scholarly journals IDDF2020-ABS-0149 Lymphadenectomy with optimal removed lymph nodes associated with improved staging and survival in stage I-III gastric cancer: is there an optimal cut-off point?

2020 ◽  
Author(s):  
Yang Li
Keyword(s):  
Gastric Cancer ◽  
Lymph Nodes ◽  
Stage I

scholarly journals Impact of the Number of Dissected Lymph Nodes on Survival for Gastric Cancer after Distal Subtotal Gastrectomy

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Chang-Ming Huang ◽  
Jian-Xian Lin ◽  
Chao-Hui Zheng ◽  
Ping Li ◽  
Jian-Wei Xie ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Survival Rate ◽  
Lymph Nodes ◽  
Distal Gastrectomy ◽  
Stage I ◽  
Stage Ii ◽  
Stage Iii ◽  
Prognostic Impact ◽  
Term Survival

Objectives. To investigate the prognostic impact of the number of dissected lymph nodes (LNs) in gastric cancer after curative distal gastrectomy.Methods. The survival of 634 patients who underwent curative distal gastrectomy from 1995 to 2004 was retrieved. Long-term surgical outcomes and associations between the number of dissected LNs and the 5-year survival rate were investigated.Results. The number of dissected LNs was one of the most important prognostic indicators. Among patients with comparable T category, the larger the number of dissected LNs was, the better the survival would be (). The linear regression showed that a significant survival improvement based on increasing retrieved LNs for stage II, III and IV (). A cut-point analysis yields the greatest variance of survival rate difference at the levels of 15 LNs (stage I), 25 LNs (stage II) and 30 LNs (stage III).Conclusion. The number of dissected LNs is an independent prognostic factor for gastric cancer. To improve the long-term survival of patients with gastric cancer, removing at least 15 LNs for stage I, 25 LNs for stage II, and 30 LNs for stage III patients during curative distal gastrectomy is recommended.

LAPAROSCOPIC DISTAL GASTRECTOMY WITH LYMPH NODES DISSECTION FOR THE TREATMENT OF GASTRIC CANCER

2014 ◽  
pp. 24-28
Author(s):  
Hai Thanh Phan ◽  
Nhu Hiep Pham ◽  
Loc Le ◽  
Van Lieu Nguyen ◽  
Anh Vu Pham ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Nodes ◽  
Distal Gastrectomy ◽  
Average Length ◽  
Survival Rates ◽  
Disease Free Survival ◽  
Length Of Hospital Stay ◽  
Operation Time ◽  
Stage I ◽  
Lymph Nodes Dissection

Objective: The goal of this study was to investigate the feasibility, safety, and associated survival outcomes of laparoscopy-assisted distal gastrectomy (LADG) with lymph nodes dissection for gastric cancer. Methods: we analyzed the clinical data from 64 consecutive patients with gastric cancer who received LADG at our department of abdominal emergency surgery-Hue central hospital from January of 2007 to January of 2013. Results: LADG was successfully carried out in 62 patients; 2 cases were converted to open surgery. The mean operation time was 210 minutes (150-300 minutes), and mean number of dissected lymph nodes was 13 (5-25). The average length of hospital stay were 9,1 days (7-16 days). The morbididity and mortality was 15% and 1,5%. A total of 62 patients were followed for a subsequent 6-71 months (median, 24 months). The 3-year disease-free survival (DFS) and overall survival (OS) rates were 71,3% and 83,2%, respectively. When divided by stage, the 3-year DFS for stage I, II, and III were 88%, 84,9%, and 41%, respectively; and the 3-year OS for stage I, II, and III were 100%, 86%, and 45%, respectively. Conclusion: In this preliminary report, LADG was found to be a safe, feasible, and efficacious procedure for the treatment of gastric cancer with encouraging 3-year overall and stage-by-stage survival rates

Prognostic factors for survival in gastric cancer after radical resection: A retrospective study of 1,594 patients in Shanghai.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e14575-e14575
Author(s):  
Yihong Sun ◽  
Cong Wang ◽  
Zhenbin Shen ◽  
Naiqing Zhao ◽  
Weidong Chen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prognostic Factors ◽  
Lymph Nodes ◽  
Cox Regression ◽  
Venous Invasion ◽  
Radical Resection ◽  
Tnm Stage ◽  
Stage I ◽  
Tumor Site ◽  
Cumulative Survival

