IDDF2018-ABS-0164 The temporal relationship of daily life stress, emotions and bowel symptoms in irritable bowel syndrome: a smartphone-based experience sampling study

Irritable bowel syndrome (IBS) is a common recurrent functional gastrointestinal disorder that impacts on patients physically and mentally. Studies on IBS have focused on adults, yet few studies have examined IBS among female university students. The aim of this study was to investigate the prevalence of IBS for female university students and its related factors. Using a cross-sectional study design, a total of 2520 female university students were recruited in southern Taiwan. The structured questionnaires, including the Rome III IBS diagnostic questionnaire, IBS symptom severity scale, Perceived Stress Scale, and World Health Organization Quality of Life BREF questionnaire (WHOQOL-BREF) were used for data collection. A total of 1894 female students complete the questionnaires. The response rate was 75.15%. The results indicated 193 female students with IBS and the prevalence of IBS was 10.1%. IBS female students had higher levels of stress and lower QOL than non-IBS female students. The risk factors for female university students developing IBS were dysmenorrhea, food avoidance, class absenteeism, and the lower physical domain of QOL. It is advised to consider these factors when providing students with counselling and relevant services in the expectation of alleviating their IBS symptoms, reducing the incidence rate of IBS, and further improving their QOL.

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The Relationship of Irritable Bowel Syndrome (IBS) and Panic Disorder1

Annals of Clinical Psychiatry ◽

10.3109/10401239609148805 ◽

1996 ◽

Vol 8 (2) ◽

pp. 81-88 ◽

Cited By ~ 33

Author(s):

David Kaplan ◽

Prakash Masand ◽

Sanjay Gupta

Keyword(s):

Irritable Bowel Syndrome ◽

Irritable Bowel ◽

Relationship Of ◽

The Relationship

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The Relationship of Overlapping Affective and Somatization Symptoms With Homeostatic Afferent Processing Network Activations in Irritable Bowel Syndrome (IBS)

Gastroenterology ◽

10.1016/s0016-5085(11)61486-8 ◽

2011 ◽

Vol 140 (5) ◽

pp. S-364

Author(s):

Gregory S. Sayuk ◽

Christina L. Fales ◽

C. Prakash Gyawali ◽

Billy D. Nix ◽

Yvette I. Sheline

Keyword(s):

Irritable Bowel Syndrome ◽

Irritable Bowel ◽

Relationship Of ◽

The Relationship ◽

Processing Network

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Overexpression of corticotropin-releasing factor in intestinal mucosal eosinophils is associated with clinical severity in Diarrhea-Predominant Irritable Bowel Syndrome

Scientific Reports ◽

10.1038/s41598-020-77176-x ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Eloísa Salvo-Romero ◽

Cristina Martínez ◽

Beatriz Lobo ◽

Bruno K. Rodiño-Janeiro ◽

Marc Pigrau ◽

...

Keyword(s):

Irritable Bowel Syndrome ◽

Life Stress ◽

Secretory Activity ◽

Corticotropin Releasing Factor ◽

Clinical Severity ◽

Jejunal Mucosa ◽

Gut Dysfunction ◽

Transmission Electron ◽

Activation Profile ◽

Irritable Bowel

AbstractCorticotropin-releasing factor (CRF) has been identified in intestinal mucosal eosinophils and associated with psychological stress and gut dysfunction. Irritable bowel syndrome (IBS) is commonly characterized by altered intestinal motility, immune activation, and increased gut barrier permeability along with heightened susceptibility to psychosocial stress. Despite intensive research, the role of mucosal eosinophils in stress-associated gut dysfunction remains uncertain. In this study, we evaluated eosinophil activation profile and CRF content in the jejunal mucosa of diarrhea-predominant IBS (IBS-D) and healthy controls (HC) by gene/protein expression and transmission electron microscopy. We also explored the association between intestinal eosinophil CRF and chronic stress, and the potential mechanisms underlying the stress response by assessing eosinophil response to neuropeptides. We found that mucosal eosinophils displayed higher degranulation profile in IBS-D as compared to HC, with increased content of CRF in the cytoplasmic granules, which significantly correlated with IBS clinical severity, life stress background and depression. Eosinophils responded to substance P and carbachol by increasing secretory activity and CRF synthesis and release, without promoting pro-inflammatory activity, a profile similar to that found in mucosal eosinophils from IBS-D. Collectively, our results suggest that intestinal mucosal eosinophils are potential contributors to stress-mediated gut dysfunction through CRF production and release.

