EP1290 The possible role of cell polarity for cancer disease – the implication of cancer regression by human body axes interaction

2019 ◽  
Author(s):  
MC Ou ◽  
D Ou ◽  
CC Pang
Keyword(s):  
Cell Polarity ◽  
Human Body ◽  
Cancer Disease ◽  
Cancer Regression

Role of Vasavaleha in the management of Covid19

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 259-261
Author(s):  
Aamir Khan ◽  
Rajni K. Gurmule
Keyword(s):  
Immune System ◽  
Human Body ◽  
Respiratory Diseases ◽  
Spreading Rate ◽  
Host Immune System ◽  
Shortness Of Breath ◽  
Antitussive Effect ◽  
Corona Viruses ◽  
Very High

Vasavaleha is one of the best medicine given for respiratory diseases. Corona viruses typically affect the respiratory system, causing symptoms such as coughing, fever and shortness of breath. It also affects host immune system of human body. Spreading rate of this disease is very high. Whole world is seeking for the treatment which can uproots this diseases. There in no vaccine available till date against this pandemic disease. Ayurveda mainly focuses on prevention of diseases alongwith its total cure. Rajyakshma Vyadhi is MadhyamMarga Roga as per Ayurveda. It shows many symptoms such as Kasa, Shwasa etc. By overall view of Covid 19, shows its resemblance with Rajyakshma Vyadhi described in Ayurveda. Vasavaleha is a Kalpa which is described in Rogadhikara of Rajyakshma. It shows Kasahara, Shwashara properties. It consists of Vasa, Pipalli, Madhu and Goghrita. These components shows actions like bronchodilation, antitussive effect and many more other actions. Pipalli shows important Rasayana effect. So in present review, we have tried to focus on role of Vasavaleha in the management of Covid 19. This can be used as preventive as well as adjuvant medication in treating Covid 19. There is need of further clinical research to rule of exact action of Vasavaleha against Covid 19.

Studying structure of Coronaviridae, analyzing their geometry and focusing on the role of electronic applications in health awareness of viruses

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Eman Almuhur ◽  
Manal Al-Labadi ◽  
Amani Shatarah ◽  
Nazneen Khan ◽  
Raeesa Bashir
Keyword(s):  
Human Body ◽  
Design Methodology ◽  
Health Technology ◽  
Content Type ◽  
Mathematical Structures ◽  
Infected People ◽  
Movement Mechanism ◽  
Effective Role ◽  
Health Applications

Purpose This study aims to focus on electronic applications that have an effective role in raising the awareness of the dangers of viruses’ transmission from person-to-person and their positive and important impact on people’s lives. Design/methodology/approach The authors illustrated the effects of socializing with infected people on a human body by a model in geometry and how the prospected antibiotic annihilates the structure of the virus. The authors discussed vital operations inside the human body to expound the geometry of objects that are closed under their operations, such as viruses, especially Coronaviridae. Findings Also, the authors discussed some of the e-health applications in Jordan. As e-health activities, programs and applications have been given attention, the authors focused on potentials for constructing strategies that lead to create a featuring health technology. Originality/value Moreover, in this study, the authors explored the structure and geometry of Coronaviridae family, especially coronavirus that causes lots of diseases, and explained its movement mechanism using the mathematical structures.

scholarly journals The role of GPI-anchored proteins in chondrogenesis and cell polarity

2008 ◽  
Vol 319 (2) ◽  
pp. 482
Author(s):  
Molly J. Ahrens ◽  
Andrew T. Dudley
Keyword(s):  
Cell Polarity

Role of Cognitive Processes in Immuno-Modulation in Cancer Disease

1991 ◽  
pp. 417-422
Author(s):  
Kurt S. Zänker ◽  
Ronald M. Kroczek ◽  
Irene Hubertz ◽  
Volker Hodapp
Keyword(s):  
Cognitive Processes ◽  
Cancer Disease

scholarly journals Electrostatic plasma membrane targeting contributes to Dlg function in cell polarity and tumorigenesis

Development ◽  
2021 ◽  
pp. dev.196956
Author(s):  
Juan Lu ◽  
Wei Dong ◽  
Yan Tao ◽  
Yang Hong
Keyword(s):  
Plasma Membrane ◽  
Tumor Suppressor ◽  
Epithelial Cells ◽  
Cell Polarity ◽  
Significant Role ◽  
Discs Large ◽  
Cortical Localization ◽  
Polarity Proteins ◽  
Positively Charged

