most adults were between 70 and 79 years old (67 percent). After program completion, before and after mean QOL scores for the intervention group at 60.15 and 95.82, respectively, were statistically significant with p-value<0.05. Post-program QOL shown by the intervention group was significantly higher than the control group (p<0.05). Originality/value Application of social dance exercise and social support program is an alternative to traditional methods to improve QOL and maintain functional capacity for older adults.

scholarly journals Treating Small Bowel Obstruction with a Manual Physical Therapy: A Prospective Efficacy Study

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Amanda D. Rice ◽  
Kimberley Patterson ◽  
Evette D. Reed ◽  
Belinda F. Wurn ◽  
Bernhard Klingenberg ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Therapy ◽  
Small Bowel ◽  
Small Bowel Obstruction ◽  
Bowel Obstruction ◽  
Treatment Options ◽  
Gastrointestinal Symptoms ◽  
Effective Treatment Option ◽  
Before And After

Small bowel obstructions (SBOs) caused by adhesions are a common, often life-threatening postsurgical complication with few treatment options available for patients. This study examines the efficacy of a manual physical therapy treatment regimen on the pain and quality of life of subjects with a history of bowel obstructions due to adhesions in a prospective, controlled survey based study. Changes in six domains of quality of life were measured via ratings reported before and after treatment using the validated Small Bowel Obstruction Questionnaire (SBO-Q). Improvements in the domains for pain (p=0.0087), overall quality of life (p=0.0016), and pain severity (p=0.0006) were significant when average scores before treatment were compared with scores after treatment. The gastrointestinal symptoms (p=0.0258) domain was marginally significant. There was no statistically significant improvement identified in the diet or medication domains in the SBO-Q for this population. Significant improvements in range of motion in the trunk (p≤0.001), often limited by adhesions, were also observed for all measures. This study demonstrates in a small number of subjects that this manual physical therapy protocol is an effective treatment option for patients with adhesive small bowel obstructions as measured by subject reported symptoms and quality of life.

scholarly journals Effectiveness of exercise training program on postural control and quality of life in middle-aged men with unilateral lower limb amputation

2021 ◽  
Vol 13 (2) ◽  
pp. 29-35
Author(s):  
Masoud Kashfi ◽  
◽  
Iman Khakroo Abkenar ◽  
Ali Fakourian ◽  
Giovanni Lombardi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Exercise Training ◽  
Postural Control ◽  
Training Program ◽  
Lower Limb ◽  
Rehabilitation Program ◽  
Limb Amputation ◽  
Exercise Training Program ◽  
Before And After

This study aimed to investigate whether the exercise-based amputee rehabilitation program improves postural control and quality of life in people with unilateral transtibial amputation (TTA). Twenty middle-aged men (48.4±3.8 y) with lower limb amputation, in a randomized-controlled longitudinal design, volunteered to participate in the study and were divided into experimental (EXP, n=10) and control (CON, n=10) groups. Before and after 8 weeks of the exercise training program, postural control performance, using one-leg standing (OLS) and Y-balance tests, was measured. The quality of life was also assessed before and after 8 weeks training period using standard questionnaires. Group x time interactions were observed for the EXP group in OLS and Y-balance tests and quality of life scores in comparison to pre- training values and the CON group (p<0.05). People with unilateral TTA who received exercise-based amputee rehabilitation program demonstrated significant improvement in balance performance with significant effects on quality of life.

scholarly journals Effects of Metreleptin on Patient Outcomes and Quality of Life in Generalized and Partial Lipodystrophy

2021 ◽  
Vol 5 (4) ◽  
Author(s):  
Keziah Cook ◽  
Kelly Adamski ◽  
Aparna Gomes ◽  
Edward Tuttle ◽  
Henner Kalden ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Treatment Options ◽  
Quality Adjusted Life Year ◽  
Reproductive Age ◽  
Partial Lipodystrophy ◽  
The Us ◽  
Before And After ◽  
Subcutaneous Adipose ◽  
Quality Adjusted Life

Abstract Generalized and partial lipodystrophy are rare and complex diseases with progressive clinical and humanistic burdens stemming from selective absence of subcutaneous adipose tissue, which causes reduced energy storage capacity and a deficiency of adipokines such as leptin. Treatment options were limited before leptin replacement therapy (metreleptin) became available. This retrospective study evaluates both clinical and humanistic consequences of the disease and treatment. Chart data were abstracted from a cohort of metreleptin-treated patients with generalized and partial lipodystrophy (n = 112) treated at the US National Institutes of Health. To quantify the quality-of-life consequences of the lipodystrophy disease attributes recorded in chart data, a discrete choice experiment was completed in 6 countries (US, n = 250; EU, n = 750). Resulting utility decrements were used to estimate the quality-adjusted life-year consequences of changes in lipodystrophy attribute prevalence before and after metreleptin. In addition to metabolic impairment, patients with generalized and partial lipodystrophy experienced a range of lipodystrophy consequences, including liver abnormality (94%), hyperphagia (79%), impaired physical appearance (77%), kidney abnormality (63%), reproductive dysfunction (80% of females of reproductive age), and pancreatitis (39%). Improvement was observed in these attributes following initiation of metreleptin. Quality-adjusted life-year gains associated with 12 months of treatment with metreleptin were estimated at 0.313 for generalized and 0.117 for partial lipodystrophy, reducing the gap in quality of life between untreated lipodystrophy and perfect health by approximately 59% and 31%, respectively. This study demonstrates that metreleptin is associated with meaningful clinical and quality-of-life improvements.

