scholarly journals Understanding the mechanism of tumor regression

2021 ◽  
pp. 71-73
Author(s):  
А.В. Макрушин
Keyword(s):  
Human Body ◽  
Malignant Tumor ◽  
Seasonal Changes ◽  
Tumor Regression ◽  
Current Understanding ◽  
Tumor Destruction ◽  
Cancer Regression

В статье подвергается сомнению существующее представление о природе рака. Предлагается другое объяснение природы этой болезни. Механизм рака атавистический. Он возник у докембрийских Metazoa, которые были сидячими и колониальными. У них он обеспечивал приспособление к сезонному ухудшению среды. Готовящиеся к диапаузе растущие почки этих животных стали эволюционными предшественниками злокачественной опухоли. Разрушения в организме, происходящие у этих Metazoa при подготовке к диапаузе, стали эволюционными предшественниками разрушений в организме, происходящих при раке. Рассасывания готовящихся к диапаузе почек у них стало эволюционным предшественником регрессии опухоли. Регрессия опухоли - явление редкое и для изучения поэтому трудное. Исследовать его следует не у высоко организованных животных и не у человека, а у колониальных асцидий. Поняв, как работает у них механизм рассасывания готовящихся к диапаузе почек, легче будет понять механизм регрессии опухоли. У растений готовящиеся к покою почки тоже иногда разрушаются. Исследование этого процесса у растений тоже может помочь пониманию механизма регрессии опухоли. The current understanding of the nature of cancer is being questioned, and another explanation of the nature of this disease has been proposed. The mechanism of cancer is atavistic. It emerged in the Precambrian Metazoa, which were sedentary and colonized. This mechanism provided them with a means to adapt to seasonal changes in the environment. The developing kidneys of these animals preparing for diapause were the evolutionary precursors of a malignant tumor. The destruction that occurred in their kidneys when preparing for diapause was the evolutionary predecessor of the tumor destruction in the human body that occurs during cancer regression. Resorption of diapause-preparing kidneys was an evolutionary precursor to tumor regression. Tumor regression is rare and therefore difficult to study. Thus, this phenomenon should not be investigated in highly organized animals or in humans, but in colonized ascidians. Having understood how the mechanism of resorption of their kidneys functions when preparing for diapause, it will be easier to understand the mechanism of tumor regression. In plants, buds preparing for dormancy are sometimes also destroyed. Studying this process can similarly help decipher the mechanism of tumor regression.

Listening to the Musicking Body

2018 ◽  
pp. 417-436
Author(s):  
Youn Kim
Keyword(s):  
Human Body ◽  
Auditory Perception ◽  
The Body ◽  
Current Understanding ◽  
Historical Changes ◽  
The Past ◽  
Late Nineteenth ◽  
Shed Light

Listening is generally discussed in connection with auditory perception, with the ear as the primary perceptual organ. Recently, however, more comprehensive approaches are being emphasized along with the need to understand listening in the context of cultural and historical changes. This chapter investigates the plasticity of the idea of listening, both across disciplines and across historical contexts. By engaging with various discourses on seeing, hearing, and kinesthetics in the late nineteenth and early twentieth centuries, the present chapter examines how a holistic conceptualization of listening that goes beyond the ear and functions in the context of the whole human body emerged and argues how understanding the past can shed light on the current understanding of music and the body.

scholarly journals Histopathology of residual rectal carcinoma following preoperative radiochemotherapy

2004 ◽  
Vol 51 (2) ◽  
pp. 99-108 ◽  
Author(s):  
Marjan Micev ◽  
M. Micev-Cosic ◽  
Vera Todorovic ◽  
M. Krsmanovic ◽  
Zoran Krivokapic ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Rectal Carcinoma ◽  
Tumor Regression ◽  
Locally Advanced ◽  
Prospective Trial ◽  
Tumour Regression ◽  
Ki 67 ◽  
Free Survival ◽  
Regression Grade ◽  
Cancer Regression