Discs large (Dlg) is an essential polarity protein and a tumor suppressor originally characterized in Drosophila but is also well conserved in vertebrates. Like the majority of polarity proteins, plasma membrane (PM)/cortical localization of Dlg is required for its function in polarity and tumorigenesis, but the exact mechanisms targeting Dlg to PM remain to be fully elucidated. Here we show that, similar to the recently discovered polybasic polarity proteins such as Lgl and aPKC, Dlg also contains a positively charged polybasic domain that electrostatically binds the PM phosphoinositides PI4P and PI(4,5)P2. Electrostatic targeting by the polybasic domain contributes significantly to the PM localization of Dlg in follicular and early embryonic epithelial cells, and is crucial for Dlg to regulate both polarity and tumorigenesis. The electrostatic PM targeting of Dlg is controlled by a potential phosphorylation-dependent allosteric regulation of its polybasic domain, and is specifically enhanced by the interactions between Dlg and another basolateral polarity protein and tumor suppressor Scrib. Our studies highlight an increasingly significant role of electrostatic PM targeting of polarity proteins in regulating cell polarity.

scholarly journals Understanding the mechanism of tumor regression

2021 ◽  
pp. 71-73
Author(s):  
А.В. Макрушин
Keyword(s):  
Human Body ◽  
Malignant Tumor ◽  
Seasonal Changes ◽  
Tumor Regression ◽  
Current Understanding ◽  
Tumor Destruction ◽  
Cancer Regression

В статье подвергается сомнению существующее представление о природе рака. Предлагается другое объяснение природы этой болезни. Механизм рака атавистический. Он возник у докембрийских Metazoa, которые были сидячими и колониальными. У них он обеспечивал приспособление к сезонному ухудшению среды. Готовящиеся к диапаузе растущие почки этих животных стали эволюционными предшественниками злокачественной опухоли. Разрушения в организме, происходящие у этих Metazoa при подготовке к диапаузе, стали эволюционными предшественниками разрушений в организме, происходящих при раке. Рассасывания готовящихся к диапаузе почек у них стало эволюционным предшественником регрессии опухоли. Регрессия опухоли - явление редкое и для изучения поэтому трудное. Исследовать его следует не у высоко организованных животных и не у человека, а у колониальных асцидий. Поняв, как работает у них механизм рассасывания готовящихся к диапаузе почек, легче будет понять механизм регрессии опухоли. У растений готовящиеся к покою почки тоже иногда разрушаются. Исследование этого процесса у растений тоже может помочь пониманию механизма регрессии опухоли. The current understanding of the nature of cancer is being questioned, and another explanation of the nature of this disease has been proposed. The mechanism of cancer is atavistic. It emerged in the Precambrian Metazoa, which were sedentary and colonized. This mechanism provided them with a means to adapt to seasonal changes in the environment. The developing kidneys of these animals preparing for diapause were the evolutionary precursors of a malignant tumor. The destruction that occurred in their kidneys when preparing for diapause was the evolutionary predecessor of the tumor destruction in the human body that occurs during cancer regression. Resorption of diapause-preparing kidneys was an evolutionary precursor to tumor regression. Tumor regression is rare and therefore difficult to study. Thus, this phenomenon should not be investigated in highly organized animals or in humans, but in colonized ascidians. Having understood how the mechanism of resorption of their kidneys functions when preparing for diapause, it will be easier to understand the mechanism of tumor regression. In plants, buds preparing for dormancy are sometimes also destroyed. Studying this process can similarly help decipher the mechanism of tumor regression.

scholarly journals Role of Sex Hormones at Different Physiobiological Conditions and Therapeutic Potential in MBD2 Mediated Severe Asthma

2021 ◽  
Vol 2021 ◽  
pp. 1-16
Author(s):  
Binaya Wasti ◽  
Zhifeng Chen ◽  
Yi Ke ◽  
Wen Tao Duan ◽  
Shao-Kun Liu ◽  
...  
Keyword(s):  
Severe Asthma ◽  
Sex Hormones ◽  
Human Body ◽  
Therapeutic Potential ◽  
Corticosteroid Treatment ◽  
Sex Hormone ◽  
Asthma Prevalence ◽  
Term Survival

Sex hormone has become a “hot topic” to evaluate the hormonal therapeutic potential in severe asthma. Th17 cell is one of the main influencing factors involved in the pathogenesis of severe asthma, hence also called as kernel of severe asthma, and Th17 subtype of non-T2 asthma is less responsive (resistance) to inhaled corticosteroid (ICS), so severe in nature. Methyl-CpG binding domain protein 2 (MBD2) is overexpressed and regulates the Th17 differentiation, showing the possibility of therapeutic target in treating Th17 mediated severe asthma. Sex hormone fluctuates at the different physiobiological conditions of the human body and affects the asthma pathobiology showing its role in asthma prevalence, severity, remission, and therapy. This review briefly overviews the sex hormones, their influence in asthma at the different physiobiological conditions of human body, and MBD2 severe asthma connection with the possible therapeutic potential of sex steroids in MBD2 mediated Th17 predominant severe asthma. Male sex hormone tends to show a beneficial effect and possibly downregulates the expression of Th17 cells via regulating MBD2 through a mechanism distinct from corticosteroid treatment and guides us towards discovery of new therapeutic agent, reduces the asthma-related complications, and promotes long-term survival by lowering the risk of therapy-resistant issues of old age severe asthma.

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