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Level of chronic life stress predicts clinical outcome in irritable bowel syndrome

Gut ◽

10.1136/gut.43.2.256 ◽

1998 ◽

Vol 43 (2) ◽

pp. 256-261 ◽

Cited By ~ 264

Author(s):

E J Bennett ◽

C C Tennant ◽

C Piesse ◽

C-A Badcock ◽

J E Kellow

Keyword(s):

Irritable Bowel Syndrome ◽

Clinical Outcome ◽

Life Stress ◽

Research Evidence ◽

Powerful Predictor ◽

Rome Criteria ◽

Intensity Measures ◽

Symptom Intensity ◽

Irritable Bowel ◽

Over Time

Background—Life stress contributes to symptom onset and exacerbation in the majority of patients with irritable bowel syndrome (IBS) and functional dyspepsia (FD); research evidence is conflicting, however, as to the strength of these effects.Aims—To test prospectively the relation of chronic life stress threat to subsequent symptom intensity over time.Patients—One hundred and seventeen consecutive outpatients satisfying the modified Rome criteria for IBS (66% with one or more concurrent FD syndromes) participated.Methods—The life stress and symptom intensity measures were determined from interview data collected independently at entry, and at six and 16 months; these measures assessed the potency of chronic life stress threat during the prior six months or more, and the severity and frequency of IBS and FD symptoms during the following two weeks.Results—Chronic life stress threat was a powerful predictor of subsequent symptom intensity, explaining 97% of the variance on this measure over 16 months. No patient exposed to even one chronic highly threatening stressor improved clinically (by 50%) over the 16 months; all patients who improved did so in the absence of such a stressor.Conclusion—The level of chronic life stress threat predicts the clinical outcome in most patients with IBS/FD.

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A Conservative Weight Loss Intervention Relieves Bowel Symptoms in Morbidly Obese Subjects with Irritable Bowel Syndrome: A Prospective Cohort Study

Journal of Obesity ◽

10.1155/2018/3732753 ◽

2018 ◽

Vol 2018 ◽

pp. 1-9 ◽

Cited By ~ 7

Author(s):

Martin Aasbrenn ◽

Stian Lydersen ◽

Per G. Farup

Keyword(s):

Body Mass Index ◽

Morbid Obesity ◽

Weight Loss ◽

Irritable Bowel Syndrome ◽

Cohort Study ◽

Body Mass ◽

Prospective Cohort ◽

Weight Loss Intervention ◽

Bowel Symptoms ◽

Irritable Bowel

Background. Irritable bowel syndrome (IBS) is common in subjects with morbid obesity; the effect of weight loss programs on bowel symptoms is largely unknown. Methods. This prospective cohort study explored bowel symptoms, health scores, and biomarkers in subjects with morbid obesity during a six-month-long conservative weight loss intervention. Bowel symptoms were assessed with IBS-severity scoring system (IBS-SSS) and Gastrointestinal Symptom Rating Scale-IBS. Changes in all variables and associations between the changes in bowel symptoms and the other variables were analysed. Results. Eighty-eight subjects (81% females) were included. Body mass index was reduced from 42.0 (3.6) to 38.7 (3.5) (p<0.001). IBS-SSS was reduced from 116 (104) to 81 (84) (p=0.001). In all, 19 out of 25 variables improved significantly. In subjects with and without IBS at inclusion, the improvement in IBS-SSS was 88 (95% CI 55 to 121) and 10 (95% CI −9 to 29), respectively. Improved bowel symptoms were associated with improved subjective well-being, sense of humour, and vitamin D and negatively associated with reduced body mass index. Conclusion. Body mass index and health scores improved during a conservative weight loss intervention. Subjects with IBS before the intervention had a clinically significant improvement in bowel symptoms.

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