scholarly journals Life course socioeconomic position and DNA methylation age acceleration in mid-life

2021 ◽  
pp. jech-2020-215608
Author(s):  
Anitha George ◽  
Rebecca Hardy ◽  
Juan Castillo Fernandez ◽  
Yvonne Kelly ◽  
Jane Maddock
Keyword(s):  
Social Class ◽  
Life Course ◽  
Socioeconomic Position ◽  
First Generation ◽  
Second Generation ◽  
Social Disadvantage ◽  
Biological Ageing ◽  
Dna Methylation Age ◽  
Using Data ◽  
The Life Course

BackgroundAgeing biomarkers can help us better understand how well-established socioeconomic position (SEP) disparities in ageing occur. A promising new set of DNAm methylation (DNAm)-based ageing biomarkers indicate through their age acceleration (AA) measures if biological ageing is slower or faster than chronological ageing. Few studies have investigated the association between SEP and DNAm AA.MethodsWe used linear regression to examine the sex-adjusted relationships between childhood social class, adult social class, intergenerational social class change, education and adult household earnings with first (Horvath AA and Hannum AA) and second generation (PhenoAge AA and GrimAge AA) DNAm AA markers using data from the MRC National Survey of Health and Development.ResultsIn the first-generation biomarkers, there was little evidence of any associations with Horvath AA but associations of childhood social class and income with Hannum AA were observed. Strong associations were seen between greater disadvantage in childhood and adult SEP and greater AA in the second generation biomarkers. For example, those with fathers in an unskilled occupational social class in childhood had 3.6 years greater PhenoAge AA (95% CI 1.8 to 5.4) than those with fathers from a professional social class. Individuals without qualifications had higher AA compared with those with higher education (4.1 years greater GrimAge AA (95% CI 3.1 to 5.0)).ConclusionOur findings highlight the importance of exposure to social disadvantage in childhood to the biological ageing process. The second generation clocks appear to be more sensitive to the accumulation of social disadvantage across the life course.

scholarly journals Socioeconomic Position and DNA Methylation Age Acceleration Across the Life Course

2018 ◽  
Vol 187 (11) ◽  
pp. 2346-2354 ◽  
Author(s):  
Amanda Hughes ◽  
Melissa Smart ◽  
Tyler Gorrie-Stone ◽  
Eilis Hannon ◽  
Jonathan Mill ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Life Course ◽  
Socioeconomic Position ◽  
Dna Methylation Age ◽  
The Life Course

scholarly journals Associations of Successful Aging With Socioeconomic Position Across the Life-Course: The West of Scotland Twenty-07 Prospective Cohort Study

2016 ◽  
Vol 30 (1) ◽  
pp. 52-74 ◽  
Author(s):  
Elise Whitley ◽  
Michaela Benzeval ◽  
Frank Popham
Keyword(s):  
Life Course ◽  
Socioeconomic Position ◽  
Successful Aging ◽  
Strong Association ◽  
Later Life ◽  
Life Stages ◽  
The West ◽  
Men And Women ◽  
Using Data ◽  
The Life Course

Objective: The aim of this study is to investigate how socioeconomic position (SEP) is associated with multidimensional measures of successful aging (SA), and how this varies and accumulates across the life-course. Method: Using data from 1,733 Scottish men and women from two cohorts aged around 57 and 76, respectively, we explored associations of SA, based on the Rowe–Kahn model, with 10 measures of SEP measured in childhood and, distally and proximally, in adulthood. Results: Individual SEP associations with SA score were generally consistent across different indicators and life stages: Respondents with the most versus least favorable SEP had two additional positive SA dimensions. There was also a strong association between SA and cumulative SEP based on all 10 measures combined; respondents with the most versus least favorable lifelong SEP had four additional positive SA dimensions. Conclusion: SEP advantages/disadvantages act and accumulate across the life-course, resulting in widening socioeconomic inequalities in SA in later life.

scholarly journals Socioeconomic Position Across the Life Course and Stroke Risk at Older Ages

2006 ◽  
Vol 163 (suppl_11) ◽  
pp. S67-S67
Author(s):  
M.M Glymour ◽  
M Avendano ◽  
L.F Berkman
Keyword(s):  
Life Course ◽  
Socioeconomic Position ◽  
Stroke Risk ◽  
The Life Course

Associations of fibrinogen and C-reactive protein with prevalent and incident coronary heart disease are attenuated by adjustment for confounding factors

2005 ◽  
Vol 93 (05) ◽  
pp. 955-963 ◽  
Author(s):  
George Smith ◽  
Ann Rumley ◽  
Gordon Lowe ◽  
Shah Ebrahim ◽  
Debbie Lawlor
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Life Course ◽  
Socioeconomic Position ◽  
Cumulative Effect ◽  
Positive Association ◽  
Confounding Factors ◽  
Cross Sectional ◽  
Reactive Protein ◽  
The Life Course