Preoperative radiotherapy with (CRT) or without chemotherapy (RT) in the management of patients with locally advanced rectal carcinoma is increasingly accepted as therapeutic modality to reduce local recurrence and improve survival, decrease tumor size and/or stage, has less toxicity compared to postoperative therapy, improves sphincter preservation and the ability to perform a curative resection. In a brief review of literature we discussed the possible prognostic role of most important pathologic parameters and their clinical implications. At present, predictive value of tumor response to neoadjuvant therapy remains uncertain, whether evaluated as five-point histological tumor regression grade (TRG) or recently proposed three-point rectal cancer regression grade (RCRG). However, most reports emphasize reduced local reccurence rates and disease-free survival advantage in patients with complete tumour regression or tumour down-staging, occuring in up to 20% and 60% of cases, respectively. Patients with advanced post-treatment tumour stage (ypT3/4), positive lymph nodes (ypN1/2), vascular invasion, positive circumferential resection margin, clearance <2mm, or absence of tumor regression are shown to have poor clinical outcome. Among CRT-induced morphological features, only "fibrotic-type" stromal response with minimal inflammatory infiltrates and absence of surface ulceration are correlated to recurrence-free survival. Preliminary unpublished results of a pilot study from our multidisciplinary prospective trial relate to correlation of histopathologic parameters and morphologic changes to rectal cancer regression grade (RCRG). Therefore, we studied 22 consecutive patients, mean age 56 (range 23-69) years, with transmural cT3/4 stage and were subgrouped as follows: RCRG-1 (7 patients, 31,8%), RCRG-2 (9 patients, 40,9%) and RCRG-3 (6 patients, 27,2%). In addition, 14 patients (63%) showed tumour downstaging and only 1 patient (4,5%) nodal down-staging after ypTNM restaging. There was the predominance of fibrotic-type stroma (16 patients, 72,8%) versus fibro-inflammatory response (6 patients, 27,2%), frequent tumoral necrosis (13 patients, 59%) but infrequent surface ulceration (5 patients, 22,7%) and peritumoural eosinophylic infiltration as well as endocrine cell differentiation (4 patients, 18%). The second aim of our study was to investigate determinants of radiosensitivity, i.e. the relationship between proliferative activity indices (Ki- 67 and PCNA) as well as the induction of apoptosis (p53) and the tumour regression (RCRG) after neoadjuvant CRT. The interaction between Ki-67 and PCNA immunoexpression levels and the benefit of CRT was significant for Ki-67 (p = 0.03), but not for PCNA (p = 0.08) and p53 levels (p = 0.4). In a conclusion, high percentage of Ki-67-positive tumor cells in the preoperative biopsy predicts an decreased treatment response after preoperative CRT of rectal cancer. However, long-term follow-up and large studies are necessary to establish the value of regression grade and the need for its prediction by reliable biological markers.

RUTUCHARYA AN AYURVEDOKTA REGIMEN & ITS PRESENT-DAY IMPLICATION

2021 ◽  
Vol 9 (4) ◽  
pp. 848-855
Author(s):  
Yuvaraj Patil ◽  
Sachin S. Waghmare
Keyword(s):  
Circadian Rhythms ◽  
Human Body ◽  
Seasonal Changes ◽  
Environmental Changes ◽  
Biological Clock ◽  
Modern Science ◽  
Noncommunicable Diseases

World is suffering a huge crisis because of COVID 19 pandemic. Apart from this burden of noncommunicable diseases (NCD’s) is also too high. We get very good comprehensive measures in Ayurveda, which will protect our body from both Infective diseases & NCD’s. It is recently; Modern science has come to know about disturbance in circadian rhythms (biological clock) by means of faulty diet, untimely eating & performing tasks at wrong time’s causes many diseases. Ayurveda already knew that environmental changes in whole day have effects on our body and to synchronize with them they mentioned Dincharya. Apart from this they were also aware of ef- fects of seasonal changes on human body and to synchronize with them they have mentioned Rutucharya. Based on seasonal changes Aacharyas have classified six Rutu’s namely Shishira, Vasanta, Grishma, Varsha, Sharad and Hemant. According to their effects on body different Rutucharyas are told. At present Indian calendar seems to be slightly out of phase with seasons but with help of tropical phenomena like solstices, equinoxes with respect Uttarayan, Dakshinayan & seasonal markers mentioned in Samhitas we can mark exact seasons. Based on Ayur- vedic Siddhantas we can understand different Rutucharyas & can implicate them in our present routine. Keywords: Rutucharya, Seasonal Regimen, Lifestyle, Diet, Dakshinayan, Uttarayan.

scholarly journals A Multiscale Immuno-Oncology on-Chip System (MIOCS) establishes that collective T cell behaviors govern tumor regression

2021 ◽  
Author(s):  
Gustave Ronteix ◽  
Shreyansh Jain ◽  
Christelle Angely ◽  
Marine Cazaux ◽  
Roxana Khazen ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Tumor Regression ◽  
Checkpoint Inhibitors ◽  
Cell Activity ◽  
Spatiotemporal Resolution ◽  
Patient Response ◽  
Collective Behaviors ◽  
Cell Behaviors ◽  
Tumor Destruction

T cell-based tumor immunotherapies such as CAR T cells or immune checkpoint inhibitors harness the cytotoxic potential of T cells to promote tumor regression. However, patient response to immunotherapy remains heterogeneous, highlighting the need to better understand the rules governing a successful T cell attack. Here, we develop a microfluidic-based method to track the outcome of T cell activity on many individual cancer spheroids simultaneously, with a high spatiotemporal resolution. By combining these parallel measurements of T cell behaviors and tumor fate with probabilistic modeling, we establish that the first recruited T cells initiate a positive feedback loop leading to an accelerated effector accumulation on the spheroid. We also provide evidence that cooperation between T cells on the spheroid during the killing phase facilitates tumor destruction. We propose that tumor destruction does not simply reflect the sum of individual T cell activities but relies instead on collective behaviors promoting both T cell accumulation and function. The possibility to track many replicates of immune-tumor interactions with such a level of detail should help delineate the mechanisms and efficacy of various immunotherapeutic strategies.

scholarly journals Seasonal Changes of Number of Airborne Bacteria Dispersed from Human Body under the Fully Air-conditioned Operating Room

1985 ◽  
Vol 55 (9) ◽  
pp. 441-446
Author(s):  
Yasuko TAKAHASHI ◽  
Kiiko HAYASHI ◽  
Toyoki KUGIMIYA ◽  
Hiroyoshi KOBAYASHI ◽  
Masakazu TSUZUKI
Keyword(s):  
Operating Room ◽  
Human Body ◽  
Seasonal Changes ◽  
Airborne Bacteria
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