Antidepressant therapy

1965 ◽  
Vol 3 (11) ◽  
pp. 41-43

In diagnosing depression, the most important maxim is to remember its existence. Depression may present overtly or covertly; it may be associated with suicide, alcoholism, or addiction to amphetamines. Perhaps half the depressions seen in general practice require specific treatment, of which a quarter may need referral to a psychiatrist or a psychiatric hospital. If left untreated about 1 in 7 severe depressives die, commit suicide, or become chronic invalids. About these observations there is general agreement. Unfortunately, views about treatment are more diverse, and it is impossible to discuss all of them in a short article, especially if the conclusions are to be firm enough for general use. What follows, therefore, does not represent a consensus of psychiatric opinion, for this does not exist. It is an account of a consistent approach to therapy well supported by experimental evidence and found useful in practice.

1974 ◽  
Vol 2 (4) ◽  
pp. 316-328 ◽  
Author(s):  
Struan K. Sutherland

Potentially fatal bites and stings by Australian terrestrial and marine animals are relatively common, but with correct management of victims, death should be an infrequent occurrence. The known pharmacopathological actions of some of these venoms are enumerated and specific antidotes are described. In cases of certain venoms against which no “specific” treatment has yet been developed, an approach to management based upon clinical and experimental evidence is presented.


2010 ◽  
Vol 122 (3) ◽  
pp. 208-212 ◽  
Author(s):  
Helga Gardarsdottir ◽  
Toine C.G. Egberts ◽  
Liset van Dijk ◽  
Eibert R. Heerdink

1979 ◽  
Vol 17 (20) ◽  
pp. 77-78

The general practitioner is in a unique position to prevent suicide because most patients who commit suicide are in contact with their doctor shortly beforehand. This article discusses the problems faced by the GP in dealing with suicidal patients and with those liable to take a non-fatal drug overdose.


2011 ◽  
Vol 702-703 ◽  
pp. 80-84
Author(s):  
Apu Sarkar ◽  
J.K. Chakravartty

The viscoplastic self-consistent (VPSC) formulation is by now a well established approach for simulating texture development and constitutive response during plastic forming of high and low-symmetry polycrystals. In this work we have used the VPSC approach to model the uniaxial tensile and compressive deformation characteristics of pure magnesium with random and extruded texture. We compare our results with experimental data and find that they are in good agreement with the available experimental evidence.


2010 ◽  
Vol 10 (1) ◽  
Author(s):  
Benjamas Prukkanone ◽  
Theo Vos ◽  
Philip Burgess ◽  
Nathorn Chaiyakunapruk ◽  
Melanie Bertram

1995 ◽  
Vol 77 (1) ◽  
pp. 27-34 ◽  
Author(s):  
Wayne Briner

Studies of the physiological and psychological characteristics of tinnitus and its treatment have yielded a variety of conclusions The variation in results may reflect heterogeneous patient populations. Although the sources of variation are many, one may be derived from combining patients of several severities of tinnitus into a single group. A nosology is proposed for tinnitus severity to be classified by the patient's behavioral responses. Classifying patients allows direction to specific treatment modalities and will facilitate research. The concept of phantom auditory pain and a rational basis for the use of antidepressant therapy are discussed.


1984 ◽  
Vol 145 (1) ◽  
pp. 15-19 ◽  
Author(s):  
Peter Tyrer ◽  
Nicholas Seivewright ◽  
Stanley Wollerton

SummaryThe impact of devolving out-patient care to general practice (GP) psychiatric clinics over a two-year period is examined by comparing the frequency of contact with different psychiatric services in practices with and without psychiatric clinics. The clinics led to an increase in the number of outpatients seen, but to a fall in the number of new referrals. There was also a relative increase in the number of domiciliary visits and increase in acute day hospital referrals. The most important result was a 20 per cent fall in the number of admissions to the psychiatric hospital, which took place at a time when the national trend of falling admission rates was reversed. The findings suggest that psychiatric resources for in-patients can be deployed successfully in primary care without any increase in staffing.


2019 ◽  
Vol 42 ◽  
Author(s):  
Olya Hakobyan ◽  
Sen Cheng

Abstract We fully support dissociating the subjective experience from the memory contents in recognition memory, as Bastin et al. posit in the target article. However, having two generic memory modules with qualitatively different functions is not mandatory and is in fact inconsistent with experimental evidence. We propose that quantitative differences in the properties of the memory modules can account for the apparent dissociation of recollection and familiarity along anatomical lines.


1997 ◽  
Vol 161 ◽  
pp. 437-442
Author(s):  
Salvatore Di Bernardo ◽  
Romana Fato ◽  
Giorgio Lenaz

AbstractOne of the peculiar aspects of living systems is the production and conservation of energy. This aspect is provided by specialized organelles, such as the mitochondria and chloroplasts, in developed living organisms. In primordial systems lacking specialized enzymatic complexes the energy supply was probably bound to the generation and maintenance of an asymmetric distribution of charged molecules in compartmentalized systems. On the basis of experimental evidence, we suggest that lipophilic quinones were involved in the generation of this asymmetrical distribution of charges through vectorial redox reactions across lipid membranes.


Author(s):  
Michael T. Bucek ◽  
Howard J. Arnott

It is believed by the authors, with supporting experimental evidence, that as little as 0.5°, or less, knife clearance angle may be a critical factor in obtaining optimum quality ultrathin sections. The degree increments located on the knife holder provides the investigator with only a crude approximation of the angle at which the holder is set. With the increments displayed on the holder one cannot set the clearance angle precisely and reproducibly. The ability to routinely set this angle precisely and without difficulty would obviously be of great assistance to the operator. A device has been contrived to aid the investigator in precisely setting the clearance angle. This device is relatively simple and is easily constructed. It consists of a light source and an optically flat, front surfaced mirror with a minute black spot in the center. The mirror is affixed to the knife by placing it permanently on top of the knife holder.


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