scholarly journals Evaluation of quality of life in dogs with atopic dermatitis and their owners after lokivetmab therapy

2021 ◽  
Vol 10 (11) ◽  
pp. e392101119775
Author(s):  
Vanessa Stuart Marques ◽  
Jessica Ragazzi Celesso ◽  
Adriane Pimenta da Costa Val Bicalho
Keyword(s):  
Quality Of Life ◽  
Atopic Dermatitis ◽  
Measurement Tool ◽  
Therapeutic Success ◽  
Validated Questionnaire ◽  
Before And After ◽  
Veterinary School ◽  
The Impact ◽  
Veterinary Hospital

Canine atopic dermatitis is an inflammatory and pruritic skin disease, with clinical characteristics associated with IgE antibodies, most commonly directed against environmental allergens which impact the quality of life in affected animals and their owners. Treatment is multifaceted and must be adapted to each patient individually. Currently, a medication based on caninized monoclonal antibody (mAb), called lokivetmab, has shown promise for controlling the signs of the disease, as it neutralizes interleukin IL-31, a cytokine that plays an important role in the pathogenesis of atopy. The impact of dermatological diseases in the life of the dog and its owner has only been studied in recent years through validated questionnaires. This additional measurement tool is important for evaluating the therapeutic success of interventions in atopic dermatitis, as clinical improvement may not correlate with an increased quality of life. This study aimed to evaluate the quality of life in dogs with atopic dermatitis and their owners after lokivetmab therapy. Ten atopic dogs treated at the dermatology service of the Veterinary Hospital of the Veterinary School from UFMG were selected. Quality of life was assessed using a validated questionnaire, before and after lokivetmab therapy. It concludes that treatment with lokivetmab significantly improved the quality of life of dogs with atopic dermatitis and their owners.

Outcomes of a new wrap compression system for patients with lower limb ulceration and oedema

2019 ◽  
Vol 28 (20) ◽  
pp. S38-S42
Author(s):  
Alison Barker ◽  
Marie Todd
Keyword(s):  
Quality Of Life ◽  
Case Studies ◽  
Lower Limb ◽  
Self Care ◽  
Psychological Problems ◽  
Improve Quality ◽  
Compression System

JOBST® FarrowWrap® is indicated in patients presenting with venous leg ulceration in combination with mild-to-moderate oedema. These symptoms result in significant physical and psychological problems and management can be costly in terms of duration of input and resources. This article will present four case studies demonstrating the benefits and outcomes for patients with lower limb issues and will consider how the product helps improve shape, reduce oedema, heal ulceration, improve quality of life in relation to the lower limb and encourage self-care.

scholarly journals The impact of cataract surgery on vision-related quality of life for cataract patients in China: a prospective study

2020 ◽  
Author(s):  
changsen Tu ◽  
Ji Ni ◽  
Xu Xu ◽  
Zhuoma Mima
Keyword(s):  
Quality Of Life ◽  
Cataract Surgery ◽  
Estimating Equation ◽  
Validated Questionnaire ◽  
Before And After ◽  
Related Quality ◽  
The One ◽  
A Prospective Study ◽  
The Impact

Abstract Background: Cataract is one of the most common blinding eye diseases, and patients' psychological, life and social activities will be significantly affected. Thus, the aim of this study is to to assess the impact of cataract surgery on vision-related quality of life (VRQOL) in China’s poor areaTibet. Methods: This study was a prospective cohort study. Subjects were invited to complete a validated questionnaire before and three months after cataract surgery. The 25-item National Eye Institute Visual Functioning Questionnaire (NEI VFQ-25) was used to assess the Vision-related quality of life. Generalized linear estimating equation (GEE) analysis and descriptive analyses were performed to record change of VRQOL before and after surgery. Results: One hundred and twenty-two patients were included. Among the One hundred and twenty-two patients, one hundred and seventeen (94.26%) completed the follow-up assessment after surgery. The total VRQOL was significantly improved after cataract surgery (p <0.001). the item of stereopsis and Binocular contrast sensitivity were also related to changes in VRQOL. Conclusions: The majority of patients had significantly improved VRQOL after cataract surgery in Chinese population.

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