SummaryA cross sectional and prospective analysis of 3,745 British women aged 60–79 years at baseline was undertaken. Among these women there were 570 prevalent cases of coronary heart disease (CHD) and 151 new cases among 12,641 person-years of follow up of women who were free of CHD at baseline. Both fibrinogen and CRP were associated with indicators of socioeconomic position in childhood and adulthood and there was a cumulative effect of socioeconomic position from across the life course. The age-adjusted odds ratio (95% confidence interval) of prevalent CHD for a 1 unit (1 g/L) increase in fibrinogen was 1.29 (1.12, 1.49); with full adjustment for all potential confounding factors this attenuated to 1.09 (0.93, 1.28). The hazards ratio for incident CHD among those free of disease at baseline was 1.28 (1.00, 1.64); with full adjustment for all potential confounding factors this attenuated to 1.09 (0.84, 1.44). Similar effects of adjustment for confounding factors were seen for the associations between CRP and both prevalent and incident CHD. By contrast, the strong positive association between smoking (an established causal risk factor for CHD) and CHD was not attenuated by adjustment for life course socioeconomic position or other risk factors. We conclude that fibrinogen and CRP predict CHD but may not be causally related to it.

scholarly journals Trajectories of Unsecured Debt across the Life Course and Mental Health at Midlife

2018 ◽  
Vol 10 (1) ◽  
pp. 61-79 ◽  
Author(s):  
Amy Ruining Sun ◽  
Jason N. Houle
Keyword(s):  
Mental Health ◽  
Depressive Symptoms ◽  
Life Course ◽  
Debt Accumulation ◽  
Unsecured Debt ◽  
Trajectory Models ◽  
Low Levels ◽  
Using Data ◽  
The Life Course ◽  
Substantial Heterogeneity

In this paper, we contribute to a growing literature on debt and mental health and ask whether patterns of unsecured debt accumulation and repayment over two decades are associated with depressive symptoms at age 50. Using data from the National Longitudinal Study of Youth 1979 Cohort and group trajectory models, we have three key findings. First, we find substantial heterogeneity in debt trajectories across the life course. Second, respondents who report consistently high debt levels across the life course or who cycle in and out of high debt report significantly more depressive symptoms than respondents who hold consistently low levels of debt. These findings hold for both absolute and relative (debt-to-income) debt. Third, we find that the association between debt and depressive symptoms is strongest among respondents with less than a college degree, but we find less evidence for heterogeneity by race in this cohort.

scholarly journals “They Live in Indifference Together”: Marriage Mobility in Zeeland, The Netherlands, 1796–1922

2005 ◽  
Vol 50 (S13) ◽  
pp. 247-274 ◽  
Author(s):  
Hilde Bras ◽  
Jan Kok
Keyword(s):  
Nineteenth Century ◽  
Social Class ◽  
The Netherlands ◽  
Life Course ◽  
Urban Areas ◽  
Personal Relationships ◽  
Mixed Marriage ◽  
Government Report ◽  
Logistic Regressions ◽  
The Life Course

This article investigates developments in and antecedents of socially mixed marriage in the rural Dutch province of Zeeland during the long nineteenth century, taking individual and family histories, community contexts, and temporal influences into account. A government report of the 1850s said of Zeeland that farmers and workers lived “in indifference together”. However, our analysis of about 163,000 marriage certificates reveals that 30 to 40 per cent of these rural inhabitants continued to marry outside their original social class. Multivariate logistic regressions show that heterogamous marriages can be explained first and foremost by the life-course experiences of grooms and brides prior to marriage. Previous transitions in their occupational careers (especially to non-rural occupations for grooms, and to service for brides), in their migration trajectories (particularly moves to urban areas), and changes in the sphere of personal relationships (entering widowhood, ageing) are crucial in understanding marriage mobility.

The Importance of School Attendance: Findings From the Cambridge Study in Delinquent Development on the Life-Course Effects of Truancy

2016 ◽  
Vol 63 (5) ◽  
pp. 592-612 ◽  
Author(s):  
Michael Rocque ◽  
Wesley G. Jennings ◽  
Alex R. Piquero ◽  
Turgut Ozkan ◽  
David P. Farrington
Keyword(s):  
Life Course ◽  
Problem Drinking ◽  
School Attendance ◽  
Later Life ◽  
School Dropout ◽  
Life Outcomes ◽  
Using Data ◽  
Childhood Risk Factors ◽  
The Life Course ◽  
The Relationship

School dropout has been extensively studied in the literature as a correlate of negative life outcomes. A precursor to school dropout is truancy, the unexcused or illegitimate student absence from school. Few studies have examined the relationship between truancy and involvement in crime and adjustment more generally over the life-course. This study extends previous work by exploring whether truancy at age 12 to 14 is related to later life outcomes such as crime, aggression, and adjustment using data from the Cambridge Study in Delinquent Development. Results indicate that truancy has long-lasting associations with negative life outcomes, especially for non-violent crime and problem drinking. Importantly, these findings hold for certain outcomes controlling for a comprehensive host of environmental and individual childhood risk factors.

Social class and inequality in later life

2020 ◽  
pp. 19-40
Author(s):  
Chris Gilleard ◽  
Paul Higgs
Keyword(s):  
Social Class ◽  
Life Course ◽  
Working Life ◽  
Later Life ◽  
Cumulative Advantage ◽  
Social Gerontology ◽  
The Life Course

This chapter begins with a consideration of models and theories concerning social class. It focuses upon the distinctions between relational and gradational models of class. It then explores how these different models seem to be articulated in later life and the model of cumulative advantage and disadvantage employed in much social gerontology. Following from such considerations, it explores both the connections and the disjunctions that exists between working and post working life. The chapter concludes with a consideration of how consumption and consumerism have grown in significance as markers of distinction and determinants of difference, not just in later life but throughout the life course.

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