scholarly journals Marital status, telomere length and cardiovascular disease risk in a Swedish prospective cohort

Heart ◽  
2019 ◽  
Vol 106 (4) ◽  
pp. 267-272 ◽  
Author(s):  
Ruoqing Chen ◽  
Yiqiang Zhan ◽  
Nancy Pedersen ◽  
Katja Fall ◽  
Unnur A Valdimarsdóttir ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Marital Status ◽  
Telomere Length ◽  
Prospective Cohort ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Living Alone ◽  
Twin Registry ◽  
Incident Cases ◽  
Swedish Twin Registry

ObjectiveTo investigate if marital status is associated with risk of cardiovascular disease (CVD) and to explore the potential influence of leucocyte telomere length (LTL), a marker of biological ageing, on such association.DesignPopulation-based prospective cohort studySettingsSwedish Twin Registry.ParticipantsBased on the Screening Across the Lifespan Twin Study from the Swedish Twin Registry, we included 10 058 twins born between 1900 and 1958 who underwent an interview between 1998 and 2002 during which information about marital status was collected. Blood samples from these participants were subsequently collected between 2004 and 2008 and used for LTL assessment using quantitative PCR technique.Main outcome measuresIncident cases of CVD were identified through the Swedish Patient Register and Causes of Death Register through December 31, 2016. Multivariable linear regression and Cox proportional hazards regression models were used to estimate the regression coefficients (βs) and HRs with 95% CIs respectively. Potential confounders included age, sex, educational attainment and body mass index.ResultsA total of 2010 participants were diagnosed with CVD during a median follow-up of 9.8 years. LTL was shorter among individuals living singly, including those who were divorced or separated (β:−0.014, 95% CI: −0.035, 0.007), widowed (β:−0.035, 95% CI: −0.061, –0.010), or living alone (β:−0.033, 95% CI: −0.052, –0.014), than individuals who were married or cohabitating. One SD increase of LTL was associated with a lower risk of CVD (HR: 0.79, 95% CI: 0.66, 0.93). Individuals who were divorced or separated, widowed, or living alone had a higher risk of CVD than individuals who were married or cohabitating. The summary HR of CVD was 1.21 (95% CI: 1.08, 1.35) when comparing individuals who were living singly, regardless of reason, with the individuals who were married or cohabitating. LTL appeared to mediate little of the association between marital status and CVD (HR additionally adjusted for LTL: 1.20; 95% CI: 1.08, 1.34).ConclusionsLiving singly, regardless of reason, was associated with a shorter LTL and a higher risk of CVD. The association between marital status and CVD was however not greatly attributable to telomere shortening.

scholarly journals Leukocyte Telomere Length in Relation to 17 Biomarkers of Cardiovascular Disease Risk: A Cross-Sectional Study of US Adults

PLoS Medicine ◽  
2016 ◽  
Vol 13 (11) ◽  
pp. e1002188 ◽  
Author(s):  
David H. Rehkopf ◽  
Belinda L. Needham ◽  
Jue Lin ◽  
Elizabeth H. Blackburn ◽  
Ami R. Zota ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Telomere Length ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Cross Sectional Study ◽  
Leukocyte Telomere Length ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Cellular Aging Reflected by Leukocyte Telomere Length Predicts Advanced Atherosclerosis and Cardiovascular Disease Risk

2010 ◽  
Vol 30 (8) ◽  
pp. 1649-1656 ◽  
Author(s):  
Peter Willeit ◽  
Johann Willeit ◽  
Anita Brandstätter ◽  
Silvia Ehrlenbach ◽  
Agnes Mayr ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Telomere Length ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Cellular Aging ◽  
Leukocyte Telomere Length

scholarly journals Egg consumption and risk of cardiovascular disease: three large prospective US cohort studies, systematic review, and updated meta-analysis

BMJ ◽  
2020 ◽  
pp. m513 ◽  
Author(s):  
Jean-Philippe Drouin-Chartier ◽  
Siyu Chen ◽  
Yanping Li ◽  
Amanda L Schwab ◽  
Meir J Stampfer ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cardiovascular Disease ◽  
Cohort Studies ◽  
Prospective Cohort ◽  
Disease Risk ◽  
Meta Analysis ◽  
Cardiovascular Disease Risk ◽  
Egg Consumption ◽  
Prospective Cohort Studies ◽  
Incident Cardiovascular Disease

Abstract Objective To evaluate the association between egg intake and cardiovascular disease risk among women and men in the United States, and to conduct a meta-analysis of prospective cohort studies. Design Prospective cohort study, and a systematic review and meta-analysis of prospective cohort studies. Setting Nurses’ Health Study (NHS, 1980-2012), NHS II (1991-2013), Health Professionals’ Follow-Up Study (HPFS, 1986-2012). Participants Cohort analyses included 83 349 women from NHS, 90 214 women from NHS II, and 42 055 men from HPFS who were free of cardiovascular disease, type 2 diabetes, and cancer at baseline. Main outcome measures Incident cardiovascular disease, which included non-fatal myocardial infarction, fatal coronary heart disease, and stroke. Results Over up to 32 years of follow-up (>5.54 million person years), 14 806 participants with incident cardiovascular disease were identified in the three cohorts. Participants with a higher egg intake had a higher body mass index, were less likely to be treated with statins, and consumed more red meats. Most people consumed between one and less than five eggs per week. In the pooled multivariable analysis, consumption of at least one egg per day was not associated with incident cardiovascular disease risk after adjustment for updated lifestyle and dietary factors associated with egg intake (hazard ratio for at least one egg per day v less than one egg per month 0.93, 95% confidence interval 0.82 to 1.05). In the updated meta-analysis of prospective cohort studies (33 risk estimates, 1 720 108 participants, 139 195 cardiovascular disease events), an increase of one egg per day was not associated with cardiovascular disease risk (pooled relative risk 0.98, 95% confidence interval 0.93 to 1.03, I 2 =62.3%). Results were similar for coronary heart disease (21 risk estimates, 1 411 261 participants, 59 713 coronary heart disease events; 0.96, 0.91 to 1.03, I 2 =38.2%), and stroke (22 risk estimates, 1 059 315 participants, 53 617 stroke events; 0.99, 0.91 to 1.07, I 2 =71.5%). In analyses stratified by geographical location (P for interaction=0.07), no association was found between egg consumption and cardiovascular disease risk among US cohorts (1.01, 0.96 to 1.06, I 2 =30.8%) or European cohorts (1.05, 0.92 to 1.19, I 2 =64.7%), but an inverse association was seen in Asian cohorts (0.92, 0.85 to 0.99, I 2 =44.8%). Conclusions Results from the three cohorts and from the updated meta-analysis show that moderate egg consumption (up to one egg per day) is not associated with cardiovascular disease risk overall, and is associated with potentially lower cardiovascular disease risk in Asian populations. Systematic review registration PROSPERO CRD42019129650.

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