e14575 Background: Gastric Cancer (GC) is the second leading cause of cancer death in Shanghai,and the overall treatment response remains poor. This study aimed to describe overall survival and identify prognostic factors for survival among GC patients (pts) after radical resection. Methods: Clinical data of 1594 GC pts (Shanghai residents) who had undergone R0 or R1 resection in Zhongshan hospital, January 2003 to June 2010, were analyzed. Potential prognostic factors including demographic and tumor characteristics were collected. Survival was calculated by the Kaplan-Meier method and Log-rank test was used to determine statistical significance. Prognostic factors were analyzed using Cox regression multivariate analysis. Results: Overall 5-year cumulative survival for all pts was 55.8%. The 5-year cumulative survival by TNM stage I, II, III, and IV (classified using AJCC 7th edition staging system) were 93.8%, 72.7%, 33.3%, and 12.7%, respectively. The distribution of pts by AJCC stage I-IV was 22.5%, 23.1%, 51.7% and 2.8% respectively. In univariate analyses, gender and the number of lymph nodes removed was not associated with survival (p>0.05). However, age, tumor differentiation, tumor site, lympahtic/venous invasion, depth of infiltration, presence of lymph node metastasis, and presence of distant metastasis were related to survival (p<0.05). In multivariate Cox regression model analysis, age (p<0.001), tumor site (p=0.004), lymphatic/venous invasion (p<0.001), TNM stage(p<0.001) were independent prognosticators. Among pts with TNM stage III , number of lymph nodes removed was also an independent prognostic factor (p<0.001). Conclusions: Age, tumor site, lymphatic/venous invasion, TNM stage in all patients, and the number of lymph nodes removed in TNM stage III patients, were independent prognostic factors. GC remains a significant unmet medical need in China and effective therapies are urgently needed.

A case of primary biliary cirrhosis with sarcoid reaction in the regional lymph nodes after surgery of early gastric cancer

Kanzo ◽  
2005 ◽  
Vol 46 (7) ◽  
pp. 437-442 ◽  
Author(s):  
Tadashi YOSHIDA ◽  
Atsushi NAGASAKA ◽  
Yayoi OGAWA ◽  
Syuji NISHIKAWA ◽  
Akifumi HIGUCHI
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Primary Biliary Cirrhosis ◽  
Lymph Nodes ◽  
Biliary Cirrhosis ◽  
Regional Lymph Nodes ◽  
Sarcoid Reaction

BIOPSY OF THE SIGNALING LYMPH NODES IN GASTRIC CANCER - CURRENT STATUS OF THE PROBLEM AND PROSPECTS

2018 ◽  
Vol 64 (3) ◽  
pp. 335-344
Author(s):  
Aleksey Karachun ◽  
Yuriy Pelipas ◽  
Oleg Tkachenko ◽  
D. Asadchaya
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Nodes ◽  
Stomach Cancer ◽  
Current Status ◽  
Regional Lymph Nodes ◽  
Systematic Analysis ◽  
Tumor Spread ◽  
Special Value

The concept of biopsy of sentinel lymph node as the first lymph node in the pathway of lymphogenous tumor spread has been actively discussed over the past decades and has already taken its rightful place in breast and melanoma surgery. The goal of this method is to exclude vain lymphadenectomy in patients without solid tumor metastases in regional lymph nodes. In the era of minimally invasive and organ-saving operations interventions it seems obvious an idea to introduce a biopsy of sentinel lymph node in surgery of early gastric cancer. Meanwhile the complexity of lymphatic system of the stomach and the presence of so-called skip metastases are factors limiting the introduction of a biopsy of sentinel lymph node in stomach cancer. This article presents a systematic analysis of biopsy technology of signaling lymph node as well as its safety and oncological adequacy. Based on literature data it seems to us that the special value of biopsy of sentinel lymph nodes in the future will be in the selection of personalized surgical tactics for stomach cancer.

scholarly journals Positive lymph node ratio is an index in predicting prognosis for remnant gastric cancer with insufficient retrieved lymph node in R0 resection

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Honghu Wang ◽  
Hao Qi ◽  
Xiaofang Liu ◽  
Ziming Gao ◽  
Iko Hidasa ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Lymph Node Ratio ◽  
Prognostic Index ◽  
Staging System ◽  
R0 Resection ◽  
Remnant Gastric Cancer ◽  
Curative Intent ◽  
Node Ratio

AbstractThe staging system of remnant gastric cancer (RGC) has not yet been established, with the current staging being based on the guidelines for primary gastric cancer. Often, surgeries for RGC fail to achieve the > 15 lymph nodes needed for TNM staging. Compared with the pN staging system, lymph node ratio (NR) may be more accurate for RGC staging and prognosis prediction. We retrospectively analyzed the data of 208 patients who underwent R0 gastrectomy with curative intent and who have ≤ 15 retrieved lymph nodes (RLNs) for RGC between 2000 and 2014. The patients were divided into four groups on the basis of the NR cutoffs: rN0: 0; rN1: > 0 and ≤ 1/6; rN2: > 1/6 and ≤ 1/2; and rN3: > 1/2. The 5-year overall survival (OS) rates for rN0, rN1, rN2, and rN3 were 84.3%, 64.7%, 31.5%, and 12.7%, respectively. Multivariable analyses revealed that tumor size (p = 0.005), lymphovascular invasion (p = 0.023), and NR (p < 0.001), but not pN stage (p = 0.682), were independent factors for OS. When the RLN count is ≤ 15, the NR is superior to pN as an important and independent prognostic index of RGC, thus predicting the prognosis of RGC patients more accurately.

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